{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:01:39Z","timestamp":1790996499861,"version":"4.1.0"},"reference-count":186,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR16655\/NER\/95\/132\/2015"],"award-info":[{"award-number":["BT\/PR16655\/NER\/95\/132\/2015"]}],"id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IIT Guwahati Institutional Start-Up Grant"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.gene.2018.11.069","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T10:34:13Z","timestamp":1542882853000},"page":"146-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"special_numbering":"C","title":["An insight into non-integrative gene delivery approaches to generate transgene-free induced pluripotent stem cells"],"prefix":"10.1016","volume":"686","author":[{"given":"Krishna Kumar","family":"Haridhasapavalan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manash P.","family":"Borgohain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrima","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bitan","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-8364","authenticated-orcid":false,"given":"Rajkumar P.","family":"Thummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2018.11.069_bb0005","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.1038\/sj.onc.1209046","article-title":"SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation","volume":"24","author":"Ahuja","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2018.11.069_bb0010","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/sj.gt.3302612","article-title":"Gutless adenovirus: last-generation adenovirus for gene therapy","volume":"12","author":"Alba","year":"2005","journal-title":"Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0015","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1172\/JCI34316","article-title":"Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice","volume":"118","author":"Allocca","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2018.11.069_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gde.2018.06.002","article-title":"Cellular trajectories and molecular mechanisms of iPSC reprogramming","volume":"52","author":"Apostolou","year":"2018","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.gene.2018.11.069_bb0025","doi-asserted-by":"crossref","first-page":"14234","DOI":"10.1073\/pnas.1103509108","article-title":"Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors","volume":"108","author":"Ban","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/19768354.2018.1451367","article-title":"Optimization of episomal reprogramming for generation of human induced pluripotent stem cells from fibroblasts","volume":"22","author":"Bang","year":"2018","journal-title":"Animal Cells Syst. (Seoul)"},{"key":"10.1016\/j.gene.2018.11.069_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/srep11319","article-title":"A cost-effective and efficient reprogramming platform for large-scale production of integration-free human induced pluripotent stem cells in chemically defined culture","volume":"5","author":"Beers","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2018.11.069_bb0040","article-title":"Integrating piggyBac transposon transgenes into mouse fibroblasts by electroporation","volume":"2017","author":"Behringer","year":"2017","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.gene.2018.11.069_bb0045","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2174\/156652311797415836","article-title":"Transposon-mediated gene transfer into adult and induced pluripotent stem cells","volume":"11","author":"Belay","year":"2011","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0050","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nrc3034","article-title":"The tumorigenicity of human embryonic and induced pluripotent stem cells","volume":"11","author":"Ben-David","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.gene.2018.11.069_bb0055","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.scr.2015.09.009","article-title":"Reprogramming of mouse amniotic fluid cells using a PiggyBac transposon system","volume":"15","author":"Bertin","year":"2015","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/bjp.2008.349","article-title":"Viral vectors: from virology to transgene expression","volume":"157","author":"Bouard","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.gene.2018.11.069_bb0065","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s12015-015-9622-8","article-title":"Choices for induction of pluripotency: recent developments in human induced pluripotent stem cell reprogramming strategies","volume":"12","author":"Brouwer","year":"2016","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.gene.2018.11.069_bb0070","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nrg3473","article-title":"Mechanisms and models of somatic cell reprogramming","volume":"14","author":"Buganim","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.gene.2018.11.069_bb0075","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1073\/pnas.0811426106","article-title":"Reprogramming of murine and human somatic cells using a single polycistronic vector","volume":"106","author":"Carey","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0080","first-page":"17","article-title":"Adeno-associated viral vectors as gene delivery vehicles","volume":"6","author":"Carter","year":"2000","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.gene.2018.11.069_bb0085","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/gt.2011.77","article-title":"Supercoiled Minivector DNA resists shear forces associated with gene therapy delivery","volume":"19","author":"Catanese","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0090","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/gt.2011.215","article-title":"Minicircle DNA electrotransfer for efficient tissue-targeted gene delivery","volume":"20","author":"Chabot","year":"2013","journal-title":"Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1525-0016(03)00168-0","article-title":"Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo","volume":"8","author":"Chen","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0100","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nmeth.1593","article-title":"Chemically defined conditions for human iPSC derivation and culture","volume":"8","author":"Chen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.gene.2018.11.069_bb0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12896-015-0121-4","article-title":"A novel adenoviral vector carrying an all-in-one Tet-On system with an autoregulatory loop for tight, inducible transgene expression","volume":"15","author":"Chen","year":"2015","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.gene.2018.11.069_bb0110","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.gendis.2014.12.001","article-title":"Sustained high level transgene expression in mammalian cells mediated by the optimized piggyBac transposon system","volume":"2","author":"Chen","year":"2015","journal-title":"Genes Dis."