{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T20:51:34Z","timestamp":1774299094828,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["K2015-52X-14691-13-4"],"award-info":[{"award-number":["K2015-52X-14691-13-4"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005390","name":"Alfred \u00d6sterlunds Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006075","name":"Greta och Johan Kocks stiftelser","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006189","name":"Direkt\u00f6r\u00a0Albert P\u00e5hlssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007949","name":"Reumatikerf\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.gene.2019.100009","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T03:16:17Z","timestamp":1550114177000},"page":"100009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S","title":["Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women"],"prefix":"10.1016","volume":"721","author":[{"given":"Jai","family":"Prakash","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Herlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitender","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina E.","family":"Akesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Grabowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim M.","family":"Skerry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth O.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona E.A.","family":"McGuigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.gene.2019.100009_bb0005","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0002-9343(93)90218-E","article-title":"Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis","volume":"94","author":"Anonymous","year":"1993","journal-title":"Am. J. Med."},{"issue":"4","key":"10.1016\/j.gene.2019.100009_bb0010","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.peptides.2009.12.016","article-title":"Functional characterization of two human receptor activity-modifying protein 3 variants","volume":"31","author":"Bailey","year":"2010","journal-title":"Peptides"},{"issue":"45","key":"10.1016\/j.gene.2019.100009_bb0015","doi-asserted-by":"crossref","first-page":"12015","DOI":"10.1073\/pnas.1713074114","article-title":"GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs","volume":"114","author":"Barbash","year":"2017","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.gene.2019.100009_bb0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00018-013-1440-z","article-title":"Osteoblast-adipocyte lineage plasticity in tissue development, maintenance and pathology","volume":"71","author":"Berendsen","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.gene.2019.100009_bb0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01623429","article-title":"Peak bone mass","volume":"4","author":"Bonjour","year":"1994","journal-title":"Osteoporos. Int."},{"issue":"12","key":"10.1016\/j.gene.2019.100009_bb0030","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1007\/s00198-014-2823-1","article-title":"Vitamin D insufficiency over 5 years is associated with increased fracture risk-an observational cohort study of elderly women","volume":"25","author":"Buchebner","year":"2014","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.gene.2019.100009_bb0035","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/1471-2105-8-301","article-title":"Genome bioinformatic analysis of nonsynonymous SNPs","volume":"8","author":"Burke","year":"2007","journal-title":"BMC Bioinf."},{"issue":"10","key":"10.1016\/j.gene.2019.100009_bb0040","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1007\/s00198-011-1886-5","article-title":"Self-reported recreational exercise combining regularity and impact is necessary to maximize BMD in young adult women: a population-based study of 1,061 women 25 years of age","volume":"23","author":"Callreus","year":"2012","journal-title":"Osteoporos. Int."},{"issue":"6","key":"10.1016\/j.gene.2019.100009_bb0045","doi-asserted-by":"crossref","first-page":"367","DOI":"10.5830\/CVJA-2016-038","article-title":"Determinants of change in body weight and body fat distribution over 5.5 years in a sample of free-living black south African women","volume":"27","author":"Chantler","year":"2016","journal-title":"Cardiovasc. J. Afr."},{"issue":"7","key":"10.1016\/j.gene.2019.100009_bb0050","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Death Differ."},{"issue":"25","key":"10.1016\/j.gene.2019.100009_bb0055","doi-asserted-by":"crossref","first-page":"18094","DOI":"10.1074\/jbc.M703544200","article-title":"Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age","volume":"282","author":"Dackor","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.gene.2019.100009_bb0060","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1302\/0301-620X.89B12.18946","article-title":"Rates of fracture in participants and non-participants in the osteoporosis prospective risk assessment study","volume":"89","author":"Gerdhem","year":"2007","journal-title":"J. Bone Joint Surg."},{"issue":"4","key":"10.1016\/j.gene.2019.100009_bb0065","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1210\/me.2006-0156","article-title":"Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling","volume":"21","author":"Gibbons","year":"2007","journal-title":"Mol. Endocrinol."