{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T21:37:12Z","timestamp":1778967432289,"version":"3.51.4"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.gene.2018.06.011","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T22:00:47Z","timestamp":1528236047000},"page":"115-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Data integration for functional annotation of regulatory single nucleotide polymorphisms associated with Alzheimer's disease susceptibility"],"prefix":"10.1016","volume":"672","author":[{"given":"Sanila","family":"Amber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saadia","family":"Zahid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.gene.2018.06.011_bb0005","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/db09-0986","article-title":"The transcription factor Rfx3 regulates \u03b2-cell differentiation, function, and glucokinase expression","volume":"59","author":"Ait-Lounis","year":"2010","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.gene.2018.06.011_bb0010","first-page":"4","article-title":"The use of SNPs in pharmacogenomics studies","volume":"12","author":"Alwi","year":"2005","journal-title":"Malays. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0959-437X(94)90098-1","article-title":"Myc\u2014Max\u2014Mad: a transcription factor network controlling cell cycle progression, differentiation and death","volume":"4","author":"Amati","year":"1994","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gm249","article-title":"The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease","volume":"3","author":"Ant\u00fanez","year":"2011","journal-title":"Genome Med."},{"issue":"9","key":"10.1016\/j.gene.2018.06.011_bb0025","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrn2194","article-title":"Tau-mediated neurodegeneration in Alzheimer's disease and related disorders","volume":"8","author":"Ballatore","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"9","key":"10.1016\/j.gene.2018.06.011_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004606","article-title":"Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias","volume":"10","author":"Beecham","year":"2014","journal-title":"PLoS Genet."},{"issue":"9","key":"10.1016\/j.gene.2018.06.011_bb0035","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res."},{"issue":"15","key":"10.1016\/j.gene.2018.06.011_bb0040","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1074\/jbc.M706579200","article-title":"NF\u03baB-dependent control of BACE1 promoter transactivation by A\u03b242","volume":"283","author":"Buggia-Prevot","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.gene.2018.06.011_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002822","article-title":"Genome-wide association studies","volume":"8","author":"Bush","year":"2012","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0050","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/carcin\/bgn261","article-title":"Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans","volume":"30","author":"Chang","year":"2009","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.gene.2018.06.011_bb0055","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1523\/JNEUROSCI.23-07-02572.2003","article-title":"Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons","volume":"23","author":"Chen","year":"2003","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0060","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/leu.2010.256","article-title":"A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity","volume":"25","author":"Chen","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.gene.2018.06.011_bb0065","series-title":"Gene Discovery in Nonsyndromic Cleft Lip with or without Cleft Palate","author":"Chiquet","year":"2011"},{"issue":"12","key":"10.1016\/j.gene.2018.06.011_bb0070","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/mp.2013.185","article-title":"A genome-wide association meta-analysis of plasma A\u03b2 peptides concentrations in the elderly","volume":"19","author":"Chouraki","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"7414","key":"10.1016\/j.gene.2018.06.011_bb0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Consortium","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0080","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1469-1809.2012.00721.x","article-title":"Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene","volume":"76","author":"Cummings","year":"2012","journal-title":"Ann. Hum. Genet."},{"issue":"209","key":"10.1016\/j.gene.2018.06.011_bb0085","first-page":"e201","article-title":"Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression","volume":"37","author":"Davis","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"47","key":"10.1016\/j.gene.2018.06.011_bb0090","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001892","article-title":"Genome-wide meta-analysis on the sense of smell among US older adults","volume":"94","author":"Dong","year":"2015","journal-title":"Medicine"},{"issue":"22","key":"10.1016\/j.gene.2018.06.011_bb0095","doi-asserted-by":"crossref","first-page":"10083","DOI":"10.1128\/MCB.24.22.10083-10098.2004","article-title":"Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53","volume":"24","author":"Dornan","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0100","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0092-8674(89)90940-9","article-title":"The erythroid-specific transcription factor Eryf1: a new finger protein","volume":"58","author":"Evans","year":"1989","journal-title":"Cell"},{"issue":"15","key":"10.1016\/j.gene.2018.06.011_bb0105","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1242\/dev.000141","article-title":"Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner","volume":"134","author":"Ferri","year":"2007","journal-title":"Development"},{"issue":"11","key":"10.1016\/j.gene.2018.06.011_bb0110","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/mp.2010.123","article-title":"Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease","volume":"16","author":"Furney","year":"2011","journal-title":"Mol. Psychiatry"},{"issue":"15","key":"10.1016\/j.gene.2018.06.011_bb0115","doi-asserted-by":"crossref","first-page":"20305","DOI":"10.18632\/oncotarget.7945","article-title":"ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses","volume":"7","author":"Gao","year":"2016","journal-title":"Oncotarget"},{"issue":"51","key":"10.1016\/j.gene.2018.06.011_bb0120","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1038\/sj.onc.1209954","article-title":"Introduction