{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:08:49Z","timestamp":1790752129181,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008062","name":"Alicia Koplowitz Foundation","doi-asserted-by":"publisher","award":["GR15012"],"award-info":[{"award-number":["GR15012"]}],"id":[{"id":"10.13039\/100008062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.gene.2018.02.035","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T18:18:53Z","timestamp":1518718733000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Effect of dopamine receptor D4 ( DRD4 ) haplotypes on general psychopathology in patients with eating disorders"],"prefix":"10.1016","volume":"654","author":[{"given":"Guillermo","family":"Gervasini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz M.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gamero-Villarroel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Mota-Zamorano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isalud","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angustias","family":"Garc\u00eda-Herr\u00e1iz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.gene.2018.02.035_bb0005","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0026-895X(25)09692-0","article-title":"Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes","volume":"46","author":"Asghari","year":"1994","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.gene.2018.02.035_bb0010","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1046\/j.1471-4159.1995.65031157.x","article-title":"Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants","volume":"65","author":"Asghari","year":"1995","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.gene.2018.02.035_bb0015","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/ajmg.b.30505","article-title":"Anorexia nervosa, perfectionism, and dopamine D4 receptor (DRD4)","volume":"144B","author":"Bachner-Melman","year":"2007","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"1","key":"10.1016\/j.gene.2018.02.035_bb0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/1096-8628(20010108)105:1<84::AID-AJMG1068>3.0.CO;2-Q","article-title":"5\u2032-untranslated region of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder","volume":"105","author":"Barr","year":"2001","journal-title":"Am. J. Med. Genet."},{"issue":"1","key":"10.1016\/j.gene.2018.02.035_bb0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pbb.2010.04.016","article-title":"Dopamine and binge eating behaviors","volume":"97","author":"Bello","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2\u20133","key":"10.1016\/j.gene.2018.02.035_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1017\/S0140525X10000592","article-title":"The rocky road from Axis I to Axis II: extending the network model of diagnostic comorbidity to personality pathology","volume":"33","author":"Bornstein","year":"2010","journal-title":"Behav. Brain Sci."},{"issue":"7","key":"10.1016\/j.gene.2018.02.035_bb0035","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.cpr.2005.04.012","article-title":"Personality and eating disorders: a decade in review","volume":"25","author":"Cassin","year":"2005","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.gene.2018.02.035_bb0040","series-title":"SCL-90-R: Administration, Scoring and Procedures Manual","author":"Derogaitis","year":"1977"},{"key":"10.1016\/j.gene.2018.02.035_bb0045","series-title":"SCL-90R: Cuestionario de 90 s\u00edntomas","author":"Derogaitis","year":"2002"},{"key":"10.1016\/j.gene.2018.02.035_bb0050","series-title":"Functional Genetic Polymorphisms in Serotonin and Dopamine Gene Systems and Their Significance in Behavioural Disorders","first-page":"73","volume":"172","author":"Dsouza","year":"2008"},{"issue":"9","key":"10.1016\/j.gene.2018.02.035_bb0055","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.biopsych.2004.08.008","article-title":"Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene","volume":"56","author":"D'Souza","year":"2004","journal-title":"Biol. Psychiatry"},{"issue":"12","key":"10.1016\/j.gene.2018.02.035_bb0060","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.jnutbio.2015.07.030","article-title":"DRD4 and SLC6A3 gene polymorphisms are associated with food intake and nutritional status in children in early stages of development","volume":"26","author":"Fontana","year":"2015","journal-title":"J. Nutr. Biochem."},{"issue":"8","key":"10.1016\/j.gene.2018.02.035_bb0065","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00787-013-0495-6","article-title":"BDNF genetic variability modulates psychopathological symptoms in patients with eating disorders","volume":"23","author":"Gamero-Villarroel","year":"2014","journal-title":"Eur. Child Adolesc. Psychiatry"},{"issue":"3","key":"10.1016\/j.gene.2018.02.035_bb0070","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/tpj.2014.53","article-title":"Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders","volume":"15","author":"Gamero-Villarroel","year":"2015","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.gene.2018.02.035_bb0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1744-9081-2-24","article-title":"Number of risk genotypes is a risk factor for major depressive disorder: a case control study","volume":"2","author":"Garriock","year":"2006","journal-title":"Behav. Brain Funct."