{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:33:16Z","timestamp":1780961596923,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013238","name":"Mahidol University Faculty of Medicine Siriraj Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.gene.2021.145691","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T22:42:41Z","timestamp":1620168161000},"page":"145691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Vitamin D pathway gene polymorphisms, vitamin D level, and cytokines in children with type 1 diabetes"],"prefix":"10.1016","volume":"791","author":[{"given":"Watip","family":"Tangjittipokin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pichakorn","family":"Umjai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khwanhatai","family":"Khemaprasit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichat","family":"Charoentawornpanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutima","family":"Chanprasert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipaporn","family":"Teerawattanapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tassanee","family":"Narkdontri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeerunda","family":"Santiprabhob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2021.145691_b0005","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/hmg\/ddq155","article-title":"Genome-wide association study of circulating vitamin D levels","volume":"19","author":"Ahn","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2021.145691_b0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/08820139.2017.1416398","article-title":"Association between cytokine genes polymorphisms and type 1 diabetes: a case-control study on Saudi population","volume":"47","author":"Allam","year":"2018","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.gene.2021.145691_b0015","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc18-S002","article-title":"2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018","volume":"41","author":"American Diabetes","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.gene.2021.145691_b0020","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/thy.2000.10.375","article-title":"Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves' disease","volume":"10","author":"Ban","year":"2000","journal-title":"Thyroid"},{"key":"10.1016\/j.gene.2021.145691_b0025","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2337\/diab.33.2.176","article-title":"A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus","volume":"33","author":"Bell","year":"1984","journal-title":"Diabetes"},{"key":"10.1016\/j.gene.2021.145691_b0030","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2337\/dc15-0101","article-title":"Predicting type 1 diabetes using biomarkers","volume":"38","author":"Bonifacio","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.gene.2021.145691_b0035","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3109\/07853890.2010.495951","article-title":"The pattern of inflammatory\/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time","volume":"42","author":"Chatzigeorgiou","year":"2010","journal-title":"Ann. Med."},{"key":"10.1016\/j.gene.2021.145691_b0040","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.2337\/db10-1656","article-title":"Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes","volume":"60","author":"Cooper","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.gene.2021.145691_b0045","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1172\/JCI1050","article-title":"Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene","volume":"101","author":"D'Ambrosio","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2021.145691_b0050","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1309\/AJCPJGZQX42BIAXL","article-title":"Low vitamin D levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications","volume":"135","author":"Devaraj","year":"2011","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.gene.2021.145691_b0055","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1210\/jc.2007-2702","article-title":"Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans","volume":"93","author":"Engelman","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.gene.2021.145691_b0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/09674845.2018.1545554","article-title":"Influence of single nucleotide polymorphism in IL-27 and IL-33 genes on breast cancer","volume":"76","author":"Fathi Maroufi","year":"2019","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.gene.2021.145691_b0065","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1016\/j.diabres.2014.12.008","article-title":"Lower serum 25 (OH) D concentrations in type 1 diabetes: A meta-analysis","volume":"108","author":"Feng","year":"2015","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.gene.2021.145691_b0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-510X(99)00112-4","article-title":"Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese","volume":"166","author":"Fukazawa","year":"1999","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.gene.2021.145691_b0075","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1900\/RDS.2012.9.148","article-title":"Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease","volume":"9","author":"Graham","year":"2012","journal-title":"The review of diabetic studies : RDS"},{"key":"10.1016\/j.gene.2021.145691_b0080","doi-asserted-by":"crossref","unstructured":"Diabetes Epidemiology Research International Group, 1988. Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes 37, 1113-9.","DOI":"10.2337\/diabetes.37.8.1113"},{"key":"10.1016\/j.gene.2021.145691_b0085","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.clim.2011.02.016","article-title":"Immune profiling by multiple gene expression analysis in patients at-risk and with type 1 diabetes","volume":"139","author":"Han","year":"2011","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.gene.2021.145691_b0090","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/jcb.10338","article-title":"Vitamin D: A millenium perspective","volume":"88","author":"Holick","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.gene.2021.145691_b0095","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.gene.2021.145691_b0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104825","article-title":"Vitamin D Status among Thai School Children and the Association with 1,25-Dihydroxyvitamin D and Parathyroid Hormone Levels","volume":"9","author":"Houghton","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gene.2021.145691_b0105","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0140-6736(01)06580-1","article-title":"Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study","volume":"358","author":"Hypponen","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2021.145691_b0110","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1210\/mend.14.3.0435","article-title":"The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB","volume":"14","author":"Jurutka","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.gene.2021.145691_b0115","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12865-014-0035-2","article-title":"Vitamin D-binding protein controls T cell responses to vitamin D","volume":"15","author":"Kongsbak","year":"2014","journal-title":"BMC Immunol."