{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:10Z","timestamp":1788872350571,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872579"],"award-info":[{"award-number":["31872579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.gene.2023.147431","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T14:56:23Z","timestamp":1681570583000},"page":"147431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["scd knockout activates \u03b2-oxidation of fatty acids via accumulating stearic acid (18:0) and induces anorexia in zebrafish"],"prefix":"10.1016","volume":"871","author":[{"given":"Wenpeng","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houxiong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2023.147431_b0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00041433-200306000-00005","article-title":"Recent insights into stearoyl-CoA desaturase-1","volume":"14","author":"Aljohani","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.gene.2023.147431_b0010","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.gene.2023.147431_b0015","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJM198805123181905","article-title":"Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels","volume":"318","author":"Bonanome","year":"1988","journal-title":"N. EngI. J. Med."},{"key":"10.1016\/j.gene.2023.147431_b0020","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.2337\/dc12-0033","article-title":"Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients","volume":"35","author":"Bozzetto","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.gene.2023.147431_b0025","first-page":"295","article-title":"Effects of visfatin\/PBEF\/NAMPT on feeding behaviour and hypothalamic neuromodulators in the rat","volume":"26","author":"Brunetti","year":"2012","journal-title":"J. Biol. Regul. Homeost. Agents."},{"key":"10.1016\/j.gene.2023.147431_b0030","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.3390\/foods11131982","article-title":"The Effect of MUFA-Rich Food on Lipid Profile: A Meta-Analysis of Randomized and Controlled-Feeding Trials","volume":"11","author":"Cao","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.gene.2023.147431_b0035","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0167-0115(03)00144-7","article-title":"The central melanocortin system regulates food intake in goldfish","volume":"115","author":"Cerd\u00e1-Reverter","year":"2003","journal-title":"Regul. Pept."},{"key":"10.1016\/j.gene.2023.147431_b0040","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/(SICI)1097-0215(19991126)83:5<585::AID-IJC2>3.0.CO;2-Z","article-title":"Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden","volume":"83","author":"Chaj\u00e8s","year":"1999","journal-title":"Int. J. Cancer."},{"key":"10.1016\/j.gene.2023.147431_b0045","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/science.1071527","article-title":"Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss","volume":"297","author":"Cohen","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.gene.2023.147431_b0050","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ijo.2015.188","article-title":"Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure","volume":"40","author":"de Moura","year":"2016","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.gene.2023.147431_b0055","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/ajcn\/54.6.1036","article-title":"Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men","volume":"54","author":"Denke","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.gene.2023.147431_b0060","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1172\/JCI76302","article-title":"Intestinal lipid-derived signals that sense dietary fat","volume":"125","author":"DiPatrizio","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2023.147431_b0065","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.1073\/pnas.0401627101","article-title":"Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver","volume":"101","author":"Dobrzyn","year":"2004","journal-title":"P. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.gene.2023.147431_b0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tcm.2003.12.005","article-title":"The role of stearoyl-CoA desaturase in body weight regulation","volume":"14","author":"Dobrzyn","year":"2004","journal-title":"Trends Cardiovas Med."},{"key":"10.1016\/j.gene.2023.147431_b0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plefa.2005.04.011","article-title":"The role of stearoyl-CoA desaturase in the control of metabolism","volume":"73","author":"Dobrzyn","year":"2005","journal-title":"Prostag. Leukot. Ess."},{"key":"10.1016\/j.gene.2023.147431_b0080","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/MOL.0b013e3282f9b54d","article-title":"Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism","volume":"19","author":"Flowers","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.gene.2023.147431_b0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aquaculture.2012.05.034","article-title":"Effects of dietary oxidized fish oil with vitamin E supplementation on growth performance and reduction of lipid peroxidation in tissues and blood of red sea bream Pagrus major","volume":"356\u2013357","author":"Gao","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.gene.2023.147431_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2680001","article-title":"Assembly and secretion of hepatic very-low-density lipoprotein","volume":"268","author":"Gibbons","year":"1990","journal-title":"Biochem. J."},{"key":"10.1016\/j.gene.2023.147431_b0095","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1042\/bj2490727","article-title":"Fatty acid specificity for the synthesis of triacylglycerol and phosphatidylcholine and for the secretion of very-low-density lipoproteins and lysophosphatidylcholine by cultures of rat hepatocytes","volume":"249","author":"Graham","year":"1988","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.gene.2023.147431_b0100","article-title":"Stearoyl-CoA desaturase 5 (SCD5), a \u0394-9 fatty acyl desaturase in search of a function","volume":"1866","author":"Igal","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.gene.2023.147431_b0105","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1152\/jn.91294.2008","article-title":"Oleic acid directly regulates POMC neuron excitability in the hypothalamus","volume":"101","author":"Jo","year":"2009","journal-title":"J. Neurophysiol"},{"key":"10.1016\/j.gene.2023.147431_b0110","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/zeb.2012.0861","article-title":"Zebrafish Neuroscience Research Consortium. Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond","volume":"10","author":"Kalueff","year":"2013","journal-title":"Zebrafish"},{"key":"10.1016\/j.gene.2023.147431_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(00)00044-5","article-title":"Fatty acid import into mitochondria","volume":"1486","author":"Kerner","year":"2000","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.gene.2023.147431_b0120","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cbpa.2008.06.029","article-title":"Association of cocaine- and amphetamine-regulated transcript (CART) messenger RNA level, food intake, and growth in channel catfish","volume":"151","author":"Kobayashi","year":"2008","journal-title":"Comp. Biochem. Physiol. A. Mol. Integr. Physiol."