{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:54:28Z","timestamp":1787500468523,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.gene.2023.147388","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T15:39:44Z","timestamp":1680709184000},"page":"147388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Vitamin D deficiency triggers intrinsic apoptosis by impairing SPP1-dependent antiapoptotic signaling in chronic hematogenous osteomyelitis"],"prefix":"10.1016","volume":"870","author":[{"given":"Xun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2023.147388_b0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2180-3-5","article-title":"Staphylococcus aureus \u2013 induced tumor necrosis factor \u2013 related apoptosis \u2013 inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts","volume":"3","author":"Alexander","year":"2003","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.gene.2023.147388_b0010","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007405","article-title":"Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document","volume":"13","author":"Ammirati","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.gene.2023.147388_b0015","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2310\/JIM.0b013e31821b8755","article-title":"Vitamin D and the immune system","volume":"59","author":"Aranow","year":"2011","journal-title":"J. Invest. Med."},{"key":"10.1016\/j.gene.2023.147388_b0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jor.2016.10.004","article-title":"Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies","volume":"14","author":"Birt","year":"2017","journal-title":"J. Orthop."},{"key":"10.1016\/j.gene.2023.147388_b0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.gene.2023.147388_b0030","doi-asserted-by":"crossref","first-page":"396541","DOI":"10.1155\/2013\/396541","article-title":"Vitamin D and bone disease","volume":"2013","author":"Christodoulou","year":"2013","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.gene.2023.147388_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-016-2725-y","article-title":"Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK","volume":"418","author":"Dalal","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.gene.2023.147388_b0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.gene.2023.147388_b0045","doi-asserted-by":"crossref","DOI":"10.3810\/psm.2008.12.11","article-title":"Osteomyelitis: approach to diagnosis and treatment","volume":"36","author":"Fritz","year":"2008","journal-title":"Phys. Sportsmed."},{"key":"10.1016\/j.gene.2023.147388_b0050","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10432","article-title":"Vitamin D receptor mediates a myriad of biological actions dependent on its 1,25-dihydroxyvitamin D ligand: distinct regulatory themes revealed by induction of Klotho and Fibroblast Growth Factor-23","volume":"5","author":"Haussler","year":"2021","journal-title":"JBMR Plus"},{"key":"10.1016\/j.gene.2023.147388_b0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.clinbiochem.2018.07.003","article-title":"The multiple functions and mechanisms of osteopontin","volume":"59","author":"Icer","year":"2018","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.gene.2023.147388_b0060","first-page":"4627905","article-title":"Acute hematogenous osteomyelitis in a five-month-old male with rickets","volume":"2017","author":"John","year":"2017","journal-title":"Case Rep. Pediatr."},{"key":"10.1016\/j.gene.2023.147388_b0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fcimb.2015.00085","article-title":"Staphylococcus aureus vs. osteoblast: relationship and consequences in osteomyelitis","volume":"5","author":"Josse","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"Suppl 2","key":"10.1016\/j.gene.2023.147388_b0070","doi-asserted-by":"crossref","first-page":"V2","DOI":"10.1359\/jbmr.07s216","article-title":"Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands","volume":"22","author":"Jurutka","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.gene.2023.147388_b0075","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00084-17","article-title":"Staphylococcal osteomyelitis: disease progression, treatment challenges, and future directions","volume":"31","author":"Kavanagh","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.gene.2023.147388_b0080","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/nu2070693","article-title":"Vitamin D and bone health: potential mechanisms","volume":"2","author":"Laird","year":"2010","journal-title":"Nutrients"},{"key":"10.1016\/j.gene.2023.147388_b0085","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/jcb.24462","article-title":"Osteopontin mediates macrophage chemotaxis via alpha4 and alpha9 integrins and survival via the alpha4 integrin","volume":"114","author":"Lund","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.gene.2023.147388_b0090","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.3","article-title":"PTEN-regulated AKT\/FoxO3a\/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells","volume":"4","author":"Luo","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2023.147388_b0095","doi-asserted-by":"crossref","first-page":"723498","DOI":"10.3389\/fmicb.2021.723498","article-title":"Staphylococcus aureus cell wall biosynthesis modulates bone invasion and osteomyelitis pathogenesis","volume":"12","author":"Masters","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.gene.2023.147388_b0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41579-022-00686-0","article-title":"Skeletal infections: microbial pathogenesis, immunity and clinical