{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:01:48Z","timestamp":1785808908311,"version":"3.56.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.gene.2021.146052","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T02:16:31Z","timestamp":1635473791000},"page":"146052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Pan-phylum genome-wide identification of sodium calcium exchangers reveal heterogeneous expansions and possible roles in nematode parasitism"],"prefix":"10.1016","volume":"810","author":[{"given":"Katrin","family":"Bode","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien M.","family":"O'Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2021.146052_b0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4614-4756-6_8","article-title":"Functional and structural properties of the NCKX2 Na(+)-Ca (2+)\/K (+) exchanger: a comparison with the NCX1 Na (+)\/Ca (2+) exchanger","volume":"961","author":"Altimimi","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"10.1016\/j.gene.2021.146052_b0010","doi-asserted-by":"crossref","first-page":"e201900429","DOI":"10.26508\/lsa.201900429","article-title":"Detecting sequence signals in targeting peptides using deep learning","volume":"2","author":"Almagro Armenteros","year":"2019","journal-title":"Life Sci. Alliance"},{"issue":"1","key":"10.1016\/j.gene.2021.146052_b0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/jmbi.2000.4474","article-title":"ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information","volume":"307","author":"Armon","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.gene.2021.146052_b0020","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1113\/jphysiol.1969.sp008702","article-title":"The influence of calcium on sodium efflux in squid axons","volume":"200","author":"Baker","year":"1969","journal-title":"J. Physiol."},{"key":"10.1016\/j.gene.2021.146052_b0025","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fcimb.2020.00046","article-title":"Disruption of intracellular calcium homeostasis as a therapeutic target against Trypanosoma cruzi","volume":"10","author":"Benaim","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.gene.2021.146052_b0030","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","article-title":"Sodium\/calcium exchange: its physiological implications","volume":"79","author":"Blaustein","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.gene.2021.146052_b0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12868-018-0423-2","article-title":"NCX-DB: a unified resource for integrative analysis of the sodium calcium exchanger super-family","volume":"19","author":"Bode","year":"2018","journal-title":"BMC Neurosci."},{"issue":"1","key":"10.1016\/j.gene.2021.146052_b0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/molbev\/msr149","article-title":"Ancestral Ca2+ signaling machinery in early animal and fungal evolution","volume":"29","author":"Cai","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.gene.2021.146052_b0045","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/molbev\/msh177","article-title":"The cation\/Ca(2+) exchanger superfamily: phylogenetic analysis and structural implications","volume":"21","author":"Cai","year":"2004","journal-title":"Mol. Biol. Evol."},{"issue":"3","key":"10.1016\/j.gene.2021.146052_b0050","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ceca.2014.11.007","article-title":"Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view","volume":"57","author":"Cai","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.gene.2021.146052_b0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.12688\/f1000research.10545.1","article-title":"Annotated mitochondrial genome with Nanopore R9 signal for Nippostrongylus brasiliensis","volume":"6","author":"Chandler","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.gene.2021.146052_b0060","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo generator","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.gene.2021.146052_b0065","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/bioinformatics\/btr088","article-title":"ProtTest 3: fast selection of best-fit models of protein evolution","volume":"27","author":"Darriba","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2021.146052_b0070","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12915-017-0473-4","article-title":"De novo assembly of the complex genome of Nippostrongylus brasiliensis using MinION long reads","volume":"16","author":"Eccles","year":"2018","journal-title":"BMC Biol."},{"key":"10.1016\/j.gene.2021.146052_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpls.2012.00001","article-title":"Protein Phylogenetic Analysis of Ca(2+)\/cation Antiporters and Insights into their Evolution in Plants","volume":"3","author":"Emery","year":"2012","journal-title":"Front. Plant Sci."