{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:17:17Z","timestamp":1757452637630},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700806","81670820"],"award-info":[{"award-number":["81700806","81670820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["17ZR1404400"],"award-info":[{"award-number":["17ZR1404400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.gene.2018.02.016","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T15:31:44Z","timestamp":1518103904000},"page":"10-13","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Evaluating the association between calpastatin (CAST) gene and keratoconus in the Han Chinese population"],"prefix":"10.1016","volume":"653","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2018.02.016_bb0005","doi-asserted-by":"crossref","first-page":"641708","DOI":"10.1155\/2014\/641708","article-title":"Genetics of keratoconus: where do we stand?","volume":"2014","author":"Abu-Amero","year":"2014","journal-title":"J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.gene.2018.02.016_bb0010","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00003226-199601000-00016","article-title":"Keratoconus in two pairs of identical twins","volume":"15","author":"Bechara","year":"1996","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.gene.2018.02.016_bb0015","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/cxo.12024","article-title":"Insights into keratoconus from a genetic perspective","volume":"96","author":"Burdon","year":"2013","journal-title":"Clin. Exp. Optom."},{"issue":"1","key":"10.1016\/j.gene.2018.02.016_bb0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00003226-200201000-00009","article-title":"Ocular surface changes in pterygium","volume":"21","author":"Chan","year":"2002","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.gene.2018.02.016_bb0025","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","author":"Consortium","year":"2013","journal-title":"Nat. Genet."},{"issue":"17","key":"10.1016\/j.gene.2018.02.016_bb0030","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1093\/hmg\/ddv211","article-title":"WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness","volume":"24","author":"Cuellar-Partida","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.gene.2018.02.016_bb0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ejhg.2011.203","article-title":"Novel mutation and three other sequence variants segregating with phenotype at keratoconus 13q32 susceptibility locus","volume":"20","author":"Czugala","year":"2012","journal-title":"Eur. J. Hum. Genet."},{"issue":"11","key":"10.1016\/j.gene.2018.02.016_bb0040","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/ejhg.2015.28","article-title":"Validation of rs2956540:G>C and rs3735520:G>A association with keratoconus in a population of European descent","volume":"23","author":"Dudakova","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.gene.2018.02.016_bb0045","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.eye.6700652","article-title":"Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients","volume":"18","author":"Georgiou","year":"2004","journal-title":"Eye"},{"issue":"2","key":"10.1016\/j.gene.2018.02.016_bb0050","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/13816810.2015.1005317","article-title":"Evaluating the association between keratoconus and reported genetic loci in a Han Chinese population","volume":"36","author":"Hao","year":"2015","journal-title":"Ophthalmic Genet."},{"issue":"5","key":"10.1016\/j.gene.2018.02.016_bb0055","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ajo.2009.06.024","article-title":"Prevalence and associations of keratoconus in rural maharashtra in central India: the central India eye and medical study","volume":"148","author":"Jonas","year":"2009","journal-title":"Am J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.gene.2018.02.016_bb0060","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/ICO.0b013e31820cd61d","article-title":"Review: keratoconus in Asia","volume":"31","author":"Kok","year":"2012","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.gene.2018.02.016_bb0065","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/hmg\/ddr460","article-title":"A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries","volume":"21","author":"Li","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.gene.2018.02.016_bb0070","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/ICO.0b013e3182821c1c","article-title":"An association between the calpastatin (CAST) gene and keratoconus","volume":"32","author":"Li","year":"2013","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.gene.2018.02.016_bb0075","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ng.2506","article-title":"Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus","volume":"45","author":"Lu","year":"2013","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.gene.2018.02.016_bb0080","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ng.3603","article-title":"Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus","volume":"48","author":"Morris","year":"2016","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.gene.2018.02.016_bb0085","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/13816810.2013.843712","article-title":"Polymorphism analysis of VSX1 and SOD1 genes in Greek patients with keratoconus","volume":"36","author":"Moschos","year":"2015","journal-title":"Ophthalmic Genet."},{"issue":"4","key":"10.1016\/j.gene.2018.02.016_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000888","article-title":"Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS","volume":"6","author":"Nicolae","year":"2010","journal-title":"PLoS Genet."},{"issue":"4","key":"10.1016\/j.gene.2018.02.016_bb0095","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"Rabinowitz","year":"1998","journal-title":"Surv. Ophthalmol."},{"issue":"4","key":"10.1016\/j.gene.2018.02.016_bb0100","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00003226-199207000-00005","article-title":"Molecular genetic analysis in autosomal dominant keratoconus","volume":"11","author":"Rabinowitz","year":"1992","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.gene.2018.02.016_bb0105","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3109\/13816810.2012.743569","article-title":"Common single nucleotide polymorphisms and keratoconus in the Han Chinese population","volume":"34","author":"Wang","year":"2013","journal-title":"Ophthalmic Genet."},{"issue":"5","key":"10.1016\/j.gene.2018.02.016_bb0110","first-page":"630","article-title":"Association of interleukin-1 gene single nucleotide polymorphisms with keratoconus in Chinese Han population","volume":"41","author":"Wang","year":"2016","journal-title":"Curr. Eye Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918301458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918301458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T02:00:08Z","timestamp":1535076008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918301458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":22,"alternative-id":["S0378111918301458"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.02.016","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the association between calpastatin (CAST) gene and keratoconus in the Han Chinese population","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}