{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:55:05Z","timestamp":1769244905202,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science and Technology fund from Bijie City","award":["[2013]63"],"award-info":[{"award-number":["[2013]63"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.gene.2018.11.009","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T02:26:01Z","timestamp":1541471161000},"page":"16-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Genetic variations in inflammation-related genes and their influence on the susceptibility of pediatric acute lung injury in a Chinese population"],"prefix":"10.1016","volume":"687","author":[{"given":"Xinqian","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2018.11.009_bb0005","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00134-007-0649-4","article-title":"Insertion\/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome","volume":"33","author":"Adamzik","year":"2007","journal-title":"Intensive Care Med."},{"issue":"4","key":"10.1016\/j.gene.2018.11.009_bb0010","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3889\/oamjms.2016.110","article-title":"Assessment of the \u2212174G\/C (rs1800795) and \u2212572G\/C (rs1800796) Interleukin 6 gene polymorphisms in Egyptian patients with rheumatoid arthritis","volume":"4","author":"Amr","year":"2016","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"10.1016\/j.gene.2018.11.009_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019469","article-title":"An NFKB1 promoter insertion\/deletion polymorphism influences risk and outcome in acute respiratory distress syndrome among Caucasians","volume":"6","author":"Bajwa","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.009_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061405","article-title":"Intratracheal IL-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice","volume":"8","author":"Bhargava","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.009_bb0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1399-0039.2010.01506.x","article-title":"Association of interleukin 18 gene polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery","volume":"76","author":"Chen","year":"2010","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.gene.2018.11.009_bb0030","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nm.2628","article-title":"An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection","volume":"18","author":"Chen","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.gene.2018.11.009_bb0035","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ccc.2010.12.005","article-title":"Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury","volume":"27","author":"Cross","year":"2011","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.gene.2018.11.009_bb0040","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1590\/S0103-507X2009000400012","article-title":"Genetic susceptibility in acute lung injury and acute respiratory distress syndrome","volume":"21","author":"Dias","year":"2009","journal-title":"Rev. Bras. Ter. Intensiva"},{"key":"10.1016\/j.gene.2018.11.009_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044987","article-title":"Sepsis-induced acute lung injury (ALI) is milder in diabetic rats and correlates with impaired NFkB activation","volume":"7","author":"Filgueiras","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.009_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.trsl.2008.05.006","article-title":"IL6 gene-wide haplotype is associated with susceptibility to acute lung injury","volume":"152","author":"Flores","year":"2008","journal-title":"Transl. Res."},{"key":"10.1016\/j.gene.2018.11.009_bb0055","first-page":"860","article-title":"Genetics of acute lung injury: past, present and future","volume":"76","author":"Flores","year":"2010","journal-title":"Minerva Anestesiol."},{"key":"10.1016\/j.gene.2018.11.009_bb0060","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1359-6101(03)00059-5","article-title":"Cytokine-mediated inflammation in acute lung injury","volume":"14","author":"Goodman","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"issue":"3\u20134","key":"10.1016\/j.gene.2018.11.009_bb0065","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.gene.2018.11.009_bb0070","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejmhg.2015.10.005","article-title":"Cytokine gene polymorphisms and their association with cervical cancer: a North Indian study","volume":"17","author":"Gupta","year":"2016","journal-title":"Egypt. J. Med. Human Genet."},{"key":"10.1016\/j.gene.2018.11.009_bb0075","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.12659\/MSM.893471","article-title":"Polymorphisms in NFKB1 and NFKBIA genes modulate the risk of developing prostate cancer among Han Chinese","volume":"21","author":"Han","year":"2015","journal-title":"Med. Sci. Monit."},{"issue":"Suppl. 1","key":"10.1016\/j.gene.2018.11.009_bb0080","doi-asserted-by":"crossref","first-page":"P368","DOI":"10.1186\/cc7532","article-title":"Assessment of IL-18 values in septic acute lung injury\/acute respiratory distress syndrome patients","volume":"13","author":"Kikkawa","year":"2009","journal-title":"Crit. Care"},{"key":"10.1016\/j.gene.2018.11.009_bb0085","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4046\/trd.2016.79.2.53","article-title":"Sepsis and acute respiratory distress syndrome: recent update","volume":"79","author":"Kim","year":"2016","journal-title":"Tuberc. Respir. Dis. (Seoul)"},{"key":"10.1016\/j.gene.2018.11.009_bb0090","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jdermsci.2004.10.002","article-title":"Influence of genetic polymorphisms on interleukin-10 mRNA expression and psoriasis susceptibility","volume":"37","author":"Kingo","year":"2005","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.gene.2018.11.009_bb0100","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s11684-012-0219-1","article-title":"Early and marked up-regulation of TNF-\u03b1 in acute respiratory distress syndrome after cardiopulmonary bypass","volume":"6","author":"Li","year":"2012","journal-title":"Front. Med."},{"key":"10.1016\/j.gene.2018.11.009_bb0105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/expphysiol.2014.083337","article-title":"Exogenous interleukin-10 attenuates hyperoxia-induced acute lung injury in mice","volume":"100","author":"Li","year":"2015","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.gene.2018.11.009_bb0110","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12899-016-0027-y","article-title":"Small interfering RNA targeting NF-\u03baB attenuates lipopolysaccharide-induced acute lung injury in rats","volume":"16","author":"Li","year":"2016","journal-title":"BMC Physiol."