{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:59:55Z","timestamp":1773449995229,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.gene.2019.144233","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T12:06:34Z","timestamp":1574337994000},"page":"144233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Down-regulation of GLT25D1 inhibited collagen secretion and involved in liver fibrogenesis"],"prefix":"10.1016","volume":"729","author":[{"given":"Lingling","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8893-653X","authenticated-orcid":false,"given":"Hongshan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2019.144233_b0005","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/696383","article-title":"Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl(4)-) induced liver injury in mice","volume":"2014","author":"Rocha","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.gene.2019.144233_b0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"issue":"2","key":"10.1016\/j.gene.2019.144233_b0015","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/hep.25670","article-title":"Fibrosis-dependent mechanisms of hepatocarcinogenesis","volume":"56","author":"Zhang","year":"2012","journal-title":"Hepatology"},{"issue":"9822","key":"10.1016\/j.gene.2019.144233_b0020","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","article-title":"Hepatocellular carcinoma","volume":"379","author":"Forner","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.gene.2019.144233_b0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0168-8278(99)80162-7","article-title":"Elevated serum type IV collagen: a sensitive indicator of the presence of cirrhosis in haemochromatosis","volume":"31","author":"George","year":"1999","journal-title":"J. Hepatol."},{"key":"10.1016\/j.gene.2019.144233_b0030","doi-asserted-by":"crossref","unstructured":"Trinchet, J.C., et al., Serum type I collagen and N-terminal peptide of type III procollagen in chronic hepatitis. Relationship to liver histology and conventional liver tests. J. Hepatol., 1991. 12(2): p. 139\u201344.","DOI":"10.1016\/0168-8278(91)90929-6"},{"issue":"2","key":"10.1016\/j.gene.2019.144233_b0035","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1530-0277.1992.tb01388.x","article-title":"Serum type I collagen and N-terminal peptide of type III procollagen in patients with alcoholic liver disease: relationship to liver histology","volume":"16","author":"Trinchet","year":"1992","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"6","key":"10.1016\/j.gene.2019.144233_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004465","article-title":"Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta","volume":"10","author":"Cabral","year":"2014","journal-title":"PLoS Genet."},{"issue":"4","key":"10.1016\/j.gene.2019.144233_b0045","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1128\/MCB.02085-07","article-title":"Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases","volume":"29","author":"Schegg","year":"2009","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.gene.2019.144233_b0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13287-017-0595-1","article-title":"Transplantation of human bone marrow mesenchymal stromal cells reduces liver fibrosis more effectively than Wharton's jelly mesenchymal stromal cells","volume":"8","author":"Rengasamy","year":"2017","journal-title":"Stem Cell Res. Ther."},{"issue":"4","key":"10.1016\/j.gene.2019.144233_b0055","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.gene.2019.144233_b0060","first-page":"3611","article-title":"Downregulation of Glt25d1 aggravates carbon tetrachlorideinduced acute hepatic injury through activation of the TGFbeta1\/Smad2 signaling pathway","volume":"18","author":"Ye","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"35","key":"10.1016\/j.gene.2019.144233_b0065","doi-asserted-by":"crossref","first-page":"18514","DOI":"10.1074\/jbc.M116.723379","article-title":"Collagen accumulation in osteosarcoma cells lacking GLT25D1 collagen galactosyltransferase","volume":"291","author":"Baumann","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.gene.2019.144233_b0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1679\/aohc.63.137","article-title":"Histometrical and three-dimensional analyses of liver hematopoiesis in the mouse embryo","volume":"63","author":"Sasaki","year":"2000","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.gene.2019.144233_b0075","first-page":"87","article-title":"Haemopoietic cells of yolk sac and liver in the mouse embryo: a light and electron microscopical study","volume":"148","author":"Sasaki","year":"1986","journal-title":"J. Anat."},{"issue":"15","key":"10.1016\/j.gene.2019.144233_b0080","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1128\/MCB.22.15.5527-5538.2002","article-title":"Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development","volume":"22","author":"Migliorini","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2019.144233_b0085","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-213X-9-28","article-title":"O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development","volume":"9","author":"Webster","year":"2009","journal-title":"BMC Dev. Biol."},{"issue":"46","key":"10.1016\/j.gene.2019.144233_b0090","doi-asserted-by":"crossref","first-page":"36158","DOI":"10.1074\/jbc.M006203200","article-title":"Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity","volume":"275","author":"Heikkinen","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.gene.2019.144233_b0095","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0945-053X(02)00071-9","article-title":"The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro","volume":"21","author":"Wang","year":"2002","journal-title":"Matrix Biol."