{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:57:47Z","timestamp":1793278667309,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.gene.2024.148575","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:18:16Z","timestamp":1715941096000},"page":"148575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Preliminary study on the mechanism by which exosomes derived from human exfoliated deciduous teeth improve the proliferation and osteogenic inhibitory effect of glucocorticoid-induced BMSCs"],"prefix":"10.1016","volume":"923","author":[{"given":"Fei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.148575_b0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00277-018-3465-8","article-title":"Glucocorticoids in multiple myeloma: Past, present, and future","volume":"98","author":"Burwick","year":"2019","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.gene.2024.148575_b0010","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.gene.2024.148575_b0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1574888X11666160815095733","article-title":"Expression of odontogenic and osteogenic markers in DPSCs and SHED: A review","volume":"12","author":"Ching","year":"2017","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.gene.2024.148575_b0020","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.2147\/IJN.S244453","article-title":"Magnetic targeting of HU-MSCs in the treatment of glucocorticoid-associated osteonecrosis of the femoral head through Akt\/Bcl2\/Bad\/Caspase-3 pathway","volume":"15","author":"Duan","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.gene.2024.148575_b0025","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2174\/1574888X15666200929125840","article-title":"Guiding lineage specific differentiation of SHED for target tissue\/organ regeneration","volume":"16","author":"Han","year":"2021","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.gene.2024.148575_b0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/15476278.2016.1229726","article-title":"IL-7 suppresses osteogenic differentiation of periodontal ligament stem cells through inactivation of mitogen-activated protein kinase pathway","volume":"12","author":"Jian","year":"2016","journal-title":"Organogenesis"},{"key":"10.1016\/j.gene.2024.148575_b0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.gene.2024.148575_b0040","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/pmic.201200373","article-title":"The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles","volume":"13","author":"Katsuda","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.gene.2024.148575_b0045","doi-asserted-by":"crossref","first-page":"1069804","DOI":"10.3389\/fbioe.2022.1069804","article-title":"Self-assembled microtissues loaded with osteogenic MSCs for in vivo bone regeneration","volume":"10","author":"Li","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.gene.2024.148575_b0050","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1515\/biol-2021-0102","article-title":"Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway","volume":"16","author":"Li","year":"2021","journal-title":"Open Life Sci."},{"key":"10.1016\/j.gene.2024.148575_b0055","article-title":"Transcriptome profiling of osteoblasts in a Medaka (Oryzias latipes) osteoporosis model identifies Mmp13b as crucial for osteoclast activation","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2024.148575_b0060","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1111\/os.13393","article-title":"Research progress on exosomes in osteonecrosis of the femoral head","volume":"14","author":"Liu","year":"2022","journal-title":"Orthop. Surg."},{"key":"10.1016\/j.gene.2024.148575_b0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00441-004-0951-1","article-title":"Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues","volume":"319","author":"Luukko","year":"2005","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.gene.2024.148575_b0070","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: Stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura","year":"2003","journal-title":"PNAS"},{"key":"10.1016\/j.gene.2024.148575_b0075","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1634\/stemcells.22-3-405","article-title":"Functional expression of HGF and HGF receptor\/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing","volume":"22","author":"Neuss","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.gene.2024.148575_b0080","doi-asserted-by":"crossref","first-page":"417","DOI":"10.20452\/pamw.2355","article-title":"New advances in stem cell research: Practical implications for regenerative medicine","volume":"124","author":"Ratajczak","year":"2014","journal-title":"Pol. Arch. Med. Wewn."},{"key":"10.1016\/j.gene.2024.148575_b0085","doi-asserted-by":"crossref","unstructured":"S, E.L.A., Mager, I., Breakefield, X.O. and Wood, M.J., 2013. