{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:22:33Z","timestamp":1787505753355,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"am","delay-in-days":315,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010679","name":"Pasteur Institute of Iran","doi-asserted-by":"publisher","award":["1235"],"award-info":[{"award-number":["1235"]}],"id":[{"id":"10.13039\/501100010679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.gene.2023.147776","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T16:40:53Z","timestamp":1694104853000},"page":"147776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Frequency and prognostic influence of ASXL1 mutations and its potential association with BCR-ABL1 transcript type and smoke in chronic myeloid leukemia patients"],"prefix":"10.1016","volume":"886","author":[{"given":"Aras","family":"Rafiq Mohammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dlnya","family":"Assad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golale","family":"Rostami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-0713","authenticated-orcid":false,"given":"Mohammad","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.gene.2023.147776_b0005","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/leu.2011.58","article-title":"Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms","volume":"25","author":"Abdel-Wahab","year":"2011","journal-title":"Leukemia."},{"issue":"3","key":"10.1016\/j.gene.2023.147776_b0010","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1182\/bloodadvances.2019000943","article-title":"Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia","volume":"4","author":"Adnan Awad","year":"2020","journal-title":"Blood Adv."},{"issue":"9","key":"10.1016\/j.gene.2023.147776_b0015","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1080\/10428194.2021.1894652","article-title":"Mutational landscape of chronic myeloid leukemia: More than a single oncogene leukemia","volume":"62","author":"Adnan-Awad","year":"2021","journal-title":"Leuk Lymphoma."},{"issue":"6312","key":"10.1016\/j.gene.2023.147776_b0020","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1126\/science.aag0299","article-title":"Mutational signatures associated with tobacco smoking in human cancer","volume":"354","author":"Alexandrov","year":"2016","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.gene.2023.147776_b0025","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1182\/blood-2006-02-005686","article-title":"Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet","volume":"108","author":"Baccarani","year":"2006","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.gene.2023.147776_b0030","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood-2013-05-501569","article-title":"European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013","volume":"122","author":"Baccarani","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.gene.2023.147776_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43042-022-00248-2","article-title":"Chronic myeloid leukemia: cytogenetics and molecular biology\u2019s part in the comprehension and management of the pathology and treatment evolution","volume":"23","author":"Benchikh","year":"2022","journal-title":"Egypt J. Med. Hum. Genet."},{"issue":"10","key":"10.1016\/j.gene.2023.147776_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41408-022-00742-1","article-title":"Prognostic impact of ASXL1 mutations in chronic phase chronic myeloid leukemia","volume":"12","author":"Bidikian","year":"2022","journal-title":"Blood Cancer J."},{"issue":"1","key":"10.1016\/j.gene.2023.147776_b0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tibs.2005.11.001","article-title":"The PHD finger, a nuclear protein-interaction domain","volume":"31","author":"Bienz","year":"2006","journal-title":"Trends Biochem. Sci."},{"issue":"6","key":"10.1016\/j.gene.2023.147776_b0050","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/leu.2010.65","article-title":"High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression","volume":"24","author":"Boultwood","year":"2010","journal-title":"Leukemia."},{"issue":"9","key":"10.1016\/j.gene.2023.147776_b0055","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1182\/blood-2018-02-832253","article-title":"Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease","volume":"132","author":"Branford","year":"2018","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.gene.2023.147776_b0060","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1182\/blood.V98.10.2887","article-title":"Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein","volume":"98","author":"Clark","year":"2001","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.gene.2023.147776_b0065","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1101\/gad.1652908","article-title":"Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease","volume":"22","author":"Cloos","year":"2008","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.gene.2023.147776_b0070","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.beha.2009.04.001","article-title":"Standardisation of molecular monitoring for chronic myeloid leukaemia","volume":"22","author":"Cross","year":"2009","journal-title":"Best Pract. Res. Clin. Haematol."},{"issue":"10","key":"10.1016\/j.gene.2023.147776_b0075","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1038\/s41375-020-0896-8","article-title":"Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking","volume":"34","author":"Dawoud","year":"2020","journal-title":"Leukemia."},{"issue":"3","key":"10.1016\/j.gene.2023.147776_b0080","doi-asserted-by":"crossref","first-page":"977","DOI":"10.31557\/APJCP.2022.23.3.977","article-title":"High Frequency of ASXL1 and IDH Mutations in Young Acute Myeloid Leukemia Egyptian Patients","volume":"23","author":"El Nahass","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"6","key":"10.1016\/j.gene.2023.147776_b0085","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1365-2141.2009.07697.x","article-title":"Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia","volume":"145","author":"Gelsi-Boyer","year":"2009","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.gene.2023.147776_b0090","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/leu.2010.298","article-title":"A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases","volume":"25","author":"Grossmann","year":"2011","journal-title":"Leukemia."