{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:58:03Z","timestamp":1762955883708},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.gene.2018.03.061","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T02:49:58Z","timestamp":1521600598000},"page":"128-135","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["NOD2 expression, DNA damage and oxido-inflammatory status in atopic bronchial asthma: Exploring their nexus to disease severity"],"prefix":"10.1016","volume":"660","author":[{"given":"Hanaa H.","family":"Gaballah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha A.","family":"Gaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragia S.","family":"Sharshar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah A.","family":"Elshweikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.gene.2018.03.061_bb0005","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.rmed.2010.02.018","article-title":"Increased serum IL-17 is an independent risk factor for severe asthma","volume":"104","author":"Agache","year":"2010","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11882-009-0081-7","article-title":"Pathogenesis of allergic airway inflammation","volume":"10","author":"Agrawal","year":"2010","journal-title":"Curr Allergy Asthma Rep"},{"issue":"10","key":"10.1016\/j.gene.2018.03.061_bb0015","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.humimm.2013.06.009","article-title":"3-Nitrotyrosine: a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions","volume":"74","author":"Ahsan","year":"2013","journal-title":"Hum. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1398-9995.2006.00996.x","article-title":"3-Nitrotyrosine, a marker of nitrosative stress, is increased in breath condensate of allergic asthmatic children","volume":"61","author":"Baraldi","year":"2006","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0025","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jaci.2011.11.004","article-title":"Effects of air pollutants on innate immunity: the role of toll-like receptors and nucleotide-binding oligomerization domain\u2013like receptors","volume":"129","author":"Bauer","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1398-9995.2006.01305.x","article-title":"GINA guidelines on asthma and beyond","volume":"62","author":"Bousquet","year":"2007","journal-title":"Allergy"},{"issue":"12","key":"10.1016\/j.gene.2018.03.061_bb0035","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.140178","article-title":"Insights into the molecular basis of the NOD2 signalling pathway","volume":"4","author":"Boyle","year":"2014","journal-title":"Open Biology"},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0040","article-title":"A possible role of chitin in the pathogenesis of asthma and allergy","volume":"18","author":"Brinchmann","year":"2011","journal-title":"Ann. Agric. Environ. Med."},{"issue":"5","key":"10.1016\/j.gene.2018.03.061_bb0045","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0091-6749(79)90127-1","article-title":"The relationship of respiratory allergy, skin test reactivity, and serum IgE in a community population sample","volume":"63","author":"Brown","year":"1979","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003080","article-title":"Innate sensing of chitin and chitosan","volume":"9","author":"Bueter","year":"2013","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0055","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jaci.2016.02.017","article-title":"House dust mite\u2013induced asthma causes oxidative damage and DNA double-strand breaks in the lungs","volume":"138","author":"Chan","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"10","key":"10.1016\/j.gene.2018.03.061_bb0060","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1164\/rccm.201405-0859PP","article-title":"IL-17 in severe asthma. Where do we stand?","volume":"190","author":"Chesn\u00e9","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.gene.2018.03.061_bb0065","first-page":"870","article-title":"Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis","volume":"120","author":"Cho","year":"2010","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.gene.2018.03.061_bb0075","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry: 1994 update","volume":"152","author":"Crapo","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.gene.2018.03.061_bb0080","first-page":"1","article-title":"Autophagy balances inflammation in innate immunity","author":"Deretic","year":"2017","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0085","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12013-012-9471-x","article-title":"Modulation of chitotriosidase during macrophage differentiation","volume":"66","author":"Di Rosa","year":"2013","journal-title":"Cell Biochem. Biophys."},{"issue":"04","key":"10.1016\/j.gene.2018.03.061_bb0090","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4236\/mri.2013.24011","article-title":"Comparison of YKL-39 and CHIT-1 expression during macrophages differentiation and polarization","volume":"2","author":"Di Rosa","year":"2013","journal-title":"Modern Res. Inflamm."},{"issue":"5","key":"10.1016\/j.gene.2018.03.061_bb0095","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3889\/oamjms.2017.149","article-title":"Relationship of oxidant and antioxidant markers to asthma severity in Egyptian asthmatic children","volume":"5","author":"EL-Alameey","year":"2017","journal-title":"Open Access Macedonian J. Med. Sci."},{"key":"10.1016\/j.gene.2018.03.061_bb0100","article-title":"Immunomodulatory effects of chitotriosidase enzyme","volume":"2016","author":"Elmonem","year":"2016","journal-title":"J. Enzym. Res."