},{"issue":"39","key":"10.1016\/j.gene.2019.144233_b0100","doi-asserted-by":"crossref","first-page":"14120","DOI":"10.1073\/pnas.0404966101","article-title":"Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice","volume":"101","author":"Rautavuoma","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.gene.2019.144233_b0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/jcp.21036","article-title":"Expanding the lysyl hydroxylase toolbox: new insights into the localization and activities of lysyl hydroxylase 3 (LH3)","volume":"212","author":"Myllyla","year":"2007","journal-title":"J. Cell Physiol."},{"issue":"7","key":"10.1016\/j.gene.2019.144233_b0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2004812","article-title":"Roles of fibronectin isoforms in neonatal vascular development and matrix integrity","volume":"16","author":"Kumra","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.gene.2019.144233_b0115","doi-asserted-by":"crossref","first-page":"13237","DOI":"10.1038\/srep13237","article-title":"Blocking endogenous leukemia inhibitory factor during placental development in mice leads to abnormal placentation and pregnancy loss","volume":"5","author":"Winship","year":"2015","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.gene.2019.144233_b0120","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/humupd\/6.5.485","article-title":"Villous sprouting: fundamental mechanisms of human placental development","volume":"6","author":"Castellucci","year":"2000","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.gene.2019.144233_b0125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/0300985811429811","article-title":"Pathology methods for the evaluation of embryonic and perinatal developmental defects and lethality in genetically engineered mice","volume":"49","author":"Ward","year":"2012","journal-title":"Vet. Pathol."},{"issue":"4","key":"10.1016\/j.gene.2019.144233_b0130","doi-asserted-by":"crossref","first-page":"G583","DOI":"10.1152\/ajpgi.00422.2005","article-title":"Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways","volume":"290","author":"Schwabe","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"5","key":"10.1016\/j.gene.2019.144233_b0135","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/hep.21976","article-title":"Keratins let liver live: mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies","volume":"46","author":"Ku","year":"2007","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.gene.2019.144233_b0140","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1523-1747.1999.00735.x","article-title":"Overhydroxylation of lysyl residues is the initial step for altered collagen cross-links and fibril architecture in fibrotic skin","volume":"113","author":"Brinckmann","year":"1999","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.gene.2019.144233_b0145","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/S0021-9258(18)45930-3","article-title":"Temperature-induced post-translational over-modification of type I procollagen. Effects of over-modification of the protein on the rate of cleavage by procollagen N-proteinase and on self-assembly of collagen into fibrils","volume":"267","author":"Torre-Blanco","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"33","key":"10.1016\/j.gene.2019.144233_b0150","doi-asserted-by":"crossref","first-page":"22636","DOI":"10.1074\/jbc.M113.528513","article-title":"Glycosylation and cross-linking in bone type I collagen","volume":"289","author":"Terajima","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.gene.2019.144233_b0155","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20170105","article-title":"Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) is required for the secretion of high molecular weight adiponectin and affects lipid accumulation","volume":"37","author":"Webster","year":"2017","journal-title":"Biosci. Rep."},{"issue":"6","key":"10.1016\/j.gene.2019.144233_b0160","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/ana.25367","article-title":"Biallelic COLGALT1 variants are associated with cerebral small vessel disease","volume":"84","author":"Miyatake","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.gene.2019.144233_b0165","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/ncomms1874","article-title":"O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components","volume":"3","author":"Tian","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2019.144233_b0170","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13069-016-0041-5","article-title":"Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice","volume":"9","author":"McCracken","year":"2016","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.gene.2019.144233_b0175","doi-asserted-by":"crossref","first-page":"7808656","DOI":"10.1155\/2018\/7808656","article-title":"Andrographolide ameliorates liver fibrosis in mice: involvement of TLR4\/NF-kappaB and TGF-beta1\/Smad2 signaling pathways","volume":"2018","author":"Lin","year":"2018","journal-title":"Oxid. Med. Cell Longev"},{"issue":"1","key":"10.1016\/j.gene.2019.144233_b0180","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/jhep.2002.30083","article-title":"Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury","volume":"35","author":"Tahashi","year":"2002","journal-title":"Hepatology"},{"issue":"6651","key":"10.1016\/j.gene.2019.144233_b0185","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/39369","article-title":"Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling","volume":"389","author":"Nakao","year":"1997","journal-title":"Nature"},{"issue":"6958","key":"10.1016\/j.gene.2019.144233_b0190","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919308923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919308923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:28:47Z","timestamp":1759854527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111919308923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":38,"alternative-id":["S0378111919308923"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2019.144233","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of GLT25D1 inhibited collagen secretion and involved in liver fibrogenesis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2019.144233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"144233"}}