{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:27:54Z","timestamp":1784892474742,"version":"3.55.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["6181"],"award-info":[{"award-number":["6181"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.gene.2023.148003","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:06:57Z","timestamp":1700075217000},"page":"148003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Epigallocatechin-3-gallate maintains Th1\/Th2 response balance and mitigates type-1 autoimmune diabetes induced by streptozotocin through promoting the effect of bone-marrow-derived mesenchymal stem cells"],"prefix":"10.1016","volume":"894","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-8628","authenticated-orcid":false,"given":"Fatemeh","family":"Ahmadzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mozhgan","family":"Esmaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed","family":"Ehsan Enderami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Azadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4287-2670","authenticated-orcid":false,"given":"Saeid","family":"Abediankenari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.gene.2023.148003_b0005","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.4049\/jimmunol.173.9.5794","article-title":"Green tea epigallocatechin-3-gallate mediates T cellular NF-\u03baB inhibition and exerts neuroprotection in autoimmune encephalomyelitis","volume":"173","author":"Aktas","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2023.148003_b0010","article-title":"EGCG maintains Th1\/Th2 balance and mitigates ulcerative colitis induced by dextran sulfate sodium through TLR4\/MyD88\/NF-\u03baB signaling pathway in rats. Canadian","volume":"2017","author":"Bing","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.gene.2023.148003_b0015","first-page":"373","article-title":"Shifting the imbalance from Th1\/Th2 to Th17\/treg: the changing rheumatoid arthritis paradigm","author":"Boissier","year":"2008","journal-title":"Elsevier"},{"issue":"12","key":"10.1016\/j.gene.2023.148003_b0020","doi-asserted-by":"crossref","first-page":"e636","DOI":"10.1016\/j.lpm.2012.10.003","article-title":"Pancreatic islet autoimmunity","volume":"41","author":"Boitard","year":"2012","journal-title":"Presse Med."},{"issue":"08","key":"10.1016\/j.gene.2023.148003_b0025","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1055\/s-0043-109000","article-title":"Environmental risk factors for type 1 diabetes mellitus development","volume":"125","author":"Boljat","year":"2017","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.gene.2023.148003_b0030","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fimmu.2020.00054","article-title":"The immunomodulatory properties of the human amnion-derived mesenchymal stromal\/stem cells are induced by INF-\u03b3 produced by activated lymphomonocytes and are mediated by cell-to-cell contact and soluble factors","volume":"11","author":"Bulati","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2023.148003_b0035","doi-asserted-by":"crossref","unstructured":"Cameron, M.J., Arreaza, G.A., Zucker, P., Chensue, S.W., Strieter, R.M., Chakrabarti, S., et al. 1997. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J. Immunol. (Baltimore, Md: 1950). 159(10):4686-92. Doi: 10.4049\/jimmunol.159.10.4686.","DOI":"10.4049\/jimmunol.159.10.4686"},{"issue":"8","key":"10.1016\/j.gene.2023.148003_b0040","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/stem.117","article-title":"Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells","volume":"27","author":"Chandra","year":"2009","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.gene.2023.148003_b0045","doi-asserted-by":"crossref","first-page":"e0126537","DOI":"10.1371\/journal.pone.0126537","article-title":"High glucose induces bone marrow-derived mesenchymal stem cell senescence by upregulating autophagy","volume":"10","author":"Chang","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.gene.2023.148003_b0050","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1152\/japplphysiol.00471.2016","article-title":"Green tea epigallocatechin gallate enhances cardiac function restoration through survival signaling expression in diabetes mellitus rats with autologous adipose tissue-derived stem cells","volume":"123","author":"Chen","year":"2017","journal-title":"J. Appl. Physiol."