{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:50:53Z","timestamp":1778781053110,"version":"3.51.4"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Pamukkale University Research Foundation","award":["2017SAE024"],"award-info":[{"award-number":["2017SAE024"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.gene.2019.06.025","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T01:52:16Z","timestamp":1561341136000},"page":"143935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The triazole linked galactose substituted dicyano compound can induce autophagy in NSCLC cell lines"],"prefix":"10.1016","volume":"712","author":[{"given":"Ozge","family":"Alvur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Tokgun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Baygu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilgun","family":"Kabay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasar","family":"Gok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Akca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.gene.2019.06.025_bb0010","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1200\/JCO.2005.10.462","article-title":"Epidemiology of lung cancer: looking to the future","volume":"23","author":"Alberg","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.gene.2019.06.025_bb0015","author":"American Cancer Society"},{"issue":"71","key":"10.1016\/j.gene.2019.06.025_bb0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.inoche.2016.07.001","article-title":"Novel magnesium and zinc porphyrazines containing galactose moieties: synthesis via click reaction and characterization","volume":"71","author":"Baygu","year":"2016","journal-title":"Inorg. Chem. Commun."},{"issue":"9","key":"10.1016\/j.gene.2019.06.025_bb0025","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2174\/187152011797655131","article-title":"Regulation of autophagy by sphingolipids","volume":"11","author":"Bedia","year":"2011","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0030","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.devcel.2013.04.004","article-title":"Autophagosome formation: tracing the source","volume":"25","author":"Bernard","year":"2013","journal-title":"Dev. Cell"},{"issue":"51","key":"10.1016\/j.gene.2019.06.025_bb0035","doi-asserted-by":"crossref","first-page":"22243","DOI":"10.1073\/pnas.1009479107","article-title":"Astrocyte elevated gene-1 induces protective autophagy","volume":"107","author":"Bhutia","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"9","key":"10.1016\/j.gene.2019.06.025_bb0040","doi-asserted-by":"crossref","first-page":"944","DOI":"10.2174\/187152009789377727","article-title":"Apoptosis imaging: anti-cancer agents in medicinal chemistry","volume":"9","author":"Blankenberg","year":"2009","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.gene.2019.06.025_bb0045","doi-asserted-by":"crossref","unstructured":"Botti, J.; Djavaheri-Mergny, M.; Pilatte, Y.; Codogno, P. Autophagy signaling and the cogwheels of cancer. Autophagy 2 (2), 67\u201373.","DOI":"10.4161\/auto.2.2.2458"},{"issue":"Pt 7","key":"10.1016\/j.gene.2019.06.025_bb0050","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1242\/jcs.113.7.1189","article-title":"Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments","volume":"113","author":"Bursch","year":"2000","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0055","first-page":"193","article-title":"Membrane dynamics in autophagosome biogenesis","volume":"128","author":"Carlsson","year":"2015","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0060","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.devcel.2008.08.012","article-title":"The role of autophagy in mammalian development: cell makeover rather than cell death","volume":"15","author":"Cecconi","year":"2008","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0065","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4161\/auto.26927","article-title":"Autophagy-mediated regulation of macrophages and its applications for cancer","volume":"10","author":"Chen","year":"2014","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/icb.2014.85","article-title":"Autophagy as a pro-death pathway","volume":"93","author":"Denton","year":"2015","journal-title":"Immunol. Cell Biol."},{"issue":"9","key":"10.1016\/j.gene.2019.06.025_bb0075","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nrurol.2014.196","article-title":"Autophagy as a modulator and target in prostate cancer","volume":"11","author":"Farrow","year":"2014","journal-title":"Nat. Rev. Urol."},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0080","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/cdd.2014.150","article-title":"Oxidative stress and autophagy: the clash between damage and metabolic needs","volume":"22","author":"Filomeni","year":"2015","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0085","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.500","article-title":"Chemical modulators of autophagy as biological probes and potential therapeutics","volume":"7","author":"Fleming","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.gene.2019.06.025_bb0090","doi-asserted-by":"crossref","first-page":"630","DOI":"10.4161\/onci.20297","article-title":"Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease","volume":"1","author":"Fujii","year":"2012","journal-title":"Oncoimmunology"},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0095","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1158\/0008-5472.CAN-13-2966","article-title":"The four faces of autophagy: implications for cancer therapy","volume":"74","author":"Gewirtz","year":"2014","journal-title":"Cancer Res."},{"issue":"April","key":"10.1016\/j.gene.2019.06.025_bb0100","first-page":"1","article-title":"Autophagy-regulating microRNAs and cancer","volume":"7","author":"Gozuacik","year":"2017","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cell.2014.02.049","article-title":"To be or not to be? How selective autophagy and cell death govern cell fate","volume":"157","author":"Green","year":"2014","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.gene.2019.06.025_bb0110","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.molonc.2014.05.004","article-title":"Drug resistance to targeted therapies: D\u00e9j\u00e0 vu all over again","volume":"8","author":"Groenendijk","year":"2014","journal-title":"Mol. Oncol."