{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:11:41Z","timestamp":1768461101798,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.gene.2018.01.021","type":"journal-article","created":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T04:30:27Z","timestamp":1515213027000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["The association of polymorphic variants, rs2267788, rs1333049 and rs2383207 with coronary artery disease, its severity and presentation in North Indian population"],"prefix":"10.1016","volume":"648","author":[{"given":"Shiridhar","family":"Kashyap","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-5265","authenticated-orcid":false,"given":"Sudeep","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durga P.","family":"Misra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohit K.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2018.01.021_bb0005","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0735-1097(03)00187-6","article-title":"Preventing myocardial infarction in the young adult in the first place: how do the National Cholesterol Education Panel III guidelines perform?","volume":"41","author":"Akosah","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.gene.2018.01.021_bb0010","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.atherosclerosis.2009.09.077","article-title":"The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles","volume":"209","author":"Arai","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.gene.2018.01.021_bb0015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/dna.2010.1046","article-title":"Haplotypes on 9p21 modify the risk for coronary artery disease among Indians","volume":"30","author":"Ashok Kumar","year":"2011","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.gene.2018.01.021_bb0020","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.arcmed.2011.09.003","article-title":"Variant on 9p21 is strongly associated with coronary artery disease but lacks association with myocardial infarction and disease severity in a population in western India","volume":"42","author":"Bhanushali","year":"2011","journal-title":"Arch. Med. Res."},{"issue":"6","key":"10.1016\/j.gene.2018.01.021_bb0025","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/hmg\/ddm352","article-title":"Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p","volume":"17","author":"Broadbent","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.gene.2018.01.021_bb0030","article-title":"The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis","volume":"9","author":"Chen","year":"2009","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.gene.2018.01.021_bb0035","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s11033-008-9259-7","article-title":"A common variation chromosome 9p21 affects the risk of early-onset coronary artery disease","volume":"36","author":"Chen","year":"2009","journal-title":"Mol. Biol. Rep."},{"issue":"26","key":"10.1016\/j.gene.2018.01.021_bb0045","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1056\/NEJMoa0902604","article-title":"Genetic variants associated with Lp(a) lipoprotein level and coronary disease","volume":"361","author":"Clarke","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.gene.2018.01.021_bb0050","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jacc.2014.03.050","article-title":"A functional variant in APOA5\/A4\/C3\/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency","volume":"64","author":"Cui","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.gene.2018.01.021_bb0055","doi-asserted-by":"crossref","first-page":"346","DOI":"10.4103\/1735-1995.158252","article-title":"The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population","volume":"20","author":"El-Menyar","year":"2015","journal-title":"J. Res. Med. Sci."},{"issue":"6","key":"10.1016\/j.gene.2018.01.021_bb0060","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00439-002-0825-0","article-title":"Association found between the promoter region polymorphism in the apolipoprotein A\u2013V gene and the serum triglyceride level in Japanese schoolchildren","volume":"111","author":"Endo","year":"2002","journal-title":"Hum. Genet."},{"issue":"3","key":"10.1016\/j.gene.2018.01.021_bb0065","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ng.307","article-title":"New susceptibility locus for coronary artery disease on chromosome 3q22.3","volume":"41","author":"Erdmann","year":"2009","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.gene.2018.01.021_bb0070","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/eurheartj\/ehq405","article-title":"Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23","volume":"32","author":"Erdmann","year":"2011","journal-title":"Eur. Heart J."},{"issue":"1\u20132","key":"10.1016\/j.gene.2018.01.021_bb0075","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.clinbiochem.2012.09.007","article-title":"The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research","volume":"46","author":"Garelnabi","year":"2013","journal-title":"Clin. Biochem."},{"issue":"6494","key":"10.1016\/j.gene.2018.01.021_bb0080","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/371257a0","article-title":"p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest","volume":"371","author":"Hannon","year":"1994","journal-title":"Nature"},{"issue":"5830","key":"10.1016\/j.gene.2018.01.021_bb0085","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1142842","article-title":"A common variant on chromosome 9p21 affects the risk of myocardial infarction","volume":"316","author":"Helgadottir","year":"2007","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.gene.2018.01.021_bb0090","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1161\/01.ATV.0000133605.89421.79","article-title":"Smad expression in human atherosclerotic lesions: evidence for impaired TGF-beta\/Smad signaling in smooth muscle cells of fibrofatty lesions","volume":"24","author":"Kalinina","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.gene.2018.01.021_bb0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.75","article-title":"Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans","volume":"40","author":"Kathiresan","year":"2008","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.gene.2018.01.021_bb0100","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1001\/jama.290.7.898","article-title":"Prevalence of conventional risk factors in patients with coronary heart disease","volume":"290","author":"Khot","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.gene.2018.01.021_bb0105","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1194\/jlr.M400192-JLR200","article-title":"Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study","volume":"45","author":"Lai","year":"2004","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.gene.2018.01.021_bb0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/01.mol.0000162320.54795.68","article-title":"The APOA1\/C3\/A4\/A5 gene cluster, lipid metabolism and cardiovascular disease risk","volume":"16","author":"Lai","year":"2005","journal-title":"Curr. Opin. Lipidol."