{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:42:53Z","timestamp":1793922173913,"version":"4.8.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["20-75-00003"],"award-info":[{"award-number":["20-75-00003"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.gene.2022.146820","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T15:05:31Z","timestamp":1660748731000},"page":"146820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Expression of the \u03b21-adrenergic receptor (ADRB1) gene in the myocardium and \u03b2-adrenergic reactivity of the body in patients with a history of myocardium infraction"],"prefix":"10.1016","volume":"844","author":[{"given":"Elvira","family":"Muslimova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Rebrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Kondratieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viacheslav","family":"Korepanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdeni","family":"Sonduev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Kozlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Afanasiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.gene.2022.146820_b0005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.14341\/DM9735","article-title":"Features the interaction of functional and metabolic remodeling of myocardium in comorbid course of ischemic heart disease and 2 type diabetes mellitus","volume":"22","author":"Afanasiev","year":"2019","journal-title":"Diabetes Mellitus"},{"issue":"1","key":"10.1016\/j.gene.2022.146820_b0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cardfail.2011.10.008","article-title":"Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure","volume":"18","author":"Ag\u00fcero","year":"2012","journal-title":"J. Card. Fail."},{"issue":"4","key":"10.1016\/j.gene.2022.146820_b0015","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/pace.14479","article-title":"Ventricular tachycardia incidence and erythrocyte membranes \u03b2-adrenoreactivity in patients with implanted cardioverter-defibrillator","volume":"45","author":"Atabekov","year":"2022","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.gene.2022.146820_b0020","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0031-6997(24)01425-X","article-title":"Adrenergic and muscarinic receptors in the human heart","volume":"51","author":"Brodde","year":"1999","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.gene.2022.146820_b0025","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"issue":"3","key":"10.1016\/j.gene.2022.146820_b0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.amjms.2017.11.002","article-title":"The association of ADRB1 and CYP2D6 polymorphisms with antihypertensive effects and analysis of their contribution to hypertension risk","volume":"355","author":"Chen","year":"2018","journal-title":"Am. J. Med. Sci."},{"issue":"13","key":"10.1016\/j.gene.2022.146820_b0035","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1161\/01.CIR.98.13.1329","article-title":"Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the \u03b2-adrenergic pathway","volume":"98","author":"Communal","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2022.146820_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00246","article-title":"Adrenal adrenoceptors in heart failure","volume":"5","author":"de Lucia","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.gene.2022.146820_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00904","article-title":"New insights in cardiac \u03b2-adrenergic signaling during heart failure and aging","volume":"9","author":"de Lucia","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"22","key":"10.1016\/j.gene.2022.146820_b0050","doi-asserted-by":"crossref","first-page":"7920","DOI":"10.1073\/pnas.84.22.7920","article-title":"Cloning of the cDNA for the human beta1-adrenergic receptor","volume":"84","author":"Frielle","year":"1987","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.gene.2022.146820_b0055","doi-asserted-by":"crossref","first-page":"20","DOI":"10.15829\/1560-4071-2020-1-3407","article-title":"Beta-adrenergic reactivity of erythrocytes and the progression of heart failure in patients after myocardial infarction","volume":"25","author":"Garganeeva","year":"2020","journal-title":"Russ. J. Cardiol."},{"key":"10.1016\/j.gene.2022.146820_b0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.15829\/1560-4071-2013-4-52-63","article-title":"Autonomic nervous system in arterial hypertension and heart failure: current understanding of its pathophysiologic role and innovative treatment approaches","volume":"4","author":"Konradi","year":"2013","journal-title":"Russ. J. Cardiol."},{"key":"10.1016\/j.gene.2022.146820_b0065","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.gene.2017.04.006","article-title":"Selection of reference genes for gene expression studies in heart failure for left and right ventricles","volume":"620","author":"Li","year":"2017","journal-title":"Gene"},{"issue":"10","key":"10.1016\/j.gene.2022.146820_b0070","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.RES.0000102042.83024.CA","article-title":"What is the role of \u03b2-adrenergic signaling in heart failure?","volume":"93","author":"Lohse","year":"2003","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.gene.2022.146820_b0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1161\/01.RES.75.3.401","article-title":"Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of \u03b2-agonist stimulation","volume":"75","author":"Luo","year":"1994","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.gene.2022.146820_b0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/cvr\/cvx182","article-title":"Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart","volume":"114","author":"Molina","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.gene.2022.146820_b0085","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1134\/S1022795421110089","article-title":"Expression of the \u03b21 adrenergic receptor gene (ADRB1) in the myocardium of patients with chronic heart failure","volume":"57","author":"Muslimova","year":"2021","journal-title":"Russian J. Genet."