{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:11:55Z","timestamp":1772824315674,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["454865\/2014-7"],"award-info":[{"award-number":["454865\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"FAPERGS","doi-asserted-by":"publisher","award":["16\/2551-0000520-6"],"award-info":[{"award-number":["16\/2551-0000520-6"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.gene.2019.02.056","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T20:10:42Z","timestamp":1551730242000},"page":"157-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Systems biology approach identifies key regulators and the interplay between miRNAs and transcription factors for pathological cardiac hypertrophy"],"prefix":"10.1016","volume":"698","author":[{"given":"Mariana","family":"Recamonde-Mendoza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano V.","family":"Werhli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia","family":"Biolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.gene.2019.02.056_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0108051","article-title":"RNA expression profiling of human iPSC-derived cardiomyocytes in a cardiac hypertrophy model","volume":"9","author":"Aggarwal","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.gene.2019.02.056_bb0010","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.gene.2019.02.056_bb0015","doi-asserted-by":"crossref","first-page":"16830","DOI":"10.1038\/srep16830","article-title":"Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma","volume":"5","author":"Azevedo","year":"2015","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.gene.2019.02.056_bb0020","doi-asserted-by":"crossref","first-page":"23086","DOI":"10.3390\/ijms141123086","article-title":"Let-7 in cardiovascular diseases, heart development and cardiovascular differentiation from stem cells","volume":"14","author":"Bao","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"1-2","key":"10.1016\/j.gene.2019.02.056_bb0025","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11010-008-9848-8","article-title":"Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin\/NFAT signaling pathway","volume":"317","author":"Bao","year":"2008","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.gene.2019.02.056_bb0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.gene.2019.02.056_bb0035","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng0504-431","article-title":"The genetic association database","volume":"36","author":"Becker","year":"2004","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.gene.2019.02.056_bb0040","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.110.223768","article-title":"WNT signaling in adult cardiac hypertrophy and remodeling","volume":"107","author":"Bergmann","year":"2010","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"D1","key":"10.1016\/j.gene.2019.02.056_bb0050","doi-asserted-by":"crossref","first-page":"D239","DOI":"10.1093\/nar\/gkv1258","article-title":"MiRTarbase 2016: updates to the experimentally validated miRNA-target interactions database","volume":"44","author":"Chou","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.gene.2019.02.056_bb0055","first-page":"1","article-title":"The igraph software package for complex network research","volume":"1695","author":"Csardi","year":"2006","journal-title":"InterJ. Complex Syst."},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1752-0509-4-153","article-title":"In vitro gene regulatory networks predict in vivo function of liver","volume":"4","author":"Deng","year":"2010","journal-title":"BMC Syst. Biol."},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.apsb.2011.04.010","article-title":"Role of microRNAs in cardiac hypertrophy, myocardial fibrosis and heart failure","volume":"1","author":"Dong","year":"2011","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.gene.2019.02.056_bb0070","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"Affy-analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"issue":"suppl 1","key":"10.1016\/j.gene.2019.02.056_bb0075","first-page":"D107","article-title":"OREganno: an open-access community-driven resource for regulatory annotation","volume":"36","author":"Griffith","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"suppl 1","key":"10.1016\/j.gene.2019.02.056_bb0080","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"MiRBase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"Griffiths-Jones","year":"2006","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0085","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1752-0509-4-10","article-title":"A novel microRNA and transcription factor mediated regulatory network in schizophrenia","volume":"4","author":"Guo","year":"2010","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.gene.2019.02.056_bb0090","doi-asserted-by":"crossref","first-page":"11432","DOI":"10.1038\/srep11432","article-title":"TRRUST: a reference database of human transcriptional regulatory interactions","volume":"5","author":"Han","year":"2015","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.gene.2019.02.056_bb0095","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.gene.2019.02.056_bb0100","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.tibs.2004.07.001","article-title":"Common logic of transcription factor and microRNA action","volume":"29","author":"Hobert","year":"2004","journal-title":"Trends Biochem. Sci."},{"issue":"suppl 1","key":"10.1016\/j.gene.2019.02.056_bb0105","doi-asserted-by":"crossref","first-page":"D137","DOI":"10.1093\/nar\/gkl1041","article-title":"TRED: a transcriptional regulatory element database, new entries and other development","volume":"35","author":"Jiang","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"suppl 1","key":"10.1016\/j.gene.2019.02.056_bb0110","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkn714","article-title":"miR2Disease: a manually curated database for microRNA deregulation in human disease","volume":"37","author":"Jiang","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.gene.2019.02.056_bb0115","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/bib\/bbv107","article-title":"Systematic dissection of dysregulated transcription factor-miRNA feed-forward loops across tumor types","volume":"17","author":"Jiang","year":"2016","journal-title":"Brief. Bioinform."