},{"key":"10.1016\/j.gene.2021.145691_b0120","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.4049\/jimmunol.134.5.3032","article-title":"1,25-Dihydroxyvitamin D3 suppresses human T helper\/inducer lymphocyte activity in vitro","volume":"134","author":"Lemire","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2021.145691_b0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1507\/endocrj.EJ13-0369","article-title":"Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese","volume":"61","author":"Li","year":"2014","journal-title":"Endocr. J."},{"key":"10.1016\/j.gene.2021.145691_b0130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/iji.12472","article-title":"Association of cytokine Th2 gene polymorphisms with autoimmune thyroid diseases in Tunisian population","volume":"47","author":"Mestiri","year":"2020","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.gene.2021.145691_b0135","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/hmg\/5.7.1075","article-title":"The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes","volume":"5","author":"Nistico","year":"1996","journal-title":"Belgian Diabetes Registry. Hum Mol Genet"},{"key":"10.1016\/j.gene.2021.145691_b0140","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.clim.2009.08.004","article-title":"Vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Crete, Greece","volume":"133","author":"Panierakis","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.gene.2021.145691_b0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4049\/jimmunol.178.1.145","article-title":"1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells","volume":"178","author":"Penna","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2021.145691_b0150","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1055\/s-2005-870578","article-title":"Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes","volume":"37","author":"Pozzilli","year":"2005","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.gene.2021.145691_b0155","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3390\/nu5072502","article-title":"Vitamin D and immune function","volume":"5","author":"Prietl","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.gene.2021.145691_b0160","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00007890-199508270-00012","article-title":"Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft","volume":"60","author":"Rabinovitch","year":"1995","journal-title":"Transplantation"},{"key":"10.1016\/j.gene.2021.145691_b0165","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/dmrr.719","article-title":"CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans","volume":"23","author":"Ramos-Lopez","year":"2007","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.gene.2021.145691_b0170","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1017\/S0007114512001675","article-title":"Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore","volume":"109","author":"Robien","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.gene.2021.145691_b0175","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/hmg\/ddt529","article-title":"The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells","volume":"23","author":"Shahijanian","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2021.145691_b0180","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2337\/diab.22.6.429","article-title":"Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus","volume":"22","author":"Singal","year":"1973","journal-title":"Diabetes"},{"key":"10.1016\/j.gene.2021.145691_b0185","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0168-8227(02)00195-X","article-title":"Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in the Dalmatian population","volume":"59","author":"Skrabic","year":"2003","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.gene.2021.145691_b0190","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/09513590.2018.1528220","article-title":"Association of IL-10, IL-18, and IL-33 genetic polymorphisms with recurrent pregnancy loss risk in Iranian women","volume":"35","author":"Soheilyfar","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.gene.2021.145691_b0195","first-page":"1159","article-title":"A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness)","volume":"57","author":"Strawbridge","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.gene.2021.145691_b0200","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2337\/db13-1559","article-title":"Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term","volume":"63","author":"Takiishi","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.gene.2021.145691_b0205","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00198-004-1601-x","article-title":"Haplotype analysis of VDR gene polymorphisms: a meta-analysis","volume":"15","author":"Thakkinstian","year":"2004","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.gene.2021.145691_b0210","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jsbmb.2014.03.011","article-title":"Contribution of VDR polymorphisms to type 1 diabetes susceptibility: Systematic review of case-control studies and meta-analysis","volume":"143","author":"Tizaoui","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2021.145691_b0215","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ni.1851","article-title":"Vitamin D controls T cell antigen receptor signaling and activation of human T cells","volume":"11","author":"von Essen","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.gene.2021.145691_b0220","doi-asserted-by":"crossref","first-page":"15650","DOI":"10.1073\/pnas.1315006110","article-title":"CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111921002857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111921002857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:45:11Z","timestamp":1759855511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111921002857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":44,"alternative-id":["S0378111921002857"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2021.145691","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D pathway gene polymorphisms, vitamin D level, and cytokines in children with type 1 diabetes","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2021.145691","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"145691"}}