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Chem."},{"key":"10.1016\/j.gene.2019.05.003_bb0475","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/ecco-jcc\/jjv123","article-title":"Fragments of citrullinated and MMP-degraded vimentin and MMP-degraded type III collagen are novel serological biomarkers to differentiate Crohn's disease from ulcerative colitis","volume":"9","author":"Mortensen","year":"2015","journal-title":"J. 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Res."},{"key":"10.1016\/j.gene.2019.05.003_bb0515","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/bioinformatics\/bts091","article-title":"Unipro UGENE: a unified bioinformatics toolkit","volume":"28","author":"Okonechnikov","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2019.05.003_bb0520","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0140-6736(10)60960-9","article-title":"Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial","volume":"376","author":"Ong","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2019.05.003_bb0525","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1034\/j.1399-0004.2003.00075.x","article-title":"Neurological presentation of Ehlers-Danlos syndrome type IV in a family with parental mosaicism","volume":"63","author":"Palmeri","year":"2003","journal-title":"Clin. 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A."},{"key":"10.1016\/j.gene.2019.05.003_bb0545","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1136\/jmg.14.3.200","article-title":"Inheritance of Ehlers-Danlos type IV syndrome","volume":"14","author":"Pope","year":"1977","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.gene.2019.05.003_bb0550","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2133.1996.tb01143.x","article-title":"COL3A1 mutations cause variable clinical phenotypes including acrogeria and vascular rupture","volume":"135","author":"Pope","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.gene.2019.05.003_bb0555","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.gene.2019.05.003_bb0560","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1056\/NEJM198408093110606","article-title":"Heritable diseases of collagen","volume":"311","author":"Prockop","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2019.05.003_bb0565","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.bi.64.070195.002155","article-title":"Collagens: molecular biology, diseases, and potentials for therapy","volume":"64","author":"Prockop","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.gene.2019.05.003_bb0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170023","article-title":"Development of a novel enzyme-linked immunosorbent assay targeting a neo-epitope generated by cathepsin-mediated turnover of type III collagen and its application in chronic obstructive pulmonary disease","volume":"12","author":"Rasmussen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2019.05.003_bb0575","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0344-0338(11)80654-0","article-title":"Synthesis of type III collagen and type IV collagen by tubular epithelial cells in diabetic nephropathy","volume":"191","author":"Razzaque","year":"1995","journal-title":"Pathol. Res. 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Gynecol."},{"key":"10.1016\/j.gene.2019.05.003_bb0605","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2016.01.011","article-title":"New frontiers in fibrotic disease therapies: the focus of the Joan and Joel Rosenbloom Center for Fibrotic Diseases at Thomas Jefferson University","volume":"51","author":"Rosenbloom","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.gene.2019.05.003_bb0610","doi-asserted-by":"crossref","first-page":"eaap7294","DOI":"10.1126\/scitranslmed.aap7294","article-title":"NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension","volume":"10","author":"Samokhin","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.gene.2019.05.003_bb0615","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0934-8832(89)80025-3","article-title":"Construction of a human pro alpha 1(III) collagen cDNA clone and localization of type III collagen expression in human fetal tissues","volume":"9","author":"Sandberg","year":"1989","journal-title":"Matrix"},{"key":"10.1016\/j.gene.2019.05.003_bb0620","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1086\/301641","article-title":"Splicing defects in the COL3A1 gene: marked preference for 5\u2032 (donor) spice-site mutations in patients with exon-skipping mutations and Ehlers-Danlos syndrome type IV","volume":"61","author":"Schwarze","year":"1997","journal-title":"Am. J. Hum. 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Pharmacol."},{"key":"10.1016\/j.gene.2019.05.003_bb0635","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-017-3204-9","article-title":"Exogenous growth factors enhance the expression of cola1, cola3, and elastin in fibroblasts via activating MAPK signaling pathway","volume":"442","author":"Shen","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.gene.2019.05.003_bb0640","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s10930-017-9723-0","article-title":"Hydroxylation of human type III collagen alpha chain by recombinant coexpression with a viral prolyl 4-hydroxylase in Escherichia coli","volume":"36","author":"Shi","year":"2017","journal-title":"Protein J."},{"key":"10.1016\/j.gene.2019.05.003_bb0645","doi-asserted-by":"crossref","unstructured":"Shibamura, H., Olson, J.M., van Vlijmen-Van Keulen, C., Buxbaum, S.G., Dudek, D.M., Tromp, G., Ogata, T., Skunca, M., Sakalihasan, N., Pals, G., Limet, R., MacKean, G.L., Defawe, O., Verloes, A., Arthur, C., Lossing, A.G., Burnett, M., Sueda, T. and Kuivaniemi, H., 2004. Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13. 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