},{"issue":"20","key":"10.1016\/j.gene.2019.02.056_bb0120","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/bioinformatics\/btt423","article-title":"Identification of active transcription factor and miRNA regulatory pathways in Alzheimer's disease","volume":"29","author":"Jiang","year":"2013","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.gene.2019.02.056_bb0125","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.gene.2019.02.056_bb0130","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nphys1746","article-title":"Identification of influential spreaders in complex networks","volume":"6","author":"Kitsak","year":"2010","journal-title":"Nat. Phys."},{"issue":"3","key":"10.1016\/j.gene.2019.02.056_bb0135","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jtbi.2007.05.038","article-title":"Ranking of network elements based on functional substructures","volume":"248","author":"Kosch\u00fctzki","year":"2007","journal-title":"J. Theor. Biol."},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0140","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1752-0509-7-122","article-title":"Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer","volume":"7","author":"Li","year":"2013","journal-title":"BMC Syst. Biol."},{"issue":"D1","key":"10.1016\/j.gene.2019.02.056_bb0145","doi-asserted-by":"crossref","first-page":"D1070","DOI":"10.1093\/nar\/gkt1023","article-title":"HMDD v2.0: a database for experimentally supported human microRNA and disease associations","volume":"42","author":"Li","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"14","key":"10.1016\/j.gene.2019.02.056_bb0150","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/bioinformatics\/btv159","article-title":"A novel motif-discovery algorithm to identify co-regulatory motifs in large transcription factor and microRNA co-regulatory networks in human","volume":"31","author":"Liang","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2019.02.056_bb0155","doi-asserted-by":"crossref","first-page":"9653","DOI":"10.1038\/srep09653","article-title":"MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction","volume":"5","author":"Lin","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2019.02.056_bb0160","first-page":"cvs013","article-title":"MicroRNAs in control of cardiac hypertrophy","author":"Martins","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"5594","key":"10.1016\/j.gene.2019.02.056_bb0165","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.298.5594.824","article-title":"Network motifs: simple building blocks of complex networks","volume":"298","author":"Milo","year":"2002","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejheart.2007.11.008","article-title":"Role of \u03b2 adrenergic receptor polymorphisms in heart failure: systematic review and meta-analysis","volume":"10","author":"Muthumala","year":"2008","journal-title":"Eur. J. Heart Fail."},{"issue":"9","key":"10.1016\/j.gene.2019.02.056_bb0175","doi-asserted-by":"crossref","first-page":"e1004504","DOI":"10.1371\/journal.pcbi.1004504","article-title":"Automated identification of core regulatory genes in human gene regulatory networks","volume":"11","author":"Narang","year":"2015","journal-title":"PLoS Comput. Biol."},{"issue":"5","key":"10.1016\/j.gene.2019.02.056_bb0180","doi-asserted-by":"crossref","first-page":"e5526","DOI":"10.1371\/journal.pone.0005526","article-title":"Network analysis of differential expression for the identification of disease-causing genes","volume":"4","author":"Nitsch","year":"2009","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.gene.2019.02.056_bb0185","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/15476286.2016.1181251","article-title":"Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: implications for treating cardiac pathology and other diseases","volume":"14","author":"Ooi","year":"2017","journal-title":"RNA Biol."},{"issue":"3","key":"10.1016\/j.gene.2019.02.056_bb0190","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.stemcr.2018.01.016","article-title":"Modeling human cardiac hypertrophy in stem cell-derived cardiomyocytes","volume":"10","author":"Ovchinnikova","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.gene.2019.02.056_bb0195","doi-asserted-by":"crossref","first-page":"bav028","DOI":"10.1093\/database\/bav028","article-title":"DisgeNET: a discovery platform for the dynamical exploration of human diseases and their genes","volume":"2015","author":"Pinero","year":"2015","journal-title":"Database"},{"issue":"6","key":"10.1016\/j.gene.2019.02.056_bb0200","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s00439-001-0615-0","article-title":"The HUGO gene nomenclature committee (HGNC)","volume":"109","author":"Povey","year":"2001","journal-title":"Hum. Genet."},{"issue":"7","key":"10.1016\/j.gene.2019.02.056_bb0205","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2019.02.056_bb0210","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1038\/srep09742","article-title":"Unraveling novel TF-miRNA regulatory crosstalk in metastasis of soft tissue sarcoma","volume":"5","author":"Samantarrai","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2019.02.056_bb0215","series-title":"New Frontiers in Graph Theory, Intech","first-page":"16","article-title":"Centralities based analysis of complex networks","author":"Scardoni","year":"2012"},{"issue":"2","key":"10.1016\/j.gene.2019.02.056_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1001313","article-title":"The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs","volume":"7","author":"Schlesinger","year":"2011","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.gene.2019.02.056_bb0225","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1039\/c3mb25518b","article-title":"Topological patterns in microRNA-gene regulatory network: studies in colorectal and breast cancer","volume":"9","author":"Sengupta","year":"2013","journal-title":"Mol. Biosyst."