{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:18:39Z","timestamp":1790162319093,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSF","award":["CHE-1412920"],"award-info":[{"award-number":["CHE-1412920"]}]},{"name":"NSF","award":["1058719"],"award-info":[{"award-number":["1058719"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.gene.2018.02.063","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T22:46:04Z","timestamp":1520289964000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs"],"prefix":"10.1016","volume":"656","author":[{"given":"Noel-Marie","family":"Plonski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9395-8220","authenticated-orcid":false,"given":"Bianca","family":"Bissoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madara Hetti","family":"Arachchilage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Romstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar E.","family":"Kooijman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1844-864X","authenticated-orcid":false,"given":"Helen","family":"Piontkivska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2018.02.063_bb0005","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0010","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gku989","article-title":"UniProt: a hub for protein information","volume":"43","author":"Bateman","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0015","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.ijpara.2007.04.003","article-title":"Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies","volume":"37","author":"Bates","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0020","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/jpy.12334","article-title":"The diversity of algal phospholipase D homologs revealed by biocomputational analysis","volume":"51","author":"Beligni","year":"2015","journal-title":"J. Phycol."},{"key":"10.1016\/j.gene.2018.02.063_bb0025","doi-asserted-by":"crossref","first-page":"D30","DOI":"10.1093\/nar\/gku1216","article-title":"GenBank","volume":"43","author":"Benson","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1550-7408.2001.tb00421.x","article-title":"Phospholipase D (PLD) is present in Leishmania donovani and its activity increases in response to acute osmotic stress","volume":"48","author":"Blum","year":"2001","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.gene.2018.02.063_bb0035","doi-asserted-by":"crossref","DOI":"10.1186\/1745-6150-7-12","article-title":"Domain enhanced lookup time accelerated BLAST","volume":"7","author":"Boratyn","year":"2012","journal-title":"Biol. Direct"},{"key":"10.1016\/j.gene.2018.02.063_bb0040","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/ncb1487","article-title":"A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis","volume":"8","author":"Choi","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0960-9822(97)70090-3","article-title":"Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization","volume":"7","author":"Colley","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0050","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pt.2004.10.004","article-title":"Sabotage and exploitation in macrophages parasitized by intracellular protozoans","volume":"21","author":"Denkers","year":"2005","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0055","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/molbev\/msq289","article-title":"Phylogenomic analysis of kinetoplastids supports that trypanosomatids arose from within bodonids","volume":"28","author":"Deschamps","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.gene.2018.02.063_bb0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0925-4439(99)00065-4","article-title":"Glycoconjugates in Leishmania infectivity","volume":"1455","author":"Descoteaux","year":"1999","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.gene.2018.02.063_bb0065","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0166-6851(94)00123-5","article-title":"Ca2+ signal induced by Trypanosoma cruzi metacyclic trypomastigote surface molecules implicated in mammalian cell invasion","volume":"73","author":"Dorta","year":"1995","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0070","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S1286-4579(02)01616-7","article-title":"Glycoinositol phospholipids from Trypanosoma cruzi transmit signals to the cells of the host immune system through both ceramide and glycan chains","volume":"4","author":"DosReis","year":"2002","journal-title":"Microbes Infect."},{"issue":"5","key":"10.1016\/j.gene.2018.02.063_bb9830","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0075","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1126\/science.1066015","article-title":"Phosphatidic acid-mediated mitogenic activation of mTOR signaling","author":"Fang","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.gene.2018.02.063_bb0080","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future","volume":"44","author":"Finn","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tips.2015.01.001","article-title":"The phospholipase D superfamily as therapeutic targets","volume":"36","author":"Frohman","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.gene.2018.02.063_bb0090","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s11745-011-3577-6","article-title":"Regulation of phosphatidic acid levels in Trypanosoma cruzi","volume":"46","author":"Gimenez","year":"2011","journal-title":"Lipids"},{"key":"10.1016\/j.gene.2018.02.063_bb9870","first-page":"18 11 11","article-title":"1Dhe Oxford Nanopore MinION: delivery of nanopore sequencing to the genomics commuON","volume":"94","author":"Goodwin","year":"2017","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"10.1016\/j.gene.2018.02.063_bb0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0166-6851(97)00185-0","article-title":"The