{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:29:25Z","timestamp":1759883365212,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.gene.2022.146764","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T11:31:26Z","timestamp":1658921486000},"page":"146764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Association between the rs2279238 of the Liver X receptor alpha gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort"],"prefix":"10.1016","volume":"840","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-2666","authenticated-orcid":false,"given":"Emin","family":"Grbi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nata\u0161a","family":"Gorki\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale\u0161","family":"Pleskovi\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1143-1941","authenticated-orcid":false,"given":"Farid","family":"Ljuca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mladen","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-1839","authenticated-orcid":false,"given":"Bo\u017eidar","family":"Mr\u0111a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Cilen\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zlatko","family":"Fras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Petrovi\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2022.146764_b0005","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.gene.2022.146764_b0010","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/ATVBAHA.109.191197","article-title":"Liver X receptor signaling pathways and atherosclerosis","volume":"30","author":"Calkin","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.gene.2022.146764_b0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1097-2765(01)00164-2","article-title":"A PPAR\u03b3-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis","volume":"7","author":"Chawla","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2022.146764_b0020","first-page":"2375","article-title":"Carotid atherosclerosis and cognitive impairment in nonstroke patients","volume":"130","author":"Chen","year":"2017","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.gene.2022.146764_b0025","first-page":"11958","article-title":"Gene polymorphism of LXR\u03b1 is associated with the pathogenesis of ischemic stroke in Han population in northern China","volume":"9","author":"Dai","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.gene.2022.146764_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/5926381","article-title":"Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review","volume":"2020","author":"Deng","year":"2020","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"10.1016\/j.gene.2022.146764_b0035","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1001\/jama.1995.03530190019017","article-title":"Endarterectomy for asymptomatic carotid artery stenosis","volume":"274","author":"Foster","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.gene.2022.146764_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.698138","article-title":"Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis","volume":"12","author":"Huwait","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.gene.2022.146764_b0045","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ejvs.2005.11.001","article-title":"Inflammation and atherosclerosis","volume":"31","author":"Kaperonis","year":"2006","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.gene.2022.146764_b0050","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/ATVBAHA.113.302781","article-title":"Activation of liver X receptor decreases atherosclerosis in Ldlr mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells","volume":"34","author":"Kappus","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.gene.2022.146764_b0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0002-9149(98)00808-X","article-title":"The antiatherogenic role of high-density lipoprotein cholesterol","volume":"82","author":"Kwiterovich","year":"1998","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.gene.2022.146764_b0060","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.atherosclerosis.2011.01.031","article-title":"Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study","volume":"216","author":"Legry","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.gene.2022.146764_b0065","first-page":"3945","article-title":"Quercetin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in THP-1 macrophages","volume":"20","author":"Lu","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.gene.2022.146764_b0070","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.carpath.2014.12.004","article-title":"Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPAR\u03b3\/LXR\u03b1 signaling pathway in THP-1 macrophage-derived foam cells","volume":"24","author":"Ma","year":"2015","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.gene.2022.146764_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.707529","article-title":"Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus on Molecular and Cellular Mechanisms","volume":"8","author":"Malekmohammad","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.gene.2022.146764_b0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1388-1981(02)00366-9","article-title":"Liver X receptors and the control of cholesterol homeostasis: Potential therapeutic targets for the treatment of atherosclerosis","volume":"1631","author":"Millatt","year":"2003","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"},{"key":"10.1016\/j.gene.2022.146764_b0090","unstructured":"NR1H3 - SNPedia [WWW Document], n.d. URL https:\/\/www.snpedia.com\/index.php\/NR1H3 (accessed 12.7.21)."},{"key":"10.1016\/j.gene.2022.146764_b0095","unstructured":"NR1H3 Gene - GeneCards | NR1H3 Protein | NR1H3 Antibody [WWW Document], n.d. URL https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=NR1H3&keywords=LXRA (accessed 9.9.21)."},{"key":"10.1016\/j.gene.2022.146764_b0100","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/FPC.0b013e3283452fec","article-title":"Liver X receptor \u03b1 gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: Results from the INVEST-GENES study","volume":"21","author":"Price","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"issue":"2","key":"10.1016\/j.gene.2022.146764_b0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1191\/1358863x05vm593ra","article-title":"ABCA1 and atherosclerosis","volume":"10","author":"Soumian","year":"2005","journal-title":"Vasc. Med."},{"issue":"7","key":"10.1016\/j.gene.2022.146764_b0110","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1161\/01.ATV.0000075912.83860.26","article-title":"Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux","volume":"23","author":"Wang","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.gene.2022.146764_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2022.109057","article-title":"Associations between liver X receptor polymorphisms and blood lipids: A systematic review and meta-analysis","volume":"185","author":"Zhang","year":"2022","journal-title":"Steroids"},{"key":"10.1016\/j.gene.2022.146764_b0120","doi-asserted-by":"crossref","unstructured":"Zhao, C., Dahlman-Wright, K., 2010. Liver X receptor in cholesterol metabolism. J. Endocrinol. https:\/\/doi.org\/10.1677\/JOE-09-0271.","DOI":"10.1677\/JOE-09-0271"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111922005832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111922005832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:56:06Z","timestamp":1759856166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111922005832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":23,"alternative-id":["S0378111922005832"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2022.146764","relation":{},"ISSN":["0378-1119"],"issn-type":[{"type":"print","value":"0378-1119"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between the rs2279238 of the Liver X receptor alpha gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2022.146764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"146764"}}