{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:36:18Z","timestamp":1789072578084,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.gene.2019.144156","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T12:02:26Z","timestamp":1571140946000},"page":"144156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["MiR-122-5p and miR-326-3p: Potential novel biomarkers for early detection of cadmium exposure"],"prefix":"10.1016","volume":"724","author":[{"given":"Wenya","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaotang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2019.144156_b0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1081\/ESE-100000473","article-title":"Application of path analysis to urinary findings of cadmium-induced renal dysfunction","volume":"36","author":"Abe","year":"2001","journal-title":"J. Environ. Sci. Health A Tox. Hazard. Substain. Environ. Eng."},{"key":"10.1016\/j.gene.2019.144156_b0010","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1289\/ehp.8033","article-title":"Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure","volume":"113","author":"Akesson","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.gene.2019.144156_b0015","first-page":"103","article-title":"Rising environmental cadmium levels in developing countries: threat to genome stability and health","volume":"27","author":"Anetor","year":"2012","journal-title":"Niger J. Physiol. Sci."},{"key":"10.1016\/j.gene.2019.144156_b0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan microRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.gene.2019.144156_b0025","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/01.ATV.0000205616.70614.e5","article-title":"Increased serum cadmium and strontium levels in young smokers: effects on arterial endothelial cell gene transcription","volume":"26","author":"Bernhard","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.gene.2019.144156_b0030","doi-asserted-by":"crossref","first-page":"F602","DOI":"10.1152\/ajprenal.00727.2010","article-title":"microRNAs in kidneys: biogenesis, regulation, and pathophysiological roles","volume":"300","author":"Bhatt","year":"2011","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.gene.2019.144156_b0035","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.bbrc.2018.11.176","article-title":"CircPUM1 promotes the malignant behavior of lung adenocarcinoma by regulating miR-326","volume":"508","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2019.144156_b0040","first-page":"6","article-title":"Cadmium nephrotoxicity is associated with altered MicroRNA expression in the rat renal cortex","author":"Fay","year":"2018","journal-title":"Toxics"},{"key":"10.1016\/j.gene.2019.144156_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1289\/ehp.84541","article-title":"Cadmium and the kidney","volume":"54","author":"Friberg","year":"1984","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.gene.2019.144156_b0050","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/cdd.2009.105","article-title":"MicroRNAs as regulators of death receptors signaling","volume":"17","author":"Garofalo","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.gene.2019.144156_b0055","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00018-016-2342-7","article-title":"Interplay of mitochondrial metabolism and microRNAs","volume":"74","author":"Geiger","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.gene.2019.144156_b0060","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1053\/ajkd.2001.28589","article-title":"Cadmium exposure and end-stage renal disease","volume":"38","author":"Hellstrom","year":"2001","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.gene.2019.144156_b0065","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1681\/ASN.2008020162","article-title":"Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury","volume":"19","author":"Ho","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.gene.2019.144156_b0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/14737159.2018.1415145","article-title":"MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury","volume":"18","author":"Howell","year":"2018","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.gene.2019.144156_b0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1293\/tox.2017-0051","article-title":"MicroRNAs associated with the development of kidney diseases in humans and animals","volume":"31","author":"Ichii","year":"2018","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.gene.2019.144156_b0080","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1002\/jcp.26949","article-title":"The MicroRNA-326: autoimmune diseases, diagnostic biomarker, and therapeutic target","volume":"233","author":"Jadideslam","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.gene.2019.144156_b0085","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of cadmium as an environmental health problem","volume":"238","author":"Jarup","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.gene.2019.144156_b0090","first-page":"1","article-title":"Health effects of cadmium exposure\u2013a review of the literature and a risk estimate","volume":"24","author":"Jarup","year":"1998","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.gene.2019.144156_b0095","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/ki.2012.261","article-title":"Autophagy in proximal tubules protects against acute kidney injury","volume":"82","author":"Jiang","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.gene.2019.144156_b0100","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1080\/15476286.2017.1367888","article-title":"Sources to variability in circulating human miRNA signatures","volume":"14","author":"Keller","year":"2017","journal-title":"RNA Biol."