molecular phylogeny of trypanosomes: evidence for an early divergence of the Salivaria","volume":"91","author":"Haag","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0100","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1074\/jbc.272.6.3860","article-title":"Characterization of two alternately spliced forms of phospholipase D1 activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and rho family monomeric GTP-binding proteins and protein kinase C-\u03b1","volume":"272","author":"Hammond","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2018.02.063_bb0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1550-7408.2004.tb00387.x","article-title":"Ribosomal RNA phylogeny of bodonid and diplonemid flagellates and the evolution of Euglenozoa","volume":"51","author":"Heyden","year":"2004","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.gene.2018.02.063_bb0110","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1550-7408.1964.tb01741.x","article-title":"Morphological and taxonomic studies on mammalian trypanosomes. X. Revision of the systematics","volume":"11","author":"Hoare","year":"1964","journal-title":"J. Protozool."},{"key":"10.1016\/j.gene.2018.02.063_bb0115","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.mib.2010.08.009","article-title":"Molecular mechanisms underlying the control of antigenic variation in African trypanosomes","volume":"13","author":"Horn","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.gene.2018.02.063_bb0120","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1517\/14728222.11.5.707","article-title":"The potential for phospholipase D as a new therapeutic target","volume":"11","author":"Huang","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"issue":"4","key":"10.1016\/j.gene.2018.02.063_bb0125","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/molbev\/msg062","article-title":"Phylogeny of Trypanosomatidae and Bodonidae (Kinetoplastida) based on 18S rRNA: evidence for paraphyly of Trypanosoma and six other genera","volume":"20","author":"Hughes","year":"2003","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"10.1016\/j.gene.2018.02.063_bb9820","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1475-9292-2-15","article-title":"Molecular phylogenetics of Trypanosomatidae: contrasting results from 18S rRNA and protein phylogenies","volume":"2","author":"Hughes","year":"2003","journal-title":"Kinetoplastid Biol. Dis."},{"key":"10.1016\/j.gene.2018.02.063_bb0130","first-page":"290","article-title":"Phospholipase D from Streptomyces antibioticus: cloning, sequencing, expression, and relationship to other phospholipases","volume":"42","author":"Iwasaki","year":"1994","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.gene.2018.02.063_bb0135","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1186\/1471-2164-9-594","article-title":"Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa)","volume":"9","author":"Jackson","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.gene.2018.02.063_bb0140","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cub.2015.11.055","article-title":"Kinetoplastid phylogenomics reveals the evolutionary innovations associated with the origins of parasitism","volume":"26","author":"Jackson","year":"2016","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.gene.2018.02.063_bb9855","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13059-016-1103-0","article-title":"The Oxford Nanopore MinION: delivery of nanopore sequencing to the genomics community","volume":"17","author":"Jain","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0145","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1073\/pnas.1423790112","article-title":"Factors mediating plastid dependency and the origins of parasitism in apicomplexans and their close relatives","volume":"112","author":"Janouskovec","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.02.063_bb0150","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/bioinformatics\/8.3.275","article-title":"The rapid generation of mutation data matrices from protein sequences","volume":"8","author":"Jones","year":"1992","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2018.02.063_bb0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.pt.2006.06.012","article-title":"Phlebotomine sand flies and Leishmania parasites: friends or foes?","volume":"22","author":"Kamhawi","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0160","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2018.02.063_bb0165","doi-asserted-by":"crossref","first-page":"D574","DOI":"10.1093\/nar\/gkv1209","article-title":"Ensembl Genomes 2016: more genomes, more complexity","volume":"44","author":"Kersey","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0170","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0968-0004(96)30024-8","article-title":"A duplicated catalytic motif in a new superfamily of phosphohydrolases and phospholipid synthases that includes poxvirus envelope proteins","volume":"21","author":"Koonin","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.gene.2018.02.063_bb0175","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.gene.2018.02.063_bb0180","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/molbev\/msn067","article-title":"An improved general amino acid replacement matrix","volume":"25","author":"Le","year":"2008","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.gene.2018.02.063_bb0185","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1093\/molbev\/msx149","article-title":"SMS: smart model selection in PhyML","volume":"34","author":"Lefort","year":"2017","journal-title":"Mol. Biol. Evol."