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0105","first-page":"O21","article-title":"O21-the role of DNA damage and repair in allergic airway inflammation","volume":"4","author":"Engelward","year":"2014","journal-title":"Clin. Trans. Allergy"},{"issue":"4","key":"10.1016\/j.gene.2018.03.061_bb0110","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.4049\/jimmunol.0902185","article-title":"Importance of cytokines in murine allergic airway disease and human asthma","volume":"184","author":"Finkelman","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2018.03.061_bb0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.taap.2016.12.012","article-title":"Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: crosstalk between apoptotic and JNK-mediated autophagic cell death platforms","volume":"316","author":"Gaballah","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/cea.12032","article-title":"Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma","volume":"43","author":"Gavala","year":"2013","journal-title":"Clin. Exp. Allergy"},{"issue":"22","key":"10.1016\/j.gene.2018.03.061_bb0125","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.gene.2018.03.061_bb0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1753-4887.2012.00476.x","article-title":"Free radicals and antioxidants: updating a personal view","volume":"70","author":"Halliwell","year":"2012","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.gene.2018.03.061_bb0135","article-title":"DNA damage and glutathione level in children with asthma bronchiale: effect of antiasthmatic therapy","volume":"21","author":"Hasbal","year":"2010","journal-title":"Pediatr. Allergy Immunol."},{"issue":"5","key":"10.1016\/j.gene.2018.03.061_bb0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2731","article-title":"Innate and adaptive immune responses in asthma","volume":"18","author":"Holgate","year":"2012","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.gene.2018.03.061_bb0145","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1172\/JCI117084","article-title":"Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease","volume":"93","author":"Hollak","year":"1994","journal-title":"J. Clin. Investig."},{"issue":"5","key":"10.1016\/j.gene.2018.03.061_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126035","article-title":"Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV1","volume":"10","author":"Hosoki","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0155","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbrc.2004.01.046","article-title":"Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration","volume":"315","author":"Ito","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.gene.2018.03.061_bb0160","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12038-012-9218-2","article-title":"DNA damage by reactive species: mechanisms, mutation and repair","volume":"37","author":"Jena","year":"2012","journal-title":"J. Biosci."},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/02770903.2017.1318141","article-title":"Elevated serum levels of TNF-\u03b1, IL-8, and ECP can be involved in the development and progression of bronchial asthma","volume":"55","author":"Jiang","year":"2018","journal-title":"J. Asthma"},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0170","doi-asserted-by":"crossref","DOI":"10.2174\/1875044301205010001","article-title":"Role of chitotriosidase (chitinase 1) under normal and disease conditions","volume":"5","author":"Kanneganti","year":"2012","journal-title":"J. Epithelial Biol. & Pharmacol."},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0175","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.gene.2012.01.059","article-title":"Impact of glutathione-S-transferase gene polymorphisms on enzyme activity, lung function and bronchial asthma susceptibility in Egyptian children","volume":"497","author":"Karam","year":"2012","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.gene.2018.03.061_bb0180","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jaci.2005.12.1346","article-title":"IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity","volume":"117","author":"Kawaguchi","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.gene.2018.03.061_bb0185","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.gene.2018.03.061_bb0190","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bcmd.2007.06.013","article-title":"Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity","volume":"39","author":"Lee","year":"2007","journal-title":"Blood Cell Mol. Dis."},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0195","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2353\/ajpath.2010.090455","article-title":"Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation","volume":"176","author":"L\u00e9tuv\u00e9","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.gene.2018.03.061_bb0200","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7150\/ijbs.10927","article-title":"NOD2 is involved in the inflammatory response after cerebral ischemia-reperfusion injury and triggers NADPH oxidase 2-derived reactive oxygen species","volume":"11","author":"Liu","year":"2015","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.gene.2018.03.061_bb0205","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.gene.2018.03.061_bb0210","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cbi.2014.10.016","article-title":"Free radicals, reactive oxygen species, oxidative stress and its classification","volume":"224","author":"Lushchak","year":"2014","journal-title":"Chem. Biol. Interact."