{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:29:01Z","timestamp":1759883341012,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.gene.2021.146093","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T11:47:23Z","timestamp":1639050443000},"page":"146093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Gene expression profiling and functional analysis of ventricular tissues from murine transverse aortic constriction"],"prefix":"10.1016","volume":"813","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-9977","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2021.146093_b0005","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1074\/jbc.M411069200","article-title":"Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site","volume":"280","author":"Alphey","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2021.146093_b0010","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cell.2013.07.013","article-title":"BET bromodomains mediate transcriptional pause release in heart failure","volume":"154","author":"Anand","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.gene.2021.146093_b0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00395-019-0722-5","article-title":"Inflammation and fibrosis in murine models of heart failure","volume":"114","author":"Bacmeister","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.gene.2021.146093_b0020","article-title":"The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis","author":"Bosch","year":"2020","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.gene.2021.146093_b0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2010.165","article-title":"Epidemiology and risk profile of heart failure","volume":"8","author":"Bui","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.gene.2021.146093_b0030","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaa467","article-title":"miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2021.146093_b0035","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/nprot.2007.324","article-title":"Integration of biological networks and gene expression data using Cytoscape","volume":"2","author":"Cline","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2021.146093_b0040","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling\u2013concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.gene.2021.146093_b0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nchembio.1429","article-title":"Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes","volume":"10","author":"Dominguez","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.gene.2021.146093_b0050","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/CIRCULATIONAHA.106.632430","article-title":"Transcriptional genomics associates FOX transcription factors with human heart failure","volume":"114","author":"Hannenhalli","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2021.146093_b0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.gene.2021.146093_b0060","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1096\/fj.201900067R","article-title":"Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARalpha","volume":"33","author":"Horscroft","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2021.146093_b0065","doi-asserted-by":"crossref","first-page":"D1013","DOI":"10.1093\/nar\/gky1010","article-title":"HMDD v3.0: a database for experimentally supported human microRNA-disease associations","volume":"47","author":"Huang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2021.146093_b0070","doi-asserted-by":"crossref","first-page":"14680","DOI":"10.1038\/ncomms14680","article-title":"T cell costimulation blockade blunts pressure overload-induced heart failure","volume":"8","author":"Kallikourdis","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2021.146093_b0075","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2021.146093_b0080","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ygeno.2014.12.002","article-title":"RNA-Seq identifies novel myocardial gene expression signatures of heart failure","volume":"105","author":"Liu","year":"2015","journal-title":"Genomics"},{"key":"10.1016\/j.gene.2021.146093_b0085","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.7150\/ijbs.28103","article-title":"Cardiac fibrosis: new insights into the pathogenesis","volume":"14","author":"Ma","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.gene.2021.146093_b0090","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/CIRCRESAHA.115.306721","article-title":"Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure","volume":"117","author":"Mayer","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.gene.2021.146093_b0095","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41596-019-0128-8","article-title":"Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0)","volume":"14","author":"Mi","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2021.146093_b0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2131\/jts.35.131","article-title":"Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor alpha (PPARalpha) stimulation","volume":"35","author":"Miyazaki","year":"2010","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.gene.2021.146093_b0105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fphys.2020.00092","article-title":"Heart Plasticity in Response to Pressure- and Volume-Overload: A Review of Findings in Compensated and Decompensated Phenotypes","volume":"11","author":"Pitoulis","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.gene.2021.146093_b0110","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006445","article-title":"Enter Stage A, Exit Stage D: A Curtain Call for Delay in Heart Failure Prevention","volume":"12","author":"Reza","year":"2019","journal-title":"Circ. Heart Fail"},{"key":"10.1016\/j.gene.2021.146093_b0115","doi-asserted-by":"crossref","first-page":"8277","DOI":"10.1073\/pnas.88.18.8277","article-title":"Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy","volume":"88","author":"Rockman","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.gene.2021.146093_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206239","article-title":"miRWalk: An online resource for prediction of microRNA binding sites","volume":"13","author":"Sticht","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gene.2021.146093_b0125","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.gene.2021.146093_b0130","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2021.146093_b0135","first-page":"1447","article-title":"Identification of differentially expressed genes and preliminary validations in cardiac pathological remodeling induced by transverse aortic constriction","volume":"44","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.gene.2021.146093_b0140","doi-asserted-by":"crossref","first-page":"7536803","DOI":"10.1155\/2019\/7536803","article-title":"The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARalpha","volume":"2019","author":"Wu","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.gene.2021.146093_b0145","doi-asserted-by":"crossref","first-page":"5058313","DOI":"10.1155\/2019\/5058313","article-title":"Transcriptome Analysis of Hypertrophic Heart Tissues from Murine Transverse Aortic Constriction and Human Aortic Stenosis Reveals Key Genes and Transcription Factors Involved in Cardiac Remodeling Induced by Mechanical Stress","volume":"2019","author":"Yu","year":"2019","journal-title":"Dis. Markers"},{"key":"10.1016\/j.gene.2021.146093_b0150","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.7150\/thno.22878","article-title":"MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress","volume":"8","author":"Yuan","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.gene.2021.146093_b0155","doi-asserted-by":"crossref","first-page":"7159592","DOI":"10.1155\/2019\/7159592","article-title":"Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature","volume":"2019","author":"Zhou","year":"2019","journal-title":"Biomed. Res. Int."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111921006880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111921006880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:46:07Z","timestamp":1759855567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111921006880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":31,"alternative-id":["S0378111921006880"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2021.146093","relation":{},"ISSN":["0378-1119"],"issn-type":[{"type":"print","value":"0378-1119"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression profiling and functional analysis of ventricular tissues from murine transverse aortic constriction","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2021.146093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146093"}}