{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:23:10Z","timestamp":1776298990271,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.gene.2018.05.008","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T17:33:33Z","timestamp":1525368813000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"special_numbering":"C","title":["Lung adenocarcinoma cell-derived exosomal miR-21 facilitates osteoclastogenesis"],"prefix":"10.1016","volume":"666","author":[{"given":"Zhen","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingwang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huisheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0389-8851","authenticated-orcid":false,"given":"Caijun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2018.05.008_bb0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/JTO.0b013e31819518fc","article-title":"Prevention and management of bone metastases in lung cancer: a review","volume":"4","author":"Al Husaini","year":"2009","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.gene.2018.05.008_bb0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.gene.2018.05.008_bb0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.05.008_bb0020","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ccell.2016.10.009","article-title":"Extracellular vesicles in cancer: cell-to-cell mediators of metastasis","volume":"30","author":"Becker","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.gene.2018.05.008_bb0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.05.008_bb0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2105-15-29","article-title":"A tool for design of primers for microRNA-specific quantitative RT-qPCR","volume":"15","author":"Busk","year":"2014","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.gene.2018.05.008_bb0035","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/bcr2835","article-title":"Therapeutic targets for bone metastases in breast cancer","volume":"13","author":"Clezardin","year":"2011","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.gene.2018.05.008_bb0040","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/jnci\/djs263","article-title":"Effects of bone-targeted agents on cancer progression and mortality","volume":"104","author":"Coleman","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"issue":"690\u2013690","key":"10.1016\/j.gene.2018.05.008_bb0045","article-title":"SnapShot: bone metastasis","volume":"151","author":"Ell","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.05.008_bb0050","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/JTO.0b013e3181651c0e","article-title":"Zoledronic acid and survival in patients with metastatic bone disease from lung cancer and elevated markers of osteoclast activity","volume":"3","author":"Hirsh","year":"2008","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.gene.2018.05.008_bb0055","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.05.008_bb0060","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri.2017.28","article-title":"Monocyte differentiation and antigen-presenting functions","volume":"17","author":"Jakubzick","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.gene.2018.05.008_bb0065","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1534-5807(02)00157-0","article-title":"Reaching a genetic and molecular understanding of skeletal development","volume":"2","author":"Karsenty","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.gene.2018.05.008_bb0070","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2006.09.009","article-title":"The diverse functions of microRNAs in animal development and disease","volume":"11","author":"Kloosterman","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.gene.2018.05.008_bb0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1582-4934.2008.00556.x","article-title":"miR-21: a small multi-faceted RNA","volume":"13","author":"Krichevsky","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.gene.2018.05.008_bb0080","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1158\/1078-0432.CCR-08-3053","article-title":"MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor","volume":"15","author":"Li","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.gene.2018.05.008_bb0085","article-title":"Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2018.05.008_bb0090","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1158\/0008-5472.CAN-15-1625","article-title":"Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype","volume":"76","author":"Li","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2018.05.008_bb0095","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/cr.2015.153","article-title":"Organotropic metastasis: role of tumor exosomes","volume":"26","author":"Liu","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.gene.2018.05.008_bb0100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.canlet.2015.10.011","article-title":"STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells","volume":"370","author":"Liu","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.gene.2018.05.008_bb0105","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/emboj.2008.278","article-title":"Structural basis for translational inhibition by the tumour suppressor Pdcd4","volume":"28","author":"Loh","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2018.05.008_bb0110","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: extracellular organelles important in intercellular communication","volume":"73","author":"Mathivanan","year":"2010","journal-title":"J. Proteome"},{"key":"10.1016\/j.gene.2018.05.008_bb0115","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1172\/JCI46039","article-title":"A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration","volume":"122","author":"Ng","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2018.05.008_bb0120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.semcancer.2011.01.002","article-title":"The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts","volume":"21","author":"Peinado","year":"2011","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.gene.2018.05.008_bb0125","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3322\/caac.20121","article-title":"Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths","volume":"61","author":"Siegel","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.gene.2018.05.008_bb0130","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.gene.2018.05.008_bb0135","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1182\/blood-2010-10-311415","article-title":"A microRNA expression signature of osteoclastogenesis","volume":"117","author":"Sugatani","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.gene.2018.05.008_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2016.15","article-title":"Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity","volume":"2","author":"Sun","year":"2016","journal-title":"Cell Discov."},{"issue":"22","key":"10.1016\/j.gene.2018.05.008_bb0145","doi-asserted-by":"crossref","first-page":"36137","DOI":"10.18632\/oncotarget.16661","article-title":"Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21\/VEGF signal","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.gene.2018.05.008_bb0155","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.0105-2896.2005.00327.x","article-title":"Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system","volume":"208","author":"Tanaka","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.gene.2018.05.008_bb0160","doi-asserted-by":"crossref","first-page":"30420","DOI":"10.18632\/oncotarget.8483","article-title":"Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via exosomal miR-21","volume":"7","author":"Taverna","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.gene.2018.05.008_bb0165","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.gene.2018.05.008_bb0170","doi-asserted-by":"crossref","first-page":"3.22.1","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","volume":"30","author":"Thery","year":"2006","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.gene.2018.05.008_bb0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/imr.12050","article-title":"MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer","volume":"253","author":"Tili","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.gene.2018.05.008_bb0180","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.05.008_bb0185","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.gene.2018.05.008_bb0190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jb\/mvj128","article-title":"Exosomes: a common pathway for a specialized function","volume":"140","author":"van Niel","year":"2006","journal-title":"J. Biochem."},{"issue":"Suppl. 1","key":"10.1016\/j.gene.2018.05.008_bb0195","doi-asserted-by":"crossref","first-page":"i86","DOI":"10.1136\/ard.2009.119396","article-title":"Bone development and inflammatory disease is regulated by AP-1 (Fos\/Jun)","volume":"69","author":"Wagner","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.gene.2018.05.008_bb0200","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ccr.2013.10.001","article-title":"Cancer-associated osteoclast differentiation takes a good look in the miR(NA)ror","volume":"24","author":"Waning","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.gene.2018.05.008_bb0205","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrc3055","article-title":"Cancer to bone: a fatal attraction","volume":"11","author":"Weilbaecher","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.gene.2018.05.008_bb0210","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00204-014-1291-x","article-title":"Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis","volume":"89","author":"Xu","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.gene.2018.05.008_bb0215","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature15376","article-title":"Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth","volume":"527","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.05.008_bb0220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13046-017-0528-y","article-title":"Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells","volume":"36","author":"Zheng","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918304852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918304852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T20:28:26Z","timestamp":1534883306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918304852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":43,"alternative-id":["S0378111918304852"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.05.008","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung adenocarcinoma cell-derived exosomal miR-21 facilitates osteoclastogenesis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}