{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:53:32Z","timestamp":1793962412734,"version":"4.8.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.gene.2019.144324","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T11:37:02Z","timestamp":1577965022000},"page":"144324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Suppression of long noncoding RNA NEAT1 attenuates hypoxia-induced cardiomyocytes injury by targeting miR-378a-3p"],"prefix":"10.1016","volume":"731","author":[{"given":"Jiali","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fudi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.gene.2019.144324_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1099800404264777","article-title":"New and emerging theories of cardiovascular disease: infection and elevated iron","volume":"6","author":"Alpert","year":"2004","journal-title":"Biol. Res. Nurs."},{"issue":"5","key":"10.1016\/j.gene.2019.144324_b0010","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/cpt.355","article-title":"lncRNA\/MicroRNA interactions in the vasculature","volume":"99","author":"Ballantyne","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.gene.2019.144324_b0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The Oxygen Rich Postnatal Environment Induces Cardiomyocyte Cell Cycle Arrest Through DNA Damage Response","volume":"157","author":"Bao","year":"2014","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.gene.2019.144324_b0020","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/CS20050086","article-title":"Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis","volume":"109","author":"Bustin","year":"2005","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.gene.2019.144324_b0025","first-page":"1","article-title":"The Emerging Role of MicroRNA-155 in Cardiovascular Diseases","volume":"2016","author":"Cao","year":"2016","journal-title":"BioMed Res. Int."},{"issue":"7","key":"10.1016\/j.gene.2019.144324_b0030","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/cam4.710","article-title":"HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer","volume":"5","author":"Chai","year":"2016","journal-title":"Cancer Med."},{"key":"10.1016\/j.gene.2019.144324_b0035","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1038\/ncomms6383","article-title":"The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer","volume":"5","author":"Chakravarty","year":"2014","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.gene.2019.144324_b0040","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/nar\/gki200","article-title":"Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis","volume":"33","author":"Cheng","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"14","key":"10.1016\/j.gene.2019.144324_b0045","first-page":"1799","article-title":"Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis","volume":"294","author":"Danesh","year":"2005","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.gene.2019.144324_b0050","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/vde.12412","article-title":"Western blot analysis of sera from dogs with suspected food allergy","volume":"28","author":"Favrot","year":"2017","journal-title":"Vet. Dermatol."},{"key":"10.1016\/j.gene.2019.144324_b0055","doi-asserted-by":"crossref","unstructured":"Geng C, Wang Z, Wang D, Qiu C, Liu M, Xing C, Zhang Q, Yan G, Cui Q. 2013. LncRNADisease: a database for long-non-coding RNA-associated diseases. Nucleic Acids Research 41 (Database issue) D983-D986.","DOI":"10.1093\/nar\/gks1099"},{"issue":"2","key":"10.1016\/j.gene.2019.144324_b0060","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.devcel.2012.12.012","article-title":"The Tissue-Specific lncRNA Is an Essential Regulator of Heart and Body Wall Development in the Mouse","volume":"24","author":"Grote","year":"2013","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.gene.2019.144324_b0065","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nm1199","article-title":"G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes","volume":"11","author":"Harada","year":"2005","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.gene.2019.144324_b0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation Mechanisms and Signaling Pathways of Autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"issue":"1","key":"10.1016\/j.gene.2019.144324_b0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2014.12.055","article-title":"MiR-378a-3p enhances adipogenesis by targeting mitogen-activated protein kinase 1","volume":"457","author":"Huang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2019.144324_b0080","doi-asserted-by":"crossref","first-page":"13170","DOI":"10.1038\/srep13170","article-title":"miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A","volume":"5","author":"Ikeda","year":"2015","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.gene.2019.144324_b0085","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1136\/heartjnl-2016-310115","article-title":"Cardiac \u03b1V\u03b23 integrin expression following acute myocardial infarction in humans","volume":"103","author":"Jenkins","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.gene.2019.144324_b0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymeth.2014.11.021","article-title":"LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells","volume":"75","author":"Jiang","year":"2015","journal-title":"Methods"},{"key":"10.1016\/j.gene.2019.144324_b0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.atherosclerosis.2016.09.067","article-title":"The role of miRNAs in cardiovascular disease risk factors","volume":"254","author":"Jones Buie","year":"2016","journal-title":"Atherosclerosis"},{"issue":"10","key":"10.1016\/j.gene.2019.144324_b0100","doi-asserted-by":"crossref","first-page":"23651","DOI":"10.3390\/ijms161023651","article-title":"Long Non-Coding RNAs as Master Regulators in Cardiovascular Diseases","volume":"16","author":"Krystal","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.gene.2019.144324_b0105","first-page":"148","article-title":"The clinical epidemiology of cardiovascular diseases in chronic kidney disease: Clinical Epidemiology of Cardiovascular Disease in Chronic Kidney Disease Prior to Dialysis","volume":"16","author":"Levin","year":"2010","journal-title":"Semin. Dial."