},{"issue":"6","key":"10.1016\/j.gene.2023.148003_b0055","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.3390\/ijms23063165","article-title":"Adipose-derived stem cells preincubated with green tea EGCG enhance pancreatic tissue regeneration in rats with type 1 diabetes through ROS\/Sirt1 signaling regulation","volume":"23","author":"Chen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.gene.2023.148003_b0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.yjmcc.2008.04.003","article-title":"Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE\u2212\/\u2212 mice through modulation of Th1\/Th2 balance","volume":"45","author":"Cheng","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.gene.2023.148003_b0065","doi-asserted-by":"crossref","unstructured":"Cheung, T.S., Dazzi, F. 2018. editors. Mesenchymal-myeloid interaction in the regulation of immunity. Semin. Immunol. Elsevier. Doi: 10.1016\/j.smim.2018.01.002.","DOI":"10.1016\/j.smim.2018.01.002"},{"issue":"5","key":"10.1016\/j.gene.2023.148003_b0070","doi-asserted-by":"crossref","first-page":"328","DOI":"10.5966\/sctm.2012-0116","article-title":"Stem cell therapy to cure type 1 diabetes: from hype to hope","volume":"2","author":"Chhabra","year":"2013","journal-title":"Stem Cells Transl. Med."},{"issue":"12","key":"10.1016\/j.gene.2023.148003_b0075","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1089\/scd.2010.0009","article-title":"Persistent high glucose concentrations alter the regenerative potential of mesenchymal stem cells","volume":"19","author":"Cramer","year":"2010","journal-title":"Stem Cells Dev."},{"issue":"24","key":"10.1016\/j.gene.2023.148003_b0080","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1001\/jama.297.24.2716","article-title":"Incidence of diabetes in youth in the United States","volume":"297","author":"Dabelea","year":"2007","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.gene.2023.148003_b0085","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.hbpd.2021.03.008","article-title":"In vitro-derived insulin-producing cells modulate Th1 immune responses and induce IL-10 in streptozotocin-induced mouse model of pancreatic insulitis","volume":"20","author":"Daryabor","year":"2021","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"issue":"1","key":"10.1016\/j.gene.2023.148003_b0090","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/17450390903169138","article-title":"Effect of dietary tea polyphenols on growth performance and cell-mediated immune response of post-weaning piglets under oxidative stress","volume":"64","author":"Deng","year":"2010","journal-title":"Arch. Anim. Nutr."},{"issue":"2","key":"10.1016\/j.gene.2023.148003_b0095","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0891-6632(88)90002-5","article-title":"Type I diabetes as a chronic autoimmune disease","volume":"2","author":"Eisenbarth","year":"1988","journal-title":"J. Diabet. Complicat."},{"issue":"suppl_1","key":"10.1016\/j.gene.2023.148003_b0100","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.2337\/diabetes.50.2007.S64","article-title":"beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes","volume":"50","author":"Eizirik","year":"2001","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.gene.2023.148003_b0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/mt.2011.189","article-title":"Human MSC suppression correlates with cytokine induction of indoleamine 2, 3-dioxygenase and bystander M2 macrophage differentiation","volume":"20","author":"Fran\u00e7ois","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2023.148003_b0110","first-page":"611","article-title":"Effect of epigallocatechin gallate on Th1\/Th2 immune balance in patients with plaque-type psoriasis","author":"Fu","year":"2019","journal-title":"Chin. J. Dermatol."},{"issue":"8","key":"10.1016\/j.gene.2023.148003_b0115","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1017\/S0007114510004824","article-title":"Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice","volume":"105","author":"Fu","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.gene.2023.148003_b0120","article-title":"Mesenchymal stem cells and immunomodulation: current status and future prospects","volume":"7(1):e2062-e","author":"Gao","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2023.148003_b0125","doi-asserted-by":"crossref","first-page":"3562753","DOI":"10.1155\/2020\/3562753","article-title":"The Sufficient Immunoregulatory Effect of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation on Regulatory T Cells in Patients with Refractory Rheumatoid Arthritis","volume":"2020","author":"Ghoryani","year":"2020","journal-title":"J. Immunol. Res."},{"issue":"2","key":"10.1016\/j.gene.2023.148003_b0130","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/emm.2003.19","article-title":"Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic \u03b2-cell damage","volume":"35","author":"Han","year":"2003","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.gene.2023.148003_b0135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.trim.2010.04.006","article-title":"The immunosuppressive effect of embryonic stem cells and mesenchymal stem cells on both primary and secondary alloimmune responses","volume":"23","author":"Han","year":"2010","journal-title":"Transpl. Immunol."