{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:33:01Z","timestamp":1736400781764,"version":"3.32.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.gene.2023.147673","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T11:38:06Z","timestamp":1690457886000},"page":"147673","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association of CYP1A1 T3801C (rs4646903) variant with the susceptibility and progression of B-chronic lymphocytic Leukemia (B-CLL) in the Egyptian population"],"prefix":"10.1016","volume":"883","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3021-5748","authenticated-orcid":false,"given":"Menna","family":"Al-Adl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afaf","family":"El-Said","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"EL-Sebaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif","family":"Refaat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdy M.","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.gene.2023.147673_b0005","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00204-020-02968-z","article-title":"Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway","volume":"95","author":"Abbass","year":"2021","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.gene.2023.147673_b0010","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/cancers12020524","article-title":"Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role","volume":"12","author":"Allegra","year":"2020","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.gene.2023.147673_b0015","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3897\/pharmacia.68.e71621","article-title":"Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population","volume":"68","author":"Alvarado","year":"2021","journal-title":"Pharmacia"},{"key":"10.1016\/j.gene.2023.147673_b0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1471-2407-9-187","article-title":"Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention","volume":"9","author":"Androutsopoulos","year":"2009","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.gene.2023.147673_b0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4103\/ajm.AJM_171_16","article-title":"An unusual presentation of chronic lymphocytic leukemia","volume":"7","author":"Atwal","year":"2017","journal-title":"Avicenna J. Med."},{"issue":"7","key":"10.1016\/j.gene.2023.147673_b0030","doi-asserted-by":"crossref","first-page":"896","DOI":"10.3390\/cancers11070896","article-title":"Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Na\u00efve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12","volume":"11","author":"Autore","year":"2019","journal-title":"Cancers"},{"issue":"14","key":"10.1016\/j.gene.2023.147673_b0035","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.3390\/ijerph17145174","article-title":"Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study","volume":"17","author":"Benavente","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.gene.2023.147673_b0040","doi-asserted-by":"crossref","first-page":"1112616","DOI":"10.3389\/fonc.2023.1112616","article-title":"Measurable residual disease in chronic lymphocytic leukemia","volume":"13","author":"Benintende","year":"2023","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.gene.2023.147673_b0045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V","article-title":"A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis","volume":"48","author":"Binet","year":"1981","journal-title":"Cancer"},{"issue":"38","key":"10.1016\/j.gene.2023.147673_b0050","article-title":"Impact of Cytochromes P450 3A4 and 2B6 gene polymorphisms on predisposition and prognosis of acute myeloid leukemia: an Egyptian case-control study. Egypt Journal Medical","volume":"22","author":"Botros","year":"2021","journal-title":"Hum. Genet."},{"issue":"11","key":"10.1016\/j.gene.2023.147673_b0055","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.3390\/ijms23116348","article-title":"Benzo[a]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity","volume":"23","author":"Bukowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.gene.2023.147673_b0060","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/ajh.24808","article-title":"IGHV mutational status testing in chronic lymphocytic leukemia","volume":"92","author":"Crombie","year":"2017","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.gene.2023.147673_b0065","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3389\/fimmu.2018.00683","article-title":"Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective","volume":"9","author":"Darwiche","year":"2018","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.gene.2023.147673_b0070","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/carcin\/bgq028","article-title":"The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth","volume":"31","author":"Dietrich","year":"2010","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/j.gene.2023.147673_b0075","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1007\/s11033-012-2423-0","article-title":"CYP1A1 MspI polymorphism is associated with prostate cancer susceptibility: evidence from a meta-analysis","volume":"40","author":"Ding","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.gene.2023.147673_b0080","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/asheducation-2016.1.149","article-title":"Prognostication of chronic lymphocytic leukemia in the era of new agents","volume":"2016","author":"Eichhorst","year":"2016","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"issue":"3","key":"10.1016\/j.gene.2023.147673_b0085","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/jox11030007","article-title":"The Central Role of Cytochrome P450 in Xenobiotic Metabolism-A Brief Review on a Fascinating Enzyme Family","volume":"11","author":"Esteves","year":"2021","journal-title":"J. Xenobiotics"},{"key":"10.1016\/j.gene.2023.147673_b0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s41021-016-0066-4","article-title":"Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer","volume":"39","author":"Ezzeldin","year":"2017","journal-title":"Genes Environ.: Off. J. Japanese Environ. Mutagen Soc."