{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:36:00Z","timestamp":1790019360384,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.gene.2023.148023","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:23:04Z","timestamp":1700760184000},"page":"148023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["MTNR1B gene variations and high pre-pregnancy BMI increase gestational diabetes mellitus risk in Chinese women"],"prefix":"10.1016","volume":"894","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3254-9105","authenticated-orcid":false,"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-2104","authenticated-orcid":false,"given":"Hongsong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2023.148023_b0005","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.3390\/ijms21145003","article-title":"Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes","volume":"21","author":"Alejandro","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2023.148023_b0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5144\/0256-4947.2019.309","article-title":"MTNR1B genetic polymorphisms as risk factors for gestational diabetes mellitus: a case-control study in a single tertiary care center","volume":"39","author":"Alharbi","year":"2019","journal-title":"Ann. Saudi Med."},{"key":"10.1016\/j.gene.2023.148023_b0015","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s40618-015-0427-z","article-title":"Predicting gestational diabetes mellitus during the first trimester using anthropometric measurements and HOMA-IR","volume":"39","author":"Alptekin","year":"2016","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.gene.2023.148023_b0020","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10654-005-7835-x","article-title":"Calculating measures of biological interaction","volume":"20","author":"Andersson","year":"2005","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.gene.2023.148023_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2019.144302","article-title":"The roles of ADIPOQ rs266729 and MTNR1B rs10830963 polymorphisms in patients with gestational diabetes mellitus: A meta-analysis","volume":"730","author":"Bai","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.gene.2023.148023_b0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ng.277","article-title":"A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk","volume":"41","author":"Bouatia-Naji","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.gene.2023.148023_b0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","article-title":"Mammalian melatonin receptors: molecular biology and signal transduction","volume":"309","author":"Charlotte Von Gall","year":"2002","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.gene.2023.148023_b0040","first-page":"e202183","article-title":"Estimated global overweight and obesity burden in pregnant women based on panel data model","volume":"13","author":"Chen","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2023.148023_b0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123734","article-title":"The MTNR1B rs10830963 Variant in Interaction with Pre-Pregnancy BMI is a Pharmacogenetic Marker for the Initiation of Antenatal Insulin Therapy in Gestational Diabetes Mellitus","volume":"19","author":"Firneisz","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gene.2023.148023_b0050","doi-asserted-by":"crossref","unstructured":"Huang B, Wang YK, Qin LY, Wei Q, Liu N, Jiang M, et al. A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus. Biosci Rep 2019;39(12): BSR20190744. 10.1042\/BSR20190744.","DOI":"10.1042\/BSR20190744"},{"key":"10.1016\/j.gene.2023.148023_b0055","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00438-020-01706-5","article-title":"MTNR1B gene on susceptibility to gestational diabetes mellitus: a two-stage hospital-based study in Southern China","volume":"295","author":"Jia","year":"2020","journal-title":"Mol Genet Genomics"},{"key":"10.1016\/j.gene.2023.148023_b0060","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.tem.2018.09.004","article-title":"Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications","volume":"29","author":"Johns","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.gene.2023.148023_b0065","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.gene.2015.05.024","article-title":"The MTNR1B gene polymorphism rs10830963 is associated with gestational diabetes in a Brazilian population","volume":"568","author":"Junior","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.gene.2023.148023_b0070","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/ije\/dyr218","article-title":"Recommendations for presenting analyses of effect modification and interaction","volume":"41","author":"Knol","year":"2012","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.gene.2023.148023_b0075","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2337\/db11-1034","article-title":"A genome-wide association study of gestational diabetes mellitus in Korean women","volume":"61","author":"Kwak","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.gene.2023.148023_b0080","doi-asserted-by":"crossref","first-page":"e11786","DOI":"10.1016\/j.heliyon.2022.e11786","article-title":"Melatonin receptor 1B gene rs10830963 C\/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants","volume":"8","author":"Li","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.gene.2023.148023_b0085","first-page":"955","article-title":"Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf-1\/ERK signaling pathway","volume":"41","author":"Li","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.gene.2023.148023_b0090","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1177\/1933719118765983","article-title":"Association Between a Melatonin Receptor 1B Genetic Polymorphism and Its Protein Expression in Gestational Diabetes Mellitus","volume":"26","author":"Li","year":"2019","journal-title":"Reprod Sci"},{"key":"10.1016\/j.gene.2023.148023_b0095","doi-asserted-by":"crossref","first-page":"e40113","DOI":"10.1371\/journal.pone.0040113","article-title":"Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women","volume":"7","author":"Liao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2023.148023_b0100","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2147\/DMSO.S345036","article-title":"Melatonin Receptor 1B Genetic Variants on Susceptibility to Gestational Diabetes Mellitus: A Hospital-Based Case-Control Study in Wuhan","volume":"15","author":"Liu","year":"2022","journal-title":"Central China. Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.gene.2023.148023_b0105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3904\/kjim.2016.203","article-title":"Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus","volume":"32","author":"Moon","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.gene.2023.148023_b0110","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1007\/s00125-009-1359-y","article-title":"Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene","volume":"52","author":"Mulder","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.gene.2023.148023_b0115","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/07853890.2010.502125","article-title":"Genetic variants in MTNR1B affecting insulin secretion","volume":"42","author":"M\u00fcssig","year":"2010","journal-title":"Ann Med"},{"key":"10.1016\/j.gene.2023.148023_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2021.06.018","article-title":"Risk of gestational diabetes mellitus by pre-pregnancy body mass index: A systematic review and meta-analysis","volume":"15","author":"Najafi","year":"2021","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.gene.2023.148023_b0125","first-page":"737","article-title":"Application of SAS macro to evaluated multiplicative and additive interaction in logistic and Cox regression in clinical practices","volume":"37","author":"Nie","year":"2016","journal-title":"Chinese Journal of Epidemiology"},{"key":"10.1016\/j.gene.2023.148023_b0130","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3945\/ajcn.115.121178","article-title":"Universal equation for estimating ideal body weight and body weight at any BMI","volume":"103","author":"Peterson","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.gene.2023.148023_b0135","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1101\/gad.1550907","article-title":"Mechanisms of obesity-associated insulin resistance: many choices on the menu","volume":"21","author":"Qatanani","year":"2007","journal-title":"Genes Dev"},{"issue":"16","key":"10.1016\/j.gene.2023.148023_b0140","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1097\/BRS.0b013e3180b9f0ff","article-title":"Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis","volume":"32","author":"Qiu","year":"2007","journal-title":"Spine (phila Pa 1976)"},{"key":"10.1016\/j.gene.2023.148023_b0145","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s00125-009-1297-8","article-title":"A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals","volume":"52","author":"R\u00f6nn","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.gene.2023.148023_b0150","first-page":"78","article-title":"Meta-analysis of the association between MTNR1B rs10830963 gene polymorphism and type 2 diabetes in Chinese population","volume":"16","author":"Shanshan","year":"2021","journal-title":"Chinese Medicinal Biotechnology"},{"key":"10.1016\/j.gene.2023.148023_b0155","doi-asserted-by":"crossref","first-page":"e611","DOI":"10.1002\/mgg3.611","article-title":"Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A meta-analysis","volume":"7","author":"Shen","year":"2019","journal-title":"Mol Genet Genomic Med"},{"key":"10.1016\/j.gene.2023.148023_b0160","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12884-022-04615-0","article-title":"Prediction of gestational diabetes mellitus by different obesity indices","volume":"22","author":"Song","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.gene.2023.148023_b0165","doi-asserted-by":"crossref","first-page":"e3962","DOI":"10.1371\/journal.pone.0003962","article-title":"Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function","volume":"3","author":"Staiger","year":"2008","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.gene.2023.148023_b0170","doi-asserted-by":"crossref","first-page":"e003324","DOI":"10.1136\/bmjdrc-2023-003324","article-title":"Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China","volume":"11","author":"Sun","year":"2023","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1016\/j.gene.2023.148023_b0175","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/joim.12994","article-title":"Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank","volume":"287","author":"Tan","year":"2020","journal-title":"J Intern Med"},{"key":"10.1016\/j.gene.2023.148023_b0180","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/09513590.2016.1276556","article-title":"MTNR1A and MTNR1B gene polymorphisms in women with gestational diabetes","volume":"33","author":"Tarnowski","year":"2017","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"10.1016\/j.gene.2023.148023_b0185","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2016.04.009","article-title":"Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes","volume":"2","author":"Tuomi","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.gene.2023.148023_b0190","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.orcp.2021.10.005","article-title":"Impact of maternal pre-pregnancy body mass index on maternal, fetal and neonatal adverse outcomes in the worldwide populations: A systematic review and meta-analysis","volume":"15","author":"Vats","year":"2021","journal-title":"Obes Res Clin Pract"},{"key":"10.1016\/j.gene.2023.148023_b0195","article-title":"The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal Glucose","volume":"13","author":"Vejrazkova","year":"2022","journal-title":"Insulin and C-Peptide Kinetics. Front Endocrinol (lausanne)"},{"key":"10.1016\/j.gene.2023.148023_b0200","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/oby.23517","article-title":"BMI and lipidomic biomarkers with risk of gestational diabetes in pregnant women","volume":"30","author":"Wang","year":"2022","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.gene.2023.148023_b0205","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1055\/a-1546-1652","article-title":"Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the Disease","volume":"53","author":"Wei","year":"2021","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.gene.2023.148023_b0210","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1631\/jzus.B2200136","article-title":"Role of melatonin receptor 1B gene polymorphism and its effect on the regulation of glucose transport in gestational diabetes mellitus","volume":"24","author":"Wei","year":"2023","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.gene.2023.148023_b0215","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1038\/s41598-019-41605-3","article-title":"Association of rs10830962 polymorphism with gestational diabetes mellitus risk in a Chinese population","volume":"9","author":"Xie","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.gene.2023.148023_b0220","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2174\/1389202917666160513102612","article-title":"GMDR: Versatile Software for Detecting Gene-Gene and Gene-Environ- ment Interactions Underlying Complex Traits","volume":"17","author":"Xu","year":"2016","journal-title":"Curr Genomics"},{"key":"10.1016\/j.gene.2023.148023_b0225","doi-asserted-by":"crossref","unstructured":"Zhang, X., Xie, L., Zhong, M., Yang, B., Yang, Q., Yang, H., et al., 2020. The association between melatonin receptor 1B gene polymorphisms and type 2 diabetes mellitus (T2DM) in Chinese populations: a meta-analysis. Ann. Palliat. Med. 9:957-966. 10.21037\/apm-20-691.","DOI":"10.21037\/apm-20-691"},{"issue":"3","key":"10.1016\/j.gene.2023.148023_bib229","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.4238\/2015.August.3.1","article-title":"Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic \u03b2-cell function in gestational diabetes mellitus","volume":"14","author":"Zhan","year":"2015","journal-title":"Genet Mol Res"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923008648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111923008648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:11:42Z","timestamp":1759857102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111923008648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":46,"alternative-id":["S0378111923008648"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2023.148023","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MTNR1B gene variations and high pre-pregnancy BMI increase gestational diabetes mellitus risk in Chinese women","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2023.148023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"148023"}}