},{"issue":"8","key":"10.1016\/j.gene.2018.03.061_bb0215","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1600-0625.2007.00589.x","article-title":"Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis","volume":"16","author":"Macaluso","year":"2007","journal-title":"Exp. Dermatol."},{"issue":"9","key":"10.1016\/j.gene.2018.03.061_bb0220","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.4049\/jimmunol.166.9.5763","article-title":"Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species","volume":"166","author":"MacPherson","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2018.03.061_bb0225","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pharmthera.2017.08.011","article-title":"Oxidative stress and cellular pathways of asthma and inflammation: therapeutic strategies and pharmacological targets","volume":"181","author":"Mishra","year":"2017","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0230","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/physrev.00009.2014","article-title":"NOD-like receptors: versatile cytosolic sentinels","volume":"95","author":"Motta","year":"2015","journal-title":"Physiol. Rev."},{"issue":"Suppl. 1","key":"10.1016\/j.gene.2018.03.061_bb0235","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000337801","article-title":"Neutrophilic inflammation in severe asthma","volume":"158","author":"Nakagome","year":"2012","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0240","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0245","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3565","article-title":"NOD proteins: regulators of inflammation in health and disease","volume":"14","author":"Philpott","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.gene.2018.03.061_bb0250","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/ar300234c","article-title":"Protein tyrosine nitration: biochemical mechanisms and structural basis of functional effects","volume":"46","author":"Radi","year":"2012","journal-title":"Acc. Chem. Res."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0255","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cyto.2014.09.011","article-title":"T cell subsets and their signature cytokines in autoimmune and inflammatory diseases","volume":"74","author":"Raphael","year":"2015","journal-title":"Cytokine"},{"issue":"12","key":"10.1016\/j.gene.2018.03.061_bb0260","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.it.2017.07.003","article-title":"Neutrophilic inflammation in asthma and association with disease severity","volume":"38","author":"Ray","year":"2017","journal-title":"Trends Immunol."},{"issue":"10","key":"10.1016\/j.gene.2018.03.061_bb0265","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/WOX.0b013e318232389e","article-title":"Oxidative stress in asthma","volume":"4","author":"Sahiner","year":"2011","journal-title":"World Allergy Organ. J."},{"issue":"3","key":"10.1016\/j.gene.2018.03.061_bb0270","first-page":"634","article-title":"Validation of ESR analyzer using Westergren ESR method","volume":"50","author":"Sikka","year":"2007","journal-title":"Indian J. Pathol. Microbiol."},{"issue":"6","key":"10.1016\/j.gene.2018.03.061_bb0275","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1165\/rcmb.2015-0038OC","article-title":"IL-17RA signaling in airway inflammation and bronchial hyperreactivity in allergic asthma","volume":"53","author":"Willis","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"7","key":"10.1016\/j.gene.2018.03.061_bb0280","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1080\/08820130903062756","article-title":"Activation of peripheral Th17 lymphocytes in patients with asthma","volume":"38","author":"Wong","year":"2009","journal-title":"Immunol. Investig."},{"issue":"1","key":"10.1016\/j.gene.2018.03.061_bb0285","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10753-014-0038-4","article-title":"Aberrant expression of regulatory cytokine IL-35 and pattern recognition receptor NOD2 in patients with allergic asthma","volume":"38","author":"Wong","year":"2015","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.gene.2018.03.061_bb0290","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1399-3038.2008.00780.x","article-title":"DNA damage in children with asthma bronchiale and its association with oxidative and antioxidative measurements","volume":"20","author":"Zeyrek","year":"2009","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.gene.2018.03.061_bb0295","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fimmu.2013.00333","article-title":"Functions of NOD-like receptors in human diseases","volume":"4","author":"Zhong","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2018.03.061_bb0300","series-title":"Frontiers in Clinical Drug Research\u2013Anti Allergy Agents","first-page":"45","article-title":"Allergic asthma pathogenesis and antioxidant therapy","volume":"2","author":"Zuo","year":"2016"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918303056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918303056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T15:49:29Z","timestamp":1660664969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918303056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":60,"alternative-id":["S0378111918303056"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.03.061","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOD2 expression, DNA damage and oxido-inflammatory status in atopic bronchial asthma: Exploring their nexus to disease severity","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.03.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}