},{"issue":"3","key":"10.1016\/j.gene.2023.148003_b0140","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.3892\/mmr.2017.7018","article-title":"Epigallocatechin gallate attenuates overload-induced cardiac ECM remodeling via restoring T cell homeostasis","volume":"16","author":"Han","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.gene.2023.148003_b0145","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00534-006-1207-0","article-title":"Green-tea polyphenol (-)-epigallocatechin-3-gallate provides resistance to apoptosis in isolated islets","volume":"14","author":"Hara","year":"2007","journal-title":"J. Hepatobiliary Pancreat. Surg."},{"key":"10.1016\/j.gene.2023.148003_b0150","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s10787-019-00661-x","article-title":"Investigating the route of administration and efficacy of adipose tissue-derived mesenchymal stem cells and conditioned medium in type 1 diabetic mice","volume":"28","author":"Hashemi","year":"2020","journal-title":"Inflammopharmacology"},{"issue":"15","key":"10.1016\/j.gene.2023.148003_b0155","first-page":"2989","article-title":"NFAT pulls the strings during CD4+ T helper cell effector functions","volume":"115","author":"Hermann-Kleiter","year":"2010","journal-title":"Blood, J. Am. Soc. Hematol."},{"issue":"3","key":"10.1016\/j.gene.2023.148003_b0160","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.4049\/jimmunol.1000788","article-title":"IL-17 immunity in human type 1 diabetes","volume":"185","author":"Honkanen","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2023.148003_b0165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/MOT.0000000000000036","article-title":"Mesenchymal stromal cells for organ transplantation: different sources and unique characteristics?","volume":"19","author":"Hoogduijn","year":"2014","journal-title":"Curr. Opin. Organ Transplant."},{"issue":"1","key":"10.1016\/j.gene.2023.148003_b0170","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/icb.2012.64","article-title":"Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells","volume":"91","author":"Jacobs","year":"2013","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.gene.2023.148003_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2020.104236","article-title":"Regulating the regulators: Is introduction of an antigen-specific approach in regulatory T cells the next step to treat autoimmunity?","volume":"358","author":"Janssens","year":"2020","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.gene.2023.148003_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11892-017-0916-x","article-title":"The role of epigenetics in type 1 diabetes","volume":"17","author":"Jerram","year":"2017","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.gene.2023.148003_b0185","doi-asserted-by":"crossref","unstructured":"Jin, P., Zhang, X., Wu, Y., Li, L., Yin, Q., Zheng, L., et al. 2010. editors. Streptozotocin-induced diabetic rat\u2013derived bone marrow mesenchymal stem cells have impaired abilities in proliferation, paracrine, antiapoptosis, and myogenic differentiation. Transplant. Proc.: Elsevier. Doi: 10.1016\/j.transproceed.2010.05.145.","DOI":"10.1016\/j.transproceed.2010.05.145"},{"key":"10.1016\/j.gene.2023.148003_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02173-4","article-title":"Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration","volume":"12","author":"Khatri","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"10.1016\/j.gene.2023.148003_b0195","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cyto.2014.06.013","article-title":"The cytokine production of peripheral blood mononuclear cells reflects the autoantibody profile of patients suffering from type 1 diabetes","volume":"69","author":"Labikova","year":"2014","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.gene.2023.148003_b0200","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbrc.2007.08.161","article-title":"Effects of high glucose on mesenchymal stem cell proliferation and differentiation","volume":"363","author":"Li","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.gene.2023.148003_b0205","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/1440-1681.12652","article-title":"Epigallocatechin-3-gallate augments therapeutic effects of mesenchymal stem cells in skin wound healing","volume":"43","author":"Li","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.gene.2023.148003_b0210","first-page":"14","article-title":"T cells and their products in diabetic kidney disease","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.gene.2023.148003_b0215","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1006\/bcmd.2001.0424","article-title":"Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep","volume":"27","author":"Mackenzie","year":"2001","journal-title":"Blood Cell Mol. Dis."