{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:47:11Z","timestamp":1788504431573,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.gene.2023.147481","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T02:15:49Z","timestamp":1683857749000},"page":"147481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union"],"prefix":"10.1016","volume":"874","author":[{"given":"Federico","family":"La Manna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-8607","authenticated-orcid":false,"given":"Daniel","family":"Hanhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-4771","authenticated-orcid":false,"given":"Peter","family":"Kloen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre J","family":"van Wijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George N.","family":"Thalmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Kruithof-de Julio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1527-3151","authenticated-orcid":false,"given":"Panagiotis","family":"Chouvardas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2023.147481_b0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bone.2014.03.046","article-title":"Cellular and molecular bases of skeletal regeneration: what can we learn from genetic mouse models?","volume":"64","author":"Abou-Khalil","year":"2014","journal-title":"Bone [Internet]."},{"issue":"8","key":"10.1016\/j.gene.2023.147481_b0010","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.3593","article-title":"Functional characterization of somatic mutations in cancer using network-based inference of protein activity","volume":"48","author":"Alvarez","year":"2016","journal-title":"Nat Genet."},{"key":"10.1016\/j.gene.2023.147481_b0015","article-title":"Single-cell RNAseq provides insight into altered immune cell populations in human fracture nonunions","author":"Avin","year":"2022","journal-title":"J. Orthop. Res. [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0020","doi-asserted-by":"crossref","unstructured":"Badia-i-Mompel P, V\u00e9lez Santiago J, Braunger J, Geiss C, Dimitrov D, M\u00fcller-Dott S, et al. decoupleR: ensemble of computational methods to infer biological activities from omics data. Kuijjer ML, editor. Bioinforma Adv [Internet]. 2022 Jan 10;2(1). Available from: https:\/\/academic.oup.com\/bioinformaticsadvances\/article\/doi\/10.1093\/bioadv\/vbac016\/6544613.","DOI":"10.1093\/bioadv\/vbac016"},{"key":"10.1016\/j.gene.2023.147481_b0025","doi-asserted-by":"crossref","unstructured":"Bais, M., McLean, J., Sebastiani, P., Young, M., Wigner, N., Smith, T., et al., 2009. Transcriptional Analysis of Fracture Healing and the Induction of Embryonic Stem Cell\u2013Related Genes. Sham MH, editor. PLoS One [Internet]. 2009 May 5;4(5):e5393. Available from: https:\/\/dx.plos.org\/10.1371\/journal.pone.0005393.","DOI":"10.1371\/journal.pone.0005393"},{"key":"10.1016\/j.gene.2023.147481_b0030","doi-asserted-by":"crossref","unstructured":"Bolander J, Herpelinck T, Chaklader M, Gklava C, Geris L, Luyten FP. Single\u2010cell characterization and metabolic profiling of in vitro cultured human skeletal progenitors with enhanced in vivo bone forming capacity. Stem Cells Transl Med [Internet]. 2020 Mar 18 [cited 2020 Nov 10];9(3):389\u2013402. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/sctm.19-0151.","DOI":"10.1002\/sctm.19-0151"},{"key":"10.1016\/j.gene.2023.147481_b0035","article-title":"The changing epigenetic landscape of Mesenchymal Stem\/Stromal Cells during aging","volume":"137","author":"Cakouros","year":"2020","journal-title":"Bone [Internet]."},{"issue":"1","key":"10.1016\/j.gene.2023.147481_b0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cell.2018.07.029","article-title":"Identification of the human skeletal stem cell","volume":"175","author":"Chan","year":"2018","journal-title":"Cell."},{"issue":"3","key":"10.1016\/j.gene.2023.147481_b0045","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","article-title":"Fracture healing under healthy and inflammatory conditions","volume":"8","author":"Claes","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3","key":"10.1016\/j.gene.2023.147481_b0050","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1083\/jcb.111.3.1313","article-title":"c-fos expression precedes osteogenic differentiation of cartilage cells in vitro","volume":"111","author":"Closs","year":"1990","journal-title":"J Cell Biol [Internet]."