{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:25:06Z","timestamp":1778282706432,"version":"3.51.4"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Hubei Natural Science Foundation of China","award":["2017CFB172"],"award-info":[{"award-number":["2017CFB172"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.gene.2017.11.001","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T20:31:01Z","timestamp":1509741061000},"page":"159-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The pathogenic gene screening in a Chinese familial dilated cardiomyopathy pedigree from Hubei"],"prefix":"10.1016","volume":"642","author":[{"given":"Yongnan","family":"Lyu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.gene.2017.11.001_bb0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ng815","article-title":"Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy","volume":"30","author":"B1","year":"2002","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.gene.2017.11.001_bb0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0735-1097(97)00433-6","article-title":"Familial dilated cardiomyopathy: cardiac abnormalities are common in asymptomatic relatives and may represent early disease","volume":"31","author":"Baig","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"issue":"14","key":"10.1016\/j.gene.2017.11.001_bb0015","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1212\/WNL.0b013e3182a6ca62","article-title":"Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy","volume":"81","author":"Ceyhan-Birsoy","year":"2013","journal-title":"J. Neurol."},{"key":"10.1016\/j.gene.2017.11.001_bb0020","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/HCO.0b013e328337ba52","article-title":"The genetics of dilated cardiomyopathy","volume":"25","author":"Dellefave","year":"2010","journal-title":"J. Curr. Opin. Cardiol."},{"issue":"11","key":"10.1016\/j.gene.2017.11.001_bb0025","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.hlc.2011.07.008","article-title":"Guidelines for the diagnosis and management of familial dilated cardiomyopathy","volume":"20","author":"Fatkin","year":"2011","journal-title":"J. Heart Lung Circ."},{"issue":"9293","key":"10.1016\/j.gene.2017.11.001_bb0030","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(01)06657-0","article-title":"Cardiomyopathies: from genetics to the prospect of treatment","volume":"358","author":"Franz","year":"2001","journal-title":"J. Lancet"},{"issue":"6","key":"10.1016\/j.gene.2017.11.001_bb0035","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00109-006-0060-6","article-title":"Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy","volume":"84","author":"Gerull","year":"2006","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.gene.2017.11.001_bb0040","first-page":"753675","article-title":"Titin diversity-alternative splicing gone wild","author":"Guo","year":"2010","journal-title":"J Biomed Biotechnol"},{"issue":"1","key":"10.1016\/j.gene.2017.11.001_bb0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/gim.2014.147","article-title":"A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment","volume":"17","author":"Hampel","year":"2015","journal-title":"J. Genet. Med."},{"issue":"7","key":"10.1016\/j.gene.2017.11.001_bb0050","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1056\/NEJMoa1110186","article-title":"Truncations of titin causing dilated cardiomyopathy","volume":"366","author":"Herman","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"16","key":"10.1016\/j.gene.2017.11.001_bb0055","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.jacc.2011.01.015","article-title":"Update 2011: clinical and genetic issues in familial dilated cardiomyopathy","volume":"57","author":"Hershberger","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.gene.2017.11.001_bb0060","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/GIM.0b013e3181f2481f","article-title":"Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals","volume":"12","author":"Hershberger","year":"2010","journal-title":"J. Genet. Med."},{"issue":"9","key":"10.1016\/j.gene.2017.11.001_bb0065","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/oxfordjournals.eurheartj.a059803","article-title":"Factors predicting mortality in idiopathic dilated cardiomyopathy","volume":"11","author":"Komajda","year":"1990","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.gene.2017.11.001_bb0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI62862","article-title":"Genetic mutations and mechanisms in dilated cardiomyopathy","volume":"123","author":"Mcnally","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.gene.2017.11.001_bb0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0735-1097(99)00172-2","article-title":"Familial dilated cardiomyopathy: evidence for genetic and phenotypic heterogeneity","volume":"34","author":"Mestroni","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.gene.2017.11.001_bb0080","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199201093260201","article-title":"The frequency of familial dilated cardio-myopathy in a series of patients with idiopathic dilated cardiomyopathy","volume":"326","author":"Michels","year":"1992","journal-title":"N. Engl. J. Med."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811191730937X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811191730937X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T13:27:42Z","timestamp":1541424462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811191730937X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":16,"alternative-id":["S037811191730937X"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2017.11.001","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pathogenic gene screening in a Chinese familial dilated cardiomyopathy pedigree from Hubei","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2017.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}