{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:14:27Z","timestamp":1778512467427,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","award":["SP2-WP4\/5"],"award-info":[{"award-number":["SP2-WP4\/5"]}],"id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","award":["SP2-WP4-WP5"],"award-info":[{"award-number":["SP2-WP4-WP5"]}],"id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.gene.2024.148387","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T21:08:58Z","timestamp":1710623338000},"page":"148387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes"],"prefix":"10.1016","volume":"913","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-1904","authenticated-orcid":false,"given":"Debora","family":"Salerno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Peruzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Giuseppe\u00a0Rubens\u00a0Pascucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Levrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Belloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3359-6205","authenticated-orcid":false,"given":"Natalia","family":"Pediconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.148387_b0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/jcp.30908","article-title":"MicroRNAs: small molecules with big impacts in liver injury","volume":"238","author":"Abdel Halim","year":"2023","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.gene.2024.148387_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.643055","article-title":"Epigenetic regulation of cell-fate changes that determine adult liver regeneration after injury","volume":"9","author":"Aloia","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.gene.2024.148387_b0015","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1096\/fj.14-261537","article-title":"The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration","volume":"29","author":"Bae","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.gene.2024.148387_b0020","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1038\/sj.onc.1210314","article-title":"Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle","volume":"26","author":"Buchsbaum","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2024.148387_b0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41420-021-00709-4","article-title":"Over-expression of lncRNA TMEM161B-AS1 promotes the malignant biological behavior of glioma cells and the resistance to temozolomide via up-regulating the expression of multiple ferroptosis-related genes by sponging hsa-miR-27a-3p","volume":"7","author":"Chen","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.gene.2024.148387_b0030","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1159\/000430381","article-title":"MicroRNAs in liver regeneration","volume":"37","author":"Chen","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.gene.2024.148387_b0035","doi-asserted-by":"crossref","first-page":"e85024","DOI":"10.1371\/journal.pone.0085024","article-title":"An extensive evaluation of read trimming effects on illumina NGS data analysis","volume":"8","author":"Del Fabbro","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2024.148387_b0040","doi-asserted-by":"crossref","DOI":"10.3791\/59843","article-title":"Inducing and Characterizing Vesicular steatosis in differentiated HepaRG cells","author":"Di Cocco","year":"2019","journal-title":"J vis Exp."},{"key":"10.1016\/j.gene.2024.148387_b0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2024.148387_b0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13046-021-02233-w","article-title":"MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer","volume":"41","author":"Ferri","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.gene.2024.148387_b0055","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal2380","article-title":"Epigenetic plasticity and the hallmarks of cancer","volume":"357","author":"Flavahan","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.gene.2024.148387_b0060","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.stem.2020.08.016","article-title":"Epithelial plasticity during liver injury and regeneration","volume":"27","author":"Gadd","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2024.148387_b0065","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/hep.28563","article-title":"DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration","volume":"64","author":"Kaji","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.gene.2024.148387_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108334","article-title":"DNA methylation in cell plasticity and malignant transformation in liver diseases","volume":"241","author":"Kim","year":"2023","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.gene.2024.148387_b0075","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4254\/wjh.v13.i3.270","article-title":"Molecular pathways of liver regeneration: a comprehensive review","volume":"13","author":"Kiseleva","year":"2021","journal-title":"World J Hepatol"},{"key":"10.1016\/j.gene.2024.148387_b0080","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ncb3309","article-title":"Stem cells versus plasticity in liver and pancreas regeneration","volume":"18","author":"Kopp","year":"2016","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.gene.2024.148387_b0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbrc.2016.10.084","article-title":"The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration","volume":"482","author":"Lauschke","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.gene.2024.148387_b0090","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1242\/jcs.114.8.1447","article-title":"Initiating DNA synthesis: from recruiting to activating the MCM complex","volume":"114","author":"Lei","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.gene.2024.148387_b0095","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2019.06.008","article-title":"A homeostatic Arid1a-dependent permissive chromatin state licenses hepatocyte responsiveness to liver-injury-associated YAP signaling","volume":"25","author":"Li","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2024.148387_b0100","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.gene.2024.148387_b0105","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1016\/j.febslet.2005.10.028","article-title":"The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication","volume":"579","author":"Nallamshetty","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.gene.2024.148387_b0110","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ceb.2018.01.003","article-title":"The epigenetic basis of cellular plasticity","volume":"49","author":"Paksa","year":"2017","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.gene.2024.148387_b0115","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41419-019-1755-2","article-title":"EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells","volume":"10","author":"Pediconi","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.gene.2024.148387_b0120","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.gene.2024.148387_b0125","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/hep.23547","article-title":"MicroRNAs control hepatocyte proliferation during liver regeneration","volume":"51","author":"Song","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.gene.2024.148387_b0130","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.stem.2016.03.001","article-title":"Suppression of the SWI\/SNF component Arid1a promotes mammalian regeneration","volume":"18","author":"Sun","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2024.148387_b0135","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1242\/dev.114249","article-title":"A developmental framework for induced pluripotency","volume":"142","author":"Takahashi","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.gene.2024.148387_b0140","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tcb.2014.09.003","article-title":"Plasticity within stem cell hierarchies in mammalian epithelia","volume":"25","author":"Tetteh","year":"2015","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.gene.2024.148387_b0145","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1080\/21691401.2019.1669623","article-title":"An integrated analysis of the circRNA-miRNA-mRNA network reveals novel insights into potential mechanisms of cell proliferation during liver regeneration","volume":"47","author":"Wang","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"10.1016\/j.gene.2024.148387_b0150","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s11010-022-04382-8","article-title":"LncRNA CRNDE promotes cell proliferation, migration and invasion of ovarian cancer via miR-423-5p\/FSCN1 axis","volume":"477","author":"Wang","year":"2022","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.gene.2024.148387_b0155","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.devcel.2019.05.034","article-title":"Epigenetic compensation promotes liver regeneration","volume":"50","author":"Wang","year":"2019","journal-title":"Dev Cell"},{"key":"10.1016\/j.gene.2024.148387_b0160","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.18632\/oncotarget.23262","article-title":"MiR-27a as a predictor for the activation of hepatic stellate cells and hepatitis B virus-induced liver cirrhosis","volume":"9","author":"Zhang","year":"2018","journal-title":"Oncotarget"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924002683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924002683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:48:01Z","timestamp":1778510881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924002683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":32,"alternative-id":["S0378111924002683"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148387","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"148387"}}