},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090151","article-title":"Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1","volume":"9","author":"Gu","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0120","doi-asserted-by":"crossref","first-page":"e1624","DOI":"10.1038\/cddis.2014.546","article-title":"DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX","volume":"6","author":"Guan","year":"2015","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0125","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.molonc.2012.02.004","article-title":"Discovery of small molecule cancer drugs: successes, challenges and opportunities","volume":"6","author":"Hoelder","year":"2012","journal-title":"Mol. Oncol."},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0130","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/cancers6031769","article-title":"Drug resistance in cancer: an overview","volume":"6","author":"Housman","year":"2014","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/cr.2013.161","article-title":"Autophagy and human diseases","volume":"24","author":"Jiang","year":"2014","journal-title":"Cell Res."},{"issue":"7","key":"10.1016\/j.gene.2019.06.025_bb0140","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1167\/iovs.11-9062","article-title":"Downregulation of \u03b2-actin gene and human antigen R in human keratoconus","volume":"53","author":"Joseph","year":"2012","journal-title":"Investig. Opthalmology Vis. Sci."},{"issue":"7","key":"10.1016\/j.gene.2019.06.025_bb0145","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"MTOR regulation of autophagy","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0150","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.flm.2017.06.001","article-title":"Molecular targeted therapy of cancer: the progress and future prospect","volume":"1","author":"Ke","year":"2017","journal-title":"Front. Lab. Med."},{"issue":"40","key":"10.1016\/j.gene.2019.06.025_bb0155","doi-asserted-by":"crossref","first-page":"28713","DOI":"10.1074\/jbc.M113.488346","article-title":"The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters","volume":"288","author":"Kim","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2019.06.025_bb0160","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.lungcan.2016.05.032","article-title":"Downregulation of SATB2 is critical for induction of epithelial-to-mesenchymal transition and invasion of NSCLC cells","volume":"98","author":"Kucuksayan","year":"2016","journal-title":"Lung Cancer"},{"key":"10.1016\/j.gene.2019.06.025_bb0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2334-7-96","article-title":"The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis","volume":"7","author":"Lala","year":"2007","journal-title":"BMC Infect. Dis."},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0170","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox Signalling","volume":"441","author":"Lee","year":"2012","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0175","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.gene.2019.06.025_bb0180","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI26390","article-title":"Autophagy in cell death: an innocent convict?","volume":"115","author":"Levine","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.gene.2019.06.025_bb0185","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1016\/j.ejca.2010.02.021","article-title":"Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model","volume":"46","author":"Li","year":"2010","journal-title":"Eur. J. Cancer"},{"issue":"6","key":"10.1016\/j.gene.2019.06.025_bb0190","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s10495-015-1110-8","article-title":"The dual role of autophagy under hypoxia-involvement of interaction between autophagy and apoptosis","volume":"20","author":"Li","year":"2015","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40880-017-0219-2","article-title":"Autophagy and multidrug resistance in cancer","volume":"36","author":"Li","year":"2017","journal-title":"Chin. J. Cancer"},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"19","key":"10.1016\/j.gene.2019.06.025_bb0205","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1021\/jm101144f","article-title":"Discovery of 1-(4-(4-propionylpiperazin-1-Yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-Yl)benzo[h][1,6]naphthyridin-2(1 H)-one as a highly potent, selective mammalian target of rapamycin (MTOR) inhibitor for the treatment of cancer","volume":"53","author":"Liu","year":"2010","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.gene.2019.06.025_bb0210","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10534-014-9773-0","article-title":"Zinc and autophagy","volume":"27","author":"Liuzzi","year":"2014","journal-title":"BioMetals"},{"issue":"6","key":"10.1016\/j.gene.2019.06.025_bb0215","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nrm1660","article-title":"Autophagy in metazoans: cell survival in the land of plenty","volume":"6","author":"Lum","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.gene.2019.06.025_bb0220","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0225","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2174\/187152012800228805","article-title":"Chemotherapeutic targeting of cell death pathways","volume":"12","author":"Mansilla","year":"2012","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"7148","key":"10.1016\/j.gene.2019.06.025_bb0230","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nature05925","article-title":"Ambra1 regulates autophagy and development of the nervous system","volume":"447","author":"Maria Fimia","year":"2007","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0235","first-page":"214","article-title":"Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy\/apoptosis toggle switch","volume":"2","author":"Marquez","year":"2012","journal-title":"Am. J. Cancer Res."