},{"key":"10.1016\/j.gene.2018.11.069_bb0115","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.stem.2012.01.005","article-title":"Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression","volume":"10","author":"Cheng","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0120","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/cr.2011.12","article-title":"Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures","volume":"21","author":"Chou","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0125","doi-asserted-by":"crossref","first-page":"320","DOI":"10.5966\/sctm.2014-0214","article-title":"A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach","volume":"4","author":"Chou","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.gene.2018.11.069_bb0130","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/sj.gt.3300540","article-title":"A new DNA vehicle for nonviral gene delivery: supercoiled minicircle","volume":"4","author":"Darquet","year":"1997","journal-title":"Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0135","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.diff.2013.06.002","article-title":"Generation of induced pluripotent stem cells from human foetal fibroblasts using the Sleeping Beauty transposon gene delivery system","volume":"86","author":"Davis","year":"2013","journal-title":"Differentiation"},{"key":"10.1016\/j.gene.2018.11.069_bb0140","series-title":"Cardiac Tissue Engineering","first-page":"1","article-title":"Second generation codon optimized minicircle (CoMiC) for nonviral reprogramming of human adult fibroblasts","author":"Diecke","year":"2014"},{"key":"10.1016\/j.gene.2018.11.069_bb0145","doi-asserted-by":"crossref","first-page":"8081","DOI":"10.1038\/srep08081","article-title":"Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency","volume":"5","author":"Diecke","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2018.11.069_bb0150","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.1158799","article-title":"Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons","volume":"321","author":"Dimos","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.gene.2018.11.069_bb0155","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/hum.2011.138","article-title":"Hyperactive piggyBac gene transfer in human cells and in vivo","volume":"23","author":"Doherty","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0160","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cell.2011.05.034","article-title":"The human brain in a dish: the promise of iPSC-derived neurons","volume":"145","author":"Dolmetsch","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/mt.2009.258","article-title":"Characterization of genome integrity for oversized recombinant AAV vector","volume":"18","author":"Dong","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0170","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1038\/nprot.2012.121","article-title":"Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression","volume":"7","author":"Dowey","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2018.11.069_bb0175","doi-asserted-by":"crossref","first-page":"8568","DOI":"10.1128\/JVI.72.11.8568-8577.1998","article-title":"Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue","volume":"72","author":"Duan","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0180","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/mthe.2001.0456","article-title":"Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison","volume":"4","author":"Duan","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0185","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","author":"Ebert","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.11.069_bb0190","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/sj.gt.3302991","article-title":"Sendai virus-mediated CFTR gene transfer to the airway epithelium","volume":"14","author":"Ferrari","year":"2007","journal-title":"Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2013.02.037","article-title":"How induced pluripotent stem cells are redefining personalized medicine","volume":"520","author":"Ferreira","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.gene.2018.11.069_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113052","article-title":"New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee blood","volume":"9","author":"Fujie","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0205","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2183\/pjab.85.348","article-title":"Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome","volume":"85","author":"Fusaki","year":"2009","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.gene.2018.11.069_bb0210","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.1093\/nar\/gkr384","article-title":"Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery","volume":"39","author":"Galla","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0215","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/mthe.2000.0140","article-title":"Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo","volume":"2","author":"Gerdes","year":"2000","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0020156","article-title":"Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers","volume":"2","author":"Geurts","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.gene.2018.11.069_bb0225","series-title":"The