},{"issue":"1","key":"10.1016\/j.gene.2019.144324_b0110","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.gene.2019.144324_b0115","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.oraloncology.2014.02.003","article-title":"GALNT2 enhances migration and invasion of oral squamous cell carcinoma by regulating EGFR glycosylation and activity","volume":"50","author":"Lin","year":"2014","journal-title":"Oral Oncol."},{"issue":"4","key":"10.1016\/j.gene.2019.144324_b0120","first-page":"3911","article-title":"Effect of basic fibroblast growth factor on cat corneal endothelial cell proliferation","volume":"13","author":"Luo","year":"2011","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.gene.2019.144324_b0125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-4939-3753-0_17","article-title":"Cardiac Myocyte Exosome Isolation","volume":"1448","author":"Malik","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"13","key":"10.1016\/j.gene.2019.144324_b0130","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ygyno.2014.03.255","article-title":"HGF\/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer","volume":"133","author":"Mariani","year":"2014","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.gene.2019.144324_b0135","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.rvsc.2013.12.015","article-title":"Wistar rats from different suppliers have a different response in an acute myocardial infarction model","volume":"96","author":"Naaijkens","year":"2014","journal-title":"Res. Vet. Sci."},{"issue":"7","key":"10.1016\/j.gene.2019.144324_b0140","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrm2708","article-title":"Dynamics and diversity in autophagy mechanisms: lessons from yeast","volume":"10","author":"Nakatogawa","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7485","key":"10.1016\/j.gene.2019.144324_b0145","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nature12943","article-title":"The evolution of lncRNA repertoires and expression patterns in tetrapods","volume":"505","author":"Necsulea","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gene.2019.144324_b0150","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-1-4939-3378-5_21","article-title":"Analyzing MiRNA-LncRNA Interactions","volume":"1402","author":"Paraskevopoulou","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.gene.2019.144324_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2016.03.017","article-title":"Data on necrotic and apoptotic cell death in acute myocardial ischemia\/reperfusion injury: the effects of CaMKII and angiotensin AT1 receptor inhibition","author":"Rajtik","year":"2016","journal-title":"Data Brief"},{"issue":"2","key":"10.1016\/j.gene.2019.144324_b0160","article-title":"Reliable LC3 and p62 Autophagy Marker Detection in Formalin Fixed Paraffin Embedded Human Tissue by Immunohistochemistry","volume":"59","author":"Schl\u00e4fli","year":"2015","journal-title":"European Journal of Histochemistry Ejh"},{"issue":"21","key":"10.1016\/j.gene.2019.144324_b0165","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1001\/archinte.166.21.2307","article-title":"Primary Prevention of Cardiovascular Diseases With Statin Therapy: A Meta-analysis of Randomized Controlled Trials","volume":"166","author":"Thavendiranathan","year":"2006","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"10.1016\/j.gene.2019.144324_b0170","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCRESAHA.116.302521","article-title":"Long Noncoding RNAs in Cardiovascular Diseases","volume":"116","author":"Uchida","year":"2015","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.gene.2019.144324_b0175","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1517\/17425247.3.6.783","article-title":"Progressive stent technologies: new approaches for the treatment of cardiovascular diseases","volume":"3","author":"Vaina","year":"2006","journal-title":"Expert Opinion on Drug Delivery"},{"key":"10.1016\/j.gene.2019.144324_b0180","doi-asserted-by":"crossref","first-page":"30921","DOI":"10.1038\/srep30921","article-title":"miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.gene.2019.144324_b0185","doi-asserted-by":"crossref","unstructured":"Y Z, JF R, A L, V V, M vD, AN M, T T, MT M, RJ S, D S., 2007. Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2. Cell 129(2) 303-317.","DOI":"10.1016\/j.cell.2007.03.030"},{"issue":"11","key":"10.1016\/j.gene.2019.144324_b0190","first-page":"1097","article-title":"LncRNA: A link between RNA and cancer","volume":"1839","author":"Yang","year":"2014","journal-title":"BBA"},{"issue":"3","key":"10.1016\/j.gene.2019.144324_b0195","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s12013-014-0142-y","article-title":"Bioinformatics method to predict two regulation mechanism: TF-miRNA-mRNA and lncRNA-miRNA-mRNA in pancreatic cancer","volume":"70","author":"Ye","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.gene.2019.144324_b0200","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2009.01.046","article-title":"Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway","volume":"607","author":"Zhang","year":"2009","journal-title":"Eur. J. Pharmacol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919309837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111919309837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:27:20Z","timestamp":1759854440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111919309837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":40,"alternative-id":["S0378111919309837"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2019.144324","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of long noncoding RNA NEAT1 attenuates hypoxia-induced cardiomyocytes injury by targeting miR-378a-3p","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2019.144324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"144324"}}