},{"issue":"D1","key":"10.1016\/j.gene.2021.146052_b0080","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkt1223","article-title":"Pfam: the protein families database","volume":"42","author":"Finn","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"36","key":"10.1016\/j.gene.2021.146052_b0085","doi-asserted-by":"crossref","first-page":"28117","DOI":"10.1074\/jbc.M110.127001","article-title":"Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1","volume":"285","author":"Giladi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2021.146052_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039985","article-title":"A common Ca2+-driven interdomain module governs eukaryotic NCX regulation","volume":"7","author":"Giladi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2021.146052_b0095","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fphys.2016.00030","article-title":"Structural features of ion transport and allosteric regulation in sodium-calcium exchanger (NCX) proteins","volume":"7","author":"Giladi","year":"2016","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.gene.2021.146052_b0100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/bioinformatics\/19.1.163","article-title":"ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information","volume":"19","author":"Glaser","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2021.146052_b0105","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/1471-2105-8-312","article-title":"MaxAlign: maximizing usable data in an alignment","volume":"8","author":"Gouveia-Oliveira","year":"2007","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.gene.2021.146052_b0110","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/sysbio\/syq010","article-title":"New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0","volume":"59","author":"Guindon","year":"2010","journal-title":"Syst. Biol."},{"key":"10.1016\/j.gene.2021.146052_b0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2307\/3275400","article-title":"Biology of the rat nematode, Nippostrongylus brasiliensis (Travassos, 1914). II. Preparastic stages and development in the laboratory rat","volume":"48","author":"Haley","year":"1962","journal-title":"J. Parasitol."},{"key":"10.1016\/j.gene.2021.146052_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112841","article-title":"Analysis of the Na+\/Ca2+ exchanger gene family within the phylum Nematoda","volume":"9","author":"He","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2021.146052_b0125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-1-4614-4756-6_29","article-title":"Toward an understanding of the complete NCX1 lifetime in the cardiac sarcolemma","volume":"961","author":"Hilgemann","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.gene.2021.146052_b0130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molbiopara.2016.11.005","article-title":"WormBase ParaSite \u2013 a comprehensive resource for helminth genomics","volume":"215","author":"Howe","year":"2017","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2021.146052_b0135","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/bib\/bbx108","article-title":"MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization","volume":"20","author":"Katoh","year":"2017","journal-title":"Brief Bioinform"},{"issue":"25","key":"10.1016\/j.gene.2021.146052_b0140","doi-asserted-by":"crossref","first-page":"23161","DOI":"10.1074\/jbc.M102314200","article-title":"Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3","volume":"276","author":"Kraev","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.gene.2021.146052_b0145","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijpara.2020.09.007","article-title":"NemChR-DB: a database of parasitic nematode chemosensory G-protein coupled receptors","volume":"51","author":"Langeland","year":"2021","journal-title":"Int. J. Parasitol."},{"issue":"4953","key":"10.1016\/j.gene.2021.146052_b0150","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.2158146","article-title":"Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum","volume":"248","author":"Leblanc","year":"1990","journal-title":"Science"},{"issue":"1 Sodium-Calciu","key":"10.1016\/j.gene.2021.146052_b0155","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1749-6632.1991.tb17327.x","article-title":"Role of reverse-mode Na(+)-Ca2+ exchange in excitation-contraction coupling in the heart","volume":"639","author":"Levesque","year":"1991","journal-title":"Ann. N.Y. Acad. Sci."},{"issue":"26","key":"10.1016\/j.gene.2021.146052_b0160","doi-asserted-by":"crossref","first-page":"17434","DOI":"10.1016\/S0021-9258(17)32458-4","article-title":"Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger","volume":"269","author":"Li","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"6069","key":"10.1016\/j.gene.2021.146052_b0165","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1126\/science.1215759","article-title":"Structural insight into the ion-exchange mechanism of the sodium\/calcium exchanger","volume":"335","author":"Liao","year":"2012","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.gene.2021.146052_b0170","doi-asserted-by":"crossref","first-page":"C415","DOI":"10.1152\/ajpcell.1998.274.2.C415","article-title":"Functional comparison of the three isoforms of the Na+\/Ca2+ exchanger (NCX1, NCX2, NCX3)","volume":"274","author":"Linck","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"3","key":"10.1016\/j.gene.2021.146052_b0175","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ceca.2006.06.004","article-title":"Cellular and subcellular localization of Na+-Ca2+ exchanger protein isoforms, NCX1, NCX2, and NCX3 in cerebral cortex and hippocampus of adult rat","volume":"41","author":"Minelli","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.gene.2021.146052_b0180","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1093\/nar\/gkt263","article-title":"Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions","volume":"41","author":"Mistry","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"20","key":"10.1016\/j.gene.2021.146052_b0185","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.1523\/JNEUROSCI.6296-10.2011","article-title":"Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory","volume":"31","author":"Molinaro","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.gene.2021.146052_b0190","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1084\/jem.180.4.1535","article-title":"Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion","volume":"180","author":"Moreno","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.gene.2021.146052_b0195","first-page":"passim","article-title":"Strongyloides stercoralis infection","volume":"52, 25","author":"Napier","year":"1949","journal-title":"J. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2021.146052_b0200","article-title":"Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling","volume":"4","author":"Neal","year":"2015","journal-title":"Elife"},{"issue":"31","key":"10.1016\/j.gene.2021.146052_b0205","doi-asserted-by":"crossref","first-page":"21577","DOI":"10.1074\/jbc.C600117200","article-title":"The crystal structure of the primary Ca2+ sensor of the Na+\/Ca2+ exchanger reveals a novel Ca2+ binding motif","volume":"281","author":"Nicoll","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"84","key":"10.1016\/j.gene.2021.146052_b0210","first-page":"e50975","article-title":"A practical guide to phylogenetics for nonexperts","author":"Ohalloran","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.gene.2021.146052_b0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230327","article-title":"Simulation model of CA1 pyramidal neurons reveal opposing roles for the Na+\/Ca2+ exchange current and Ca2+-activated K+ current during spike-timing dependent synaptic plasticity","volume":"15","author":"O\u2019Halloran","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2021.146052_b0220","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.yjmcc.2013.06.001","article-title":"Na\/Ca exchange and contraction of the heart","volume":"61","author":"Ottolia","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.gene.2021.146052_b0225","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1073\/pnas.0908099107","article-title":"NCLX is an essential component of mitochondrial Na+\/Ca2+ exchange","volume":"107","author":"Palty","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.gene.2021.146052_b0230","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2174\/138945011795378559","article-title":"Triple threat: the Na+\/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure","volume":"12","author":"Pott","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.gene.2021.146052_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003506","article-title":"The Secretory Pathway Calcium ATPase PMR-1\/SPCA1 Has Essential Roles in Cell Migration during Caenorhabditis elegans Embryonic Development","volume":"9","author":"Praitis","year":"2013","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.gene.2021.146052_b0240","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2021.146052_b0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009421","article-title":"A novel substrate for arrhythmias in Chagas disease","volume":"15","author":"Santos-Miranda","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"20","key":"10.1016\/j.gene.2021.146052_b0250","doi-asserted-by":"crossref","first-page":"7310","DOI":"10.1073\/pnas.84.20.7310","article-title":"Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design","volume":"84","author":"Scheibel","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.gene.2021.146052_b0255","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1242\/dev.083428","article-title":"Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans","volume":"139","author":"Schumacher","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.gene.2021.146052_b0260","doi-asserted-by":"crossref","DOI":"10.1534\/genetics.113.153106","article-title":"Insight into the family of Na+\/Ca2+ exchangers of Caenorhabditis elegans","author":"Sharma","year":"2013","journal-title":"Genetics"},{"issue":"2","key":"10.1016\/j.gene.2021.146052_b0265","first-page":"93","article-title":"Recent structural and functional insights into the family of sodium calcium exchangers. genesis","volume":"52","author":"Sharma","year":"2014","journal-title":"J. Genet. Develop."