},{"issue":"1\u20132","key":"10.1016\/j.gene.2019.100009_bb0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pharmthera.2005.06.015","article-title":"GPCR modulation by RAMPs","volume":"109","author":"Hay","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.gene.2019.100009_bb0075","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1210\/me.2004-0142","article-title":"Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism","volume":"19","author":"Hewitt","year":"2005","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.gene.2019.100009_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020360","article-title":"Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment","volume":"19","author":"Hu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.gene.2019.100009_bb0085","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1210\/jc.2017-01531","article-title":"Identification of novel potentially pleiotropic variants associated with osteoporosis and obesity using the cFDR method","volume":"103","author":"Hu","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.gene.2019.100009_bb0090","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/jech.48.5.489","article-title":"Remembering fractures: fracture registration and proband recall in southern Sweden","volume":"48","author":"Jonsson","year":"1994","journal-title":"J. Epidemiol. Community Health"},{"issue":"11","key":"10.1016\/j.gene.2019.100009_bb0095","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1210\/jc.2010-1030","article-title":"The central regulation of bone mass, the first link between bone remodeling and energy metabolism","volume":"95","author":"Karsenty","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.gene.2019.100009_bb0100","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/ijo.2012.220","article-title":"Sex-specific effects of weight-affecting gene variants in a life course perspective-the HUNT study, Norway","volume":"37","author":"Kvaloy","year":"2013","journal-title":"Int. J. Obes."},{"issue":"12","key":"10.1016\/j.gene.2019.100009_bb0105","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1017\/S1368980014002857","article-title":"Changes in total and central adiposity and body fat distribution among 7-10-year-old schoolchildren in Brazil","volume":"18","author":"Leal","year":"2015","journal-title":"Public Health Nutr."},{"issue":"4","key":"10.1016\/j.gene.2019.100009_bb0110","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jocd.2010.04.004","article-title":"Effect of precision on longitudinal follow-up of bone mineral density measurements in elderly women and men","volume":"13","author":"Lenora","year":"2010","journal-title":"J. Clin. Densitom."},{"issue":"8","key":"10.1016\/j.gene.2019.100009_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006827","article-title":"Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males","volume":"4","author":"Liu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2019.100009_bb0120","series-title":"Role of Receptor Activity Modifying Protein 3 in the Response of Bone to Mechanical Loading. Paper Presented at the ECTS, Lisbon, Portugal (18\u201321 May) 2013","author":"Livesey","year":"2013"},{"issue":"1","key":"10.1016\/j.gene.2019.100009_bb0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41467-017-00108-3","article-title":"Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1\/TOM1L2 locus","volume":"8","author":"Medina-Gomez","year":"2017","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.gene.2019.100009_bb0130","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/jbmr.5650070902","article-title":"Perspective. How many women have osteoporosis?","volume":"7","author":"Melton","year":"1992","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.gene.2019.100009_bb0135","volume":"3","author":"The state of GPCR Research in 2004","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.gene.2019.100009_bb0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/bbrc.2000.2606","article-title":"Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis","volume":"271","author":"Ono","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2019.100009_bb0145","series-title":"Accelerated Skeletal Development and High Bone Mass in Mice Lacking RAMP3. Paper Presented at the 2011 Joint Meeting of the Bone Research Society & the British Orthopaedic Research Society, Cambridge, UK (27\u201329 Jun, 2011)","author":"Pacharne","year":"2011"},{"issue":"6","key":"10.1016\/j.gene.2019.100009_bb0150","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1172\/JCI21311","article-title":"Fat's loss is bone's gain","volume":"113","author":"Pei","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.gene.2019.100009_bb0155","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1467-789x.2001.00031.x","article-title":"Beyond body mass index","volume":"2","author":"Prentice","year":"2001","journal-title":"Obes. Rev."},{"key":"10.1016\/j.gene.2019.100009_bb0160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mce.2017.03.033","article-title":"The effects of RAMPs upon cell signalling","volume":"449","author":"Routledge","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.gene.2019.100009_bb0165","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00198-012-2048-0","article-title":"Degenerative changes at the lumbar spine--implications for bone mineral density measurement in elderly women","volume":"24","author":"Tenne","year":"2013","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.gene.2019.100009_bb0170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1677\/jme.1.01825","article-title":"The estrogen-responsive adrenomedullin and receptor-modifying protein 3 gene identified by DNA microarray analysis are directly regulated by estrogen receptor","volume":"36","author":"Watanabe","year":"2006","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.gene.2019.100009_bb0175","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-3-319-41523-9_13","article-title":"Control of skeletal muscle cell growth and size through adhesion GPCRs","volume":"234","author":"White","year":"2016","journal-title":"Handb. Exp. Pharmacol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590158319300063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590158319300063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:02:35Z","timestamp":1762898555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590158319300063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":35,"alternative-id":["S2590158319300063"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2019.100009","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2019.100009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100009"}}