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 12, 347-57.","DOI":"10.1038\/nrd3978"},{"key":"10.1016\/j.gene.2024.148575_b0090","doi-asserted-by":"crossref","first-page":"e55769","DOI":"10.1371\/journal.pone.0055769","article-title":"High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage","volume":"8","author":"Satija","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2024.148575_b0095","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1159\/000491541","article-title":"Plastrum Testudinis extracts promote BMSC proliferation and osteogenic differentiation by regulating Let-7f-5p and the TNFR2\/PI3K\/AKT signaling pathway","volume":"47","author":"Shen","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.gene.2024.148575_b0100","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1182\/blood-2006-07-034884","article-title":"HGF inhibits BMP-induced osteoblastogenesis: Possible implications for the bone disease of multiple myeloma","volume":"109","author":"Standal","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.gene.2024.148575_b0105","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/jbmr.4500","article-title":"A novel EphA4 signaling-based therapeutic strategy for osteoarthritis in mice","volume":"37","author":"Stiffel","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.gene.2024.148575_b0110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbrc.2022.02.112","article-title":"Dexamethasone induces ferroptosis via P53\/SLC7A11\/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head","volume":"602","author":"Sun","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2024.148575_b0115","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1007\/s00394-021-02554-8","article-title":"The SHED index: A tool for assessing a sustainable HEalthy diet","volume":"60","author":"Tepper","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.gene.2024.148575_b0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2017.10.010","article-title":"Therapeutic mechanisms of glucocorticoids","volume":"29","author":"Vandewalle","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.gene.2024.148575_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diff.2019.10.003","article-title":"SHED-derived conditioned exosomes enhance the osteogenic differentiation of PDLSCs via Wnt and BMP signaling in vitro","volume":"111","author":"Wang","year":"2020","journal-title":"Differentiation"},{"key":"10.1016\/j.gene.2024.148575_b0130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10735-020-09896-3","article-title":"Exosomes derived from human exfoliated deciduous teeth ameliorate adult bone loss in mice through promoting osteogenesis","volume":"51","author":"Wei","year":"2020","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.gene.2024.148575_b0135","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1021\/acsbiomaterials.9b00607","article-title":"Exosomes secreted by stem cells from human exfoliated deciduous teeth promote alveolar bone defect repair through the regulation of angiogenesis and osteogenesis","volume":"5","author":"Wu","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.gene.2024.148575_b0140","doi-asserted-by":"crossref","first-page":"e447","DOI":"10.1002\/ctm2.447","article-title":"Inhibition of MAGL activates the Keap1\/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head","volume":"11","author":"Yang","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.gene.2024.148575_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146705","article-title":"Huogu injection alleviates SONFH by regulating adipogenic differentiation of BMSCs via targeting the miR-34c-5p\/MDM4 pathway","volume":"838","author":"Yang","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.gene.2024.148575_b0150","doi-asserted-by":"crossref","first-page":"e3207","DOI":"10.1002\/jgm.3207","article-title":"beta-ecdysone promotes osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"22","author":"You","year":"2020","journal-title":"J. Gene Med."},{"key":"10.1016\/j.gene.2024.148575_b0155","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/jhps\/hnab046","article-title":"Mid- to long-term results of modified avascular fibular grafting for ONFH","volume":"8","author":"Yuan","year":"2021","journal-title":"J. Hip Preserv. Surg."},{"key":"10.1016\/j.gene.2024.148575_b0160","doi-asserted-by":"crossref","DOI":"10.1177\/2040622321995685","article-title":"Melatonin restores osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells and alleviates bone loss through the HGF\/PTEN\/Wnt\/beta-catenin axis","volume":"12","author":"Zhang","year":"2021","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.gene.2024.148575_b0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00441-023-03846-7","article-title":"Huogu injection protects against SONFH by promoting osteogenic differentiation of BMSCs and preventing osteoblast apoptosis","volume":"395","author":"Zhang","year":"2024","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.gene.2024.148575_b0170","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/kjm2.12426","article-title":"Astragalus polysaccharide ameliorates steroid-induced osteonecrosis of femoral head through miR-206\/HIF-1alpha\/BNIP3 axis","volume":"37","author":"Zhang","year":"2021","journal-title":"Kaohsiung J. Med. Sci."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924004566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924004566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T08:07:57Z","timestamp":1732003677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924004566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":34,"alternative-id":["S0378111924004566"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148575","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preliminary study on the mechanism by which exosomes derived from human exfoliated deciduous teeth improve the proliferation and osteogenic inhibitory effect of glucocorticoid-induced BMSCs","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"148575"}}