},{"issue":"7182","key":"10.1016\/j.gene.2019.06.025_bb0240","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.gene.2019.06.025_bb0245","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/onc.2016.333","article-title":"Autophagy in cancer metastasis","volume":"36","author":"Mowers","year":"2017","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.gene.2019.06.025_bb0250","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10495-014-0967-2","article-title":"Autophagy and apoptosis: where do they meet?","volume":"19","author":"Mukhopadhyay","year":"2014","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0255","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1089\/ars.2014.5837","article-title":"Oxidative stress, redox signaling, and autophagy: cell death versus survival","volume":"21","author":"Navarro-Yepes","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.gene.2019.06.025_bb0260","series-title":"Cancer Drug Design and Discovery","author":"Neidle","year":"2008"},{"key":"10.1016\/j.gene.2019.06.025_bb0265","series-title":"Autophagy May Promote Carcinoma Cell Invasion and Correlate With Poor Prognosis in Cholangiocarcinoma","volume":"vol. 7","author":"Nitta","year":"2014"},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0270","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/35056522","article-title":"Molecular dissection of autophagy: two ubiquitin-like systems","volume":"2","author":"Ohsumi","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0275","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cr.2013.169","article-title":"Historical landmarks of autophagy research","volume":"24","author":"Ohsumi","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.gene.2019.06.025_bb0280","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40170-016-0145-9","article-title":"Warburg effect(s)\u2014a biographical sketch of Otto Warburg and his impacts on tumor metabolism","volume":"4","author":"Otto","year":"2016","journal-title":"Cancer Metab"},{"key":"10.1016\/j.gene.2019.06.025_bb0285","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/cdd.2012.27","article-title":"Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response","volume":"19","author":"Pagliarini","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.gene.2019.06.025_bb0290","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semcdb.2015.02.013","article-title":"Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics","volume":"39","author":"Panda","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"issue":"24","key":"10.1016\/j.gene.2019.06.025_bb0295","doi-asserted-by":"crossref","first-page":"R1330","DOI":"10.1016\/j.cub.2017.11.012","article-title":"Detection and clearance of damaged lysosomes by the endo-lysosomal damage response and lysophagy","volume":"27","author":"Papadopoulos","year":"2017","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0300","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0305","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/ars.2008.2263","article-title":"Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death","volume":"11","author":"Pivtoraiko","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"9","key":"10.1016\/j.gene.2019.06.025_bb0310","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.1016\/S2214-109X(16)30143-7","article-title":"Global burden of cancers attributable to infections in 2012: a synthetic analysis","volume":"4","author":"Plummer","year":"2016","journal-title":"Lancet Glob. Heal."},{"issue":"4","key":"10.1016\/j.gene.2019.06.025_bb0315","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbamcr.2008.12.022","article-title":"Delivery of endocytosed membrane proteins to the lysosome","volume":"1793","author":"Pryor","year":"2009","journal-title":"Biochim. Biophys. Acta - Mol. Cell Res."},{"issue":"4","key":"10.1016\/j.gene.2019.06.025_bb0320","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2010.07.018","article-title":"ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death","volume":"142","author":"Radoshevich","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.gene.2019.06.025_bb0325","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/15548627.2015.1017182","article-title":"PAWR-mediated suppression of BCL2 promotes switching of 3-azido Withaferin A (3-AWA)-induced autophagy to apoptosis in prostate Cancer cells","volume":"11","author":"Rah","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.gene.2019.06.025_bb0330","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399409001306","article-title":"The role of autophagy in tumour development and cancer therapy","volume":"11","author":"Rosenfeldt","year":"2009","journal-title":"Expert Rev. Mol. Med."},{"issue":"7","key":"10.1016\/j.gene.2019.06.025_bb0335","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/carcin\/bgr031","article-title":"The multiple roles of autophagy in cancer","volume":"32","author":"Rosenfeldt","year":"2011","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0340","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1016\/j.cub.2011.11.034","article-title":"Mechanisms of autophagosome biogenesis","volume":"22","author":"Rubinsztein","year":"2012","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0345","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1073\/pnas.90.3.980","article-title":"Do all programmed cell deaths occur via apoptosis?","volume":"90","author":"Schwartz","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5698","key":"10.1016\/j.gene.2019.06.025_bb0350","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.1099993","article-title":"Autophagy in health and disease: a double-edged sword","volume":"306","author":"Shintani","year":"2004","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.gene.2019.06.025_bb0355","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.3892\/ol.2014.2518","article-title":"Occurrence of HHIP gene CpG island methylation in gastric cancer","volume":"8","author":"Song","year":"2014","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0360","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-015-0321-5","article-title":"Apoptosis, autophagy, necroptosis, and cancer metastasis","volume":"14","author":"Su","year":"2015","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0365","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3892\/ol.2016.4644","article-title":"Ambra1 in autophagy and apoptosis: implications for cell survival and chemotherapy resistance","volume":"12","author":"Sun","year":"2016","journal-title":"Oncol. Lett."