{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:12:52Z","timestamp":1790233972120,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.gene.2020.145316","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T07:33:46Z","timestamp":1605857626000},"page":"145316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["ABCA7 links sterol metabolism to the host defense system: Molecular background for potential management measure of Alzheimer's disease"],"prefix":"10.1016","volume":"768","author":[{"given":"Sumiko","family":"Abe-Dohmae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2020.145316_b0005","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1074\/jbc.M309888200","article-title":"Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein","volume":"279","author":"Abe-Dohmae","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2020.145316_b0015","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1194\/jlr.M600145-JLR200","article-title":"Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner","volume":"47","author":"Abe-Dohmae","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.gene.2020.145316_b0020","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.febslet.2005.12.029","article-title":"ABCA7, a molecule with unknown function","volume":"580","author":"Abe-Dohmae","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.gene.2020.145316_b0025","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2217\/clp.12.67","article-title":"ABCA7: a potential mediator between cholesterol homeostasis and the host defense system","volume":"7","author":"Abe-Dohmae","year":"2012","journal-title":"Clinical Lipidology"},{"key":"10.1016\/j.gene.2020.145316_b0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/brainsci8020027","article-title":"ABCA7 and Pathogenic Pathways of Alzheimer's Disease","volume":"8","author":"Aikawa","year":"2018","journal-title":"Brain Sci."},{"key":"10.1016\/j.gene.2020.145316_b0035","doi-asserted-by":"crossref","first-page":"23790","DOI":"10.1073\/pnas.1908529116","article-title":"ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain","volume":"116","author":"Aikawa","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.gene.2020.145316_b0040","doi-asserted-by":"crossref","first-page":"22426","DOI":"10.1074\/jbc.M202996200","article-title":"Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation","volume":"277","author":"Arakawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2020.145316_b0045","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1126\/science.290.5497.1771","article-title":"Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters","volume":"290","author":"Berge","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.gene.2020.145316_b0050","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3233\/ADR-170029","article-title":"Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels","volume":"1","author":"Bhatia","year":"2017","journal-title":"J. Alzheimers Dis. Rep."},{"key":"10.1016\/j.gene.2020.145316_b0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/11914","article-title":"The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease","volume":"22","author":"Bodzioch","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2020.145316_b0060","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000056914","article-title":"Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter","volume":"92","author":"Broccardo","year":"2001","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.gene.2020.145316_b0065","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/11905","article-title":"Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency","volume":"22","author":"Brooks-Wilson","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2020.145316_b0070","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2014.07.042","article-title":"Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease","volume":"36","author":"Carrasquillo","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.gene.2020.145316_b0075","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1212\/WNL.0000000000000335","article-title":"Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD","volume":"82","author":"Carrasquillo","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.gene.2020.145316_b0080","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1038\/s41598-018-24248-8","article-title":"Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis","volume":"8","author":"Chu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2020.145316_b0085","doi-asserted-by":"crossref","first-page":"28240","DOI":"10.1074\/jbc.M003337200","article-title":"Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor\/retinoid X receptor","volume":"275","author":"Costet","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2020.145316_b0090","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3233\/JAD-160456","article-title":"ABCA7 Mediates Phagocytic Clearance of Amyloid-\u03b2 in the Brain","volume":"54","author":"Fu","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.gene.2020.145316_b0095","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1194\/jlr.M500092-JLR200","article-title":"Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7","volume":"46","author":"Hayashi","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.gene.2020.145316_b0100","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2020.145316_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemphyslip.2015.01.005","article-title":"Preferential incorporation of shorter and less unsaturated acyl phospholipids into high density lipoprotein-like particles in the ABCA1- and ABCA7-mediated biogenesis with apoA-I","volume":"187","author":"Hotta","year":"2015","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.gene.2020.145316_b0110","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbrc.2003.10.002","article-title":"Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release","volume":"311","author":"Ikeda","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2020.145316_b0115","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCRESAHA.107.151746","article-title":"ATP-binding cassette transporter A1 gene transcription is downregulated by activator protein 2alpha. Doxazosin inhibits activator protein 2alpha and