},{"issue":"7","key":"10.1016\/j.gene.2019.02.056_bb0230","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1371\/journal.pcbi.0030131","article-title":"Global and local architecture of the mammalian microRNA-transcription factor regulatory network","volume":"3","author":"Shalgi","year":"2007","journal-title":"PLoS Comput. Biol."},{"issue":"11","key":"10.1016\/j.gene.2019.02.056_bb0235","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"7330","key":"10.1016\/j.gene.2019.02.056_bb0240","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature09783","article-title":"Pervasive roles of microRNAs in cardiovascular biology","volume":"469","author":"Small","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.gene.2019.02.056_bb0245","doi-asserted-by":"crossref","first-page":"e35552","DOI":"10.1371\/journal.pone.0035552","article-title":"Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy","volume":"7","author":"Song","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.gene.2019.02.056_bb0250","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","article-title":"Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets","volume":"89","author":"Tham","year":"2015","journal-title":"Arch. Toxicol."},{"issue":"D1","key":"10.1016\/j.gene.2019.02.056_bb0255","doi-asserted-by":"crossref","first-page":"D153","DOI":"10.1093\/nar\/gku1215","article-title":"DIANA-TarBase, v7. 0: indexing more than half a million experimentally supported miRNA:mRNA interactions","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.gene.2019.02.056_bb0260","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3390\/ijms17050749","article-title":"Overview of microRNAs in cardiac hypertrophy, fibrosis, and apoptosis","volume":"17","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"suppl 1","key":"10.1016\/j.gene.2019.02.056_bb0265","doi-asserted-by":"crossref","first-page":"D119","DOI":"10.1093\/nar\/gkp803","article-title":"TransmiR: a transcription factor-microRNA regulation database","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.gene.2019.02.056_bb0270","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.gde.2009.04.002","article-title":"Angiomirs-key regulators of angiogenesis","volume":"19","author":"Wang","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"suppl 1","key":"10.1016\/j.gene.2019.02.056_bb0275","doi-asserted-by":"crossref","first-page":"D105","DOI":"10.1093\/nar\/gkn851","article-title":"miRecords: an integrated resource for microRNA-target interactions","volume":"37","author":"Xiao","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.gene.2019.02.056_bb0280","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics J. Integrative Bio."},{"issue":"4","key":"10.1016\/j.gene.2019.02.056_bb0285","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1371\/journal.pcbi.0030059","article-title":"The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics","volume":"3","author":"Yu","year":"2007","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0290","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/bioinformatics\/btp618","article-title":"Phenopedia and genopedia: disease-centered and gene-centered views of the evolving knowledge of human genetic associations","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.gene.2019.02.056_bb0295","first-page":"1","article-title":"MicroRNA and transcription factor mediated regulatory network analysis reveals critical regulators and regulatory modules in myocardial infarction","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0300","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/bib\/bbt085","article-title":"Transcription factor and microRNA co-regulatory loops: important regulatory motifs in biological processes and diseases","volume":"16","author":"Zhang","year":"2015","journal-title":"Brief. Bioinform."},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0305","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1479-5876-12-66","article-title":"Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer","volume":"12","author":"Zhang","year":"2014","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.gene.2019.02.056_bb0310","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12859-015-0512-5","article-title":"Identification of active miRNA and transcription factor regulatory pathways in human obesity-related inflammation","volume":"16","author":"Zhang","year":"2015","journal-title":"BMC Bioinforma."},{"issue":"12","key":"10.1016\/j.gene.2019.02.056_bb0315","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00109-015-1315-x","article-title":"Integrated systems approach identifies risk regulatory pathways and key regulators in coronary artery disease","volume":"93","author":"Zhang","year":"2015","journal-title":"J. Mol. Med."},{"issue":"8","key":"10.1016\/j.gene.2019.02.056_bb0320","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.bbadis.2016.11.007","article-title":"Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases","volume":"1863","author":"Zhong","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA)"},{"issue":"8","key":"10.1016\/j.gene.2019.02.056_bb0325","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1161\/CIRCRESAHA.116.303311","article-title":"The Hippo pathway in heart development, regeneration, and diseases","volume":"116","author":"Zhou","year":"2015","journal-title":"Circ. Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919301908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919301908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:21:40Z","timestamp":1759854100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111919301908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":65,"alternative-id":["S0378111919301908"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2019.02.056","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systems biology approach identifies key regulators and the interplay between miRNAs and transcription factors for pathological cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2019.02.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}