},{"key":"10.1016\/j.gene.2018.11.009_bb0115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2350-13-76","article-title":"Association between insertion\/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury\/acute respiratory distress syndrome: a meta-analysis","volume":"13","author":"Matsuda","year":"2012","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.gene.2018.11.009_bb0120","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2350-13-52","article-title":"SNP-set analysis replicates acute lung injury genetic risk factors","volume":"13","author":"Meyer","year":"2012","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.gene.2018.11.009_bb0125","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.canep.2013.05.007","article-title":"The functional \u221294 insertion\/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer","volume":"37","author":"Mohd Suzairi","year":"2013","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.gene.2018.11.009_bb0130","doi-asserted-by":"crossref","DOI":"10.5812\/hepatmon.32427","article-title":"Association between IL-10 gene promoter polymorphisms (\u2212592 A\/C, \u2212819 T\/C, \u22121082 A\/G) and susceptibility to HBV infection in an Iranian population","volume":"16","author":"Moudi","year":"2016","journal-title":"Hepat. Mon."},{"key":"10.1016\/j.gene.2018.11.009_bb0135","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1038\/jid.2014.123","article-title":"TNF-\u03b1 gene polymorphisms: association with disease susceptibility and response to anti-TNF-\u03b1 treatment in psoriatic arthritis","volume":"134","author":"Murdaca","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.gene.2018.11.009_bb0140","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3892\/br.2017.908","article-title":"Evaluation of tumor necrosis factor (TNF)-\u03b1 mRNA expression level and the rs1799964 polymorphism of the TNF-\u03b1 gene in peripheral mononuclear cells of patients with inflammatory bowel diseases","volume":"6","author":"Nourian","year":"2017","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.gene.2018.11.009_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051104","article-title":"Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study","volume":"7","author":"O'Mahony","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.009_bb0150","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1183\/09031936.00093911","article-title":"Resolution of acute lung injury and inflammation: a translational mouse model","volume":"39","author":"Patel","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.gene.2018.11.009_bb0155","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.4049\/jimmunol.1202437","article-title":"TNF-induced death signaling triggers alveolar epithelial dysfunction in acute lung injury","volume":"190","author":"Patel","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2018.11.009_bb0160","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/PCC.0000000000000350","article-title":"Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference","volume":"16","author":"Pediatric Acute Lung Injury Consensus Conference Group","year":"2015","journal-title":"Pediatr. Crit. Care Med."},{"key":"10.1016\/j.gene.2018.11.009_bb0165","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2217\/pgs.09.89","article-title":"Genetic polymorphisms associated with acute lung injury","volume":"10","author":"Reddy","year":"2009","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.gene.2018.11.009_bb0170","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/SHK.0b013e31819e2db6","article-title":"In vivo IL-18 supplementation ameliorates lethal acute lung injury in burn-primed endotoxemic mice: a novel anti-inflammatory role of IL-18","volume":"32","author":"Sekine","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.gene.2018.11.009_bb0175","doi-asserted-by":"crossref","first-page":"L677","DOI":"10.1152\/ajplung.2001.281.3.L677","article-title":"A low level of TNF-alpha mediates hemorrhage-induced acute lung injury via p55 TNF receptor","volume":"281","author":"Song","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.gene.2018.11.009_bb0180","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s12032-013-0693-6","article-title":"Gender-specific association of NFKBIA promoter polymorphisms with the risk of sporadic colorectal cancer","volume":"30","author":"Tan","year":"2013","journal-title":"Med. Oncol."},{"key":"10.1016\/j.gene.2018.11.009_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2370.1997.tb00001.x","article-title":"An investigation of polymorphism in the interleukin-10 gene promoter","volume":"24","author":"Turner","year":"1997","journal-title":"Eur. J. Immunogenet."},{"key":"10.1016\/j.gene.2018.11.009_bb0190","doi-asserted-by":"crossref","DOI":"10.17795\/ijcp-3434","article-title":"A common SNP of IL-10 (\u22121082A\/G) is associated with increased risk of premenopausal breast cancer in South Indian Women","volume":"8","author":"Vinod","year":"2015","journal-title":"Iran. J. Cancer Prev."},{"key":"10.1016\/j.gene.2018.11.009_bb0195","first-page":"CR260","article-title":"Association between inflammatory genetic polymorphism and acute lung injury after cardiac surgery with cardiopulmonary bypass","volume":"16","author":"Wang","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.gene.2018.11.009_bb0200","article-title":"Thrombocytopenia is associated with acute respiratory distress syndrome mortality: an international study","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.009_bb0205","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","article-title":"Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation","volume":"94","author":"Wilson","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.009_bb0210","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1440-1843.2009.01516.x","article-title":"Attenuation of lipopolysaccharide-induced acute lung injury by treatment with IL-10","volume":"14","author":"Wu","year":"2009","journal-title":"Respirology"},{"key":"10.1016\/j.gene.2018.11.009_bb0215","article-title":"IL-6 ameliorates acute lung injury in influenza virus infection","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2018.11.009_bb0220","first-page":"9387","article-title":"Association between interleukin-18 genetic polymorphisms and development of acute pancreatitis risk in a Chinese population","volume":"9","author":"Ye","year":"2016","journal-title":"Int. J. Clin. Exp. Pathol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918311521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918311521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T16:40:15Z","timestamp":1572540015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918311521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":43,"alternative-id":["S0378111918311521"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.11.009","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic variations in inflammation-related genes and their influence on the susceptibility of pediatric acute lung injury in a Chinese population","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}