},{"key":"10.1016\/j.gene.2023.147431_b0125","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11745-005-1485-y","article-title":"Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption","volume":"40","author":"Kris-Etherton","year":"2005","journal-title":"Lipids"},{"key":"10.1016\/j.gene.2023.147431_b0130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s101260000050","article-title":"Neuropeptide Y sequence and messenger RNA distribution in channel catfish (Ictalurus punctatus)","volume":"3","author":"Leonard","year":"2001","journal-title":"Mar. Biotechnol (NY)."},{"key":"10.1016\/j.gene.2023.147431_b0135","article-title":"Photoperiods affect growth, food intake and physiological metabolism of juvenile European Sea Bass (Dicentrachus labrax L.)","volume":"20","author":"Li","year":"2021","journal-title":"Aquacult. Rep."},{"issue":"36","key":"10.1016\/j.gene.2023.147431_b0140","doi-asserted-by":"crossref","first-page":"33904","DOI":"10.1074\/jbc.M304724200","article-title":"Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors","volume":"278","author":"Miyazaki","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.gene.2023.147431_b0145","doi-asserted-by":"crossref","first-page":"12501","DOI":"10.1073\/pnas.0503132102","article-title":"Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development","volume":"102","author":"Miyazaki","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.gene.2023.147431_b0150","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ygcen.2010.11.005","article-title":"Multiple cocaine- and amphetamine-regulated transcript (CART) genes in medaka, Oryzias latipes: cloning, tissue distribution and effect of starvation","volume":"170","author":"Murashita","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.gene.2023.147431_b0155","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2826.2006.01415.x","article-title":"Regulation by Orexin of Feeding Behaviour and Locomotor Activity in the Goldfish","volume":"18","author":"Nakamachi","year":"2006","journal-title":"J. Neuroendocrinol"},{"key":"10.1016\/j.gene.2023.147431_b0160","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00041433-200306000-00005","article-title":"Recent insights into stearoyl-CoA desaturase-1","volume":"14","author":"Ntambi","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.gene.2023.147431_b0165","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.132384699","article-title":"Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity","volume":"99","author":"Ntambi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.gene.2023.147431_b0170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.bbrc.2020.04.077","article-title":"Global deficiency of stearoyl-CoA desaturase-2 protects against diet-induced adiposity","volume":"527","author":"O'Neill","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2023.147431_b0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0003-9861(72)90335-9","article-title":"The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver","volume":"149","author":"Oshino","year":"1972","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.gene.2023.147431_b0180","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0196-9781(00)00303-X","article-title":"NPY receptors and opioidergic system are involved in NPY-induced feeding in goldfish","volume":"21","author":"Pedro","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.gene.2023.147431_b0185","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1677\/joe.1.06349","article-title":"Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)","volume":"188","author":"Pedro","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.gene.2023.147431_b0190","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.3390\/nu11102283","article-title":"Role of Oleic Acid in the Gut-Liver Axis: From Diet to the Regulation of Its Synthesis via Stearoyl-CoA Desaturase 1 (SCD1)","volume":"11","author":"Piccinin","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.gene.2023.147431_b0195","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1017\/S0007114511006775","article-title":"Role of hepatic de novo lipogenesis in the development of fasting-induced fatty liver in the American mink (Neovison vison)","volume":"108","author":"Rouvinen-Watt","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.gene.2023.147431_b0200","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1038\/s41467-018-05614-6","article-title":"Dietary stearic acid regulates mitochondria in vivo in humans","volume":"9","author":"Senyilmaz-Tiebe","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2023.147431_b0205","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11883-010-0131-6","article-title":"Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients","volume":"12","author":"Siri-Tarino","year":"2010","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.gene.2023.147431_b0210","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1096\/fj.03-1080fje","article-title":"Stearoylethanolamide exerts anorexic effects in mice via down-regulation of liver stearoyl-coenzyme A desaturase-1 mRNA expression","volume":"18","author":"Terrazzino","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2023.147431_b0215","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.271.5250.815","article-title":"Cold-induced expression of D9-desaturase in carp by transcriptional and posttranslational mechanisms","volume":"271","author":"Tiku","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.gene.2023.147431_b0220","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neures.2006.05.011","article-title":"Proliferin enhances microvilli formation and cell growth of neuroblastoma cells","volume":"56","author":"Wang","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.gene.2023.147431_b0225","series-title":"The zebrafish book, a guide for the laboratory use of zebrafish (Danio rerio)","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.gene.2023.147431_b0230","article-title":"Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis","volume":"229","author":"Yan","year":"2020","journal-title":"J. Proteomics"},{"key":"10.1016\/j.gene.2023.147431_b0235","article-title":"Identification of Scd5 as a functional regulator of visceral fat deposition and distribution","volume":"25","author":"Zhang","year":"2022","journal-title":"iScience"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192300272X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192300272X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T22:23:06Z","timestamp":1736374986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811192300272X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":47,"alternative-id":["S037811192300272X"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.147431","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"scd knockout activates \u03b2-oxidation of fatty acids via accumulating stearic acid (18:0) and induces anorexia in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.147431","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147431"}}