},{"issue":"6","key":"10.1016\/j.gene.2018.02.035_bb0080","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.comppsych.2013.03.006","article-title":"Personality subtypes in adolescents with anorexia nervosa","volume":"54","author":"Gazzillo","year":"2013","journal-title":"Compr. Psychiatry"},{"issue":"5","key":"10.1016\/j.gene.2018.02.035_bb0085","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1086\/301595","article-title":"D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects","volume":"61","author":"Gelernter","year":"1997","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.gene.2018.02.035_bb0090","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/JCP.0b013e3182970469","article-title":"Influence of dopamine polymorphisms on the risk for anorexia nervosa and associated psychopathological features","volume":"33","author":"Gervasini","year":"2013","journal-title":"J. Clin. Psychopharmacol."},{"issue":"5","key":"10.1016\/j.gene.2018.02.035_bb0095","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/bioinformatics\/btm025","article-title":"SNPassoc: an R package to perform whole genome association studies","volume":"23","author":"Gonzalez","year":"2007","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.gene.2018.02.035_bb0100","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/YPG.0b013e32831219b6","article-title":"Trajectories of depressive symptoms, dopamine D2 and D4 receptors, family socioeconomic status and social support in adolescence and young adulthood","volume":"19","author":"Guo","year":"2009","journal-title":"Psychiatr. Genet."},{"issue":"3","key":"10.1016\/j.gene.2018.02.035_bb0105","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/humu.20282","article-title":"DRD4 gene variant associated with body mass: the National Longitudinal study of adolescent health","volume":"27","author":"Guo","year":"2006","journal-title":"Hum. Mutat."},{"issue":"6","key":"10.1016\/j.gene.2018.02.035_bb0110","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<594::AID-AJMG2>3.0.CO;2-F","article-title":"No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity","volume":"88","author":"Hinney","year":"1999","journal-title":"Am. J. Med. Genet."},{"issue":"2","key":"10.1016\/j.gene.2018.02.035_bb0115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1017\/S0033291701003129","article-title":"Individual-specific risk factors for anorexia nervosa: a pilot study using a discordant sister-pair design","volume":"31","author":"Karwautz","year":"2001","journal-title":"Psychol. Med."},{"issue":"13","key":"10.1016\/j.gene.2018.02.035_bb0120","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1021\/bi992354c","article-title":"Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes","volume":"39","author":"Kazmi","year":"2000","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.gene.2018.02.035_bb0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2199-7-18","article-title":"No direct effect of the -521 C\/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity","volume":"7","author":"Kereszturi","year":"2006","journal-title":"BMC Mol. Biol."},{"issue":"2","key":"10.1016\/j.gene.2018.02.035_bb0130","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ajmg.b.30444","article-title":"Association between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: genetic and molecular analyses","volume":"144B","author":"Kereszturi","year":"2007","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"5\u20136","key":"10.1016\/j.gene.2018.02.035_bb0135","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/FBP.0b013e328357e115","article-title":"Dopamine in anorexia nervosa: a systematic review","volume":"23","author":"Kontis","year":"2012","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.gene.2018.02.035_bb0140","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainres.2010.08.064","article-title":"Association study of polymorphisms in the promoter region of DRD4 with schizophrenia, depression, and heroin addiction","volume":"1359","author":"Lai","year":"2010","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.gene.2018.02.035_bb0145","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/hmg\/2.6.767","article-title":"A hypervariable segment in the human dopamine receptor D4 (DRD4) gene","volume":"2","author":"Lichter","year":"1993","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.gene.2018.02.035_bb0150","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40519-016-0345-x","article-title":"The comorbidity of personality disorders in eating disorders: a meta-analysis","volume":"22","author":"Martinussen","year":"2017","journal-title":"Eat. Weight Disord."},{"issue":"5","key":"10.1016\/j.gene.2018.02.035_bb0155","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/sj.mp.4000770","article-title":"Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD)","volume":"5","author":"McCracken","year":"2000","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.gene.2018.02.035_bb0160","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000120623","article-title":"Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients","volume":"56","author":"Mercader","year":"2007","journal-title":"Neuropsychobiology"},{"issue":"3","key":"10.1016\/j.gene.2018.02.035_bb0165","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.psychres.2009.03.011","article-title":"Symptoms of psychosis in anorexia and bulimia nervosa","volume":"175","author":"Miotto","year":"2010","journal-title":"Psychiatry Res."