},{"key":"10.1016\/j.gene.2021.146052_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/BBI.S37130","article-title":"Nematode sodium calcium exchangers: a surprising lack of transport","volume":"10","author":"Sharma","year":"2016","journal-title":"Bioinf. Biol. Insights"},{"issue":"13","key":"10.1016\/j.gene.2021.146052_b0275","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1074\/jbc.M116.758953","article-title":"The NCLX-type Na+\/Ca2+ Exchanger NCX-9 Is Required for Patterning of Neural Circuits in Caenorhabditis elegans","volume":"292","author":"Sharma","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.gene.2021.146052_b0280","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ceca.2012.11.009","article-title":"Calcium signaling surrounding fertilization in the nematode Caenorhabditis elegans","volume":"53","author":"Singaravelu","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.gene.2021.146052_b0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001854","article-title":"RNAseq Analysis of the Parasitic Nematode Strongyloides stercoralis Reveals Divergent Regulation of Canonical Dauer Pathways","volume":"6","author":"Stoltzfus","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.gene.2021.146052_b0290","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1021\/bi0102353","article-title":"Stoichiometry of the retinal cone Na\/Ca-K exchanger heterologously expressed in insect cells: comparison with the bovine heart Na\/Ca exchanger","volume":"40","author":"Szerencsei","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.gene.2021.146052_b0295","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1080\/10635150701472164","article-title":"Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments","volume":"56","author":"Talavera","year":"2007","journal-title":"Syst. Biol."},{"key":"10.1016\/j.gene.2021.146052_b0300","doi-asserted-by":"crossref","first-page":"102337","DOI":"10.1016\/j.ceca.2020.102337","article-title":"The role of potassium and host calcium signaling in Toxoplasma gondii egress","volume":"94","author":"Vella","year":"2021","journal-title":"Cell Calcium"},{"issue":"Trop_Parasitol","key":"10.1016\/j.gene.2021.146052_b0305","first-page":"25","article-title":"On some Developmental Stages of Ancylostoma ceylanicum Looss, 1911","volume":"14","author":"Vevers","year":"1921","journal-title":"Proc. R. Soc. Med."},{"key":"10.1016\/j.gene.2021.146052_b0310","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1085\/jgp.117.2.119","article-title":"Allosteric regulation of Na\/Ca exchange current by cytosolic Ca in intact cardiac myocytes","volume":"117","author":"Weber","year":"2001","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.gene.2021.146052_b0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000723","article-title":"Genetic and functional diversification of chemosensory pathway receptors in mosquito-borne filarial nematodes","volume":"18","author":"Wheeler","year":"2020","journal-title":"PLoS Biol."},{"issue":"4","key":"10.1016\/j.gene.2021.146052_b0320","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1074\/jbc.M109.059162","article-title":"Crystal structures of progressive Ca2+ binding states of the Ca2+ sensor Ca2+ binding domain 1 (CBD1) from the CALX Na+\/Ca2+ exchanger reveal incremental conformational transitions","volume":"285","author":"Wu","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.gene.2021.146052_b0325","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jmb.2009.01.045","article-title":"Crystal structure of CBD2 from the Drosophila Na(+)\/Ca(2+) exchanger: diversity of Ca(2+) regulation and its alternative splicing modification","volume":"387","author":"Wu","year":"2009","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.gene.2021.146052_b0330","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0896-6273(01)00432-9","article-title":"Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum","volume":"31","author":"Xu","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.gene.2021.146052_b0335","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/2041-210X.12628","article-title":"ggtree: an r package for visualization and annotation of phylogenetic trees with their covariates and other associated data","volume":"8","author":"Yu","year":"2017","journal-title":"Methods Ecol. Evol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111921006478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111921006478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:45:23Z","timestamp":1759855523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111921006478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":67,"alternative-id":["S0378111921006478"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2021.146052","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pan-phylum genome-wide identification of sodium calcium exchangers reveal heterogeneous expansions and possible roles in nematode parasitism","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2021.146052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146052"}}