{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T01:27:34Z","timestamp":1787189254441,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["20\\u201375-10060"],"award-info":[{"award-number":["20\\u201375-10060"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.gene.2024.148507","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T16:32:26Z","timestamp":1713976346000},"page":"148507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer"],"prefix":"10.1016","volume":"920","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7283-0092","authenticated-orcid":false,"given":"Tatiana","family":"Gerashchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7203-8206","authenticated-orcid":false,"given":"Rostislav","family":"Skitchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Korobeynikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1170-8963","authenticated-orcid":false,"given":"Kristina","family":"Kuanysheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Khozyainova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-8479","authenticated-orcid":false,"given":"Rostislav","family":"Vorobiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-8986","authenticated-orcid":false,"given":"Evgeny","family":"Rodionov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-9840","authenticated-orcid":false,"given":"Sergey","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-0177","authenticated-orcid":false,"given":"Evgeny","family":"Topolnitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0011-8370","authenticated-orcid":false,"given":"Nikolay","family":"Shefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-7190","authenticated-orcid":false,"given":"Maxim","family":"Anisimenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Zhuikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2205-075X","authenticated-orcid":false,"given":"Mrinal","family":"Vashisth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pankova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Perelmuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4001-0943","authenticated-orcid":false,"given":"Valeria","family":"Rezapova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5282-8764","authenticated-orcid":false,"given":"Mykyta","family":"Artomov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2923-9755","authenticated-orcid":false,"given":"Evgeny","family":"Denisov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.148507_b0005","doi-asserted-by":"crossref","unstructured":"Adzhubei I, Jordan DM, Sunyaev SR. Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet. 2013 Jan;Chapter 7:Unit7.20.","DOI":"10.1002\/0471142905.hg0720s76"},{"issue":"2","key":"10.1016\/j.gene.2024.148507_b0010","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bbamem.2012.09.024","article-title":"Effects of a polar amino acid substitution on helix formation and aggregate size along the detergent-induced peptide folding pathway","volume":"1828","author":"Alvares","year":"2013","journal-title":"Biochim Biophys Acta."},{"key":"10.1016\/j.gene.2024.148507_b0060","unstructured":"Andrews, S. (2010). FastQC: A Quality Control Tool for High Throughput Sequence Data [Online]. Available online at: http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"issue":"9","key":"10.1016\/j.gene.2024.148507_b0015","doi-asserted-by":"crossref","DOI":"10.3390\/cells11091484","article-title":"Dance of the golgi: understanding golgi dynamics in cancer metastasis","volume":"11","author":"Bajaj","year":"2022","journal-title":"Cells."},{"key":"10.1016\/j.gene.2024.148507_b0020","article-title":"RGS4 controls G\u03b1i3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes","volume":"22","author":"Bastin","year":"2020","journal-title":"J Cell Sci."},{"issue":"9","key":"10.1016\/j.gene.2024.148507_b0025","article-title":"Adaptation of the golgi apparatus in cancer cell invasion and metastasis","volume":"10","author":"Bui","year":"2021","journal-title":"Front Cell Dev Biol."},{"issue":"5","key":"10.1016\/j.gene.2024.148507_b0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tig.2020.10.005","article-title":"Germline variants that affect tumor progression","volume":"37","author":"Chatrath","year":"2021","journal-title":"Trends Genet."},{"issue":"7","key":"10.1016\/j.gene.2024.148507_b0035","doi-asserted-by":"crossref","first-page":"e0236962","DOI":"10.1371\/journal.pone.0236962","article-title":"MISTIC: a prediction tool to reveal disease-relevant deleterious missense variants","volume":"15","author":"Chennen","year":"2020","journal-title":"PLoS ONE."},{"issue":"6","key":"10.1016\/j.gene.2024.148507_b0040","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/PAI.0000000000000762","article-title":"Gene expression profiling revealed 2 types of bronchial basal cell hyperplasia and squamous metaplasia with different progression potentials","volume":"28","author":"Denisov","year":"2020","journal-title":"Appl Immunohistochem Mol Morphol."