to NF-\u03baB: players, pathways, perspectives","volume":"25","author":"Gilmore","year":"2006","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.gene.2018.06.011_bb0125","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/ijc.25422","article-title":"De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one","volume":"128","author":"Goel","year":"2011","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0130","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1471-2377-10-90","article-title":"Genome-wide association reveals genetic effects on human A\u03b2 42 and \u03c4 protein levels in cerebrospinal fluids: a case control study","volume":"10","author":"Han","year":"2010","journal-title":"BMC Neurol."},{"issue":"10","key":"10.1016\/j.gene.2018.06.011_bb0135","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.gene.2018.06.011_bb0140","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00439-013-1382-4","article-title":"Male-specific genetic effect on hypertension and metabolic disorders","volume":"133","author":"Heo","year":"2014","journal-title":"Hum. Genet."},{"issue":"23","key":"10.1016\/j.gene.2018.06.011_bb0145","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"Hindorff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0150","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.gene.2018.06.011_bb0155","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/mp.2011.125","article-title":"Genome-wide association study of Alzheimer's disease with psychotic symptoms","volume":"17","author":"Hollingworth","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.gene.2018.06.011_bb0160","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/CIRCGENETICS.109.897793","article-title":"Genetic association of the CCR5 region with lipid levels in at-risk cardiovascular patients","volume":"3","author":"Hyde","year":"2010","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"9","key":"10.1016\/j.gene.2018.06.011_bb0165","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/ijc.29257","article-title":"Genes involved in the WNT and vesicular trafficking pathways are associated with melanoma predisposition","volume":"136","author":"Ibarrola-Villava","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"11","key":"10.1016\/j.gene.2018.06.011_bb0170","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.biopsych.2008.11.014","article-title":"The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis","volume":"65","author":"Ikram","year":"2009","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.gene.2018.06.011_bb0175","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1750-3639.2012.00586.x","article-title":"Upstream transcription factor 1 (USF1) polymorphisms associate with Alzheimer's disease-related neuropathological lesions: tampere autopsy study","volume":"22","author":"Isotalo","year":"2012","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0180","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/mp.2015.23","article-title":"A novel Alzheimer disease locus located near the gene encoding tau protein","volume":"21","author":"Jun","year":"2015","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.gene.2018.06.011_bb0185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1242\/dev.029900","article-title":"Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons","volume":"136","author":"Kala","year":"2009","journal-title":"Development"},{"issue":"12","key":"10.1016\/j.gene.2018.06.011_bb0190","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/mp.2011.135","article-title":"Genome-wide association analysis of age-at-onset in Alzheimer's disease","volume":"17","author":"Kamboh","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.45","article-title":"Genome-wide association study of Alzheimer's disease","volume":"2","author":"Kamboh","year":"2012","journal-title":"Transl. Psychiatry"},{"issue":"2","key":"10.1016\/j.gene.2018.06.011_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148717","article-title":"Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci","volume":"11","author":"Karch","year":"2016","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0205","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1212\/WNL.0b013e318204a397","article-title":"Genome-wide association study of CSF biomarkers A\u03b21-42, t-tau, and p-tau181p in the ADNI cohort","volume":"76","author":"Kim","year":"2011","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.gene.2018.06.011_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050325","article-title":"The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age","volume":"5","author":"Kittappa","year":"2007","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-1326-4-5","article-title":"Independent component analysis of Alzheimer's DNA microarray gene expression data","volume":"4","author":"Kong","year":"2009","journal-title":"Mol. Neurodegener."},{"issue":"9","key":"10.1016\/j.gene.2018.06.011_bb0220","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/hmg\/4.9.1527","article-title":"The upstream stimulatory factor functionally interacts with the Alzheimer amyloid \u03b2-protein precursor gene","volume":"4","author":"Kovacs","year":"1995","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.gene.2018.06.011_bb0225","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.gene.2018.06.011_bb0230","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2353\/ajpath.2009.080583","article-title":"The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse","volume":"174","author":"Lee","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.gene.2018.06.011_bb0235","doi-asserted-by":"crossref","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0240","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0197-4580(98)00077-3","article-title":"Quantitative neuronal c-fos and c-jun expression in Alzheimer's