},{"issue":"127","key":"10.1016\/j.gene.2023.147481_b0055","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bone.2019.07.022","article-title":"Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice","volume":"1","author":"Coates","year":"2019","journal-title":"Bone."},{"key":"10.1016\/j.gene.2023.147481_b0060","first-page":"45","article-title":"Molecular pathogenesis of fracture nonunion","volume":"14","author":"Ding","year":"2018","journal-title":"J. Orthop. Transl. [Internet]."},{"issue":"1","key":"10.1016\/j.gene.2023.147481_b0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics."},{"key":"10.1016\/j.gene.2023.147481_b0070","first-page":"9","article-title":"Integrative bioinformatics analysis to explore a robust diagnostic signature and landscape of immune cell infiltration in sarcoidosis","volume":"4","author":"Duo","year":"2022","journal-title":"Front Med [Internet]."},{"issue":"1","key":"10.1016\/j.gene.2023.147481_b0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat. Rev. Rheumatol. [Internet]."},{"issue":"8","key":"10.1016\/j.gene.2023.147481_b0080","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1101\/gr.240663.118","article-title":"Benchmark and integration of resources for the estimation of human transcription factor activities","volume":"29","author":"Garcia-Alonso","year":"2019","journal-title":"Genome Res [Internet]."},{"issue":"APR","key":"10.1016\/j.gene.2023.147481_b0085","article-title":"Comparison of mesenchymal stromal cells from different origins for the treatment of graft-vs.-host-disease in a humanized mouse model","volume":"10","author":"Gr\u00e9goire","year":"2019","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.gene.2023.147481_b0090","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.122.3.685","article-title":"Osteoblasts are target cells for transformation in c-fos transgenic mice","volume":"122","author":"Grigoriadis","year":"1993","journal-title":"J Cell Biol [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0095","first-page":"5","article-title":"It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration","volume":"3","author":"Grosso","year":"2017","journal-title":"Front Bioeng Biotechnol [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0100","doi-asserted-by":"crossref","unstructured":"Hoang T, Lambert JA, Martin R. SCL\/TAL1 in Hematopoiesis and Cellular Reprogramming. In: Current Topics in Developmental Biology [Internet]. 2016. p. 163\u2013204. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0070215316000053.","DOI":"10.1016\/bs.ctdb.2016.01.004"},{"key":"10.1016\/j.gene.2023.147481_b0105","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-022-00924-1","article-title":"STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis","author":"Hou","year":"2022","journal-title":"Cell Commun Signal [Internet]."},{"issue":"3","key":"10.1016\/j.gene.2023.147481_b0110","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1101\/gad.349506","article-title":"A mechanism of AP-1 suppression through interaction of c-Fos with lamin A\/C","volume":"20","author":"Ivorra","year":"2006","journal-title":"Genes Dev [Internet]."},{"issue":"11","key":"10.1016\/j.gene.2023.147481_b0115","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.stem.2022.10.002","article-title":"Bone marrow and periosteal skeletal stem\/progenitor cells make distinct contributions to bone maintenance and repair","volume":"29","author":"Jeffery","year":"2022","journal-title":"Cell Stem Cell [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0120","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2019.7170","article-title":"Identification of key transcription factors-gene regulatory network related with osteogenic differentiation of human mesenchymal stem cells based on transcription factor prognosis system","author":"Kang","year":"2019","journal-title":"Exp Ther Med [Internet]."},{"issue":"W1","key":"10.1016\/j.gene.2023.147481_b0125","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res [Internet]."},{"issue":"4","key":"10.1016\/j.gene.2023.147481_b0130","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.stemcr.2020.02.009","article-title":"Expansion of bone precursors through jun as a novel treatment for osteoporosis-associated fractures","volume":"14","author":"Lerbs","year":"2020","journal-title":"Stem Cell Reports [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0135","doi-asserted-by":"crossref","unstructured":"Li, Z., Kuppe, C., Ziegler, S., Cheng, M., Kabgani, N., Menzel, S., et al., 2021. Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen. Nat Commun [Internet]. 2021;12(1):6386. Available from: https:\/\/www.nature.com\/articles\/s41467-021-26530-2.","DOI":"10.1038\/s41467-021-26530-2"},{"issue":"6","key":"10.1016\/j.gene.2023.147481_b0140","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst [Internet]."},{"issue":"1","key":"10.1016\/j.gene.2023.147481_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sdata.2019.31","article-title":"Data descriptor: Single-cell RNA-seq of cultured human adipose-derived mesenchymal stem cells","volume":"6","author":"Liu","year":"2019","journal-title":"Sci Data."},{"issue":"12","key":"10.1016\/j.gene.2023.147481_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.gene.2023.147481_b0155","first-page":"9","article-title":"Cellular Mechanotransduction: From Tension to Function","volume":"5","author":"Martino","year":"2018","journal-title":"Front Physiol [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0160","doi-asserted-by":"crossref","unstructured":"Oguma, Y., Kuroda, Y., Wakao, S., Kushida, Y., Dezawa, M., 2022. Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations. iScience [Internet]. 2022;25(11):105395. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222016674.","DOI":"10.1016\/j.isci.2022.105395"},{"issue":"1","key":"10.1016\/j.gene.2023.147481_b0165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0014-5793(91)80757-T","article-title":"Fracture healing induces expression of the proto-oncogene c-fos in vivo Possible involvement of the Fos protein in osteoblastic differentiation","volume":"284","author":"Ohta","year":"1991","journal-title":"FEBS Lett [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0170","article-title":"RNA-sequencing reveals positional memory of multipotent mesenchymal stromal cells from oral and maxillofacial tissue transcriptomes","author":"Onizuka","year":"2020","journal-title":"BMC Genomics [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0175","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25862-3","article-title":"The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops","author":"Ottema","year":"2021","journal-title":"Nat. Commun. [Internet]."},{"issue":"3","key":"10.1016\/j.gene.2023.147481_b0180","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/jcmm.17096","article-title":"Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights","volume":"26","author":"Panteli","year":"2022","journal-title":"J. Cell Mol. Med. [Internet]."},{"issue":"4","key":"10.1016\/j.gene.2023.147481_b0185","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0190","doi-asserted-by":"crossref","unstructured":"Pfeiffenberger, M., Damerau, A, Lang, A., Buttgereit, F., Hoff, P., Gaber, T., 2022. Fracture Healing Research\u2014Shift towards In Vitro Modeling? Biomedicines [Internet]. 2021 Jun 28;9(7):748. Available from: https:\/\/www.mdpi.com\/2227-9059\/9\/7\/748.","DOI":"10.3390\/biomedicines9070748"},{"key":"10.1016\/j.gene.2023.147481_b0195","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ajhg.2017.01.005","article-title":"Neurocalcin delta suppression protects against spinal muscular atrophy in humans and across species by restoring impaired endocytosis","volume":"100","author":"Riessland","year":"2017","journal-title":"Am. J. Human Genet."},{"key":"10.1016\/j.gene.2023.147481_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment","author":"Sacchetti","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.gene.2023.147481_b0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02391-6","article-title":"Perturbation-response genes reveal signaling footprints in cancer gene expression","author":"Schubert","year":"2018","journal-title":"Nat Commun [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0210","doi-asserted-by":"crossref","unstructured":"Shapiro, F., 2020. Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cells Mater [Internet]. 2008 Apr 1 [cited 2020 May 22];15:53\u201376. Available from: http:\/\/ecmjournal.org\/journal\/papers\/vol015\/pdf\/v015a05.pdf.","DOI":"10.22203\/eCM.v015a05"},{"issue":"4","key":"10.1016\/j.gene.2023.147481_b0215","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"30","author":"Soneson","year":"2015","journal-title":"F1000Research [Internet]."},{"issue":"13","key":"10.1016\/j.gene.2023.147481_b0220","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1073\/pnas.1920860117","article-title":"Hox genes maintain critical roles in the adult skeleton","volume":"117","author":"Song","year":"2020","journal-title":"Proc Natl Acad Sci [Internet]."