{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:54:21Z","timestamp":1775307261382,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.gene.2020.144358","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T02:13:37Z","timestamp":1578708817000},"page":"144358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Association of CYP11B2 gene polymorphism with preeclampsia in north east of Iran (Khorasan province)"],"prefix":"10.1016","volume":"733","author":[{"given":"Mohsen","family":"Azimi-Nezhad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atieha","family":"Teymoori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Ebrahimzadeh-Vesal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2020.144358_b0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.preghy.2017.12.004","article-title":"Association of gene polymorphisms of aldosterone synthase and angiotensin converting enzyme in pre-eclamptic South African Black women","volume":"11","author":"Aung","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.gene.2020.144358_b0010","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S1701-2163(16)31017-9","article-title":"Genetics of preeclampsia: what are the challenges?","volume":"25","author":"Bernard","year":"2003","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"10.1016\/j.gene.2020.144358_b0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejogrb.2015.11.012","article-title":"Analysis of the gene polymorphism of aldosterone synthase (CYP11B2) and atrial natriuretic peptide (ANP) in women with preeclampsia","volume":"197","author":"Bogacz","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.gene.2020.144358_b0020","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/oxfordjournals.bmb.a072898","article-title":"Pre-eclampsia\u2013the \u201cdisease of theories\u201d","volume":"50","author":"Broughton Pipkin","year":"1994","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.gene.2020.144358_b0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.HYP.25.3.320","article-title":"Association of the alpha-adducin locus with essential hypertension","volume":"25","author":"Casari","year":"1995","journal-title":"Hypertens. (Dallas, Tex. 1979)"},{"key":"10.1016\/j.gene.2020.144358_b0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-0378(03)00048-2","article-title":"Implantation: can immunological parameters of implantation failure be of interest for pre-eclampsia?","volume":"59","author":"Chaouat","year":"2003","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.gene.2020.144358_b0035","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3346\/jkms.2004.19.2.253","article-title":"Association of Angiotensin-converting enzyme and angiotensinogen gene polymorphisms with preeclampsia","volume":"19","author":"Choi","year":"2004","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.gene.2020.144358_b0040","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/586578","article-title":"Preeclampsia 2012","volume":"2012","author":"Eiland","year":"2012","journal-title":"J. Pregnancy"},{"key":"10.1016\/j.gene.2020.144358_b0045","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1161\/01.CIR.100.14.1515","article-title":"A common variant of the endothelial nitric oxide synthase (Glu298\u2013>Asp) is a major risk factor for coronary artery disease in the UK","volume":"100","author":"Hingorani","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2020.144358_b0050","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1028-4559(09)60224-2","article-title":"Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia","volume":"45","author":"Hung","year":"2006","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.gene.2020.144358_b0055","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bpobgyn.2011.01.006","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy","volume":"25","author":"Hutcheon","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.gene.2020.144358_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(05)63430-7","article-title":"Polymorphism of alpha-adducin and hypertension","author":"Iwai","year":"1997","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.gene.2020.144358_b0065","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/01.HYP.32.1.138","article-title":"Human alpha-adducin gene, blood pressure, and sodium metabolism","volume":"32","author":"Kamitani","year":"1998","journal-title":"Hypertens. (Dallas, Tex. 1979)"},{"key":"10.1016\/j.gene.2020.144358_b0070","doi-asserted-by":"crossref","first-page":"298S","DOI":"10.1093\/ajcn\/72.1.298S","article-title":"Role of nutrition in the prevention of toxemia","volume":"72","author":"Maine","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.gene.2020.144358_b0075","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1046\/j.1523-1755.1998.00931.x","article-title":"Alpha-adducin polymorphisms and renal sodium handling in essential hypertensive patients","volume":"53","author":"Manunta","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.gene.2020.144358_b0080","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1007\/PL00000731","article-title":"Adducin: structure, function and regulation","volume":"57","author":"Matsuoka","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.gene.2020.144358_b0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mam.2007.02.005","article-title":"Molecular aspects of preeclampsia","volume":"28","author":"Mohaupt","year":"2007","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.gene.2020.144358_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2007.04.009","article-title":"Molecular mechanisms of preeclampsia","volume":"75","author":"Mutter","year":"2008","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.gene.2020.144358_b0095","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ejogrb.2005.08.030","article-title":"Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women","volume":"127","author":"Percin","year":"2006","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.gene.2020.144358_b0100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejogrb.2011.09.049","article-title":"The management of pre-eclampsia: what we think we know","volume":"160","author":"Pettit","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.gene.2020.144358_b0105","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/jhh.2010.58","article-title":"Relationship of aldosterone synthase gene (C-344T) and mineralocorticoid receptor (S810L) polymorphisms with gestational hypertension","volume":"25","author":"Ramirez-Salazar","year":"2011","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.gene.2020.144358_b0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0020-7292(94)02215-1","article-title":"Blood coagulation changes in pregnant women at risk of developing preeclampsia","volume":"48","author":"Savelieva","year":"1995","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.gene.2020.144358_b0115","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1111\/j.1523-1755.2004.66031.x","article-title":"Evidence for compromised aldosterone synthase enzyme activity in preeclampsia","volume":"66","author":"Shojaati","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.gene.2020.144358_b0120","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.gene.2020.144358_b0125","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0006-2952(95)02099-3","article-title":"Selective pharmacological inhibition of distinct nitric oxide synthase isoforms","volume":"51","author":"Southan","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.gene.2020.144358_b0130","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.preghy.2012.05.006","article-title":"Preeclampsia: no longer solely a pregnancy disease","volume":"2","author":"Tranquilli","year":"2012","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.gene.2020.144358_b0135","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1172\/JCI118737","article-title":"Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport","volume":"97","author":"Tripodi","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2020.144358_b0140","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/sj.jhh.1001484","article-title":"Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension","volume":"16","author":"Tsukada","year":"2002","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.gene.2020.144358_b0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nm0196-41","article-title":"A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene","volume":"2","author":"Wang","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.gene.2020.144358_b0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3109\/07435809509030459","article-title":"Haplotype analysis of CYP11B2","volume":"21","author":"White","year":"1995","journal-title":"Endocr. Res."},{"key":"10.1016\/j.gene.2020.144358_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2009.05.004","article-title":"Is preeclampsia an autoimmune disease?","volume":"133","author":"Xia","year":"2009","journal-title":"Clin. Immunol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111920300275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111920300275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:27:44Z","timestamp":1759854464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111920300275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":31,"alternative-id":["S0378111920300275"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2020.144358","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of CYP11B2 gene polymorphism with preeclampsia in north east of Iran (Khorasan province)","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2020.144358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"144358"}}