},{"issue":"4","key":"10.1016\/j.gene.2024.148507_b0045","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/ene.15213","article-title":"Potential biomarkers identified by tandem mass tags based quantitative proteomics for diagnosis and classification of Guillain-Barr\u00e9 syndrome","volume":"29","author":"Ding","year":"2022","journal-title":"Eur J Neurol."},{"issue":"12","key":"10.1016\/j.gene.2024.148507_b0050","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.jtho.2020.08.017","article-title":"Inherited rare, deleterious variants in ATM increase lung adenocarcinoma risk","volume":"15","author":"Esai Selvan","year":"2020","journal-title":"J Thorac Oncol."},{"issue":"3","key":"10.1016\/j.gene.2024.148507_b0055","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03957-2020","article-title":"Endothelial cells in the pathogenesis of pulmonary arterial hypertension","volume":"58","author":"Evans","year":"2021","journal-title":"Eur Respir J."},{"key":"10.1016\/j.gene.2024.148507_b0165","unstructured":"Hail Team. Hail 0.2. https:\/\/github.com\/hail-is\/hail."},{"issue":"3","key":"10.1016\/j.gene.2024.148507_b0065","doi-asserted-by":"crossref","first-page":"e00413","DOI":"10.1128\/mBio.00413-15","article-title":"Staphylococcus aureus fibronectin-binding protein a mediates cell-cell adhesion through low-affinity homophilic bonds","volume":"6","author":"Herman-Bausier","year":"2015","journal-title":"MBio."},{"issue":"7","key":"10.1016\/j.gene.2024.148507_b0070","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1916623","article-title":"The effect of advances in lung-cancer treatment on population mortality","volume":"383","author":"Howlader","year":"2020","journal-title":"N Engl J Med."},{"issue":"3","key":"10.1016\/j.gene.2024.148507_b0075","doi-asserted-by":"crossref","first-page":"556","DOI":"10.20892\/j.issn.2095-3941.2018.0506","article-title":"Prevalence and clinical significance of pathogenic germline BRCA1\/2 mutations in Chinese non-small cell lung cancer patients","volume":"16","author":"Hu","year":"2019","journal-title":"CancerBiol Med."},{"issue":"6","key":"10.1016\/j.gene.2024.148507_b0080","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.jtcvs.2012.01.078","article-title":"Five-year survival does not equal cure in non-small cell lung cancer: a surveillance, epidemiology, and end results-based analysis of variables affecting 10- to 18-year survival","volume":"143","author":"Hubbard","year":"2012","journal-title":"J Thorac Cardiovasc Surg."},{"key":"10.1016\/j.gene.2024.148507_b0085","series-title":"Molecular Pathology of Lung Cancer","first-page":"35","article-title":"The Classification of Pre-invasive Lesions","author":"Kerr","year":"2012"},{"issue":"3","key":"10.1016\/j.gene.2024.148507_b0090","doi-asserted-by":"crossref","first-page":"e555","DOI":"10.1002\/mgg3.555","article-title":"The prevalence of germline DICER1 pathogenic variation in cancer populations","volume":"7","author":"Kim","year":"2019","journal-title":"Mol Genet Genomic Med."},{"key":"10.1016\/j.gene.2024.148507_b0095","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.xjon.2022.09.001","article-title":"Germline mutations in high penetrance genes are associated with worse clinical outcomes in patients with non-small cell lung cancer","volume":"12","author":"Krantz","year":"2022","journal-title":"JTCVS Open."},{"issue":"5","key":"10.1016\/j.gene.2024.148507_b0105","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/ajmg.b.31068","article-title":"Case-control association study of TGOLN2 in attempted suicide","volume":"153B","author":"Mahon","year":"2010","journal-title":"Am J Med Genet B Neuropsychiatr Genet."},{"issue":"1","key":"10.1016\/j.gene.2024.148507_b0110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol."},{"issue":"11","key":"10.1016\/j.gene.2024.148507_b0115","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1016\/j.jprot.2012.03.041","article-title":"Alpha-Dystrobrevin and its associated proteins in human promyelocytic leukemia cells induced to apoptosis","volume":"75","author":"Navakauskien\u0117","year":"2012","journal-title":"J Proteomics."},{"issue":"13","key":"10.1016\/j.gene.2024.148507_b0120","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1093\/nar\/gkg509","article-title":"SIFT: Predicting amino acid changes that affect protein function","volume":"31","author":"Ng","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.gene.2024.148507_b0125","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/bjc.2011.311","article-title":"Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma","volume":"105","author":"Nohata","year":"2011","journal-title":"Br J Cancer."