},{"key":"10.1016\/j.gene.2023.148003_b0220","first-page":"1","article-title":"CTLA4-Ig alleviates the allogeneic immune responses against insulin-producing cells in a murine model of cell transplantation","author":"Mardomi","year":"2023","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"7","key":"10.1016\/j.gene.2023.148003_b0225","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.4049\/jimmunol.178.7.4623","article-title":"The chemokine binding protein M3 prevents diabetes induced by multiple low doses of streptozotocin","volume":"178","author":"Martin","year":"2007","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2023.148003_b0230","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/nyas.14106","article-title":"Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance","volume":"1461","author":"Martinov","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.gene.2023.148003_b0235","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S2213-8587(19)30412-7","article-title":"Type 1 diabetes\u2014early life origins and changing epidemiology","volume":"8","author":"Norris","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"8","key":"10.1016\/j.gene.2023.148003_b0240","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3945\/jn.110.124743","article-title":"Epigallocatechin-3-gallate directly suppresses T cell proliferation through impaired IL-2 utilization and cell cycle progression","volume":"140","author":"Pae","year":"2010","journal-title":"J. Nutr."},{"key":"10.1016\/j.gene.2023.148003_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2018.10.005","article-title":"Stem cells in the treatment of diabetes mellitus\u2014Focus on mesenchymal stem cells","volume":"90","author":"P\u00e4th","year":"2019","journal-title":"Metabolism"},{"issue":"8","key":"10.1016\/j.gene.2023.148003_b0250","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0006-2952(97)00492-9","article-title":"Cytokines and their roles in pancreatic islet \u03b2-cell destruction and insulin-dependent diabetes mellitus","volume":"55","author":"Rabinovitch","year":"1998","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.gene.2023.148003_b0255","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cellimm.2008.04.009","article-title":"The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function","volume":"251","author":"Ramasamy","year":"2008","journal-title":"Cell. Immunol."},{"issue":"3","key":"10.1016\/j.gene.2023.148003_b0260","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41574-020-00443-4","article-title":"Type 1 diabetes mellitus as a disease of the \u03b2-cell (do not blame the immune system?)","volume":"17","author":"Roep","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.gene.2023.148003_b0265","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1074-7613(00)80195-8","article-title":"B7\/CD28 costimulation is essential for the homeostasis of the CD4+ CD25+ immunoregulatory T cells that control autoimmune diabetes","volume":"12","author":"Salomon","year":"2000","journal-title":"Immunity"},{"issue":"2\u20133","key":"10.1016\/j.gene.2023.148003_b0270","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejphar.2010.05.054","article-title":"Epigallocatechin gallate protects H9c2 cardiomyoblasts against hydrogen dioxides-induced apoptosis and telomere attrition","volume":"641","author":"Sheng","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.gene.2023.148003_b0275","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/BF02976881","article-title":"Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice","volume":"26","author":"Song","year":"2003","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.gene.2023.148003_b0280","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2741\/4104","article-title":"Novel immunoregulatory properties of EGCG on reducing inflammation in EAE","volume":"18","author":"Sun","year":"2013","journal-title":"Front. Biosci.-Landmark."