},{"key":"10.1016\/j.gene.2022.146820_b0090","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/CIRCRESAHA.117.310520","article-title":"Adrenergic receptors in individual ventricular myocytes: the beta-1 and alpha-1b are in all cells, the alpha-1a is in a subpopulation, and the beta-2 and beta-3 are mostly absent","volume":"120","author":"Myagmar","year":"2017","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.gene.2022.146820_b0095","doi-asserted-by":"crossref","first-page":"63","DOI":"10.18087\/cardio.2018.3.10100","article-title":"Sympathetic nervous system activation in pathogenesis of development of essential hypertension and its role in target-organs damage in young and middle aged adults: the cardioprotective capabilities of bisoprolol","volume":"17","author":"Ostroumova","year":"2018","journal-title":"Kardiologiia"},{"key":"10.1016\/j.gene.2022.146820_b0100","series-title":"Quantification strategies in real-time PCR. A-Z of quantitative PCR","first-page":"87","author":"Pfaffl","year":"2004"},{"issue":"5","key":"10.1016\/j.gene.2022.146820_b0105","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cardfail.2007.01.003","article-title":"Targeting myocardial \u03b2-adrenergic receptor signaling and calcium cycling for heart failure gene therapy","volume":"13","author":"Pleger","year":"2007","journal-title":"J. Cardiac Fail."},{"issue":"27","key":"10.1016\/j.gene.2022.146820_b0110","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.gene.2022.146820_b0115","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1086\/339621","article-title":"A Polymorphism in the \u03b21 adrenergic receptor is associated with resting heart rate","volume":"70","author":"Ranade","year":"2002","journal-title":"Am. J. Hum. Genet."},{"issue":"8","key":"10.1016\/j.gene.2022.146820_b0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.17116\/terarkh201688814-18","article-title":"Criteria for selecting patients with resistant hypertension for a renal sympathetic denervation","volume":"88","author":"Ripp","year":"2016","journal-title":"Terapevticheskii arkhiv"},{"key":"10.1016\/j.gene.2022.146820_b0125","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/415206a","article-title":"Seven-transmembrane-spanning receptors and heart function","volume":"415","author":"Rockman","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.gene.2022.146820_b0130","unstructured":"R.I. Stryuk, I.G. Dlusskaya. Adrenoreactivity and cardiovascular system. M: Medicine, 2003, p. 160. ISBN: 5-225-04337-2."},{"issue":"1","key":"10.1016\/j.gene.2022.146820_b0135","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016364","article-title":"Paroxetine attenuates cardiac hypertrophy via blocking GRK2 and ADRB1 interaction in hypertension","volume":"10","author":"Sun","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.gene.2022.146820_b0140","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yjmcc.2016.08.020","article-title":"Regulation of sarcoplasmic reticulum Ca2+ release by serine-threonine phosphatases in the heart","volume":"101","author":"Terentyev","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"19","key":"10.1016\/j.gene.2022.146820_b0145","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.jacc.2009.05.015","article-title":"The sympathetic nervous system in heart failure: physiology, pathophysiology, and clinical implications","volume":"54","author":"Triposkiadis","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.gene.2022.146820_b0150","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/01.CIR.87.2.454","article-title":"Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart","volume":"87","author":"Ungerer","year":"1993","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.gene.2022.146820_b0155","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cardfail.2007.10.016","article-title":"Endomyocardial upregulation of beta1 adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy","volume":"14","author":"Vanderheyden","year":"2008","journal-title":"J. Card. Fail."},{"issue":"8","key":"10.1016\/j.gene.2022.146820_b0160","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1515\/cclm-2017-0882","article-title":"mRNA expression profile in peripheral blood mononuclear cells based on ADRB1 Ser49Gly and Arg389Gly polymorphisms in essential hypertension \u2014 a case-control pilot investigation in South Indian population","volume":"56","author":"Varakantham","year":"2018","journal-title":"Clin Chem Lab Med."},{"key":"10.1016\/j.gene.2022.146820_b0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.taap.2018.10.015","article-title":"Cardiovascular variability and \u03b2-ARs gene expression at two stages of doxorubicin \u2013 induced cardiomyopathy","volume":"362","author":"Vasi\u0107","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.gene.2022.146820_b0170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gene.2017.04.045","article-title":"The association of eight potentially functional polymorphisms in five adrenergic receptor-encoding genes with myocardial infarction risk in Han Chinese","volume":"624","author":"Xia","year":"2017","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.gene.2022.146820_b0175","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1073\/pnas.87.4.1516","article-title":"Chromosomal organization of adrenergic receptor genes","volume":"87","author":"Yang-Feng","year":"1990","journal-title":"PNAS"},{"key":"10.1016\/j.gene.2022.146820_b0180","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-12-384921-2.00009-4","article-title":"\u03b2-adrenergic receptor subtype signaling in the heart: from bench to the bedside","volume":"67","author":"Zhu","year":"2011","journal-title":"Curr. Top. Membr."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111922006394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111922006394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:55:59Z","timestamp":1759856159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111922006394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":36,"alternative-id":["S0378111922006394"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2022.146820","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of the \u03b21-adrenergic receptor (ADRB1) gene in the myocardium and \u03b2-adrenergic reactivity of the body in patients with a history of myocardium infraction","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2022.146820","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146820"}}