{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:22:05Z","timestamp":1790788925455,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.gene.2023.147976","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T18:56:12Z","timestamp":1699642572000},"page":"147976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Association of epistatic effects of MTHFR, ACE, APOB, and APOE gene polymorphisms with the risk of myocardial infarction and unstable angina in Egyptian patients"],"prefix":"10.1016","volume":"895","author":[{"given":"Mohamed","family":"Taha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Moussa Mohamed","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Sedrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.gene.2023.147976_b0005","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.gene.2016.05.032","article-title":"LDLR, ApoB and ApoE genes polymorphisms and classical risk factors in premature coronary artery disease","volume":"590","author":"Abd El-Aziz","year":"2016","journal-title":"Gene."},{"issue":"2","key":"10.1016\/j.gene.2023.147976_b0010","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/01.ATV.20.2.484","article-title":"ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites","volume":"20","author":"Agerholm-Larsen","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.gene.2023.147976_b0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijcard.2016.04.181","article-title":"C667T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene and susceptibility to myocardial infarction: A systematic review and meta-analysis","volume":"217","author":"Alizadeh","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/1076029616679505","article-title":"The effect of ACE I\/D polymorphisms alone and with concomitant risk factors on coronary artery disease","volume":"24","author":"Amara","year":"2018","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.gene.2023.147976_b0025","doi-asserted-by":"crossref","unstructured":"American Diabetes Association, 2010. Diagnosis and classification of diabetes mellitus. Diabetes Care 33 Suppl 1(Suppl 1):S62-9.","DOI":"10.2337\/dc10-S062"},{"issue":"3","key":"10.1016\/j.gene.2023.147976_b0030","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3844\/ajbbsp.2012.150.156","article-title":"Methylenetetrahydrofolate reductase (677C\/T) polymorphism in myocardial infarction and hypertension","volume":"8","author":"Amin","year":"2012","journal-title":"Am. J. Biochem. Biotechnol."},{"issue":"12","key":"10.1016\/j.gene.2023.147976_b0035","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/s41588-022-01233-6","article-title":"CARDIoGRAMplusC4D consortium. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants","volume":"54","author":"Aragam","year":"2022","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.gene.2023.147976_b0040","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1375\/twin.5.2.87","article-title":"Heritabilities of apolipoprotein and lipid levels in three countries","volume":"5","author":"Beekman","year":"2002","journal-title":"Twin Res."},{"issue":"10","key":"10.1016\/j.gene.2023.147976_b0045","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3390\/metabo11100690","article-title":"Apolipoprotein B and cardiovascular disease: biomarker and potential therapeutic target","volume":"11","author":"Behbodikhah","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.gene.2023.147976_b0050","unstructured":"Brown, J.C., Gerhardt, T.E., Kwon, E., 2023. Risk factors for coronary artery disease. 2023. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing."},{"issue":"Pt 2","key":"10.1016\/j.gene.2023.147976_b0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1469-1809.2005.00241.x","article-title":"Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies","volume":"70","author":"Casas","year":"2006","journal-title":"Ann. Hum. Genet."},{"issue":"5","key":"10.1016\/j.gene.2023.147976_b0060","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/joim.13362","article-title":"Genetics of coronary artery disease in the post-GWAS era","volume":"290","author":"Chen","year":"2021","journal-title":"J. Intern. Med."},{"issue":"7","key":"10.1016\/j.gene.2023.147976_b0065","doi-asserted-by":"crossref","first-page":"e0180365","DOI":"10.1371\/journal.pone.0180365","article-title":"Coronary artery disease-associated genetic variants and biomarkers of inflammation","volume":"12","author":"Christiansen","year":"2017","journal-title":"PLoS One"},{"issue":"641","key":"10.1016\/j.gene.2023.147976_b0070","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.gene.2017.10.043","article-title":"Association of genetic variants of hemostatic genes with myocardial infarction in Egyptian patients","volume":"30","author":"El-Fattah","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.gene.2023.147976_b0075","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12933-016-0329-1","article-title":"Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease","volume":"15","author":"El-Lebedy","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.gene.2023.147976_b0080","article-title":"Coronary artery disease among elderly egyptian patients: I. SocioDemographic, lifestyle, psychosocial, medical, and biochemical risk factors","volume":"1(2):1006","author":"El-Moselhy","year":"2018","journal-title":"Am J Gerentol Geriatr."},{"issue":"8","key":"10.1016\/j.gene.2023.147976_b0085","doi-asserted-by":"crossref","first-page":"2382S","DOI":"10.1093\/jn\/132.8.2382S","article-title":"Gene-nutrient interactions and DNA methylation","volume":"132","author":"Friso","year":"2002","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0090","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.gene.2023.147976_b0095","first-page":"102","article-title":"Epistasis analysis of metabolic genes polymorphisms associated with ischemic heart disease in Yucatan","volume":"30","author":"Garc\u00eda-Gonz\u00e1lez","year":"2018","journal-title":"Clin. Investig. Arterioscler."