{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:53:48Z","timestamp":1793926428047,"version":"4.8.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA016781"],"award-info":[{"award-number":["R01 AA016781"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA027916"],"award-info":[{"award-number":["R01 AA027916"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21 AA022203"],"award-info":[{"award-number":["R21 AA022203"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES023515"],"award-info":[{"award-number":["P30ES023515"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R00 HD097286"],"award-info":[{"award-number":["R00 HD097286"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.gene.2023.147951","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T22:39:30Z","timestamp":1698791970000},"page":"147951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["RNA-seq analysis reveals prenatal alcohol exposure is associated with placental inflammatory cells and gene expression"],"prefix":"10.1016","volume":"894","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-815X","authenticated-orcid":false,"given":"Randy P.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-6750","authenticated-orcid":false,"given":"Corina","family":"Lesseur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-2392","authenticated-orcid":false,"given":"Maya","family":"Deyssenroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Molteno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesta M.","family":"Meintjes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra W.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Wainwright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Colin","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2023.147951_b0005","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/S0024-3205(01)01070-0","article-title":"Ethanol inhibits L-arginine uptake and enhances NO formation in human placenta","volume":"68","author":"Acevedo","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2023.147951_b0010","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.placenta.2004.08.008","article-title":"Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching","volume":"26","author":"Anteby","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.gene.2023.147951_b0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The gene ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2023.147951_b0020","first-page":"89","article-title":"Placental findings in alcohol abuse in pregnancy","volume":"18","author":"Baldwin","year":"1982","journal-title":"Birth Defects Orig. Artic. Ser."},{"key":"10.1016\/j.gene.2023.147951_b0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1067\/S0022-3476(03)00442-6","article-title":"Validation of a new biomarker of fetal exposure to alcohol","volume":"143","author":"Bearer","year":"2003","journal-title":"J. Pediatr."},{"key":"10.1016\/j.gene.2023.147951_b0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbi.2018.05.004","article-title":"Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy","volume":"73","author":"Bodnar","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.gene.2023.147951_b0035","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/14767050701298365","article-title":"Ethanol and the placenta: a review","volume":"20","author":"Burd","year":"2007","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.gene.2023.147951_b0040","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.gene.2023.147951_b0045","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrn3475","article-title":"Power failure: why small sample size undermines the reliability of neuroscience","volume":"14","author":"Button","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.gene.2023.147951_b0050","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/acer.13022","article-title":"Alcohol, methamphetamine, and marijuana exposure have distinct effects on the human placenta","volume":"40","author":"Carter","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2023.147951_b0055","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0775","article-title":"Fetal alcohol growth restriction and cognitive impairment","volume":"138","author":"Carter","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.gene.2023.147951_b0060","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/acer.13808","article-title":"Alcohol-related alterations in placental imprinted gene expression in humans mediate effects of prenatal alcohol exposure on postnatal growth","volume":"42","author":"Carter","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2023.147951_b0065","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/ajcn\/nqab165","article-title":"Prenatal alcohol-related alterations in maternal, placental, neonatal, and infant iron homeostasis","volume":"114","author":"Carter","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.gene.2023.147951_b0070","unstructured":"Chang, N.C., Chao, Helen M., 1983. Early Identification of Alcohol Abuse: Proceedings of a Workshop, October 31-November 1, 1983. (U.S. Dept. of Health and Human Services, P. H. S., Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, ed), Rockville, MD."},{"key":"10.1016\/j.gene.2023.147951_b0075","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/hbm.22327","article-title":"A study of cortical morphology in children with fetal alcohol spectrum disorders","volume":"35","author":"De Guio","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.gene.2023.147951_b0080","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2174\/157488407780598135","article-title":"Ethanol metabolism and effects: nitric oxide and its interaction","volume":"2","author":"Deng","year":"2007","journal-title":"Curr. Clin. Pharmacol."