Adenoviruses","author":"Ginsberg","year":"2013"},{"key":"10.1016\/j.gene.2018.11.069_bb0230","doi-asserted-by":"crossref","first-page":"8918","DOI":"10.1073\/pnas.0901471106","article-title":"Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector","volume":"106","author":"Gonzalez","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0235","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrg2937","article-title":"Methods for making induced pluripotent stem cells: reprogramming a la carte","volume":"12","author":"Gonz\u00e1lez","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.gene.2018.11.069_bb0240","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature09805","article-title":"Somatic coding mutations in human induced pluripotent stem cells","volume":"471","author":"Gore","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.11.069_bb0245","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/mt.2010.47","article-title":"Comparative analysis of transposable element vector systems in human cells","volume":"18","author":"Grabundzija","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0250","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/nar\/gks1305","article-title":"Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells","volume":"41","author":"Grabundzija","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0255","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1089\/hum.2010.245","article-title":"Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors","volume":"22","author":"Gray","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0260","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2217\/fvl.11.6","article-title":"Implications of the innate immune response to adenovirus and adenoviral vectors","volume":"6","author":"Gregory","year":"2011","journal-title":"Futur. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039233","article-title":"Homologous recombination mediates functional recovery of dysferlin deficiency following AAV5 gene transfer","volume":"7","author":"Grose","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0270","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.scr.2017.03.022","article-title":"Generation of non-transgenic iPS cells from human cord blood CD34+ cells under animal component-free conditions","volume":"21","author":"Haase","year":"2017","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0275","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nbt0702-697","article-title":"Efficient mouse airway transduction following recombination between AAV vectors carrying parts of a larger gene","volume":"20","author":"Halbert","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.gene.2018.11.069_bb0280","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/genes8020065","article-title":"Advances in non-viral DNA vectors for gene therapy","volume":"8","author":"Hardee","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.gene.2018.11.069_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2007.10.005","article-title":"Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications","volume":"132","author":"Hartman","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0290","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1128\/JVI.73.7.6141-6146.1999","article-title":"Frequency and stability of chromosomal integration of adenovirus vectors","volume":"73","author":"Harui","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0295","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","article-title":"A simplified system for generating recombinant adenoviruses","volume":"95","author":"He","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0300","doi-asserted-by":"crossref","first-page":"10557","DOI":"10.1016\/S0021-9258(19)85121-9","article-title":"Enhanced transcription of fibroin gene in vitro on covalently closed circular templates","volume":"260","author":"Hirose","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2018.11.069_bb0305","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/mt.2009.280","article-title":"Little vector, big gene transduction: fragmented genome reassembly of adeno-associated virus","volume":"18","author":"Hirsch","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0310","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1038\/mt.2013.184","article-title":"Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway","volume":"21","author":"Hirsch","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0315","series-title":"Gene Therapy for Neurological Disorders","first-page":"21","article-title":"Delivering transgenic DNA exceeding the carrying capacity of AAV vectors","author":"Hirsch","year":"2016"},{"key":"10.1016\/j.gene.2018.11.069_bb0320","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jmv.21052","article-title":"Comparison between Sendai virus and adenovirus vectors to transduce HIV-1 genes into human dendritic cells","volume":"80","author":"Hosoya","year":"2008","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10565-009-9139-5","article-title":"Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells)","volume":"26","author":"Howarth","year":"2010","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.gene.2018.11.069_bb0330","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1089\/scd.2013.0620","article-title":"All roads lead to induced pluripotent stem cells: the technologies of iPSC generation","volume":"23","author":"Hu","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.gene.2018.11.069_bb0335","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1089\/scd.2013.0621","article-title":"Vectorology and factor delivery in induced pluripotent stem cell reprogramming","volume":"23","author":"Hu","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.gene.2018.11.069_bb0340","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1182\/blood-2010-07-298331","article-title":"Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells","volume":"117","author":"Hu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.gene.2018.11.069_bb0345","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature09871","article-title":"Copy number variation and selection during reprogramming to