disease","volume":"19","author":"Marcus","year":"1998","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.gene.2018.06.011_bb0245","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/ijc.28383","article-title":"Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk","volume":"134","author":"McCullough","year":"2014","journal-title":"Int. J. Cancer"},{"issue":"7","key":"10.1016\/j.gene.2018.06.011_bb0250","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/hmg\/ddi091","article-title":"Transcriptional targets of the chromatin-remodelling factor SMARCA4\/BRG1 in lung cancer cells","volume":"14","author":"Medina","year":"2005","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.gene.2018.06.011_bb0255","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/bdra.20720","article-title":"Studies with Wnt genes and nonsyndromic cleft lip and palate","volume":"88","author":"Menezes","year":"2010","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"issue":"2","key":"10.1016\/j.gene.2018.06.011_bb0260","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/1073858412444007","article-title":"NF-\u03baB signaling pathways role in nervous system physiology and pathology","volume":"19","author":"Mincheva-Tasheva","year":"2013","journal-title":"Neuroscientist"},{"issue":"6","key":"10.1016\/j.gene.2018.06.011_bb0265","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0092-8674(88)91307-4","article-title":"Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-\u03b2 gene regulatory elements","volume":"54","author":"Miyamoto","year":"1988","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.gene.2018.06.011_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058618","article-title":"SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians","volume":"8","author":"Miyashita","year":"2013","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb9000","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0166-2236(00)02031-2","article-title":"Alzheimer's disease-do tauists and baptists finally shake hands?","volume":"25","author":"Mudher","year":"2002","journal-title":"Trends Neurosci."},{"issue":"9","key":"10.1016\/j.gene.2018.06.011_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001130","article-title":"Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities","volume":"6","author":"Naj","year":"2010","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0280","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2018.06.011_bb0285","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","article-title":"Amyloid precursor protein processing and Alzheimer's disease","volume":"34","author":"O'Brien","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.gene.2018.06.011_bb0290","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/01.ypg.0000194445.27555.71","article-title":"Estrogen receptor alpha and risk for cognitive impairment in postmenopausal women","volume":"16","author":"Olsen","year":"2006","journal-title":"Psychiatr. Genet."},{"issue":"4","key":"10.1016\/j.gene.2018.06.011_bb0295","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0092-8674(90)90133-Y","article-title":"Globin gene regulation and switching: circa 1990","volume":"63","author":"Orkin","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.06.011_bb0300","first-page":"S62","article-title":"Novel Role of Depression-Associated Transcription Factor GATA1 in Aging and Alzheimer's Disease","volume":"Vol. 74","author":"Pasinetti","year":"2013"},{"issue":"4","key":"10.1016\/j.gene.2018.06.011_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095413","article-title":"Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies","volume":"9","author":"P\u00e9rez-Palma","year":"2014","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.gene.2018.06.011_bb0310","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0959-440X(96)80016-9","article-title":"Glutamine repeats and inherited neurodegenerative diseases: molecular aspects","volume":"6","author":"Perutz","year":"1996","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"12","key":"10.1016\/j.gene.2018.06.011_bb0315","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/hmg\/ddh138","article-title":"The structure of the tau haplotype in controls and in progressive supranuclear palsy","volume":"13","author":"Pittman","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.gene.2018.06.011_bb0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006501","article-title":"Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease","volume":"4","author":"Potkin","year":"2009","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0325","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.molbrainres.2004.03.018","article-title":"TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease","volume":"125","author":"Reid","year":"2004","journal-title":"Mol. Brain Res."},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0330","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuron.2007.05.022","article-title":"GAB2 alleles modify Alzheimer's risk in APOE \u025b4 carriers","volume":"54","author":"Reiman","year":"2007","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.gene.2018.06.011_bb0335","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00125-008-1018-8","article-title":"Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle","volume":"51","author":"R\u00f6nn","year":"2008","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.gene.2018.06.011_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095152","article-title":"Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings","volume":"9","author":"Rosenthal","year":"2014","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.gene.2018.06.011_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.2","article-title":"Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene","volume":"4","author":"Ruiz","year":"2014","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.gene.2018.06.011_bb0350","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0092-8674(88)90077-3","article-title":"fos-associated cellular p39 is related to nuclear transcription factor AP-1","volume":"54","author":"Sassone-Corsi","year":"1988","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.gene.2018.06.011_bb0355","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/stem.2001","article-title":"CHD2 is required for embryonic neurogenesis in the developing cerebral cortex","volume":"33","author":"Shen","year":"2015","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0360","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jalz.2013.01.008","article-title":"Genome-wide association study of the rate of cognitive decline in Alzheimer's disease","volume":"10","author":"Sherva","year":"2014","journal-title":"Alzheimers Dement."