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12872-022-02562-4","article-title":"Analysis of 61 SNPs from the CAD specific genomic loci reveals unique set of SNPs as significant markers in the Southern Indian population of Hyderabad","volume":"22","author":"Gorre","year":"2022","journal-title":"BMC Cardiovasc. Disord."},{"issue":"3","key":"10.1016\/j.gene.2023.147976_b0105","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3892\/br.2016.717","article-title":"Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction","volume":"5","author":"Hmimech","year":"2016","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.gene.2023.147976_b0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.arr.2017.06.002","article-title":"Evolution of human apolipoprotein E (APOE) isoforms: gene structure, protein function and interaction with dietary factors","volume":"37","author":"Huebbe","year":"2017","journal-title":"Aging Res. Rev."},{"issue":"6","key":"10.1016\/j.gene.2023.147976_b0115","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/01.HYP.26.6.886","article-title":"Hypertension prevalence, awareness, treatment, and control in Egypt: results from the egyptian national hypertension project (NHP)","volume":"26","author":"Ibrahim","year":"1995","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0120","doi-asserted-by":"crossref","first-page":"e32596","DOI":"10.1097\/MD.0000000000032596","article-title":"The LDL-C\/Apo B predicts coronary atherosclerotic heart disease in non-diabetic patients without high LDL-C","volume":"102","author":"Jung","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.gene.2023.147976_b0125","doi-asserted-by":"crossref","unstructured":"Karahan, Z., U\u011furlu, M., U\u00e7aman, B., Ulu\u011f, A.V., Kaya, \u0130., \u00c7evik, K., \u00d6zt\u00fcrk, \u00d6., Iyem, H., 2015. Relation between apolipoprotein E gene polymorphism and severity of coronary artery disease in acute myocardial infarction. Cardiol Res Pract. 2015:363458.","DOI":"10.1155\/2015\/363458"},{"issue":"6","key":"10.1016\/j.gene.2023.147976_b0130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg.2016.160","article-title":"Genetics of coronary artery disease: discovery, biology and clinical translation","volume":"18","author":"Khera","year":"2017","journal-title":"Nat. Rev. Genet."},{"issue":"5","key":"10.1016\/j.gene.2023.147976_b0135","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41569-021-00638-w","article-title":"Clinical utility of polygenic risk scores for coronary artery disease","volume":"19","author":"Klarin","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"11","key":"10.1016\/j.gene.2023.147976_b0140","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1172\/JCI6172","article-title":"Apo E structure determines VLDL clearance and atherosclerosis risk in mice","volume":"103","author":"Knouff","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2023.147976_b0145","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/jama.294.6.691","article-title":"Angiotensin-converting enzyme insertion\/deletion genotype, exercise, and physical decline","volume":"294","author":"Kritchevsky","year":"2005","journal-title":"J. Am. Med. Assoc."},{"issue":"7","key":"10.1016\/j.gene.2023.147976_b0150","doi-asserted-by":"crossref","first-page":"e014146","DOI":"10.1161\/JAHA.119.014146","article-title":"Statistical and functional studies identify epistasis of cardiovascular risk genomic variants from genome-wide association studies","volume":"9","author":"Li","year":"2020","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmg.2014.10.004","article-title":"Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases","volume":"58","author":"Liew","year":"2015","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.gene.2023.147976_b0160","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.12659\/MSM.892111","article-title":"Apo E gene polymorphism affects the development of type 2 diabetic nephropathy in Asian populations, especially in East Asians: an updated meta-analysis","volume":"20","author":"Lin","year":"2014","journal-title":"Medi. Sci. Monit.: Int. Med. J. Exp. Clin. Res."},{"issue":"9","key":"10.1016\/j.gene.2023.147976_b0165","first-page":"16571","article-title":"Polymorphisms in ApoB gene are associated with risk of myocardial infarction and serum ApoB levels in a Chinese population","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"4","key":"10.1016\/j.gene.2023.147976_b0170","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3390\/genes13040631","article-title":"Methylenetetrahydrofolate reductase polymorphism (rs1801133) and the risk of hypertension among african populations: a narrative synthesis of literature","volume":"13","author":"Mabhida","year":"2022","journal-title":"Genes (Basel)"},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0175","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejmhg.2015.08.001","article-title":"Apolipoprotein E gene polymorphism in Egyptian acute coronary syndrome patients","volume":"17","author":"Mahmoud","year":"2016","journal-title":"Egypt. J. Med. Hum. Genetics"},{"key":"10.1016\/j.gene.2023.147976_b0180","doi-asserted-by":"crossref","unstructured":"Malinowski, D., Bochniak, O., Luterek-Puszy\u0144ska, K., Puszy\u0144ski, M., Pawlik, A., 2023. Genetic risk factors related to coronary artery disease and role of transforming growth factor beta 1 polymorphisms. Genes (Basel). 