{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:28:05Z","timestamp":1759883285121,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.gene.2020.145179","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T13:41:23Z","timestamp":1601300483000},"page":"145179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The role of HLA in Balkan endemic nephropathy"],"prefix":"10.1016","volume":"767","author":[{"given":"Damir","family":"Dittrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6982-2032","authenticated-orcid":false,"given":"Marija","family":"Maskalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljko","family":"Kastelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrvoje","family":"Palenkic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorana","family":"Grubic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.gene.2020.145179_b0005","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/hmg\/ddg066","article-title":"Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC","volume":"12","author":"Ahmad","year":"2003","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.gene.2020.145179_b0010","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3109\/08820139.2012.703744","article-title":"Diversity of HLA-B*35 alleles and haplotypes among Croatians","volume":"41","author":"Calusic","year":"2012","journal-title":"Immunol. Invest."},{"issue":"12","key":"10.1016\/j.gene.2020.145179_b0015","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1007\/s00251-001-0414-8","article-title":"Co-selection of the H63D mutation and the HLA-A29 allele: a new paradigm of linkage disequilibrium?","volume":"53","author":"Cardoso","year":"2002","journal-title":"Immunogenetics"},{"issue":"3","key":"10.1016\/j.gene.2020.145179_b0020","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.acuro.2013.06.006","article-title":"Involvement of HLA class I molecules in the immune escape of urologic tumors","volume":"38","author":"Carretero","year":"2014","journal-title":"Actas Urol. Esp."},{"key":"10.1016\/j.gene.2020.145179_b0025","first-page":"5","article-title":"Epidemiological aspects of Balkan endemic nephropathy in a typical focus in Yugoslavia","volume":"115","author":"Ceovic","year":"1991","journal-title":"IARC Sci. Publ."},{"issue":"5","key":"10.1016\/j.gene.2020.145179_b0030","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1681\/ASN.2016020114","article-title":"MHC class II risk alleles and amino acid residues in idiopathic membranous nephropathy","volume":"28","author":"Cui","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.gene.2020.145179_b0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-1-59745-223-6_5","article-title":"HLA typing with sequence-specific oligonucleotide primed PCR (PCR-SSO) and use of the LuminexTM technology","volume":"134","author":"Dalva","year":"2007","journal-title":"Methods Mol. Med."},{"issue":"8","key":"10.1016\/j.gene.2020.145179_b0040","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/ejhg.2010.32","article-title":"Linkage disequilibrium and age of HLA region SNPs in relation to classic HLA gene alleles within Europe","volume":"18","author":"Evseeva","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.gene.2020.145179_b0045","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/ki.2011.371","article-title":"Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid","volume":"81","author":"Jelakovic","year":"2012","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.gene.2020.145179_b0050","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.semnephrol.2019.02.007","article-title":"Balkan endemic nephropathy and the causative role of aristolochic acid","volume":"39","author":"Jelakovic","year":"2019","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.gene.2020.145179_b0055","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/ndt\/gft384","article-title":"Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy","volume":"29","author":"Jelakovi\u0107","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.gene.2020.145179_b0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2350-13-33","article-title":"The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese","volume":"13","author":"Jiyun","year":"2012","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.gene.2020.145179_b0065","doi-asserted-by":"crossref","unstructured":"Karnes, J.H., Bastarache, L., Shaffer, C.M., Gaudieri, S., Xu, Y., Glazer, A.M., et al. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants. Sci. Transl. Med., 2017;9(389):pii:eaai8708.","DOI":"10.1126\/scitranslmed.aai8708"},{"key":"10.1016\/j.gene.2020.145179_b0070","unstructured":"Kastelan, A., HLA System and Balkan Endemic Nephropathy in Yugoslavia. 1976. (Unpublished data)."},{"key":"10.1016\/j.gene.2020.145179_b0075","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1399-0039.2006.00769.x","article-title":"PyPop update-a software pipeline for large-scale multilocus population genomics","volume":"69","author":"Lancaster","year":"2007","journal-title":"Tissue Antigens"},{"issue":"5","key":"10.1016\/j.gene.2020.145179_b0080","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1681\/ASN.2016060644","article-title":"HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-related membranous nephropathy","volume":"28","author":"Le","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.gene.2020.145179_b0085","doi-asserted-by":"crossref","unstructured":"Lipner, E.M., Tomer, Y., Noble, J.A., Monti, M.C., Lonsdale, J.T., Corso, B., et al. HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. Hum. Immunol., 2013;74(5):538\u201344.","DOI":"10.1016\/j.humimm.2013.01.013"},{"issue":"6","key":"10.1016\/j.gene.2020.145179_b0090","doi-asserted-by":"crossref","first-page":"E182","DOI":"10.25011\/cim.v39i6.27487","article-title":"HLA-DRB1 shared epitope allele polymorphisms and rheumatoid arthritis: a systemic review and meta-analysis","volume":"39","author":"Liu","year":"2016","journal-title":"Clin. Invest. Med."},{"issue":"1","key":"10.1016\/j.gene.2020.145179_b0095","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.3747\/co.23.2839","article-title":"Relationship between HLA-DRB1 allele polymorphisms and familial aggregations of hepatocellular carcinoma","volume":"23","author":"Ma","year":"2016","journal-title":"Curr. Oncol."