pluripotency","volume":"471","author":"Hussein","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.11.069_bb0350","doi-asserted-by":"crossref","first-page":"992","DOI":"10.5966\/sctm.2013-0179","article-title":"Removal of reprogramming transgenes improves the tissue reconstitution potential of keratinocytes generated from human induced pluripotent stem cells","volume":"3","author":"Igawa","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.gene.2018.11.069_bb0355","doi-asserted-by":"crossref","first-page":"11290","DOI":"10.1128\/JVI.00963-07","article-title":"DNA palindromes with a modest arm length of \u227320 base pairs are a significant target for recombinant adeno-associated virus vector integration in the liver, muscles, and heart in mice","volume":"81","author":"Inagaki","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0360","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1128\/JVI.77.5.3238-3246.2003","article-title":"Nontransmissible virus-like particle formation by F-deficient Sendai virus is temperature sensitive and reduced by mutations in M and HN proteins","volume":"77","author":"Inoue","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0365","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1759-8753-1-25","article-title":"The expanding universe of transposon technologies for gene and cell engineering","volume":"1","author":"Ivics","year":"2010","journal-title":"Mob. DNA"},{"key":"10.1016\/j.gene.2018.11.069_bb0370","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nmeth.1426","article-title":"A nonviral minicircle vector for deriving human iPS cells","volume":"7","author":"Jia","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.gene.2018.11.069_bb0375","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1089\/scd.2014.0110","article-title":"Human transgene-free amniotic-fluid-derived induced pluripotent stem cells for autologous cell therapy","volume":"23","author":"Jiang","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.gene.2018.11.069_bb0380","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/scrt435","article-title":"Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells","volume":"5","author":"Kadari","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.gene.2018.11.069_bb0385","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nature07864","article-title":"Virus-free induction of pluripotency and subsequent excision of reprogramming factors","volume":"458","author":"Kaji","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.11.069_bb0390","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.117.305365","article-title":"Human induced pluripotent stem cell\u2013derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes","volume":"117","author":"Karakikes","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0395","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/stem.730","article-title":"Site-specific recombinase strategy to create induced pluripotent stem cells efficiently with plasmid DNA","volume":"29","author":"Karow","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.gene.2018.11.069_bb0400","series-title":"Induced Pluripotent Stem (iPS) Cells","first-page":"111","article-title":"Inducible transgene expression in human iPS cells using versatile all-in-one piggyBac transposons","author":"Kim","year":"2015"},{"key":"10.1016\/j.gene.2018.11.069_bb0405","first-page":"1397","article-title":"Transposon-based reprogramming to induced pluripotency","volume":"30","author":"Kumar","year":"2015","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.gene.2018.11.069_bb0410","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/mt.2009.256","article-title":"Evidence for the failure of adeno-associated virus serotype 5 to package a viral genome \u22658.2\u202fkb","volume":"18","author":"Lai","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0415","series-title":"Fields BN","article-title":"Paramyxoviridae: the viruses and their replication","author":"Lamb","year":"1996"},{"key":"10.1016\/j.gene.2018.11.069_bb0420","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.stem.2010.12.003","article-title":"Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture","volume":"8","author":"Laurent","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0425","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gendis.2017.04.001","article-title":"Adenovirus-mediated gene delivery: potential applications for gene and cell-based therapies in the new era of personalized medicine","volume":"4","author":"Lee","year":"2017","journal-title":"Genes Dis."},{"key":"10.1016\/j.gene.2018.11.069_bb0430","first-page":"L796","article-title":"Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors","volume":"276","author":"Li","year":"1999","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.gene.2018.11.069_bb0435","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.1128\/JVI.74.14.6564-6569.2000","article-title":"A cytoplasmic RNA vector derived from nontransmissible Sendai virus with efficient gene transfer and expression","volume":"74","author":"Li","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0440","first-page":"E2279","article-title":"piggyBac transposase tools for genome engineering","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0445","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5661\/bger-26-223","article-title":"2A to the fore\u2013research, technology and applications","volume":"26","author":"Luke","year":"2009","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"10.1016\/j.gene.2018.11.069_bb0450","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s13238-016-0362-6","article-title":"Reprogramming cell fates by small molecules","volume":"8","author":"Ma","year":"2017","journal-title":"Protein Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0455","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/564612","article-title":"Generation of human-induced pluripotent stem cells by a nonintegrating RNA Sendai virus vector in feeder-free or xeno-free conditions","volume":"2012","author":"MacArthur","year":"2012","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.gene.2018.11.069_bb0460","series-title":"Pluripotent Stem Cells","first-page":"23","article-title":"A review of the methods for human iPSC derivation","author":"Malik","year":"2013"},{"key":"10.1016\/j.gene.2018.11.069_bb0465","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nbt.1890","article-title":"Recurrent copy number variations in human induced pluripotent stem cells","volume":"29","author":"Martins-Taylor","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.gene.2018.11.069_bb0470","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ng.343","article-title":"Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates","volume":"41","author":"M\u00e1t\u00e9s","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2018.11.069_bb0475","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/jgm.1310","article-title":"Transgene expression of transfected supercoiled plasmid DNA concatemers in mammalian cells","volume":"11","author":"Maucksch","year":"2009","journal-title":"J. Gene Med."