},{"issue":"9","key":"10.1016\/j.gene.2023.147481_b0225","doi-asserted-by":"crossref","first-page":"e12383","DOI":"10.7717\/peerj.12383","article-title":"Establishment and validation of an individualized macrophage-related gene signature to predict overall survival in patients with triple negative breast cancer","volume":"23","author":"Su","year":"2021","journal-title":"PeerJ [Internet]."},{"issue":"43","key":"10.1016\/j.gene.2023.147481_b0230","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0235","doi-asserted-by":"crossref","unstructured":"Swan, A.L., Sch\u00fctt, C., Rozman, J., del Mar Mu\u00f1iz Moreno, M., Brandmaier, S., Simon, M., Leuchtenberger, S., Griffiths, M., Brommage, R., Keskivali-Bond, P., Grallert, H., Werner, T., Teperino, R., Becker, L., Miller, G., Moshiri, A., Seavitt, J.R., Cissell, D.D., Meehan, T.F., Acar, E.F., Lelliott, C.J., Flenniken, A.M., Champy, M.-F., Sorg, T., Ayadi, A., Braun, R.E., Cater, H., Dickinson, M.E., Flicek, P., Gallegos, J., Ghirardello, E.J., Heaney, J.D., Jacquot, S., Lally, C., Logan, J.G., Teboul, L., Mason, J., Spielmann, N., McKerlie, C., Murray, S.A., Nutter, L.M.J., Odfalk, K.F., Parkinson, H., Prochazka, J., Reynolds, C.L., Selloum, M., Spoutil, F., Svenson, K.L., Vales, T.S., Wells, S.E., White, J.K., Sedlacek, R., Wurst, W., Lloyd, K.C.K., Croucher, P.I., Fuchs, H., Williams, G.R., Bassett, J.H.D., Gailus-Durner, V., Herault, Y., Mallon, A.-M., Brown, S.D.M., Mayer-Kuckuk, P., Hrabe de Angelis, M., 2020. Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. PLoS Genet 16, e1009190. 10.1371\/journal.pgen.1009190.","DOI":"10.1371\/journal.pgen.1009190"},{"issue":"5","key":"10.1016\/j.gene.2023.147481_b0240","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/jcp.25641","article-title":"Osteogenic differentiation of periosteal cells during fracture healing","volume":"232","author":"Wang","year":"2017","journal-title":"J Cell Physiol [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0245","doi-asserted-by":"crossref","unstructured":"Wildemann, B., Ignatius, A., Leung, F., Taitsman, L.A., Smith, R.M., Pes\u00e1ntez, R., et al., 2021. Non-union bone fractures. Nat Rev Dis Prim [Internet]. 2021 Aug 5 [cited 2022 Dec 29];7(1):57. Available from: https:\/\/www.nature.com\/articles\/s41572-021-00297-8.","DOI":"10.1038\/s41572-021-00289-8"},{"key":"10.1016\/j.gene.2023.147481_b0250","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2016.9","article-title":"TGF-\u03b2 and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease","author":"Wu","year":"2016","journal-title":"Bone Res [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0255","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-021-00176-8","article-title":"PDGFR\u03b1 reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair","author":"Xu","year":"2022","journal-title":"Bone Res [Internet]"},{"issue":"1","key":"10.1016\/j.gene.2023.147481_b0260","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1158\/1078-0432.CCR-16-0549","article-title":"Epigenome-wide tumor DNA methylation profiling identifies novel prognostic biomarkers of metastatic-lethal progression in men diagnosed with clinically localized prostate cancer","volume":"23","author":"Zhao","year":"2017","journal-title":"Clin Cancer Res [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0265","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27273-w","article-title":"STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis","author":"Zhou","year":"2021","journal-title":"Nat Commun [Internet]."},{"key":"10.1016\/j.gene.2023.147481_b0270","first-page":"8","article-title":"The smad dependent TGF-\u03b2 and BMP signaling pathway in bone remodeling and therapies","volume":"5","author":"Zou","year":"2021","journal-title":"Front Mol Biosci [Internet]."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923003220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923003220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:03:54Z","timestamp":1759856634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111923003220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":54,"alternative-id":["S0378111923003220"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.147481","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.147481","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"147481"}}