{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:16:16Z","timestamp":1790612176184,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"am","delay-in-days":313,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.gene.2022.146731","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T11:48:41Z","timestamp":1657540121000},"page":"146731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Expression and distribution of MTNR1A in the hypothalamus-pituitary-gonadal axis of Tibetan sheep during the estrous cycle"],"prefix":"10.1016","volume":"839","author":[{"given":"Dapeng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.gene.2022.146731_b0005","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1007\/s00018-014-1579-2","article-title":"Extrapineal melatonin: sources, regulation, and potential functions","volume":"71","author":"Acu\u00f1a-Castroviejo","year":"2014","journal-title":"Cell. Mol. Life. Sci."},{"issue":"2\u20133","key":"10.1016\/j.gene.2022.146731_b0010","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tox.2006.09.018","article-title":"Melatonin has dose-dependent effects on folliculogenesis, oocyte maturation capacity and steroidogenesis","volume":"228","author":"Adriaens","year":"2006","journal-title":"Toxicology."},{"issue":"5","key":"10.1016\/j.gene.2022.146731_b0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/17425255.2016.1214712","article-title":"A review of the protective effect of melatonin in pesticide\u2013induced toxicity[J]","volume":"13","author":"Asghari","year":"2017","journal-title":"Expert. Opin. Drug. Metab. Toxicol."},{"issue":"2","key":"10.1016\/j.gene.2022.146731_b0020","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12670","article-title":"Melatonin improves uterine-conceptus interaction via regulation of SIRT1 during early pregnancy","volume":"69","author":"Bae","year":"2020","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.gene.2022.146731_b0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.theriogenology.2018.02.013","article-title":"SNP rs403212791 in exon 2 of the MTNR1A gene is associated with reproductive seasonality in the Rasa aragonesa sheep breed","volume":"113","author":"Calvo","year":"2018","journal-title":"Theriogenology."},{"issue":"6","key":"10.1016\/j.gene.2022.146731_b0030","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1080\/09291016.2013.781317","article-title":"Daily rhythm of blood melatonin concentrations in sheep of different ages","volume":"44","author":"Carcangiu","year":"2013","journal-title":"Biol. Rhythm. Res."},{"issue":"3","key":"10.1016\/j.gene.2022.146731_b0035","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/mrd.21125","article-title":"Characterization of the Melatonin Receptor Gene MT1 in Mouflon (Ovis Gmelini Musimon) and Its Relationship with Reproductive Activity","volume":"77","author":"Carcangiu","year":"2010","journal-title":"Mol. Reprod. Dev."},{"issue":"1\u20132","key":"10.1016\/j.gene.2022.146731_b0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.anireprosci.2007.12.014","article-title":"Relationship between MTNR1A melatonin receptor gene polymorphism and seasonal reproduction in different goat breeds","volume":"110","author":"Carcangiu","year":"2009","journal-title":"Anim. Reprod. Sci."},{"issue":"2","key":"10.1016\/j.gene.2022.146731_b0045","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/vms3.224","article-title":"Effect of melatonin on bovine sperm characteristics and ultrastructure changes following cryopreservation","volume":"6","author":"ChaithraShree","year":"2020","journal-title":"Vet. Med. Sci."},{"issue":"3","key":"10.1016\/j.gene.2022.146731_b0055","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12590","article-title":"Melatonin receptors in Atlantic salmon stimulate cAMP levels in heterologous cell lines and show season-dependent daily variations in pituitary expression levels","volume":"67","author":"Ciani","year":"2019","journal-title":"J. Pineal. Res."},{"issue":"2","key":"10.1016\/j.gene.2022.146731_b0060","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3390\/ani11020583","article-title":"Detection of polymorphisms in the MTNR1A gene and their association with reproductive performance in awassi ewes","volume":"11","author":"Cosso","year":"2021","journal-title":"Animals"},{"issue":"14","key":"10.1016\/j.gene.2022.146731_b0065","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1096\/fj.03-1339com","article-title":"Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin","volume":"18","author":"Gerdin","year":"2004","journal-title":"FASEB. J."},{"key":"10.1016\/j.gene.2022.146731_b0070","doi-asserted-by":"crossref","first-page":"110687","DOI":"10.1016\/j.mce.2019.110687","article-title":"Temporal organization of pineal melatonin signaling in mammals","volume":"503","author":"Gorman","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"issue":"5","key":"10.1016\/j.gene.2022.146731_b0080","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1071\/RD17028","article-title":"Molecular cloning and epigenetic change detection of Kiss1 during seasonal reproduction in Chinese indigenous sheep","volume":"30","author":"He","year":"2018","journal-title":"Reprod. Fertil. Dev."