},{"key":"10.1016\/j.gene.2018.11.069_bb0480","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1472-6750-10-9","article-title":"Comparative transfection of DNA into primary and transformed mammalian cells from different lineages","volume":"10","author":"Maurisse","year":"2010","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.gene.2018.11.069_bb0485","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.stem.2010.07.017","article-title":"Identification and classification of chromosomal aberrations in human induced pluripotent stem cells","volume":"7","author":"Mayshar","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0490","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ygeno.2007.02.006","article-title":"Flow-cytometric analysis of mouse embryonic stem cell lipofection using small and large DNA constructs","volume":"89","author":"McLenachan","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/j.gene.2018.11.069_bb0495","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/mt.2011.258","article-title":"Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 alone","volume":"20","author":"Meng","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0500","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/ijms17010141","article-title":"An overview of direct somatic reprogramming: the ins and outs of iPSCs","volume":"17","author":"Menon","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2018.11.069_bb0505","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/ng1380","article-title":"Adeno-associated virus vectors integrate at chromosome breakage sites","volume":"36","author":"Miller","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2018.11.069_bb0510","doi-asserted-by":"crossref","first-page":"12417","DOI":"10.1074\/jbc.M110.168013","article-title":"Simple generation of human induced pluripotent stem cells using poly (\u03b2-amino esters) as non-viral gene delivery system","volume":"286","author":"Montserrat","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2018.11.069_bb0515","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1016\/j.yexcr.2012.07.014","article-title":"Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer","volume":"318","author":"Muenthaisong","year":"2012","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0520","doi-asserted-by":"crossref","first-page":"14152","DOI":"10.1073\/pnas.1009374107","article-title":"Promotion of direct reprogramming by transformation-deficient Myc","volume":"107","author":"Nakagawa","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0525","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ng1179","article-title":"AAV serotype 2 vectors preferentially integrate into active genes in mice","volume":"34","author":"Nakai","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2018.11.069_bb0530","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1038\/sj.emboj.7601853","article-title":"The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells","volume":"26","author":"Nanbo","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2018.11.069_bb0535","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nprot.2010.173","article-title":"Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors","volume":"6","author":"Narsinh","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2018.11.069_bb0540","doi-asserted-by":"crossref","DOI":"10.4103\/2277-9175.98152","article-title":"Viral and nonviral delivery systems for gene delivery","volume":"1","author":"Nayerossadat","year":"2012","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0545","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1128\/JVI.02953-15","article-title":"Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high throughput screen","volume":"90","author":"Nicolson","year":"2016","journal-title":"J. Virol."},{"issue":"183780","key":"10.1016\/j.gene.2018.11.069_bb0550","article-title":"Development of defective and persistent Sendai virus vector: a unique gene delivery\/expression system ideal for cell reprogramming","volume":"M110","author":"Nishimura","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2018.11.069_bb0555","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.scr.2017.06.011","article-title":"Simple and effective generation of transgene-free induced pluripotent stem cells using an auto-erasable Sendai virus vector responding to microRNA-302","volume":"23","author":"Nishimura","year":"2017","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0560","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.11.069_bb0565","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1164270","article-title":"Generation of mouse induced pluripotent stem cells without viral vectors","volume":"322","author":"Okita","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.gene.2018.11.069_bb0570","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.gene.2018.11.069_bb0575","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/stem.1293","article-title":"An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells","volume":"31","author":"Okita","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.gene.2018.11.069_bb0580","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042855","article-title":"Generation of induced pluripotent stem cells from human nasal epithelial cells using a Sendai virus vector","volume":"7","author":"Ono","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0585","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3892\/br.2017.867","article-title":"Pluripotent