},{"issue":"6","key":"10.1016\/j.gene.2018.06.011_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011244","article-title":"Intermediate phenotypes identify divergent pathways to Alzheimer's disease","volume":"5","author":"Shulman","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gene.2018.06.011_bb0370","unstructured":"Stephan, D.A.; Reiman, E.M.; Webster, J.; Heward, C.B.; Papassotiropoulos, A. Methods of diagnosing Alzheimer's disease and markers identified by set association. Google Patents, 2013."},{"issue":"18","key":"10.1016\/j.gene.2018.06.011_bb0375","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1523\/JNEUROSCI.4774-12.2013","article-title":"Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages","volume":"33","author":"Stott","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.gene.2018.06.011_bb0380","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cpb.2015.10.001","article-title":"DNase I hypersensitivity mapping, genomic footprinting, and transcription factor networks in plants","volume":"3","author":"Sullivan","year":"2015","journal-title":"Curr. Plant Biol."},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0385","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ygeno.2009.01.003","article-title":"Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese","volume":"93","author":"Takei","year":"2009","journal-title":"Genomics"},{"issue":"5507","key":"10.1016\/j.gene.2018.06.011_bb0390","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1126\/science.1058040","article-title":"The sequence of the human genome","volume":"291","author":"Venter","year":"2001","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.gene.2018.06.011_bb0395","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3233\/JAD-142442","article-title":"Genetic determinants of survival in patients with Alzheimer's disease","volume":"45","author":"Wang","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.gene.2018.06.011_bb0400","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6234043","article-title":"Bach1 induces endothelial cell apoptosis and cell-cycle arrest through ROS generation","volume":"2016","author":"Wang","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.gene.2018.06.011_bb0405","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/0959-8049(95)00060-V","article-title":"The mycN\/max protein complex in neuroblastoma. Short review","volume":"31","author":"Wenzel","year":"1995","journal-title":"Eur. J. Cancer"},{"issue":"7","key":"10.1016\/j.gene.2018.06.011_bb0410","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3945\/jn.111.157180","article-title":"Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males","volume":"142","author":"Wernimont","year":"2012","journal-title":"J. Nutr."},{"issue":"17","key":"10.1016\/j.gene.2018.06.011_bb0415","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1523\/JNEUROSCI.0410-14.2014","article-title":"Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling","volume":"34","author":"Woodling","year":"2014","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0420","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1128\/MCB.17.1.436","article-title":"Differential regulation of neurogenesis by the two Xenopus GATA-1 genes","volume":"17","author":"Xu","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0425","doi-asserted-by":"crossref","first-page":"24480","DOI":"10.1038\/srep24480","article-title":"The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.gene.2018.06.011_bb0430","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0896-6273(00)80115-4","article-title":"Mechanisms of neuronal degeneration in Alzheimer's disease","volume":"16","author":"Yankner","year":"1996","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.gene.2018.06.011_bb0435","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/jamaneurol.2016.0150","article-title":"Association between genetic traits for immune-mediated diseases and Alzheimer disease","volume":"73","author":"Yokoyama","year":"2016","journal-title":"JAMA Neurol."},{"issue":"4","key":"10.1016\/j.gene.2018.06.011_bb0440","first-page":"649","article-title":"Association of genetic variants with hemorrhagic stroke in Japanese individuals","volume":"25","author":"Yoshida","year":"2010","journal-title":"Int. J. Mol. Med."},{"issue":"52","key":"10.1016\/j.gene.2018.06.011_bb0445","doi-asserted-by":"crossref","first-page":"19198","DOI":"10.1073\/pnas.0505203102","article-title":"Brain estrogen deficiency accelerates A\u03b2 plaque formation in an Alzheimer's disease animal model","volume":"102","author":"Yue","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.gene.2018.06.011_bb0450","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0306-4522(92)90004-L","article-title":"c-fos protein-like immunoreactivity: distribution in the human brain and over-expression in the hippocampus of patients with Alzheimer's disease","volume":"46","author":"Zhang","year":"1992","journal-title":"Neuroscience"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918306590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918306590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T15:26:43Z","timestamp":1531582003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918306590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":91,"alternative-id":["S0378111918306590"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.06.011","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Data integration for functional annotation of regulatory single nucleotide polymorphisms associated with Alzheimer's disease susceptibility","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}