},{"key":"10.1016\/j.gene.2019.144156_b0105","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.biopha.2011.06.010","article-title":"Analysis of systemic inflammatory response in the carcinogenic process of uterine cervical neoplasia","volume":"65","author":"Lages","year":"2011","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.gene.2019.144156_b0110","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1373\/clinchem.2009.131797","article-title":"Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury","volume":"55","author":"Laterza","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.gene.2019.144156_b0115","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s12094-015-1294-y","article-title":"Identification of circulating MicroRNAs as novel potential biomarkers for hepatocellular carcinoma detection: a systematic review and meta-analysis","volume":"17","author":"Li","year":"2015","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.gene.2019.144156_b0120","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12885-019-5328-7","article-title":"Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs","volume":"19","author":"Liu","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.gene.2019.144156_b0125","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2019.144156_b0130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0009-3084(99)00027-4","article-title":"Possible role of phospholipase D in cellular differentiation and apoptosis","volume":"98","author":"Nakashima","year":"1999","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.gene.2019.144156_b0135","doi-asserted-by":"crossref","unstructured":"Nascimento, L.R.D. and Domingueti, C.P., 2019. MicroRNAs: new biomarkers and promising therapeutic targets for diabetic kidney disease.","DOI":"10.1590\/2175-8239-jbn-2018-0165"},{"key":"10.1016\/j.gene.2019.144156_b0140","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.taap.2009.03.015","article-title":"Historical perspectives on cadmium toxicology","volume":"238","author":"Nordberg","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.gene.2019.144156_b0145","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00204-014-1311-x","article-title":"Ochratoxin A activates opposing c-MET\/PI3K\/Akt and MAPK\/ERK 1\u20132 pathways in human proximal tubule HK-2 cells","volume":"89","author":"Ozcan","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.gene.2019.144156_b0150","article-title":"Meta-analysis of circulating microRNAs for the diagnosis of hepatocellular carcinoma","author":"Peng","year":"2018","journal-title":"Dig Liver Dis."},{"key":"10.1016\/j.gene.2019.144156_b0155","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/sj.ki.5002467","article-title":"Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity","volume":"72","author":"Prozialeck","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.gene.2019.144156_b0160","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41419-019-1610-5","article-title":"FABP4 contributes to renal interstitial fibrosis via mediating inflammation and lipid metabolism","volume":"10","author":"Qiao","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2019.144156_b0165","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fonc.2019.00381","article-title":"HypoxamiRs profiling identify miR-745 as a regulator of the early stages of vasculogenic mimicry in SKOV3 ovarian cancer cells","volume":"9","author":"Salinas-Vera","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gene.2019.144156_b0170","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/15548627.2017.1291483","article-title":"HS1BP3 inhibits autophagy by regulation of PLD1","volume":"13","author":"Soreng","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.gene.2019.144156_b0175","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.lfs.2018.11.016","article-title":"A meta-analysis of dysregulated miRNAs in coronary heart disease","volume":"215","author":"Wang","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2019.144156_b0180","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1080\/13880209.2018.1543332","article-title":"Evaluation of the potential nephrotoxicity and mechanism in rats after long-term exposure to the traditional Tibetan medicine tsothel","volume":"56","author":"Xiang","year":"2018","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.gene.2019.144156_b0185","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1039\/C8CC10311A","article-title":"NAG-targeting fluorescence based probe for precision diagnosis of kidney injury","volume":"55","author":"Yan","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.gene.2019.144156_b0190","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.3390\/ijms16011484","article-title":"Cadmium transporters in the kidney and cadmium-induced nephrotoxicity","volume":"16","author":"Yang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2019.144156_b0195","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/13547500902730698","article-title":"Biological half-life of cadmium in the urine of inhabitants after cessation of cadmium exposure","volume":"14","author":"Yasushi Suwazono","year":"2009","journal-title":"Biomarkers"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919308157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919308157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:26:22Z","timestamp":1759854382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111919308157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"alternative-id":["S0378111919308157"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2019.144156","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-122-5p and miR-326-3p: Potential novel biomarkers for early detection of cadmium exposure","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2019.144156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"144156"}}