stem cells to hepatocytes, the journey so far","volume":"6","author":"Palakkan","year":"2017","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.gene.2018.11.069_bb0590","doi-asserted-by":"crossref","first-page":"12759","DOI":"10.1073\/pnas.0904825106","article-title":"Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation","volume":"106","author":"Papapetrou","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0595","article-title":"Efficient generation of virus-free iPS cells using liposomal magnetofection","volume":"7","author":"Park","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0600","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1139\/y11-125","article-title":"Advances and applications of induced pluripotent stem cells","volume":"90","author":"Pietronave","year":"2012","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.gene.2018.11.069_bb0605","first-page":"49","article-title":"Viral expression cassette elements to enhance transgene target specificity and expression in gene therapy","volume":"19","author":"Powell","year":"2015","journal-title":"Discov. Med."},{"key":"10.1016\/j.gene.2018.11.069_bb0610","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035824","article-title":"Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors","volume":"7","author":"Ramos-Mej\u00eda","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0615","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1002\/jcb.24183","article-title":"Assessing iPSC reprogramming methods for their suitability in translational medicine","volume":"113","author":"Rao","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.gene.2018.11.069_bb0620","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1093\/nar\/gkv017","article-title":"Evaluating the potential for undesired genomic effects of the piggyBac transposon system in human cells","volume":"43","author":"Saha","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.gene.2018.11.069_bb0625","first-page":"1007","article-title":"iPS cell generation: current and future challenges","volume":"1","author":"Saha","year":"2018","journal-title":"Ann. Stem Cell Res. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0630","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164720","article-title":"Novel strategy to control transgene expression mediated by a Sendai virus-based vector using a nonstructural C protein and endogenous microRNAs","volume":"11","author":"Sano","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0635","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/sj.gt.3301624","article-title":"Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo","volume":"9","author":"Scherer","year":"2002","journal-title":"Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0640","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nbt.3070","article-title":"A comparison of non-integrating reprogramming methods","volume":"33","author":"Schlaeger","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.gene.2018.11.069_bb0645","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13287-017-0581-7","article-title":"Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming","volume":"8","author":"Schmitt","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.gene.2018.11.069_bb0650","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1099\/0022-1317-81-6-1413","article-title":"Cellular receptors for viruses: links to tropism and pathogenesis","volume":"81","author":"Schneider-Schaulies","year":"2000","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0655","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2010.06.003","article-title":"Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells","volume":"7","author":"Seki","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0660","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1517\/14712590903455989","article-title":"Gene-delivery systems for iPS cell generation","volume":"10","author":"Shao","year":"2010","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0665","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000149587","article-title":"Characteristics and taxonomy of Parvoviridae","volume":"23","author":"Siegl","year":"1985","journal-title":"Intervirology"},{"key":"10.1016\/j.gene.2018.11.069_bb0670","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13287-017-0522-5","article-title":"DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing","volume":"8","author":"Simara","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.gene.2018.11.069_bb0675","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fcell.2015.00002","article-title":"Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery","volume":"3","author":"Singh","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2018.11.069_bb0680","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-213X-10-81","article-title":"Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors","volume":"10","author":"Si-Tayeb","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.gene.2018.11.069_bb0685","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/15384101.2015.1121332","article-title":"Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined conditions","volume":"15","author":"Slamecka","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.gene.2018.11.069_bb0690","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.cell.2009.02.013","article-title":"Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors","volume":"136","author":"Soldner","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0695","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/stem.495","article-title":"Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette","volume":"28","author":"Somers","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.gene.2018.11.069_bb0700","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cell.2009.01.001","article-title":"Role of the murine reprogramming factors in the induction of pluripotency","volume":"136","author":"Sridharan","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0705","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1126\/science.1162494","article-title":"Induced