},{"issue":"7","key":"10.1016\/j.gene.2019.06.025_bb0370","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.2174\/18715206113139990130","article-title":"Natural products targeting autophagy via the PI3K\/Akt\/MTOR pathway as anticancer agents","volume":"13","author":"Sun","year":"2013","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"15","key":"10.1016\/j.gene.2019.06.025_bb0375","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1074\/jbc.R117.810739","article-title":"Autophagy and disease","volume":"293","author":"Thorburn","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.gene.2019.06.025_bb0380","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1124\/mol.114.091850","article-title":"Autophagy and cancer therapy","volume":"85","author":"Thorburn","year":"2014","journal-title":"Mol. Pharmacol."},{"issue":"12","key":"10.1016\/j.gene.2019.06.025_bb0385","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1074\/jbc.M900301200","article-title":"An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of MTORC1","volume":"284","author":"Thoreen","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.gene.2019.06.025_bb0390","first-page":"629","article-title":"The complex interplay between autophagy and NF-\u039aB signaling pathways in cancer cells","volume":"1","author":"Trocoli","year":"2011","journal-title":"Am. J. Cancer Res."},{"issue":"8","key":"10.1016\/j.gene.2019.06.025_bb0395","doi-asserted-by":"crossref","DOI":"10.21037\/atm.2018.02.07","article-title":"Implementation of immunotherapy in the treatment of advanced non-small cell lung cancer (NSCLC)","volume":"6","author":"Tsiara","year":"2018","journal-title":"Ann. Transl. Med."},{"issue":"8","key":"10.1016\/j.gene.2019.06.025_bb0400","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.4161\/auto.7065","article-title":"The role of autophagy during the oocyte-to-embryo transition","volume":"4","author":"Tsukamoto","year":"2008","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.gene.2019.06.025_bb0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006251","article-title":"Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab","volume":"4","author":"Vazquez-Martin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2019.06.025_bb0410","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3451528","article-title":"Oxidative stress and autophagy in metabolism and longevity","volume":"2017","author":"Vikram","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.gene.2019.06.025_bb0415","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1080\/15384101.2015.1038685","article-title":"Autophagy and apoptosis in liver injury","volume":"14","author":"Wang","year":"2015","journal-title":"Cell Cycle"},{"issue":"6109","key":"10.1016\/j.gene.2019.06.025_bb0420","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.1225967","article-title":"Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation","volume":"338","author":"Wang","year":"2012","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.gene.2019.06.025_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069038","article-title":"Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0430","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1172\/JCI73941","article-title":"The role for autophagy in cancer","volume":"125","author":"White","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"17","key":"10.1016\/j.gene.2019.06.025_bb0435","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1158\/1078-0432.CCR-07-5023","article-title":"The double-edged sword of autophagy modulation in cancer","volume":"15","author":"White","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.gene.2019.06.025_bb0440","author":"World Cancer Research Fund International"},{"key":"10.1016\/j.gene.2019.06.025_bb0445","author":"Worldwide cancer statistics"},{"issue":"9","key":"10.1016\/j.gene.2019.06.025_bb0450","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ncb0910-814","article-title":"Eaten alive: a history of macroautophagy","volume":"12","author":"Yang","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.gene.2019.06.025_bb0455","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1158\/1535-7163.MCT-11-0047","article-title":"The role of autophagy in cancer: therapeutic implications","volume":"10","author":"Yang","year":"2011","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.gene.2019.06.025_bb0460","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1038\/srep07697","article-title":"Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells","volume":"5","author":"Yang","year":"2015","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.gene.2019.06.025_bb0465","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.4161\/auto.7.10.16507","article-title":"A critical role for UVRAG in apoptosis","volume":"7","author":"Yin","year":"2011","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.gene.2019.06.025_bb0470","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/embor.2011.79","article-title":"UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation","volume":"12","author":"Yin","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.gene.2019.06.025_bb0475","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2017.09.049","article-title":"Autophagy in the \u201cinflammation-carcinogenesis\u201d pathway of liver and HCC immunotherapy","volume":"411","author":"Yu","year":"2017","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.gene.2019.06.025_bb0480","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/onc.2009.343","article-title":"Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells","volume":"29","author":"Zhu","year":"2010","journal-title":"Oncogene"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919305852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919305852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:24:27Z","timestamp":1759854267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111919305852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":95,"alternative-id":["S0378111919305852"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2019.06.025","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The triazole linked galactose substituted dicyano compound can induce autophagy in NSCLC cell lines","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2019.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"143935"}}