management","volume":"20","author":"Masters","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.gene.2023.147388_b0105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1359\/jbmr.071002","article-title":"Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death","volume":"23","author":"McCall","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.gene.2023.147388_b0110","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.2147\/IDR.S257517","article-title":"Acute hematogenous osteomyelitis in children: clinical presentation and management","volume":"13","author":"McNeil","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.gene.2023.147388_b0115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fphys.2014.00191","article-title":"Structural considerations of vitamin D signaling","volume":"5","author":"Molnar","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.gene.2023.147388_b0120","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11914-019-00548-4","article-title":"Mechanisms of immune evasion and bone tissue colonization that make Staphylococcus aureus the primary pathogen in osteomyelitis","volume":"17","author":"Muthukrishnan","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.gene.2023.147388_b0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation","volume":"108","author":"Nakashima","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.gene.2023.147388_b0130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/cen.12229","article-title":"The role of osteopontin in the induction of the CD40 ligand in Graves' disease","volume":"80","author":"Qi","year":"2014","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.gene.2023.147388_b0135","doi-asserted-by":"crossref","DOI":"10.3390\/nu14142847","article-title":"Vitamin D and its receptor from a structural perspective","volume":"14","author":"Rochel","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.gene.2023.147388_b0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1515\/hmbci-2014-0035","article-title":"Vitamin D-mediated apoptosis in cancer and obesity","volume":"20","author":"Sergeev","year":"2014","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"10.1016\/j.gene.2023.147388_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/nu12051392","article-title":"Vitamin D status and vitamin D-dependent apoptosis in obesity","volume":"12","author":"Sergeev","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.gene.2023.147388_b0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12891-015-0648-5","article-title":"May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients","volume":"16","author":"Signori","year":"2015","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.gene.2023.147388_b0155","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2144\/0000113876","article-title":"Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice","volume":"52","author":"Stern","year":"2012","journal-title":"Biotechniques"},{"key":"10.1016\/j.gene.2023.147388_b0160","doi-asserted-by":"crossref","first-page":"994","DOI":"10.7150\/ijbs.39945","article-title":"DNA methylation is involved in the pathogenesis of osteoarthritis by regulating CtBP expression and CtBP-mediated signaling","volume":"16","author":"Sun","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.gene.2023.147388_b0165","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00932-19","article-title":"Staphylococcus aureus Osteomyelitis: Bone, Bugs, and Surgery","volume":"88","author":"Urish","year":"2020","journal-title":"Infect. Immun."},{"key":"10.1016\/j.gene.2023.147388_b0170","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fcell.2019.00091","article-title":"TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages","volume":"7","author":"Wajant","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2023.147388_b0175","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.7150\/ijms.45960","article-title":"The Process of Osteoblastic Infection by Staphylococcus Aureus","volume":"17","author":"Wen","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.gene.2023.147388_b0180","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1302\/2633-1462.29.BJO-2020-0192.R1","article-title":"The role of Vitamin D in orthopaedic infection: a systematic literature review","volume":"2","author":"Zargaran","year":"2021","journal-title":"Bone Jt. Open"},{"key":"10.1016\/j.gene.2023.147388_b0185","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1080\/21655979.2021.2020391","article-title":"Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers","volume":"13","author":"Zeng","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.gene.2023.147388_b0190","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3892\/ijmm.2016.2573","article-title":"Molecular mechanisms of cell death in intervertebral disc degeneration (Review)","volume":"37","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.gene.2023.147388_b0195","article-title":"FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2023.147388_b0200","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.7150\/ijbs.28302","article-title":"The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex","volume":"14","author":"Zhang","year":"2018","journal-title":"Int. J. Biol. Sci."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923002299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923002299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:02:55Z","timestamp":1759856575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111923002299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":40,"alternative-id":["S0378111923002299"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.147388","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D deficiency triggers intrinsic apoptosis by impairing SPP1-dependent antiapoptotic signaling in chronic hematogenous osteomyelitis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.147388","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147388"}}