},{"key":"10.1016\/j.gene.2023.147951_b0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2023.147951_b0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijdevneu.2018.11.004","article-title":"Placental macrophages: a window into fetal microglial function in maternal obesity","volume":"77","author":"Edlow","year":"2019","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.gene.2023.147951_b0095","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2023.147951_b0100","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1002\/hbm.23218","article-title":"White matter deficits mediate effects of prenatal alcohol exposure on cognitive development in childhood","volume":"37","author":"Fan","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.gene.2023.147951_b0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jhep.2018.10.023","article-title":"Inflammatory pathways in alcoholic steatohepatitis","volume":"70","author":"Gao","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.gene.2023.147951_b0110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.placenta.2013.10.008","article-title":"Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta","volume":"35","author":"G\u00e5rdebjer","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.gene.2023.147951_b0115","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.rbmo.2020.10.015","article-title":"Perigestational alcohol consumption induces altered early placentation and organogenic embryo growth restriction by disruption of trophoblast angiogenic factors","volume":"42","author":"Gualdoni","year":"2021","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.gene.2023.147951_b0120","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.placenta.2007.10.002","article-title":"Impaired placentation in fetal alcohol syndrome","volume":"29","author":"Gundogan","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.gene.2023.147951_b0125","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/s12859-016-1323-z","article-title":"variancePartition: interpreting drivers of variation in complex gene expression studies","volume":"17","author":"Hoffman","year":"2016","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.gene.2023.147951_b0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.psyneuen.2016.01.023","article-title":"Fetal exposure to placental corticotropin-releasing hormone is associated with child self-reported internalizing symptoms","volume":"67","author":"Howland","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.gene.2023.147951_b0135","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-4256","article-title":"Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders","volume":"138","author":"Hoyme","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.gene.2023.147951_b0140","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1530-0277.1998.tb03654.x","article-title":"Specificity of neurobehavioral outcomes associated with prenatal alcohol exposure","volume":"22","author":"Jacobson","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2023.147951_b0145","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1542\/peds.109.5.815","article-title":"Validity of maternal report of prenatal alcohol, cocaine, and smoking in relation to neurobehavioral outcome","volume":"109","author":"Jacobson","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.gene.2023.147951_b0150","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1530-0277.2007.00585.x","article-title":"Impaired eyeblink conditioning in children with fetal alcohol syndrome","volume":"32","author":"Jacobson","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2023.147951_b0155","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/acer.13363","article-title":"Heavy prenatal alcohol exposure is related to smaller corpus callosum in newborn MRI scans","volume":"41","author":"Jacobson","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2023.147951_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.107054","article-title":"Pregnancy exposure to phthalates and DNA methylation in male placenta - an epigenome-wide association study","volume":"160","author":"Jedynak","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.gene.2023.147951_b0165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13059-021-02290-6","article-title":"A benchmark for RNA-seq deconvolution analysis under dynamic testing environments","volume":"22","author":"Jin","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.gene.2023.147951_b0170","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0024-3205(81)90204-6","article-title":"Placental blood flow in rats fed alcohol before and during gestation","volume":"29","author":"Jones","year":"1981","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2023.147951_b0175","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.placenta.2015.05.011","article-title":"Prenatal ethanol exposure and placental hCG and IGF2 expression","volume":"36","author":"Joya","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.gene.2023.147951_b0180","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.placenta.2016.08.080","article-title":"Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in vitro","volume":"46","author":"Kalisch-Smith","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.gene.2023.147951_b0185","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1002\/jnr.24797","article-title":"Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders","volume":"99","author":"Kane","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.gene.2023.147951_b0190","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1002\/jnr.24735","article-title":"Neuroinflammatory contribution of microglia and astrocytes in fetal alcohol spectrum disorders","volume":"99","author":"Kane","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.gene.2023.147951_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.714214","article-title":"Placental CRH as a signal of pregnancy adversity and impact on fetal neurodevelopment","volume":"12","author":"Kassotaki","year":"2021","journal-title":"Front Endocrinol. (lausanne)"},{"key":"10.1016\/j.gene.2023.147951_b0200","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1067\/mob.2000.104201","article-title":"Ethanol