pluripotent stem cells generated without viral integration","volume":"322","author":"Stadtfeld","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.gene.2018.11.069_bb0710","article-title":"Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors","volume":"8","author":"Su","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0715","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0720","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0725","doi-asserted-by":"crossref","first-page":"6839","DOI":"10.1016\/j.vaccine.2008.09.074","article-title":"Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques","volume":"26","author":"Takeda","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.gene.2018.11.069_bb0730","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bbrc.2014.06.014","article-title":"Non-viral reprogramming of fibroblasts into induced pluripotent stem cells by Sleeping Beauty and piggyBac transposons","volume":"450","author":"Talluri","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2018.11.069_bb0735","doi-asserted-by":"crossref","first-page":"586","DOI":"10.5966\/sctm.2013-0195","article-title":"Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking","volume":"3","author":"Tan","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.gene.2018.11.069_bb0740","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1016\/j.bbrc.2017.12.007","article-title":"Efficient generation of transgene-and feeder-free induced pluripotent stem cells from human dental mesenchymal stem cells and their chemically defined differentiation into cardiomyocytes","volume":"495","author":"Tan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2018.11.069_bb0745","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1073\/pnas.1718446115","article-title":"Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor","volume":"115","author":"Tan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0750","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cyto.a.21072","article-title":"Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells","volume":"79","author":"Tiemann","year":"2011","journal-title":"Cytometry A"},{"key":"10.1016\/j.gene.2018.11.069_bb0755","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20160614","article-title":"Preclinical and clinical advances in transposon-based gene therapy","volume":"37","author":"Tipanee","year":"2017","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.gene.2018.11.069_bb0760","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1089\/hum.2017.128","article-title":"Transposons: moving forward from preclinical studies to clinical trials","volume":"28","author":"Tipanee","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0765","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1741-7007-6-40","article-title":"Use of the viral 2A peptide for bicistronic expression in transgenic mice","volume":"6","author":"Trichas","year":"2008","journal-title":"BMC Biol."},{"key":"10.1016\/j.gene.2018.11.069_bb0770","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/scd.2012.0157","article-title":"Small molecule inhibitors promote efficient generation of induced pluripotent stem cells from human skeletal myoblasts","volume":"22","author":"Trokovic","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.gene.2018.11.069_bb0775","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1365-2443.2011.01528.x","article-title":"Simple and efficient method for generation of induced pluripotent stem cells using piggyBac transposition of doxycycline-inducible factors and an EOS reporter system","volume":"16","author":"Tsukiyama","year":"2011","journal-title":"Genes Cells"},{"key":"10.1016\/j.gene.2018.11.069_bb0780","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092973","article-title":"A comprehensive system for generation and evaluation of induced pluripotent stem cells using piggyBac transposition","volume":"9","author":"Tsukiyama","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0785","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1046\/j.1432-1327.2000.01645.x","article-title":"Episomal vectors for gene expression in mammalian cells","volume":"267","author":"Van Craenenbroeck","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.gene.2018.11.069_bb0790","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.1128\/JVI.79.17.10999-11013.2005","article-title":"A capsid-modified helper-dependent adenovirus vector containing the \u03b2-globin locus control region displays a nonrandom integration pattern and allows stable, erythroid-specific gene expression","volume":"79","author":"Wang","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0795","doi-asserted-by":"crossref","first-page":"9290","DOI":"10.1073\/pnas.0801017105","article-title":"Chromosomal transposition of PiggyBac in mouse embryonic stem cells","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0800","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nprot.2016.152","article-title":"Efficient, footprint-free human iPSC genome editing by consolidation of Cas9\/CRISPR and piggyBac technologies","volume":"12","author":"Wang","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2018.11.069_bb0805","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1128\/JVI.06302-11","article-title":"iPSC clones reprogrammed via rAAV-mediated transduction contain integrated vector sequences","volume":"86","author":"Weltner","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.gene.2018.11.069_bb0810","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.stemcr.2016.04.005","article-title":"Enhanced generation of integration-free iPSCs from human adult peripheral blood mononuclear cells with an optimal combination of episomal vectors","volume":"6","author":"Wen","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.gene.2018.11.069_bb0815","doi-asserted-by":"crossref","DOI":"10.1038\/srep30742","article-title":"cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness","volume":"6","author":"Wiley","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2018.11.069_bb0820","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.mt.6300028","article-title":"PiggyBac transposon-mediated gene transfer in human