},{"issue":"5","key":"10.1016\/j.gene.2023.147673_b0095","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/ejh.13833","article-title":"Implementation of International Prognostic Index with flow cytometry immunophenotyping for better risk stratification of chronic lymphocytic leukemia","volume":"109","author":"Giudice","year":"2022","journal-title":"Eur. J. Haematol."},{"issue":"4","key":"10.1016\/j.gene.2023.147673_b0100","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ajh.21113","article-title":"Polymorphisms in xenobiotic-metabolizing genes and the risk of chronic lymphocytic leukemia and non-Hodgkin's lymphoma in adult Russian patients","volume":"83","author":"Gra","year":"2008","journal-title":"Am. J. Hematol."},{"issue":"11","key":"10.1016\/j.gene.2023.147673_b0105","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/ajh.25595","article-title":"Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment","volume":"94","author":"Hallek","year":"2019","journal-title":"Am. J. Hematol."},{"issue":"1\u20132","key":"10.1016\/j.gene.2023.147673_b0110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/mas.21570","article-title":"DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans","volume":"39","author":"Hwa Yun","year":"2020","journal-title":"Mass Spectrom. Rev."},{"issue":"4","key":"10.1016\/j.gene.2023.147673_b0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3960\/jslrt.20036","article-title":"Pathogenesis of chronic lymphocytic leukemia and the development of novel therapeutic strategies","volume":"60","author":"Kikushige","year":"2020","journal-title":"J. Clin. Exp. Hematopathol.: JCEH"},{"issue":"8","key":"10.1016\/j.gene.2023.147673_b0120","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.bcp.2003.12.018","article-title":"Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells","volume":"67","author":"Lin","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.gene.2023.147673_b0125","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.2147\/OTT.S92259","article-title":"Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis","volume":"8","author":"Lu","year":"2015","journal-title":"OncoTargets Therapy"},{"issue":"10","key":"10.1016\/j.gene.2023.147673_b0130","first-page":"1640","article-title":"The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL","volume":"8","author":"Matutes","year":"1994","journal-title":"Leukemia"},{"key":"10.1016\/j.gene.2023.147673_b0135","doi-asserted-by":"crossref","first-page":"8108","DOI":"10.1038\/srep08108","article-title":"Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis","volume":"5","author":"Meng","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2023.147673_b0140","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fpubh.2018.00096","article-title":"Association of Cytochrome CYP1A1 Gene Polymorphisms and Tobacco Smoking With the Risk of Breast Cancer in Women From Iraq","volume":"6","author":"Naif","year":"2018","journal-title":"Front. Public Health"},{"key":"10.1016\/j.gene.2023.147673_b0145","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.634383","article-title":"AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression","volume":"11","author":"Oppezzo","year":"2021","journal-title":"Front. Oncol."},{"issue":"47","key":"10.1016\/j.gene.2023.147673_b0150","doi-asserted-by":"crossref","first-page":"e13337","DOI":"10.1097\/MD.0000000000013337","article-title":"Association between polymorphisms in estrogen metabolism genes and breast cancer development in Chinese women: A prospective case-control study","volume":"97","author":"Qiu","year":"2018","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/j.gene.2023.147673_b0155","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","article-title":"Clinical staging of chronic lymphocytic leukemia","volume":"46","author":"Rai","year":"1975","journal-title":"Blood"},{"key":"10.1016\/j.gene.2023.147673_b0160","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphar.2015.00123","article-title":"Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes","volume":"6","author":"Raunio","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.gene.2023.147673_b0165","first-page":"651","article-title":"CYP1A1 polymorphisms and risk of lung cancer in the ethnic Kashmiri population","volume":"10","author":"Shaffi","year":"2009","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"1\u20132","key":"10.1016\/j.gene.2023.147673_b0170","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mrfmmm.2009.07.006","article-title":"Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients","volume":"670","author":"Shah","year":"2009","journal-title":"Mutat. Res."