increases high-density lipoprotein biogenesis independent of alpha1-adrenoceptor blockade","volume":"101","author":"Iwamoto","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.gene.2020.145316_b0120","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1161\/ATVBAHA.108.174714","article-title":"Involvement of protein kinase D in phosphorylation and increase of DNA binding of activator protein 2 alpha to downregulate ATP-binding cassette transporter A1","volume":"28","author":"Iwamoto","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.gene.2020.145316_b0125","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1194\/jlr.M600127-JLR200","article-title":"ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis","volume":"47","author":"Iwamoto","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.gene.2020.145316_b0130","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.atherosclerosis.2011.01.043","article-title":"Protein kinase D regulates the adiponectin gene expression through phosphorylation of AP-2: a common pathway to the ABCA1 gene regulation","volume":"216","author":"Iwamoto","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.gene.2020.145316_b0135","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200601030","article-title":"ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages","volume":"174","author":"Jehle","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.gene.2020.145316_b0140","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1006\/bbrc.2000.2954","article-title":"Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)","volume":"273","author":"Kaminski","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2020.145316_b0145","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1006\/bbrc.2000.3880","article-title":"Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene","volume":"278","author":"Kaminski","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2020.145316_b0150","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1074\/jbc.M412602200","article-title":"Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels","volume":"280","author":"Kim","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2020.145316_b0155","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1523\/JNEUROSCI.4165-12.2013","article-title":"Deletion of Abca7 increases cerebral amyloid-\u03b2 accumulation in the J20 mouse model of Alzheimer's disease","volume":"33","author":"Kim","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.gene.2020.145316_b0160","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1073\/pnas.97.2.817","article-title":"ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport","volume":"97","author":"Klucken","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gene.2020.145316_b0165","doi-asserted-by":"crossref","unstructured":"Lambert, J.C., Ibrahim-Verbaas, C.A., Harold, D., Naj, A.C., Sims, R., Bellenguez, C., DeStafano, A.L., Bis, J.C., Beecham, G.W., Grenier-Boley, B., Russo, G., Thorton-Wells, T.A., Jones, N., Smith, A.V., Chouraki, V., Thomas, C., Ikram, M.A., Zelenika, D., Vardarajan, B.N., Kamatani, Y., Lin, C.F., Gerrish, A., Schmidt, H., Kunkle, B., Dunstan, M.L., Ruiz, A., Bihoreau, M.T., Choi, S.H., Reitz, C., Pasquier, F., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O.L., De Jager, P.L., Deramecourt, V., Johnston, J.A., Evans, D., Lovestone, S., Letenneur, L., Mor\u00f3n, F.J., Rubinsztein, D.C., Eiriksdottir, G., Sleegers, K., Goate, A.M., Fi\u00e9vet, N., Huentelman, M.W., Gill, M., Brown, K., Kamboh, M.I., Keller, L., Barberger-Gateau, P., McGuiness, B., Larson, E.B., Green, R., Myers, A.J., Dufouil, C., Todd, S., Wallon, D., Love, S., Rogaeva, E., Gallacher, J., St George-Hyslop, P., Clarimon, J., Lleo, A., Bayer, A., Tsuang, D.W., Yu, L., Tsolaki, M., Boss\u00f9, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez-Garcia, F., Fox, N.C., Hardy, J., Deniz Naranjo, M.C., Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Moebus, S., Mecocci, P., Del Zompo, M., Maier, W., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Nacmias, B., Gilbert, J.R., Mayhaus, M., Lannefelt, L., Hakonarson, H., Pichler, S., et al., 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 45, 1452-8.","DOI":"10.1038\/ng.2802"},{"key":"10.1016\/j.gene.2020.145316_b0175","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1161\/ATVBAHA.108.169482","article-title":"ApoA-I facilitates ABCA1 recycle\/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation","volume":"28","author":"Lu","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.gene.2020.145316_b0180","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1254\/jphs.10241FP","article-title":"Pitavastatin increases ABCA1 expression by dual mechanisms: SREBP2-driven transcriptional activation and PPAR\u03b1-dependent protein stabilization but without activating LXR in rat hepatoma McARH7777 cells","volume":"116","author":"Maejima","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.gene.2020.145316_b0185","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/577d9009-baf4-46ea-b44e-eda094b604db","article-title":"Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1","volume":"7","author":"Meurs","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gene.2020.145316_b0190","doi-asserted-by":"crossref","unstructured":"Naj, A.C., Jun, G., Beecham, G.W., Wang, L.S., Vardarajan, B.N., Buros, J., Gallins, P.J., Buxbaum, J.D., Jarvik, G.P., Crane, P.K., Larson, E.B., Bird, T.D., Boeve, B.F., Graff-Radford, N.R., De Jager, P.L., Evans, D., Schneider, J.A., Carrasquillo, M.M., Ertekin-Taner, N., Younkin, S.G., Cruchaga, C., Kauwe, J.S., Nowotny, P., Kramer, P., Hardy, J., Huentelman, M.J., Myers, A.J., Barmada, M.M., Demirci, F.Y., Baldwin, C.T., Green, R.C., Rogaeva, E., St George-Hyslop, P., Arnold, S.E., Barber, R., Beach, T., Bigio, E.H., Bowen, J.D., Boxer, A., Burke, J.R., Cairns, N.J., Carlson, C.S., Carney, R.M., Carroll, S.L., Chui, H.C., Clark, D.G., Corneveaux, J., Cotman, C.W., Cummings, J.L., DeCarli, C., DeKosky, S.T., Diaz-Arrastia, R., Dick, M., Dickson, D.W., Ellis, W.G., Faber, K.M., Fallon, K.B., Farlow, M.R., Ferris, S., Frosch, M.P., Galasko, D.R., Ganguli, M., Gearing, M., Geschwind, D.H., Ghetti, B., Gilbert, J.R., Gilman, S., Giordani, B., Glass, J.D., Growdon, J.H., Hamilton, R.L., Harrell, L.E., Head, E., Honig, L.S., Hulette, C.M., Hyman, B.T., Jicha, G.A., Jin, L.W., Johnson, N., Karlawish, J., Karydas, A., Kaye, J.A., Kim, R., Koo, E.H., Kowall, N.W., Lah, J.J., Levey, A.I., Lieberman, A.P., Lopez, O.L., Mack, W.J., Marson, D.C., Martiniuk, F., Mash, D.C., Masliah, E., McCormick, W.C., McCurry, S.M., McDavid, A.N., McKee, A.C., Mesulam, M., Miller, B.L., et al., 2011. Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 43, 436-41.","DOI":"10.1038\/ng.801"},{"key":"10.1016\/j.gene.2020.145316_b0200","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.bbamem.2016.09.023","article-title":"Diverse relations between ABC transporters and lipids: An overview","volume":"1859","author":"Neumann","year":"2017","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"10.1016\/j.gene.2020.145316_b0205","doi-asserted-by":"crossref","first-page":"40273","DOI":"10.1038\/srep40273","article-title":"ATP Binding CassetteTransporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content","volume":"7","author":"Nowyhed","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2020.145316_b0210","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/ATVBAHA.111.238360","article-title":"HNF4\u03b1 increases liver-specific human ATP-binding cassette transporter A1 expression and cholesterol efflux to apolipoprotein A-I in response to cholesterol depletion","volume":"32","author":"Ohoka","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.gene.2020.145316_b0215","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neurobiolaging.2015.10.037","article-title":"Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy","volume":"39","author":"Ramirez","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.gene.2020.145316_b0220","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1001\/jama.2013.2973","article-title":"Variants in the ATP-binding cassette transporter (ABCA7), apolipoproteinE \u220a4, and the risk of late-onset Alzheimer disease in African Americans","volume":"309","author":"Reitz","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.gene.2020.145316_b0225","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/11921","article-title":"Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1","volume":"22","author":"Rust","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2020.145316_b0230","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1523\/JNEUROSCI.3757-15.2016","article-title":"ABCA7 Deficiency Accelerates Amyloid-\u03b2 Generation and Alzheimer's Neuronal Pathology","volume":"36","author":"Sakae","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.gene.2020.145316_b0235","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.97.14.7987","article-title":"Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter","volume":"97","author":"Santamarina-Fojo","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gene.2020.145316_b0240","doi-asserted-by":"crossref","first-page":"24152","DOI":"10.1074\/jbc.M115.655076","article-title":"ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing","volume":"290","author":"Satoh","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2020.145316_b0245","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/ng.3246","article-title":"Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease","volume":"47","author":"Steinberg","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2020.145316_b0250","doi-asserted-by":"crossref","first-page":"21090","DOI":"10.1074\/jbc.M701228200","article-title":"Sterol regulatory element-binding protein and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status","volume":"282","author":"Tamehiro","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2020.145316_b0255","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1194\/jlr.M006049","article-title":"Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7","volume":"51","author":"Tanaka","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.gene.2020.145316_b0260","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.atherosclerosis.2011.06.031","article-title":"HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7","volume":"217","author":"Tanaka","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.gene.2020.145316_b0265","doi-asserted-by":"crossref","first-page":"274","DOI":"10.5551\/jat.6726","article-title":"Roles of ATP-binding cassette transporter A7 in cholesterol homeostasis and host defense system","volume":"18","author":"Tanaka","year":"2011","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.gene.2020.145316_b0270","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bbalip.2017.03.012","article-title":"Lysophosphatidylcholine export by human ABCA7","volume":"1862","author":"Tomioka","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Cell. Biol. Lipids"},{"key":"10.1016\/j.gene.2020.145316_b0275","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1271\/bbb.100816","article-title":"ABC proteins protect the human body and maintain optimal health","volume":"75","author":"Ueda","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.gene.2020.145316_b0280","doi-asserted-by":"crossref","first-page":"42906","DOI":"10.1074\/jbc.M307831200","article-title":"ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux","volume":"278","author":"Wang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2020.145316_b0285","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1001\/jamaneurol.2016.3783","article-title":"Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease","volume":"74","author":"Zissimopoulos","year":"2017","journal-title":"JAMA Neurol"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111920309859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111920309859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:42:58Z","timestamp":1759855378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111920309859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":54,"alternative-id":["S0378111920309859"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2020.145316","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ABCA7 links sterol metabolism to the host defense system: Molecular background for potential management measure of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2020.145316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"145316"}}