cells","volume":"15","author":"Wilson","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0825","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature07863","article-title":"piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells","volume":"458","author":"Woltjen","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.gene.2018.11.069_bb0830","series-title":"Human Pluripotent Stem Cells","first-page":"87","article-title":"Transgene-free production of pluripotent stem cells using piggyBac transposons","author":"Woltjen","year":"2011"},{"key":"10.1016\/j.gene.2018.11.069_bb0835","series-title":"Induced Pluripotent Stem (iPS) Cells","first-page":"1","article-title":"The piggyBac transposon as a platform technology for somatic cell reprogramming studies in mouse","author":"Woltjen","year":"2015"},{"key":"10.1016\/j.gene.2018.11.069_bb0840","doi-asserted-by":"crossref","first-page":"15008","DOI":"10.1073\/pnas.0606979103","article-title":"piggyBac is a flexible and highly active transposon as compared to sleeping beauty, Tol2, and Mos1 in mammalian cells","volume":"103","author":"Wu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0845","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mt.2009.255","article-title":"Effect of genome size on AAV vector packaging","volume":"18","author":"Wu","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0850","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1101\/gr.173427.114","article-title":"Seamless gene correction of \u03b2-thalassemia mutations in patient-specific iPSCs using CRISPR\/Cas9 and piggyBac","volume":"24","author":"Xie","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.gene.2018.11.069_bb0855","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cell.2009.03.034","article-title":"A fresh look at iPS cells","volume":"137","author":"Yamanaka","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0860","article-title":"Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5\u039432 mutation confers resistance to HIV infection","volume":"201407473","author":"Ye","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0865","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/mthe.2000.0036","article-title":"Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs","volume":"1","author":"Yew","year":"2000","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0870","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1006\/mthe.2002.0598","article-title":"CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo","volume":"5","author":"Yew","year":"2002","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0875","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.stem.2009.08.001","article-title":"Hypoxia enhances the generation of induced pluripotent stem cells","volume":"5","author":"Yoshida","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2018.11.069_bb0880","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12015-016-9680-6","article-title":"Genomic instability of iPSCs: challenges towards their clinical applications","volume":"13","author":"Yoshihara","year":"2017","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.gene.2018.11.069_bb0885","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/jgm.938","article-title":"Naked Sendai virus vector lacking all of the envelope-related genes: reduced cytopathogenicity and immunogenicity","volume":"8","author":"Yoshizaki","year":"2006","journal-title":"J. Gene Med."},{"key":"10.1016\/j.gene.2018.11.069_bb0890","first-page":"2","article-title":"Patient-specific induced pluripotent stem cells as a platform for disease modeling. Drug discovery and precision personalized medicine","volume":"10","author":"Young","year":"2012","journal-title":"J. Stem Cell Res. Ther. S."},{"key":"10.1016\/j.gene.2018.11.069_bb0895","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.gene.2018.11.069_bb0900","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1126\/science.1172482","article-title":"Human induced pluripotent stem cells free of vector and transgene sequences","volume":"324","author":"Yu","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.gene.2018.11.069_bb0905","article-title":"Efficient feeder-free episomal reprogramming with small molecules","volume":"6","author":"Yu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2018.11.069_bb0910","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nmeth.1323","article-title":"Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon","volume":"6","author":"Yusa","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.gene.2018.11.069_bb0915","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1073\/pnas.1008322108","article-title":"A hyperactive piggyBac transposase for mammalian applications","volume":"108","author":"Yusa","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2018.11.069_bb0920","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2174\/1566523054065039","article-title":"Immune responses to adeno-associated virus vectors","volume":"5","author":"Zaiss","year":"2005","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.gene.2018.11.069_bb0925","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/72628","article-title":"Genomic integration and gene expression by a modified adenoviral vector","volume":"18","author":"Zheng","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.gene.2018.11.069_bb0930","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1002\/stem.201","article-title":"Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells","volume":"27","author":"Zhou","year":"2009","journal-title":"Stem Cells"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918312125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111918312125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:21:17Z","timestamp":1759854077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111918312125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":186,"alternative-id":["S0378111918312125"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2018.11.069","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An insight into non-integrative gene delivery approaches to generate transgene-free induced pluripotent stem cells","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2018.11.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}