},{"issue":"6","key":"10.1016\/j.gene.2023.147673_b0175","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00281-013-0390-8","article-title":"The role of the aryl hydrocarbon receptor in normal and malignant B cell development","volume":"35","author":"Sherr","year":"2013","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.gene.2023.147673_b0180","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.gene.2023.147673_b0185","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.yrtph.2011.05.001","article-title":"Butadiene cancer exposure-response modeling: based on workers in the styrene-butadiene-rubber industry: total leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, and chronic myelogenous leukemia","volume":"60","author":"Sielken","year":"2011","journal-title":"Regulatory Toxicol. Pharmacol.: RTP"},{"year":"2021","series-title":"Stata Statistical Software: Release 17","author":"StataCorp","key":"10.1016\/j.gene.2023.147673_b0190"},{"issue":"3","key":"10.1016\/j.gene.2023.147673_b0195","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00280-020-04181-2","article-title":"Involvement of cytochrome P450 enzymes in inflammation and cancer: a review","volume":"87","author":"Stipp","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"4","key":"10.1016\/j.gene.2023.147673_b0200","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood-2015-02-585059","article-title":"Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification","volume":"126","author":"Strati","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.gene.2023.147673_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101530","article-title":"The aryl hydrocarbon receptor as a target of environmental stressors - Implications for pollution mediated stress and inflammatory responses","volume":"34","author":"Vogel","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.gene.2023.147673_b0210","doi-asserted-by":"crossref","unstructured":"Wan Mohamad Zamri, W.N., Mohd Yunus, N., Abdul Aziz, A.A., Zulkipli, N.N., Sulong, S., 2023. Perspectives on the Application of Cytogenomic Approaches in Chronic Lymphocytic Leukaemia. Diagnostics 13(5), 964. https:\/\/doi.org\/10.3390\/diagnostics13050964.","DOI":"10.3390\/diagnostics13050964"},{"issue":"5","key":"10.1016\/j.gene.2023.147673_b0215","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/ckj\/sfy026","article-title":"Renal involvement in chronic lymphocytic leukemia","volume":"11","author":"Wanchoo","year":"2018","journal-title":"Clin. Kidney J."},{"issue":"9","key":"10.1016\/j.gene.2023.147673_b0220","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1124\/dmd.120.000008","article-title":"Epigenetic Regulation of Differentially Expressed Drug-Metabolizing Enzymes in Cancer","volume":"48","author":"Wang","year":"2020","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.gene.2023.147673_b0225","unstructured":"Wierda, W.G., Byrd, J.C., Abramson, J.S., Bilgrami, S.F., Bociek, G., Brander, D., Brown, J., Chanan-Khan, A.A., Chavez, J.C., Coutre, S.E., Davis, R.S., Fletcher, C.D., Hill, B., Kahl, B.S., Kamdar, M., Kaplan, L.D., Khan, N., Kipps, T.J., Lim, M.S., Ma, S., \u2026 Sundar, H. (2020). Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma, Version 4.2020, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Comprehensive Cancer Network: JNCCN 18(2), 185\u2013217. https:\/\/doi.org\/10.6004\/jnccn.2020.0006."},{"issue":"1","key":"10.1016\/j.gene.2023.147673_b0230","doi-asserted-by":"crossref","first-page":"243","DOI":"10.31557\/APJCP.2020.21.1.243","article-title":"Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women","volume":"21","author":"Wongpratate","year":"2020","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"10","key":"10.1016\/j.gene.2023.147673_b0235","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s10654-020-00609-4","article-title":"Asbestos exposure and haematological malignancies: a Danish cohort study","volume":"35","author":"W\u00fcrtz","year":"2020","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.gene.2023.147673_b0240","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40364-020-00222-3","article-title":"Recent progress of prognostic biomarkers and risk scoring systems in chronic lymphocytic leukemia","volume":"8","author":"Yun","year":"2020","journal-title":"Biomarker Res."},{"issue":"10","key":"10.1016\/j.gene.2023.147673_b0245","first-page":"1112","article-title":"Association between CYP1A1*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia: a meta-analysis","volume":"17","author":"Zou","year":"2015","journal-title":"Chinese J. Contemp. Pediatr."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923005140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923005140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T22:24:39Z","timestamp":1736375079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111923005140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":49,"alternative-id":["S0378111923005140"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.147673","relation":{},"ISSN":["0378-1119"],"issn-type":[{"type":"print","value":"0378-1119"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of CYP1A1 T3801C (rs4646903) variant with the susceptibility and progression of B-chronic lymphocytic Leukemia (B-CLL) in the Egyptian population","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.147673","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147673"}}