},{"issue":"3","key":"10.1016\/j.gene.2022.146731_b0085","doi-asserted-by":"crossref","first-page":"140","DOI":"10.17221\/7294-CJAS","article-title":"Melatonin receptor (MTNR1A and MTNR2B) expression during the breeding season in the yak (Bos grunniens)","volume":"59","author":"Huo","year":"2014","journal-title":"Czech. J. Anim. Sci."},{"issue":"10","key":"10.1016\/j.gene.2022.146731_b0090","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1590\/S1806-92902015001000002","article-title":"Protein and mRNA expression of estradiol receptors during estrus in yaks (Bos grunniens)","volume":"44","author":"Huo","year":"2015","journal-title":"Rev. Bras. Zootecn."},{"issue":"2","key":"10.1016\/j.gene.2022.146731_b0095","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12388","article-title":"Melatonin regulates lipid metabolism in porcine oocytes","volume":"62","author":"Jin","year":"2017","journal-title":"J. Pineal. Res."},{"issue":"7","key":"10.1016\/j.gene.2022.146731_b0100","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/ar.21408","article-title":"Effect of monochromatic light on melatonin secretion and Arylalkylamine N-Acetyltransferase mRNA expression in the retina and pineal gland of broilers","volume":"294","author":"Jin","year":"2011","journal-title":"Anat. Rec."},{"issue":"6","key":"10.1016\/j.gene.2022.146731_b0105","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/bjp.2008.184","article-title":"Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?","volume":"154","author":"Jockers","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.gene.2022.146731_b0110","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/rda.12153","article-title":"Polymorphism of the melatonin receptor genes and its relationship with seasonal reproduction in the gulin ma goat breed","volume":"48","author":"Lai","year":"2013","journal-title":"Reprod. Domest. Anim."},{"issue":"2","key":"10.1016\/j.gene.2022.146731_b0115","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12622","article-title":"Two indoleamines are secreted from rat pineal gland at night and act on melatonin receptors but are not night hormones","volume":"68","author":"Lee","year":"2020","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.gene.2022.146731_b0120","doi-asserted-by":"crossref","first-page":"145256","DOI":"10.1016\/j.gene.2020.145256","article-title":"Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c","volume":"769","author":"Li","year":"2021","journal-title":"Gene."},{"key":"10.1016\/j.gene.2022.146731_b0125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fendo.2016.00038","article-title":"The role of melatonin as a hormone and an antioxidant in the control of fish reproduction","volume":"7","author":"Maitra","year":"2016","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.gene.2022.146731_b0130","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2527\/jas.2008-1688","article-title":"Association between melatonin receptor 1A gene polymorphism and reproductive performance in Dorset ewes","volume":"87","author":"Mateescu","year":"2009","journal-title":"J. Anim. Sci."},{"issue":"2","key":"10.1016\/j.gene.2022.146731_b0135","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1095\/biolreprod.104.030064","article-title":"MTNR1A melatonin receptors in the ovine premammillary hypothalamus: day-night variation in the expression of the transcripts","volume":"72","author":"Migaud","year":"2005","journal-title":"Biol. Reprod."},{"issue":"3\u20134","key":"10.1016\/j.gene.2022.146731_b0145","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.anireprosci.2014.07.022","article-title":"Influence of melatonin receptor 1A gene polymorphisms on seasonal reproduction in Sarda ewes with different body condition scores and ages","volume":"149","author":"Mura","year":"2014","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.gene.2022.146731_b0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.anireprosci.2018.11.012","article-title":"Reproductive response to male joining with ewes with different allelic variants of the MTNR1A gene","volume":"200","author":"Mura","year":"2019","journal-title":"Anim. Reprod. Sci."},{"issue":"10","key":"10.1016\/j.gene.2022.146731_b0150","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0899-9007(00)00458-5","article-title":"Gonadal steroids and energy homeostasis in the leptin era","volume":"16","author":"Mystkowski","year":"2000","journal-title":"Nutrition."},{"issue":"3","key":"10.1016\/j.gene.2022.146731_b0155","doi-asserted-by":"crossref","first-page":"R117","DOI":"10.1530\/JOE-16-0066","article-title":"Molecular basis for regulating seasonal reproduction in vertebrates[J]","volume":"229","author":"Nishiwaki-Ohkawa","year":"2016","journal-title":"J. Endocrinol."},{"issue":"6","key":"10.1016\/j.gene.2022.146731_b0160","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1210\/er.2009-0005","article-title":"Kisspeptin signaling in the brain","volume":"30","author":"Oakley","year":"2009","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.gene.2022.146731_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000219588","article-title":"Melatonin controls seasonal breeding by a network of hypothalamic targets","volume":"90","author":"Revel","year":"2009","journal-title":"Neuroendocrinology."},{"issue":"2","key":"10.1016\/j.gene.2022.146731_b0175","first-page":"157","article-title":"Melatonin Improves The Developmental Competence of Goat Oocytes","volume":"12","author":"Saeedabadi","year":"2018","journal-title":"Int. J. Fertil. Steril."