},{"issue":"Database issue","key":"10.1016\/j.gene.2018.02.063_bb0190","doi-asserted-by":"crossref","first-page":"D257","DOI":"10.1093\/nar\/gku949","article-title":"SMART: recent updates, new developments and status in 2015","volume":"43","author":"Letunic","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0195","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkr1032","article-title":"GeneDB\u2014an annotation database for pathogens","volume":"40","author":"Logan-Klumpler","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molbiopara.2014.05.007","article-title":"Evolution of parasitism in kinetoplastid flagellates","volume":"195","author":"Luke\u0161","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0205","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1574-6968.1992.tb05377.x","article-title":"Phospholipids of Trypanosoma cruzi: increase of polyphosphoinositides and phosphatidic acid after cholinergic stimulation","volume":"74","author":"Machado de Domenech","year":"1992","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.gene.2018.02.063_bb0210","author":"Maddison"},{"key":"10.1016\/j.gene.2018.02.063_bb0215","doi-asserted-by":"crossref","first-page":"W327","DOI":"10.1093\/nar\/gkh454","article-title":"CD-search: protein domain annotations on the fly","volume":"32","author":"Marchler-Bauer","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0220","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gku1221","article-title":"CDD: NCBI's conserved domain database","volume":"43","author":"Marchler-Bauer","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0225","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1139\/o03-079","article-title":"Phospholipase D","volume":"82","author":"McDermott","year":"2004","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0230","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1046\/j.1365-313x.2001.00990.x","article-title":"Hyperosmotic stress rapidly generates lyso-phosphatidic acid in Chlamydomonas","volume":"25","author":"Meijer","year":"2001","journal-title":"Plant J."},{"issue":"1","key":"10.1016\/j.gene.2018.02.063_bb9850","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20071040","article-title":"Diacylglycerol kinases: at the hub of cell signalling","volume":"409","author":"Merida","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.gene.2018.02.063_bb0235","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-313x.2000.00725.x","article-title":"Hyperosmotic stress stimulates phospholipase D activity and elevates the levels of phosphatidic acid and diacylglycerol pyrophosphate","volume":"22","author":"Munnik","year":"2000","journal-title":"Plant J."},{"key":"10.1016\/j.gene.2018.02.063_bb0240","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.genet.39.073003.112240","article-title":"Concerted and birth-and-death evolution of multigene families","volume":"39","author":"Nei","year":"2005","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.gene.2018.02.063_bb0245","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1073\/pnas.94.15.7799","article-title":"Evolution by the birth-and-death process in multigene families of the vertebrate immune system","volume":"94","author":"Nei","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2018.02.063_bb0250","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/bioinformatics\/bts091","article-title":"Unipro UGENE: a unified bioinformatics toolkit","volume":"28","author":"Okonechnikov","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2018.02.063_bb0255","doi-asserted-by":"crossref","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","article-title":"Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation","volume":"44","author":"O'Leary","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0260","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1098\/rspb.1994.0006","article-title":"Detecting correlated evolution on phylogenies: a general method for the comparative analysis of discrete characters","volume":"255","author":"Pagel","year":"1994","journal-title":"Proc. R. Soc. Lond. B"},{"key":"10.1016\/j.gene.2018.02.063_bb0265","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/oxfordjournals.molbev.a004127","article-title":"Purifying selection and birth-and-death evolution in the histone H4 gene family","volume":"19","author":"Piontkivska","year":"2002","journal-title":"Mol. Biol. Evol."},{"issue":"5","key":"10.1016\/j.gene.2018.02.063_bb0270","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/pro.5560050513","article-title":"A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues","volume":"5","author":"Ponting","year":"1996","journal-title":"Protein Sci."},{"key":"10.1016\/j.gene.2018.02.063_bb0280","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1104\/pp.010928","article-title":"The Arabidopsis phospholipase D family. Characterization of a calcium-independent and phosphatidylcholine-selective PLD\u03b61 with distinct regulatory domains","volume":"128","author":"Qin","year":"2002","journal-title":"Plant Physiol."},{"key":"10.1016\/j.gene.2018.02.063_bb0285","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1017\/S0031182010000715","article-title":"Lipidomic analysis of bloodstream and procyclic form Trypanosoma brucei","volume":"137","author":"Richmond","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.gene.2018.02.063_bb0290","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0962-8924(94)90145-7","article-title":"First thoughts on lipid second messengers","volume":"4","author":"Roberts","year":"1994","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0295","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1096\/fasebj.10.10.8751718","article-title":"Phospholipases: structural and functional motifs for working at an interface","volume":"10","author":"Roberts","year":"1996","journal-title":"FASEB J."