},{"issue":"3","key":"10.1016\/j.gene.2024.148507_b0130","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1007\/s13277-015-4196-2","article-title":"Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium","volume":"37","author":"Pankova","year":"2016","journal-title":"Tumour Biol."},{"issue":"11","key":"10.1016\/j.gene.2024.148507_b0135","article-title":"Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients","volume":"10","author":"Pankova","year":"2021","journal-title":"Front Oncol."},{"issue":"9","key":"10.1016\/j.gene.2024.148507_b0140","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1105\/tpc.19.00081","article-title":"Separating golgi proteins from cis to trans reveals underlying properties of cisternal localization","volume":"31","author":"Parsons","year":"2019","journal-title":"Plant Cell"},{"issue":"15","key":"10.1016\/j.gene.2024.148507_b0145","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1002\/cncr.33573","article-title":"Germline mutations and age at onset of lung adenocarcinoma","volume":"127","author":"Reckamp","year":"2021","journal-title":"Cancer"},{"key":"10.1016\/j.gene.2024.148507_b0150","article-title":"Regional missense constraint improves variant deleteriousness prediction","author":"Samocha","year":"2017","journal-title":"BioRxiv."},{"key":"10.1016\/j.gene.2024.148507_b0155","unstructured":"SEER Cancer Statistics Review1975-2018 [Internet]. 2021 [cited 2023 Jul 6]. Available from: https:\/\/seer.cancer.gov\/archive\/csr\/1975_2018\/."},{"issue":"3","key":"10.1016\/j.gene.2024.148507_b0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin."},{"issue":"4","key":"10.1016\/j.gene.2024.148507_b0170","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1504\/IJCBDD.2010.038396","article-title":"Structural assessment of the effects of amino acid substitutions on protein stability and protein protein interaction","volume":"3","author":"Teng","year":"2010","journal-title":"Int J Comput Biol Drug Des."},{"issue":"4","key":"10.1016\/j.gene.2024.148507_b0175","first-page":"242","article-title":"Recurrence after surgery in patients with NSCLC","volume":"3","author":"Uramoto","year":"2014","journal-title":"Transl Lung Cancer Res."},{"key":"10.1016\/j.gene.2024.148507_b0180","unstructured":"Van der Auwera GA, Carneiro MO, Hartl C, Poplin R, Del Angel G, Levy-Moonshine A, et al. From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline. Curr Protoc Bioinformatics. 2013 Oct 15;11(1110):11.10.1-11.10.33."},{"key":"10.1016\/j.gene.2024.148507_b0100","doi-asserted-by":"crossref","unstructured":"Vasimuddin Md, Sanchit Misra, Heng Li, Srinivas Aluru. Efficient Architecture-Aware Acceleration of BWA-MEM for Multicore Systems. IEEE Parallel and Distributed Processing Symposium (IPDPS), 2019. Available online at: https:\/\/github.com\/bwa-mem2\/bwa-mem2.","DOI":"10.1109\/IPDPS.2019.00041"},{"issue":"3","key":"10.1016\/j.gene.2024.148507_b0185","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00418-013-1117-6","article-title":"The Golgi puppet master: COG complex at center stage of membrane trafficking interactions","volume":"140","author":"Willett","year":"2013","journal-title":"Histochem Cell Biol."},{"issue":"1","key":"10.1016\/j.gene.2024.148507_b0190","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1186\/s12885-020-06901-6","article-title":"Integrated analysis of genome-wide miRNAs and targeted gene expression in esophageal squamous cell carcinoma (ESCC) and relation to prognosis","volume":"20","author":"Yang","year":"2020","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.gene.2024.148507_b0195","first-page":"104","article-title":"CHRNA3 rs1051730 polymorphism and lung cancer susceptibility in Asian population: a meta-analysis","volume":"4","author":"Zhan","year":"2015","journal-title":"Transl Lung Cancer Res."},{"issue":"8","key":"10.1016\/j.gene.2024.148507_b0200","doi-asserted-by":"crossref","first-page":"e23312","DOI":"10.1002\/jcla.23312","article-title":"Analysis of lncRNA UCA1-related downstream pathways and molecules of cisplatin resistance in lung adenocarcinoma","volume":"34","author":"Zhou","year":"2020","journal-title":"J Clin Lab Anal."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924003883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924003883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T15:56:27Z","timestamp":1716652587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924003883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":40,"alternative-id":["S0378111924003883"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148507","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148507","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"148507"}}