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UCSF Chimera--a visualization system for exploratory research and analysis. J. Biol. Chem. 10.1097\/MLR.0000000000000625."},{"key":"10.1016\/j.gene.2021.145530_b0305","doi-asserted-by":"crossref","unstructured":"Wishart, D.S., Feunang, Y.D., Guo, A.C., Lo, E.J., Marcu, A., Grant, J.R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., Assempour, N., Iynkkaran, I., Liu, Y., MacIejewski, A., Gale, N., Wilson, A., Chin, L., Cummings, R., Le, Di., Pon, A., Knox, C., Wilson, M., 2018. DrugBank 5.0: A major update to the DrugBank database for 2018. Nucleic Acids Res. 10.1093\/nar\/gkx1037.","DOI":"10.1093\/nar\/gkx1037"},{"key":"10.1016\/j.gene.2021.145530_b0310","doi-asserted-by":"crossref","unstructured":"Wisplinghoff, H., Bischoff, T., Tallent, S.M., Seifert, H., Wenzel, R.P., Edmond, M.B., 2004. Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study. Clin. Infect. 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