},{"issue":"6","key":"10.1016\/j.gene.2018.02.035_bb0170","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s100380050191","article-title":"Novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) gene","volume":"44","author":"Mitsuyasu","year":"1999","journal-title":"J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.gene.2018.02.035_bb0175","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.biopsych.2007.04.006","article-title":"Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data","volume":"63","author":"Munafo","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.gene.2018.02.035_bb0180","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1744-9081-6-4","article-title":"Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients","volume":"6","author":"Nemoda","year":"2010","journal-title":"Behav. Brain Funct."},{"issue":"2","key":"10.1016\/j.gene.2018.02.035_bb0185","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/bbrc.1999.0630","article-title":"A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia","volume":"258","author":"Okuyama","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.gene.2018.02.035_bb0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/sj.mp.4000563","article-title":"Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait","volume":"5","author":"Okuyama","year":"2000","journal-title":"Mol. Psychiatry"},{"issue":"5","key":"10.1016\/j.gene.2018.02.035_bb0195","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1037\/abn0000225","article-title":"Associations of borderline personality disorder traits with stressful events and emotional reactivity in women with bulimia nervosa","volume":"126","author":"Pearson","year":"2017","journal-title":"J. Abnorm. Psychol."},{"issue":"4","key":"10.1016\/j.gene.2018.02.035_bb0200","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/scan\/nst001","article-title":"DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety","volume":"9","author":"Perez-Edgar","year":"2014","journal-title":"Soc. Cogn. Affect. Neurosci."},{"issue":"2","key":"10.1016\/j.gene.2018.02.035_bb0205","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03339991","article-title":"D4 dopamine receptor gene exon III polymorphism and obesity risk","volume":"3","author":"Poston","year":"1998","journal-title":"Eat. Weight Disord."},{"issue":"12","key":"10.1016\/j.gene.2018.02.035_bb0210","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/eat.22606","article-title":"Impulsivity-related traits distinguish women with co-occurring bulimia nervosa in a psychiatric sample","volume":"49","author":"Reas","year":"2016","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.gene.2018.02.035_bb0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13034-016-0111-x","article-title":"Psychometric properties of the symptom checklist-90 in adolescent psychiatric inpatients and age- and gender-matched community youth","volume":"10","author":"Rytila-Manninen","year":"2016","journal-title":"J. Child Adolesc. Psychiatr. Ment. Health Nurs."},{"issue":"6","key":"10.1016\/j.gene.2018.02.035_bb0220","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.tpj.6500208","article-title":"The human dopamine D4 receptor repeat sequences modulate expression","volume":"3","author":"Schoots","year":"2003","journal-title":"Pharmacogenomics J."},{"issue":"6","key":"10.1016\/j.gene.2018.02.035_bb0225","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<705::AID-AJMG22>3.0.CO;2-F","article-title":"Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4)","volume":"88","author":"Seaman","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.gene.2018.02.035_bb0230","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pnpbp.2012.10.023","article-title":"DRD4 gene and obsessive compulsive disorder: do symptom dimensions have specific genetic correlates?","volume":"41","author":"Taj","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Bol. Psychiatry."},{"key":"10.1016\/j.gene.2018.02.035_bb0235","series-title":"Data Describing the Effect of DRD4 Promoter Polymorphisms on Promoter Activity","first-page":"1112","volume":"7","author":"Tei","year":"2016"},{"issue":"1","key":"10.1016\/j.gene.2018.02.035_bb0240","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pnpbp.2012.05.019","article-title":"Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology","volume":"39","author":"Thaler","year":"2012","journal-title":"Prog Neuropsychopharmacol Bol Psychiatry"},{"issue":"1","key":"10.1016\/j.gene.2018.02.035_bb0245","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.psychres.2012.11.028","article-title":"Epistatic interaction between 5HTTLPR and TPH2 polymorphisms predicts novelty seeking in women with bulimia nervosa spectrum disorders","volume":"208","author":"Thaler","year":"2013","journal-title":"Psychiatry Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918301719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918301719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T21:37:52Z","timestamp":1751405872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918301719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":49,"alternative-id":["S0378111918301719"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.02.035","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of dopamine receptor D4 (DRD4) haplotypes on general psychopathology in patients with eating disorders","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.02.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}