},{"issue":"8","key":"10.1016\/j.gene.2023.147776_b0095","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/sj.leu.2403426","article-title":"Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance","volume":"18","author":"Hochhaus","year":"2004","journal-title":"Leukemia."},{"key":"10.1016\/j.gene.2023.147776_b0100","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.leukres.2017.06.009","article-title":"Exome sequencing reveals DNMT3A and ASXL1 variants associate with progression of chronic myeloid leukemia after tyrosine kinase inhibitor therapy","volume":"59","author":"Kim","year":"2017","journal-title":"Leuk Res."},{"issue":"4","key":"10.1016\/j.gene.2023.147776_b0105","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00277-011-1330-0","article-title":"TET2, ASXL1, IDH1, IDH2, and c-CBL genes in JAK2-and MPL-negative myeloproliferative neoplasms","volume":"91","author":"Mart\u00ednez-Avil\u00e9s","year":"2012","journal-title":"Ann Hematol."},{"issue":"18","key":"10.1016\/j.gene.2023.147776_b0110","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1182\/bloodadvances.2017006825","article-title":"ASXL1 and BIM germ line variants predict response and identify CML patients with the greatest risk of imatinib failure","volume":"1","author":"Marum","year":"2017","journal-title":"Blood Adv."},{"issue":"11","key":"10.1016\/j.gene.2023.147776_b0115","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2013.54","article-title":"ASXL1, TP53 and IKZF3 mutations are present in the chronic phase and blast crisis of chronic myeloid leukemia","volume":"3","author":"Menezes","year":"2013","journal-title":"Blood Cancer J."},{"issue":"3","key":"10.1016\/j.gene.2023.147776_b0120","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.gene.2023.147776_b0125","doi-asserted-by":"crossref","first-page":"E623","DOI":"10.1002\/ajh.24865","article-title":"Somatic mutations identified at diagnosis by exome sequencing can predict response to imatinib in chronic phase chronic myeloid leukemia (CML) patients","volume":"92","author":"Mologni","year":"2017","journal-title":"Am. J. Hematol."},{"issue":"11","key":"10.1016\/j.gene.2023.147776_b0130","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/leu.2009.168","article-title":"Harmonization of molecular monitoring of CML therapy in Europe","volume":"23","author":"M\u00fcller","year":"2009","journal-title":"Leukemia."},{"issue":"12","key":"10.1016\/j.gene.2023.147776_b0135","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.3324\/haematol.2018.200220","article-title":"Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second-generation tyrosine kinase inhibitors","volume":"104","author":"Nteliopoulos","year":"2019","journal-title":"Haematologica."},{"issue":"1","key":"10.1016\/j.gene.2023.147776_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-28500-z","article-title":"Benzo (a) pyrene in Cigarette Smoke Enhances HIV-1 Replication through NF-\u03baB Activation via CYP-Mediated Oxidative Stress Pathway","volume":"8","author":"Ranjit","year":"2018","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.gene.2023.147776_b0150","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1038\/s41375-022-01648-4","article-title":"ASXL1 mutations predict inferior molecular response to nilotinib treatment in chronic myeloid leukemia","volume":"36","author":"Sch\u00f6nfeld","year":"2022","journal-title":"Leukemia."},{"issue":"4","key":"10.1016\/j.gene.2023.147776_b0155","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1182\/blood.V63.4.789.789","article-title":"Prognostic discrimination in\u201c good-risk\u201d chronic granulocytic leukemia","volume":"63","author":"Sokal","year":"1984","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.gene.2023.147776_b0160","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/leu.2010.69","article-title":"Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1","volume":"24","author":"Tefferi","year":"2010","journal-title":"Leukemia."},{"issue":"4","key":"10.1016\/j.gene.2023.147776_b0165","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2017.36","article-title":"Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia","volume":"7","author":"Togasaki","year":"2017","journal-title":"Blood Cancer J."},{"issue":"2","key":"10.1016\/j.gene.2023.147776_b0170","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1111\/ajco.12588","article-title":"ASXL1 and JAK2V617F gene mutation screening in Iranian patients with chronic myeloid leukemia","volume":"13","author":"Valikhani","year":"2017","journal-title":"Asia Pac. J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.gene.2023.147776_b0175","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3324\/haematol.2013.090217","article-title":"Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation","volume":"99","author":"West","year":"2014","journal-title":"Haematologica."},{"key":"10.1016\/j.gene.2023.147776_b0180","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.2147\/OTT.S257661","article-title":"Integrative genomic analysis reveals cancer-associated gene mutations in chronic myeloid leukemia patients with resistance or intolerance to tyrosine kinase inhibitor","volume":"13","author":"Wu","year":"2020","journal-title":"OncoTargets Ther."},{"issue":"3","key":"10.1016\/j.gene.2023.147776_b0185","first-page":"247","article-title":"Frequency of BCR-ABL fusion transcripts in Iranian patients with chronic myeloid leukemia","volume":"11","author":"Yaghmaei","year":"2008","journal-title":"Arch. Iran. Med."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923006170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923006170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:06:53Z","timestamp":1759856813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111923006170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":36,"alternative-id":["S0378111923006170"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.147776","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frequency and prognostic influence of ASXL1 mutations and its potential association with BCR-ABL1 transcript type and smoke in chronic myeloid leukemia patients","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.147776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147776"}}