exposure induces oxidative stress and impairs nitric oxide availability in the human placental villi: a possible mechanism of toxicity","volume":"182","author":"Kay","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"932\u2013945","key":"10.1016\/j.gene.2023.147951_b0205","first-page":"e937","article-title":"CRH promotes the neurogenic activity of neural stem cells in the adult hippocampus","volume":"29","author":"Koutmani","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2023.147951_b0210","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuroscience.2015.08.058","article-title":"Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain","volume":"342","author":"Lan","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.gene.2023.147951_b0215","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1001\/jamapediatrics.2017.1919","article-title":"Global prevalence of fetal alcohol spectrum disorder among children and youth: a systematic review and meta-analysis","volume":"171","author":"Lange","year":"2017","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.gene.2023.147951_b0220","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40478-017-0444-6","article-title":"PLGF, a placental marker of fetal brain defects after in utero alcohol exposure","volume":"5","author":"Lecuyer","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.gene.2023.147951_b0225","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2023.147951_b0230","doi-asserted-by":"crossref","first-page":"R155","DOI":"10.1530\/REP-20-0231","article-title":"Single cell transcriptome research in human placenta","volume":"160","author":"Li","year":"2020","journal-title":"Reproduction"},{"key":"10.1016\/j.gene.2023.147951_b0235","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2023.147951_b0240","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1159\/000508255","article-title":"IL-17D: a less studied cytokine of IL-17 family","volume":"181","author":"Liu","year":"2020","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.gene.2023.147951_b0245","doi-asserted-by":"crossref","first-page":"130.e131","DOI":"10.1016\/j.ajog.2021.07.028","article-title":"Effects of early daily alcohol exposure on placental function and fetal growth in a rhesus macaque model","volume":"226","author":"Lo","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.gene.2023.147951_b0250","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.gene.2023.147951_b0255","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.3390\/nu15194105","article-title":"Alterations in placental inflammation-related gene expression partially mediate the effects of prenatal alcohol consumption on maternal iron homeostasis","volume":"15","author":"Masehi-Lano","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.gene.2023.147951_b0260","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1542\/peds.2013-3319","article-title":"Prevalence and characteristics of fetal alcohol spectrum disorders","volume":"134","author":"May","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.gene.2023.147951_b0265","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/biom.13214","article-title":"Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies","volume":"76","author":"McCaw","year":"2020","journal-title":"Biometrics"},{"key":"10.1016\/j.gene.2023.147951_b0270","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.nicl.2014.04.001","article-title":"A tensor-based morphometry analysis of regional differences in brain volume in relation to prenatal alcohol exposure","volume":"5","author":"Meintjes","year":"2014","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.gene.2023.147951_b0275","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1101\/gr.207597.116","article-title":"Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface","volume":"27","author":"Pavlicev","year":"2017","journal-title":"Genome Res."},{"key":"10.1016\/j.gene.2023.147951_b0280","doi-asserted-by":"crossref","first-page":"e13016","DOI":"10.1111\/aji.13016","article-title":"Macrophages are a source of IL-17 in the human placenta","volume":"80","author":"Pavlov","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.gene.2023.147951_b0285","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1515\/cclm-2014-0387","article-title":"Role of leptin in female reproduction","volume":"53","author":"P\u00e9rez-P\u00e9rez","year":"2015","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.gene.2023.147951_b0290","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/jcmm.13369","article-title":"Leptin action in normal and pathological pregnancies","volume":"22","author":"P\u00e9rez-P\u00e9rez","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.gene.2023.147951_b0295","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52004","article-title":"Single cell transcriptional signatures of the human placenta in term and preterm parturition","volume":"8","author":"Pique-Regi","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.gene.2023.147951_b0300","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.3389\/fimmu.2018.02628","article-title":"Hofbauer cells: their role in healthy and complicated pregnancy","volume":"9","author":"Reyes","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2023.147951_b0305","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.alcohol.2009.10.002","article-title":"Effects of moderate drinking during pregnancy on placental gene expression","volume":"44","author":"Rosenberg","year":"2010","journal-title":"Alcohol"},{"key":"10.1016\/j.gene.2023.147951_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114121","article-title":"The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposure","volume":"355","author":"Ruffaner-Hanson","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.gene.2023.147951_b0315","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.peptides.2015.03.020","article-title":"Fetal exposure