},{"issue":"17","key":"10.1016\/j.gene.2020.145179_b0100","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s00508-005-0426-8","article-title":"Recent data on endemic nephropathy and related urothelial tumors in Croatia","volume":"117","author":"Miletic-Medved","year":"2005","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.gene.2020.145179_b0105","unstructured":"Minev, M., Mikhaylov, T., HLA System and Balkan endemic nephropathy in Bulgaria. 1976. (Unpublished data)."},{"issue":"1","key":"10.1016\/j.gene.2020.145179_b0110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1399-0039.1978.tb01222.x","article-title":"HLA System and Balkan Endemic Nephropathy (a collective study with the collaboration of all participants in the HLA workshop\u2013Sofia 1976)","volume":"11","author":"Minev","year":"1978","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.gene.2020.145179_b0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/sji.12329","article-title":"Clinical role of human leukocyte antigen in health and disease","volume":"82","author":"Mosaad","year":"2015","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.gene.2020.145179_b0120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1399-0039.1992.tb01940.x","article-title":"HLA-DR typing by PCR amplification with sequence specific primers (PCR-SSP) in 2 hours","volume":"39","author":"Olerup","year":"1992","journal-title":"Tissue Antigens"},{"issue":"3","key":"10.1016\/j.gene.2020.145179_b0125","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/ckj\/sft049","article-title":"Balkan endemic nephropathy \u2013 current status and future perspectives","volume":"6","author":"Pavlovic","year":"2013","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.gene.2020.145179_b0130","first-page":"295","article-title":"Growing occurrence of kidney injuries in the district of Slavonski Brod","volume":"81","author":"Pichler","year":"1959","journal-title":"Lijec. Vjesn."},{"issue":"10","key":"10.1016\/j.gene.2020.145179_b0135","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/s41581-018-0057-8","article-title":"HLA and kidney disease: from associations to mechanisms","volume":"14","author":"Robson","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.gene.2020.145179_b0140","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2018-000677","article-title":"Non-classical human leucocyte antigens in ankylosing spondylitis: possible association with HLA-E and HLA-F","volume":"4","author":"Santos","year":"2018","journal-title":"RMD Open"},{"issue":"8","key":"10.1016\/j.gene.2020.145179_b0145","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/em.21732","article-title":"Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romani","volume":"53","author":"Schmeiser","year":"2012","journal-title":"Environ. Mol. Mutagen."},{"issue":"2","key":"10.1016\/j.gene.2020.145179_b0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/ndt\/gfw001","article-title":"Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies","volume":"32","author":"Sekula","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"issue":"5","key":"10.1016\/j.gene.2020.145179_b0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/tan.12898","article-title":"Molecular mechanisms of HLA class I-mediated immune evasion of human tumors and their role in resistance to immunotherapies","volume":"88","author":"Seliger","year":"2016","journal-title":"HLA"},{"key":"10.1016\/j.gene.2020.145179_b0160","unstructured":"Soper, D.S., 2014. A-priori Sample Size Calculator for Student t-Tests [Software]. http:\/\/www.danielsoper.com\/statcalc."},{"issue":"7","key":"10.1016\/j.gene.2020.145179_b0165","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1009742","article-title":"Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy","volume":"364","author":"Stanescu","year":"2011","journal-title":"N. Eng. J. Med."},{"issue":"2","key":"10.1016\/j.gene.2020.145179_b0170","first-page":"101","article-title":"Genetic, genomic and epigenomic studies of balkan endemic nephropathy (Ben)","volume":"36","author":"Staneva","year":"2015","journal-title":"Pril (Makedon Akad Nauk Umet Odd Med Nauki)"},{"issue":"11","key":"10.1016\/j.gene.2020.145179_b0175","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1289\/ehp.106-1533478","article-title":"The etiology of Balkan endemic nephropathy: still more questions than answers","volume":"106","author":"Tatu","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.gene.2020.145179_b0180","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/920723","article-title":"NGS Nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to balkan endemic nephropathy","volume":"2014","author":"Toncheva","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.gene.2020.145179_b0185","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2741\/4524","article-title":"A reciprocal HLA-disease association in rheumatoid arthritis and pemphigus vulgaris","volume":"22","author":"Van Drongelen","year":"2017","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"4","key":"10.1016\/j.gene.2020.145179_b0190","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1179\/oeh.2006.12.4.369","article-title":"Critical evaluation of environmental exposure agents suspected in the etiology of Balkan endemic nephropathy","volume":"12","author":"Voice","year":"2006","journal-title":"Int. J. Occup. Environ. Health"},{"issue":"3","key":"10.1016\/j.gene.2020.145179_b0195","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S1525-1578(10)60658-7","article-title":"Human leukocyte antigen gene polymorphism and the histocompatibility laboratory","volume":"3","author":"Williams","year":"2001","journal-title":"J. Mol. Diagn."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111920308489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111920308489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:37:07Z","timestamp":1759855027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111920308489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":39,"alternative-id":["S0378111920308489"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2020.145179","relation":{},"ISSN":["0378-1119"],"issn-type":[{"type":"print","value":"0378-1119"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of HLA in Balkan endemic nephropathy","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2020.145179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"145179"}}