{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:29:33Z","timestamp":1784543373844,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701266"],"award-info":[{"award-number":["31701266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.gene.2019.02.023","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T11:47:14Z","timestamp":1550576834000},"page":"40-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart"],"prefix":"10.1016","volume":"697","author":[{"given":"Xia","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongcun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2019.02.023_bb0005","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.devcel.2007.10.003","article-title":"SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth","volume":"13","author":"Bai","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.gene.2019.02.023_bb0010","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.200603119","article-title":"Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle","volume":"173","author":"Bang","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.gene.2019.02.023_bb0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0008-6363(99)00021-8","article-title":"Regulation of cardiovascular collagen synthesis by mechanical load","volume":"42","author":"Bishop","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.gene.2019.02.023_bb0020","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0008-6363(00)00043-2","article-title":"Matrix gene expression and decompensated heart failure: the aged SHR model","volume":"46","author":"Boluyt","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.gene.2019.02.023_bb0025","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2019.02.023_bb0030","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1242\/dev.079491","article-title":"AIP1 acts with cofilin to control actin dynamics during epithelial morphogenesis","volume":"139","author":"Chu","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.gene.2019.02.023_bb0035","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1146\/annurev.cellbio.18.012502.105840","article-title":"Striated muscle cytoarchitecture: an intricate web of form and function","volume":"18","author":"Clark","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2019.02.023_bb0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvq308","article-title":"Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart","volume":"89","author":"Creemers","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.gene.2019.02.023_bb0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/377083a0","article-title":"Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytes","volume":"377","author":"Gregorio","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.gene.2019.02.023_bb0050","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jelectrocard.2017.08.005","article-title":"Heart rate dependency of JT interval sections","volume":"50","author":"Hnatkova","year":"2017","journal-title":"J. Electrocardiol."},{"key":"10.1016\/j.gene.2019.02.023_bb0055","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ydbio.2018.04.004","article-title":"WDR1-regulated actin dynamics is required for outflow tract and right ventricle development","volume":"438","author":"Hu","year":"2018","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gene.2019.02.023_bb0060","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1242\/jcs.065698","article-title":"Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo","volume":"123","author":"Lin","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.gene.2019.02.023_bb0065","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.cellbio.14.1.487","article-title":"Defining actin filament length in striated muscle: rulers and caps or dynamic stability?","volume":"14","author":"Littlefield","year":"1998","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2019.02.023_bb0070","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.semcdb.2008.08.009","article-title":"Thin filament length regulation in striated muscle sarcomeres: pointed-end dynamics go beyond a nebulin ruler","volume":"19","author":"Littlefield","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2019.02.023_bb0075","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/35078517","article-title":"Actin dynamics at pointed ends regulates thin filament length in striated muscle","volume":"3","author":"Littlefield","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.gene.2019.02.023_bb0080","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1053-2498(03)00205-5","article-title":"The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron microscopy and amino acid analysis reveals low degree of reverse remodeling","volume":"23","author":"Milting","year":"2004","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.gene.2019.02.023_bb0085","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1091\/mbc.e05-11-1016","article-title":"Enhancement of actin-depolymerizing factor\/cofilin-dependent actin disassembly by actin-interacting protein 1 is required for organized actin filament assembly in the Caenorhabditis elegans body wall muscle","volume":"17","author":"Mohri","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.gene.2019.02.023_bb0090","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1083\/jcb.152.6.1313","article-title":"The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments","volume":"152","author":"Ono","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.gene.2019.02.023_bb0095","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1021\/bi034600x","article-title":"Regulation of actin filament dynamics by actin depolymerizing factor\/cofilin and actin-interacting protein 1: new blades for twisted filaments","volume":"42","author":"Ono","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.gene.2019.02.023_bb0100","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/cm.20476","article-title":"Dynamic regulation of sarcomeric actin filaments in striated muscle","volume":"67","author":"Ono","year":"2010","journal-title":"Cytoskeleton"},{"key":"10.1016\/j.gene.2019.02.023_bb0105","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbrc.2017.10.096","article-title":"Functions of actin-interacting protein 1 (AIP1)\/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation","volume":"506","author":"Ono","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2019.02.023_bb0110","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1091\/mbc.e10-12-0934","article-title":"The two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegans","volume":"22","author":"Ono","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.gene.2019.02.023_bb0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/rheumatology\/ket338","article-title":"Prolonged QTc interval predicts all-cause mortality in patients with rheumatoid arthritis: an association driven by high inflammatory burden","volume":"53","author":"Panoulas","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.gene.2019.02.023_bb0120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10741-016-9536-9","article-title":"The fibrosis-cell death axis in heart failure","volume":"21","author":"Piek","year":"2016","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.gene.2019.02.023_bb0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1247\/csf.22.59","article-title":"Dynamics of actin in cardiac myofibrils and fibroblast stress fibers","volume":"22","author":"Shimada","year":"1997","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.gene.2019.02.023_bb0130","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jacc.2005.08.067","article-title":"Prolonged QTc interval and risk of sudden cardiac death in a population of older adults","volume":"47","author":"Straus","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.gene.2019.02.023_bb0135","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0040-8166(98)80076-1","article-title":"Exchangeability of actin in cardiac myocytes and fibroblasts as determined by fluorescence photobleaching recovery","volume":"30","author":"Suzuki","year":"1998","journal-title":"Tissue Cell"},{"key":"10.1016\/j.gene.2019.02.023_bb0140","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.hrthm.2017.05.031","article-title":"The Tpeak - tend interval as an electrocardiographic risk marker of arrhythmic and mortality outcomes: a systematic review and meta-analysis","volume":"14","author":"Tse","year":"2017","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.gene.2019.02.023_bb0145","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/cm.20063","article-title":"Dynamics of Z-band based proteins in developing skeletal muscle cells","volume":"61","author":"Wang","year":"2005","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.gene.2019.02.023_bb0150","doi-asserted-by":"crossref","first-page":"e1818","DOI":"10.1038\/cddis.2015.182","article-title":"AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment","volume":"6","author":"Xu","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2019.02.023_bb0155","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1242\/jcs.040477","article-title":"Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF\/cofilin, AIP1 and profilin in C. elegans","volume":"121","author":"Yamashiro","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.gene.2019.02.023_bb0160","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/heart.89.11.1363","article-title":"Drug induced QT prolongation and torsades de pointes","volume":"89","author":"Yap","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.gene.2019.02.023_bb0165","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1016\/j.ajpath.2014.04.007","article-title":"A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice","volume":"184","author":"Yuan","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.gene.2019.02.023_bb0170","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.7150\/ijbs.23845","article-title":"WDR1 promotes cell growth and migration and contributes to malignant phenotypes of non-small cell lung cancer through ADF\/cofilin-mediated actin dynamics","volume":"14","author":"Yuan","year":"2018","journal-title":"Int. J. Biol. Sci."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919301489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919301489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T13:40:18Z","timestamp":1565185218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111919301489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":34,"alternative-id":["S0378111919301489"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2019.02.023","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2019.02.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}