to placental corticotropin-releasing hormone (pCRH) programs developmental trajectories","volume":"72","author":"Sandman","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.gene.2023.147951_b0320","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1017\/S0954579418000664","article-title":"Prenatal CRH: An integrating signal of fetal distress","volume":"30","author":"Sandman","year":"2018","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.gene.2023.147951_b0325","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1176\/appi.ajp.2017.16121433","article-title":"Cortical thinning and neuropsychiatric outcomes in children exposed to prenatal adversity: a role for placental CRH?","volume":"175","author":"Sandman","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.gene.2023.147951_b0330","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/REP-17-0512","article-title":"Involvement of leptin in the molecular physiology of the placenta","volume":"155","author":"Schanton","year":"2018","journal-title":"Reproduction"},{"key":"10.1016\/j.gene.2023.147951_b0335","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.placenta.2007.01.010","article-title":"Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis","volume":"28","author":"Seval","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.gene.2023.147951_b0340","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.alcohol.2017.08.006","article-title":"Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure","volume":"68","author":"Sowell","year":"2018","journal-title":"Alcohol"},{"key":"10.1016\/j.gene.2023.147951_b0345","doi-asserted-by":"crossref","first-page":"607.e601","DOI":"10.1016\/j.ajog.2021.06.078","article-title":"Prenatal alcohol consumption and placental outcomes: a systematic review and meta-analysis of clinical studies","volume":"225","author":"Steane","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.gene.2023.147951_b0350","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/biom7010016","article-title":"Alcohol, Adipose Tissue and Lipid Dysregulation","volume":"7","author":"Steiner","year":"2017","journal-title":"Biomolecules"},{"key":"10.1016\/j.gene.2023.147951_b0355","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.gene.2023.147951_b0360","first-page":"138","article-title":"Placental morphology in fetal alcohol spectrum disorders","volume":"52","author":"Tai","year":"2017","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.gene.2023.147951_b0365","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.2010.05932.x","article-title":"Placental Hofbauer cells and complications of pregnancy","volume":"1221","author":"Tang","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.gene.2023.147951_b0370","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s11481-016-9691-8","article-title":"Effects of moderate prenatal alcohol exposure during early gestation in rats on inflammation across the maternal-fetal-immune interface and later-life immune function in the offspring","volume":"11","author":"Terasaki","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.gene.2023.147951_b0375","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.771054","article-title":"The ontogeny and function of placental macrophages","volume":"12","author":"Thomas","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2023.147951_b0380","doi-asserted-by":"crossref","first-page":"E7786","DOI":"10.1073\/pnas.1710470114","article-title":"Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics","volume":"114","author":"Tsang","year":"2017","journal-title":"PNAS"},{"key":"10.1016\/j.gene.2023.147951_b0385","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41467-018-08023-x","article-title":"Bulk tissue cell type deconvolution with multi-subject single-cell expression reference","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2023.147951_b0390","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1097-0029(19980901)42:5<351::AID-JEMT6>3.0.CO;2-S","article-title":"A microscopical study of wound repair in the human placenta","volume":"42","author":"Watson","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.gene.2023.147951_b0395","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1289\/ehp.1103927","article-title":"In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta","volume":"120","author":"Wilhelm-Benartzi","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.gene.2023.147951_b0400","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.nicl.2015.03.023","article-title":"Parietal dysfunction during number processing in children with fetal alcohol spectrum disorders","volume":"8","author":"Woods","year":"2015","journal-title":"Neuroimage. Clin."},{"key":"10.1016\/j.gene.2023.147951_b0405","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s43032-020-00413-1","article-title":"Alterations to placental glucocorticoid receptor expression with alcohol consumption","volume":"28","author":"Young","year":"2021","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.gene.2023.147951_b0410","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12974-018-1241-2","article-title":"Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain","volume":"15","author":"Zhang","year":"2018","journal-title":"J. Neuroinflam."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923007928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923007928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:07:34Z","timestamp":1759856854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111923007928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":82,"alternative-id":["S0378111923007928"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.147951","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNA-seq analysis reveals prenatal alcohol exposure is associated with placental inflammatory cells and gene expression","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.147951","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"147951"}}