14(7):1425.","DOI":"10.3390\/genes14071425"},{"key":"10.1016\/j.gene.2023.147976_b0185","doi-asserted-by":"crossref","unstructured":"Mallhi, T.H., Shahid, M., Rehman, K., Khan, Y.H., Alanazi, A.S., Alotaibi, N.H., Akash, M.S.H., Butt, M.H., 2023. Biochemical association of MTHFR C677T polymorphism with myocardial infarction in the presence of diabetes mellitus as a risk factor. Metabolites. 13(2):251.","DOI":"10.3390\/metabo13020251"},{"issue":"3","key":"10.1016\/j.gene.2023.147976_b0190","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1160\/TH05-11-0777","article-title":"Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction","volume":"95","author":"Mannila","year":"2006","journal-title":"Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.gene.2023.147976_b0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pathol.2018.11.002","article-title":"Apolipoprotein E in lipoprotein metabolism, health, and cardiovascular disease","volume":"51","author":"Marais","year":"2019","journal-title":"Pathology"},{"issue":"4","key":"10.1016\/j.gene.2023.147976_b0200","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.115.306566","article-title":"Genetics of coronary artery disease","volume":"118","author":"McPherson","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0205","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/ije\/dyq165","article-title":"World Health Organization definition of myocardial infarction: 2008\u201309 revision","volume":"40","author":"Mendis","year":"2011","journal-title":"Int. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0210","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.numecd.2006.09.005","article-title":"Glycated apolipoprotein B and myocardial infarction","volume":"17","author":"Misciagna","year":"2007","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.gene.2023.147976_b0215","first-page":"100701","article-title":"Role of angiotensin-converting enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction","volume":"32","author":"Moorthy","year":"2021","journal-title":"Int. J. Cardiol. Heart Vasc."},{"issue":"7","key":"10.1016\/j.gene.2023.147976_b0220","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jbt.21500","article-title":"Angiotensin-converting enzyme inhibition and angiotensin AT1 receptor blockade downregulate angiotensin-converting enzyme expression and attenuate renal injury in streptozotocin-induced diabetic rats","volume":"27","author":"Motawi","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0225","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ihj.2022.11.014","article-title":"Novel lipid biomarkers and associated gene polymorphism in young ST-segment elevation myocardial infarction","volume":"75","author":"Muheeb","year":"2023","journal-title":"Indian Heart J."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0230","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2019.02.015","article-title":"Genetics of common, complex coronary artery disease","volume":"177","author":"Musunuru","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.gene.2023.147976_b0235","unstructured":"National High Blood Pressure Education Program. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Bethesda (MD): National Heart, Lung, and Blood Institute (US); 2004. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK9630\/."},{"issue":"4","key":"10.1016\/j.gene.2023.147976_b0240","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5758\/vsi.2014.30.4.113","article-title":"Clinical implications of methylenetetrahydrofolate reductase mutations and plasma homocysteine levels in patients with thromboembolic occlusion","volume":"30","author":"Park","year":"2014","journal-title":"Vasc Spec Int."},{"issue":"4","key":"10.1016\/j.gene.2023.147976_b0245","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/01.CIR.94.4.708","article-title":"A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction","volume":"94","author":"Samani","year":"1996","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.gene.2023.147976_b0250","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1177\/0003319713511849","article-title":"Apolipoprotein B\/Apolipoprotein A-I Ratio and Apolipoprotein B: Long-Term Predictors of Myocardial Infarction in Initially Healthy Middle-Aged Men-a 13-Year Follow-Up","volume":"65","author":"Schmidt","year":"2014","journal-title":"Angiology"},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0255","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12920-023-01635-3","article-title":"Association of integrin-\u03b22 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients","volume":"16","author":"Selim","year":"2023","journal-title":"BMC Med. Genomics"},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0260","doi-asserted-by":"crossref","first-page":"12299","DOI":"10.1038\/s41598-019-48770-5","article-title":"Association of MTMR3 rs12537 at miR-181a binding site with rheumatoid arthritis and systemic lupus erythematosus risk in Egyptian patients","volume":"9","author":"Senousy","year":"2019","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.gene.2023.147976_b0265","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/acschemneuro.0c00150","article-title":"LncRNA GAS5 and miR-137 polymorphisms and expression are associated with multiple sclerosis risk: mechanistic insights and potential clinical impact","volume":"11","author":"Senousy","year":"2020","journal-title":"ACS Chem. Nerosci."},{"issue":"2","key":"10.1016\/j.gene.2023.147976_b0270","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1470320309105198","article-title":"Angiotensin-converting enzyme gene insertion\/deletion polymorphism in Egyptian patients with myocardial infarction","volume":"10","author":"Settin","year":"2009","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.gene.2023.147976_b0275","unstructured":"Shahjehan, R.D., Bhutta, B.S., 2023. Coronary Artery Disease. [Updated 2023 Feb 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK564304\/."