{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:28Z","timestamp":1790776648243,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.gene.2018.08.059","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T13:32:59Z","timestamp":1534512779000},"page":"133-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Association between SERT insertion\/deletion polymorphism and the risk of irritable bowel syndrome: A meta-analysis based on 7039 subjects"],"prefix":"10.1016","volume":"679","author":[{"given":"Yubing","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.gene.2018.08.059_bb0005","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1136\/gut.2006.097287","article-title":"Irritable bowel syndrome in twins: genes and environment","volume":"55","author":"Bengtson","year":"2006","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.gene.2018.08.059_bb0010","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S1542-3565(04)00391-X","article-title":"Effect of renzapride on transit in constipation-predominant irritable bowel syndrome","volume":"2","author":"Camilleri","year":"2004","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"47","key":"10.1016\/j.gene.2018.08.059_bb0015","doi-asserted-by":"crossref","first-page":"17693","DOI":"10.3748\/wjg.v20.i47.17693","article-title":"Genetic polymorphism in pathogenesis of irritable bowel syndrome","volume":"20","author":"Cheung","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.gene.2018.08.059_bb0020","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jama.2015.0954","article-title":"Irritable bowel syndrome: a clinical review","volume":"313","author":"Chey","year":"2015","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.gene.2018.08.059_bb0025","first-page":"311","article-title":"Role of serotonin in gastrointestinal physiology and pathology","volume":"36","author":"Cirillo","year":"2011","journal-title":"Minerva Endocrinol."},{"issue":"5","key":"10.1016\/j.gene.2018.08.059_bb0030","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1053\/j.gastro.2006.03.008","article-title":"The functional gastrointestinal disorders and the Rome III process","volume":"130","author":"Drossman","year":"2006","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.gene.2018.08.059_bb0035","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1542-3565(04)00726-8","article-title":"Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome","volume":"3","author":"Dunlop","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"12","key":"10.1016\/j.gene.2018.08.059_bb0040","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1007\/s10620-008-0666-3","article-title":"The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome","volume":"54","author":"Kohen","year":"2009","journal-title":"Dig. Dis. Sci."},{"issue":"5","key":"10.1016\/j.gene.2018.08.059_bb0045","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3109\/00365521.2013.775328","article-title":"The epidemiology of irritable bowel syndrome in Denmark. A population-based survey in adults \u226450\u202fyears of age","volume":"48","author":"Krogsgaard","year":"2013","journal-title":"Scand. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.gene.2018.08.059_bb0050","first-page":"31","article-title":"Serotonin transporter gene (SLC6A4) polymorphism in patients with irritable bowel syndrome and healthy controls","volume":"21","author":"Kumar","year":"2012","journal-title":"J. Gastrointestin. Liver Dis."},{"issue":"5292","key":"10.1016\/j.gene.2018.08.059_bb0055","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","article-title":"Association of anxiety-related traits with a polymorphism in the serotonin transportergene regulatory region","volume":"274","author":"Lesch","year":"1996","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.gene.2018.08.059_bb0060","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s00018-007-7377-3","article-title":"Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives","volume":"65","author":"Lesurtel","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.gene.2018.08.059_bb0065","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1365-2036.2006.02858.x","article-title":"Review article: intestinal serotonin signaling in irritable bowel syndrome","volume":"23","author":"Mawe","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.gene.2018.08.059_bb0070","doi-asserted-by":"crossref","first-page":"26","DOI":"10.15171\/mejdd.2016.48","article-title":"Serotonin transporter gene (SLC6A4) polymorphism and mucosal serotonin levels in southeastern Iranian patients with irritable bowel syndrome","volume":"9","author":"Mohammadi","year":"2017","journal-title":"Middle East J. Dig. Dis."},{"issue":"6","key":"10.1016\/j.gene.2018.08.059_bb0075","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1572-0241.2005.41700.x","article-title":"Genetic influences in irritable bowel syndrome: a twin study","volume":"100","author":"Mohammed","year":"2005","journal-title":"Am. J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.gene.2018.08.059_bb0080","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"PRISMA group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann. Intern. Med."},{"issue":"1\u20132","key":"10.1016\/j.gene.2018.08.059_bb0085","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0169-328X(99)00083-2","article-title":"Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells. Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells","volume":"68","author":"Mortensen","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"1","key":"10.1016\/j.gene.2018.08.059_bb0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.gtc.2010.12.011","article-title":"The role of genetics in IBS","volume":"40","author":"Saito","year":"2011","journal-title":"Gastroenterol. Clin. N. Am."},{"issue":"10","key":"10.1016\/j.gene.2018.08.059_bb0095","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/MCG.0b013e3181b37e8c","article-title":"Serotonin transporter promoter variant: analysis in Indian IBS patients and control population","volume":"43","author":"Sikander","year":"2009","journal-title":"J. Clin. Gastroenterol."},{"issue":"9","key":"10.1016\/j.gene.2018.08.059_bb0100","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918309223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918309223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T23:43:43Z","timestamp":1539128623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918309223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":20,"alternative-id":["S0378111918309223"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.08.059","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between SERT insertion\/deletion polymorphism and the risk of irritable bowel syndrome: A meta-analysis based on 7039 subjects","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.08.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}