},{"issue":"9","key":"10.1016\/j.gene.2018.01.021_bb0115","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1161\/ATVBAHA.107.141291","article-title":"A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease","volume":"27","author":"Luke","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"15","key":"10.1016\/j.gene.2018.01.021_bb0120","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1056\/NEJM199404143301503","article-title":"Genetic susceptibility to death from coronary heart disease in a study of twins","volume":"330","author":"Marenberg","year":"1994","journal-title":"N. Engl. J. Med."},{"issue":"5830","key":"10.1016\/j.gene.2018.01.021_bb0125","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1142447","article-title":"A common allele on chromosome 9 associated with coronary heart disease","volume":"316","author":"McPherson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.gene.2018.01.021_bb0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0021-9150(02)00252-6","article-title":"The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese","volume":"165","author":"Nabika","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.gene.2018.01.021_bb0135","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1515\/CCLM.2010.070","article-title":"The polymorphisms \u22121131T>C and the S19W of the APOA5 gene are not associated with coronary artery disease in a Brazilian population","volume":"48","author":"Prochaska","year":"2010","journal-title":"Clin. Chem. Lab. Med."},{"issue":"9763","key":"10.1016\/j.gene.2018.01.021_bb0140","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(10)61996-4","article-title":"Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies","volume":"377","author":"Reilly","year":"2011","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.gene.2018.01.021_bb0145","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa072366","article-title":"Genomewide association analysis of coronary artery disease","volume":"357","author":"Samani","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2018.01.021_bb0150","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1476-511X-13-74","article-title":"LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography","volume":"13","author":"Santos","year":"2014","journal-title":"Lipids Health Dis."},{"issue":"13","key":"10.1016\/j.gene.2018.01.021_bb0155","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCULATIONAHA.107.730614","article-title":"Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease","volume":"117","author":"Schunkert","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2018.01.021_bb0160","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng.784","article-title":"Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease","volume":"43","author":"Schunkert","year":"2011","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.gene.2018.01.021_bb0165","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1161\/01.ATV.0000226543.77214.e4","article-title":"Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction","volume":"26","author":"Shiffman","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.gene.2018.01.021_bb0170","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1086\/491674","article-title":"Identification of four gene variants associated with myocardial infarction","volume":"7","author":"Shiffman","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"7","key":"10.1016\/j.gene.2018.01.021_bb0175","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2310\/JIM.0b013e3182686918","article-title":"Mutation screening of the APOA5 gene in subjects with coronary artery disease","volume":"60","author":"Soufi","year":"2012","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.gene.2018.01.021_bb0180","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1093\/hmg\/11.24.3039","article-title":"Relative contribution of variation within the APOC3\/A4\/A5 gene cluster in determining plasma triglycerides","volume":"11","author":"Talmud","year":"2002","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.gene.2018.01.021_bb0185","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1161\/CIRCULATIONAHA.105.171600","article-title":"Heart disease and stroke statistics\u20142006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"113","author":"Thom","year":"2006","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.gene.2018.01.021_bb0190","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ng.314","article-title":"Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease","volume":"41","author":"Tr\u00e9gou\u00ebt","year":"2009","journal-title":"Nat. Genet."},{"issue":"7287","key":"10.1016\/j.gene.2018.01.021_bb0195","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature08801","article-title":"Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice","volume":"464","author":"Visel","year":"2010","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.gene.2018.01.021_bb0200","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ncpcardio1326","article-title":"APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia","volume":"5","author":"Wang","year":"2008","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"issue":"11","key":"10.1016\/j.gene.2018.01.021_bb0205","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1534\/g3.116.034702","article-title":"Effect of two lipoprotein (a)-associated genetic variants on plasminogen levels and fibrinolysis","volume":"6","author":"Wang","year":"2016","journal-title":"G3 (Bethesda)"},{"issue":"4","key":"10.1016\/j.gene.2018.01.021_bb0210","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/CIRCGENETICS.110.958728","article-title":"A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease","volume":"4","author":"Wild","year":"2011","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.gene.2018.01.021_bb0215","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2018.01.021_bb0220","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jacc.2007.11.087","article-title":"Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study","volume":"52","author":"Ye","year":"2008","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918300283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918300283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:26:14Z","timestamp":1693398374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918300283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":43,"alternative-id":["S0378111918300283"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.01.021","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association of polymorphic variants, rs2267788, rs1333049 and rs2383207 with coronary artery disease, its severity and presentation in North Indian population","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}