},{"issue":"2","key":"10.1016\/j.gene.2023.147976_b0280","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12013-013-9794-2","article-title":"Association of genetic variants of MTHFR, ENPP1, and ADIPOQ with myocardial infarction in Egyptian patients","volume":"69","author":"Shaker","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0285","doi-asserted-by":"crossref","first-page":"e220","DOI":"10.1016\/j.clbc.2018.09.004","article-title":"Association of SNP-SNP interactions between RANKL, OPG, CHI3L1, and VDR genes with breast cancer risk in Egyptian women","volume":"19","author":"Shaker","year":"2019","journal-title":"Clin. Breast Cancer"},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0290","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12872-022-02566-0","article-title":"Meta-analysis of the association between Apolipoprotein E polymorphism and risks of myocardial infarction","volume":"22","author":"Shao","year":"2022","journal-title":"BMC Cardiovasc. Disord."},{"issue":"2","key":"10.1016\/j.gene.2023.147976_b0295","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/ATVBAHA.107.157248","article-title":"Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease","volume":"28","author":"Shen","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.gene.2023.147976_b0300","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/clinchem\/41.8.1068","article-title":"Apolipoprotein E: an important gene and protein to follow in laboratory medicine","volume":"41","author":"Siest","year":"1995","journal-title":"Clin. Chem."},{"issue":"882","key":"10.1016\/j.gene.2023.147976_b0305","article-title":"Screening and evaluation of TBX20 and CITED2 mutations in children with congenital cardiac septal defects: Correlation with cardiac troponin T and caspase-3","volume":"5","author":"Taha","year":"2023","journal-title":"Gene"},{"key":"10.1016\/j.gene.2023.147976_b0310","doi-asserted-by":"crossref","first-page":"1091612","DOI":"10.3389\/fcvm.2023.1091612","article-title":"Association between ACE I\/D genetic polymorphism and the severity of coronary artery disease in Vietnamese patients with acute myocardial infarction","volume":"10","author":"Tran","year":"2023","journal-title":"Front Cardiovasc Med."},{"issue":"7","key":"10.1016\/j.gene.2023.147976_b0315","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/aps.2010.68","article-title":"Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD","volume":"31","author":"Tu","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"issue":"22","key":"10.1016\/j.gene.2023.147976_b0320","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJM199805283382203","article-title":"Association of mutations in the apolipoprotein B gene with hypercholesterolemia and the risk of ischemic heart disease","volume":"338","author":"Tybj\u00e6rg-Hansen","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.gene.2023.147976_b0325","first-page":"3303","article-title":"Correlation of ApoE gene polymorphism with acute myocardial infarction and aspirin resistance after percutaneous coronary intervention","volume":"14","author":"Wang","year":"2022","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.gene.2023.147976_b0330","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.fob.2015.10.006","article-title":"Association between Apolipoprotein E polymorphism and myocardial infarction risk: a systematic review and meta-analysis","volume":"5","author":"Wang","year":"2015","journal-title":"FEBS Open Biol."},{"issue":"15","key":"10.1016\/j.gene.2023.147976_b0335","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1001\/archinternmed.2009.234","article-title":"APOE genotype, lipids, and coronary heart disease risk: a prospective population study","volume":"169","author":"Ward","year":"2009","journal-title":"Arch. Intern. Med."},{"issue":"3","key":"10.1016\/j.gene.2023.147976_b0340","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/mgme.1998.2714","article-title":"A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity","volume":"64","author":"Weisberg","year":"1998","journal-title":"Mol. Genet. Metab."},{"issue":"8","key":"10.1016\/j.gene.2023.147976_b0345","doi-asserted-by":"crossref","first-page":"e104608","DOI":"10.1371\/journal.pone.0104608","article-title":"Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.gene.2023.147976_b0350","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1161\/01.HYP.37.3.851","article-title":"Ace D\/I polymorphism and incidence of post-PTCA restenosis: a prospective, angiography-based evaluation","volume":"37","author":"Zee","year":"2001","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.gene.2023.147976_b0355","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/cvr\/cvab136","article-title":"Cis-epistasis at the LPA locus and risk of cardiovascular diseases","volume":"118","author":"Zeng","year":"2022","journal-title":"Cardiovasc. Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192300817X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192300817X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T22:27:43Z","timestamp":1736375263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811192300817X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":71,"alternative-id":["S037811192300817X"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.147976","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of epistatic effects of MTHFR, ACE, APOB, and APOE gene polymorphisms with the risk of myocardial infarction and unstable angina in Egyptian patients","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.147976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147976"}}