},{"issue":"11","key":"10.1016\/j.gene.2023.148003_b0285","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0006-2952(01)00818-8","article-title":"Positive modulation by Ras of interleukin-1\u03b2-mediated nitric oxide generation in insulin-secreting clonal \u03b2 (HIT-T15) cells","volume":"62","author":"Tannous","year":"2001","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.gene.2023.148003_b0290","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.gene.2023.148003_b0295","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00125-021-05398-3","article-title":"Current and future therapies for type 1 diabetes","volume":"64","author":"von Scholten","year":"2021","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.gene.2023.148003_b0300","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nrd3402","article-title":"Immunomodulatory therapy to preserve pancreatic \u03b2-cell function in type 1 diabetes","volume":"10","author":"Waldron-Lynch","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.gene.2023.148003_b0305","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/mnfr.201200035","article-title":"Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis","volume":"56","author":"Wang","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"issue":"12","key":"10.1016\/j.gene.2023.148003_b0310","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.3390\/molecules26123755","article-title":"Immunomodulatory effects of green tea polyphenols","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.gene.2023.148003_b0315","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00109-012-0964-2","article-title":"Green tea epigallocatechin-3-gallate modulates differentiation of na\u00efve CD4+ T cells into specific lineage effector cells","volume":"91","author":"Wang","year":"2013","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.gene.2023.148003_b0320","doi-asserted-by":"crossref","unstructured":"Wu, M., Che, S., Wu, K., Zhu, M., Peng, C., Yang, G. 2023. EGCG ameliorates DSS-induced colitis potentially via suppressing GPR43-mediated Th1 polarization, 16 February 2023, PREPRINT (Version 1) available at Research Square Doi: 10.21203\/rs.3.rs-2566908\/v1.","DOI":"10.21203\/rs.3.rs-2566908\/v1"},{"issue":"5","key":"10.1016\/j.gene.2023.148003_b0325","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.freeradbiomed.2009.06.001","article-title":"Green tea EGCG suppresses T cell proliferation through impairment of IL-2\/IL-2 receptor signaling","volume":"47","author":"Wu","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.gene.2023.148003_b0330","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/mnfr.200800495","article-title":"Naturally occurring flavonoids attenuate high glucose-induced expression of proinflammatory cytokines in human monocytic THP-1 cells","volume":"53","author":"Wu","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.gene.2023.148003_b0335","doi-asserted-by":"crossref","unstructured":"Wynn, T.A. 2015. Type 2 cytokines: mechanisms and therapeutic strategies. Nat. Rev. Immunol. 15(5):271-82. Doi: doi.org\/10.1038\/nri3831.","DOI":"10.1038\/nri3831"},{"key":"10.1016\/j.gene.2023.148003_b0340","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00441-016-2499-2","article-title":"Mesenchymal stem cells moderate immune response of type 1 diabetes","volume":"368","author":"Xv","year":"2017","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.gene.2023.148003_b0345","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3389\/fimmu.2017.01508","article-title":"Interleukin-4 supports the suppressive immune responses elicited by regulatory T cells","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.gene.2023.148003_b0350","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1017\/S000711451000005X","article-title":"Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. lean volunteers","volume":"103","author":"Yun","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.gene.2023.148003_b0355","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00109-011-0816-5","article-title":"The imbalance of Th17\/Th1\/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications","volume":"90","author":"Zeng","year":"2012","journal-title":"J. Mol. Med."},{"issue":"4","key":"10.1016\/j.gene.2023.148003_b0360","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.humimm.2014.02.007","article-title":"The alteration of Th1\/Th2\/Th17\/Treg paradigm in patients with type 2 diabetes mellitus: relationship with diabetic nephropathy","volume":"75","author":"Zhang","year":"2014","journal-title":"Hum. Immunol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923008442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923008442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:11:17Z","timestamp":1759857077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111923008442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":72,"alternative-id":["S0378111923008442"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.148003","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigallocatechin-3-gallate maintains Th1\/Th2 response balance and mitigates type-1 autoimmune diabetes induced by streptozotocin through promoting the effect of bone-marrow-derived mesenchymal stem cells","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.148003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"148003"}}