},{"issue":"Database issue","key":"10.1016\/j.gene.2018.02.063_bb9835","doi-asserted-by":"crossref","first-page":"D345","DOI":"10.1093\/nar\/gku1214","article-title":"The RCSB Protein Data Bank: views of structural biology for basic and applied research and education","volume":"43","author":"Rose","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0300","doi-asserted-by":"crossref","first-page":"D5","DOI":"10.1093\/nar\/gkn741","article-title":"Database resources of the National Center for Biotechnology Information","volume":"37","author":"Sayers","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0305","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbalip.2005.12.010","article-title":"Signalling diacylglycerol pyrophosphate, a new phosphatidic acid metabolite","volume":"1761","author":"van Schooten","year":"2006","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.gene.2018.02.063_bb0310","series-title":"Atlas of Protein Sequences","first-page":"353","article-title":"Matrices for detecting distant relationships","author":"Schwarz","year":"1979"},{"key":"10.1016\/j.gene.2018.02.063_bb0315","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1021\/cr200296t","article-title":"Phospholipase D - enzymology, functionality, and chemical modulation","volume":"111","author":"Selvy","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.gene.2018.02.063_bb0320","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrm2934","article-title":"Lipidomics: coming to grips with lipid diversity","volume":"11","author":"Shevchenko","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0325","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1741-7007-9-85","article-title":"Putting the pH into phosphatidic acid signaling","volume":"9","author":"Shin","year":"2011","journal-title":"BMC Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0330","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004697","article-title":"Membrane organization and lipid rafts","volume":"3","author":"Simons","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0335","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1078\/1434461042650389","article-title":"Early evolution within kinetoplastids (Euglenozoa), and the late emergence of trypanosomatids","volume":"155","author":"Simpson","year":"2004","journal-title":"Protist"},{"key":"10.1016\/j.gene.2018.02.063_bb0340","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pt.2006.02.006","article-title":"The evolution and diversity of kinetoplastid flagellates","volume":"22","author":"Simpson","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0345","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.molbiopara.2010.04.001","article-title":"Lipid metabolism in Trypanosoma brucei","volume":"172","author":"Smith","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb9840","series-title":"Protein microarrays","first-page":"43","article-title":"Practical guide to protein microarrays: assay systems, methods and algorithms","author":"Soloviev","year":"2005"},{"key":"10.1016\/j.gene.2018.02.063_bb0350","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/6716","article-title":"Crystal structure of a phospholipase D family member","volume":"6","author":"Stuckey","year":"1999","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.gene.2018.02.063_bb0355","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1093\/emboj\/16.15.4519","article-title":"Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity","volume":"16","author":"Sung","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2018.02.063_bb0360","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1074\/jbc.274.1.494","article-title":"Molecular analysis of mammalian phospholipase D2","volume":"274","author":"Sung","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2018.02.063_bb0365","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1074\/jbc.274.6.3659","article-title":"Structural analysis of human phospholipase D1","volume":"274","author":"Sung","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2018.02.063_bb0370","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0166-6851(02)00281-5","article-title":"Phospholipids in parasitic protozoa","volume":"126","author":"Vial","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0375","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.plipres.2006.01.005","article-title":"Signaling functions of phosphatidic acid","volume":"45","author":"Wang","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.gene.2018.02.063_bb0380","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06974","article-title":"Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites","volume":"4","author":"Woo","year":"2015","journal-title":"elife"},{"key":"10.1016\/j.gene.2018.02.063_bb0385","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1126\/science.1191026","article-title":"Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism","volume":"329","author":"Young","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.gene.2018.02.063_bb0390","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molbiopara.2009.12.004","article-title":"Phospholipid and sphingolipid metabolism in Leishmania","volume":"170","author":"Zhang","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2018.02.063_bb0395","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.bbalip.2009.05.013","article-title":"Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases","volume":"1791","author":"Zhang","year":"2009","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918302129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918302129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T12:25:49Z","timestamp":1535027149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918302129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":85,"alternative-id":["S0378111918302129"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.02.063","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.02.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}