},{"issue":"2","key":"10.1016\/j.gene.2022.146731_b0180","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.gene.2015.04.064","article-title":"MTNR1B gene polymorphisms and susceptibility to type 2 diabetes: a pilot study in South Indians","volume":"566","author":"Salman","year":"2015","journal-title":"Gene."},{"issue":"3","key":"10.1016\/j.gene.2022.146731_b0185","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/rda.12503","article-title":"Assessment of genetic variability in the coding sequence of melatonin receptor gene (MTNR1A) in tropical arid sheep breeds of india","volume":"50","author":"Saxena","year":"2015","journal-title":"Reprod. Domest. Anim."},{"issue":"3","key":"10.1016\/j.gene.2022.146731_b0190","first-page":"889","article-title":"MT (1) melatonin receptor in the human retina: Expression and localization[J]","volume":"43","author":"Scher","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.gene.2022.146731_b0195","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3109\/09513590903159649","article-title":"Melatonin and human reproduction: shedding light on the darkness hormone","volume":"25","author":"Srinivasan","year":"2009","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.gene.2022.146731_b0200","doi-asserted-by":"crossref","first-page":"106352","DOI":"10.1016\/j.anireprosci.2020.106352","article-title":"Reproductive performance in three Slovenian sheep breeds with different alleles for the MTNR1A gene","volume":"216","author":"Stari\u010d","year":"2020","journal-title":"Anim. Reprod. Sci."},{"issue":"1","key":"10.1016\/j.gene.2022.146731_b0205","first-page":"67","article-title":"Melatonin receptors subtypes (MT1 and MT2) in the uterus masculinus of mature male european bison. Biological and seasonal repr- reproductive role","volume":"69","author":"Tabecka-Lonczynska","year":"2018","journal-title":"J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.gene.2022.146731_b0210","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.fertnstert.2008.05.016","article-title":"Melatonin and the ovary: physiological and pathophysiological implications","volume":"92","author":"Tamura","year":"2009","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.gene.2022.146731_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jog.12177","article-title":"Melatonin and female reproduction","volume":"40","author":"Tamura","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"9","key":"10.1016\/j.gene.2022.146731_b0220","doi-asserted-by":"crossref","first-page":"15858","DOI":"10.3390\/ijms150915858","article-title":"Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions[J]","volume":"15","author":"Tan","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.gene.2022.146731_b0225","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3390\/ijms18040834","article-title":"Beneficial effects of melatonin on the in vitro maturation of sheep oocytes and its relation to melatonin receptors","volume":"18","author":"Tian","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.gene.2022.146731_b0230","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.livsci.2010.08.007","article-title":"Blood mineral status of grazing tibetan sheep in the northeast of the qinghai-tibetan plateau","volume":"136","author":"Xin","year":"2011","journal-title":"Livest. Sci."},{"issue":"3","key":"10.1016\/j.gene.2022.146731_b0235","first-page":"2220","article-title":"Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome","volume":"19","author":"Xu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.gene.2022.146731_b0240","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.theriogenology.2020.09.039","article-title":"Melatonin slightly alleviates the effect of heat shock on bovine oocytes and resulting blastocysts","volume":"158","author":"Yaacobi-Artzi","year":"2020","journal-title":"Theriogenology."},{"issue":"1","key":"10.1016\/j.gene.2022.146731_b0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00216032","article-title":"The influence of different 5-methoxyindoles on the process of protein\/peptide secretion characterized by the formation of granular vesicles in the mouse pineal gland. an in vitro study[J]","volume":"230","author":"Haldar-Misra","year":"1983","journal-title":"Cell. Tissue. Res."},{"issue":"1","key":"10.1016\/j.gene.2022.146731_b0050","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","article-title":"Mammalian melatonin receptors: molecular biology and signal transduction[J]","volume":"309","author":"Von Gall","year":"2002","journal-title":"Cell. Tissue. Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111922005509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111922005509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:55:16Z","timestamp":1759856116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111922005509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":47,"alternative-id":["S0378111922005509"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2022.146731","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression and distribution of MTNR1A in the hypothalamus-pituitary-gonadal axis of Tibetan sheep during the estrous cycle","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2022.146731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146731"}}