{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:00:12Z","timestamp":1788188412987,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.gene.2024.148691","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T13:35:40Z","timestamp":1718285740000},"page":"148691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["JAK1, SKI, ZBTB16 as potential biomarkers mediate the inflammatory response in keratoconjunctivitis sicca"],"prefix":"10.1016","volume":"927","author":[{"given":"Zijian","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4394-2578","authenticated-orcid":false,"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannan","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-5274","authenticated-orcid":false,"given":"Ning","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.148691_b0010","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1210\/clinem\/dgab670","article-title":"The Cortisol Response of Male and female choroidal endothelial cells: implications for central serous chorioretinopathy","volume":"107","author":"Brinks","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.gene.2024.148691_b0015","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1172\/JCI126022","article-title":"IL-6\/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion","volume":"129","author":"Chan","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.gene.2024.148691_b0020","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.2147\/OPTH.S388289","article-title":"How can we best diagnose severity levels of dry eye disease: current perspectives","volume":"17","author":"Chester","year":"2023","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.gene.2024.148691_b0025","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.ophtha.2017.05.031","article-title":"Meibomian gland disease: the role of gland dysfunction in dry eye disease","volume":"124","author":"Chhadva","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.gene.2024.148691_b0030","doi-asserted-by":"crossref","first-page":"e29017","DOI":"10.1371\/journal.pone.0029017","article-title":"Disruption of TGF-beta signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca","volume":"6","author":"De Paiva","year":"2011","journal-title":"PLoS One"},{"issue":"2016\u20132020","key":"10.1016\/j.gene.2024.148691_b0035","first-page":"e5","article-title":"JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome","volume":"139","author":"Del Bel","year":"2017","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.gene.2024.148691_b0045","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s00438-022-01912-3","article-title":"Comprehensive bioinformatics analyses reveal immune genes responsible for altered immune microenvironment in intervertebral disc degeneration","volume":"297","author":"Hai","year":"2022","journal-title":"Mol Genet Genom."},{"issue":"8","key":"10.1016\/j.gene.2024.148691_b0040","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s41433-022-02197-x","article-title":"A clinical decision support system for diagnosing and determining severity of dry eye disease","volume":"37","author":"Ebrahimi","year":"2023","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.gene.2024.148691_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100173","article-title":"Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111\/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL\/SnoN in TGF-beta Signaling Pathway","volume":"20","author":"Laigle","year":"2021","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.gene.2024.148691_b0055","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1423-0127-20-98","article-title":"Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf)","volume":"20","author":"Lin","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.gene.2024.148691_b0060","article-title":"Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjgren's Syndrome: Identification of New Targets","volume":"23","author":"Lisi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2024.148691_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102364","article-title":"Sjogren's syndrome: Old and new therapeutic targets","volume":"110","author":"Mavragani","year":"2020","journal-title":"J Autoimmun"},{"key":"10.1016\/j.gene.2024.148691_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15030990","article-title":"A Review on Dry Eye Disease Treatment: Recent Progress, Diagnostics, and Future Perspectives","volume":"15","author":"Mondal","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.gene.2024.148691_b0075","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jtos.2023.05.011","article-title":"Dry eye disease and blinking behaviors: A narrative review of methodologies for measuring blink dynamics and inducing blink response","volume":"29","author":"Oganov","year":"2023","journal-title":"Ocul Surf"},{"issue":"2548\u20132557","key":"10.1016\/j.gene.2024.148691_b0080","first-page":"e4","article-title":"Quantitative Difference in PLZF Protein Expression Determines iNKT Lineage Fate and Controls Innate CD8 T Cell Generation","volume":"27","author":"Park","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.gene.2024.148691_b0085","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ajo.2013.12.023","article-title":"Dry Eye in the Beaver Dam Offspring Study: Prevalence, Risk Factors, and Health-Related Quality of Life","volume":"157","author":"Paulsen","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.gene.2024.148691_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108294","article-title":"Inflammatory basis for dry eye disease flares","volume":"201","author":"Perez","year":"2020","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.gene.2024.148691_b0095","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.gene.2024.148691_b0100","doi-asserted-by":"crossref","first-page":"17528","DOI":"10.1074\/jbc.270.29.17528","article-title":"The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors","volume":"270","author":"Sakatsume","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gene.2024.148691_b0105","doi-asserted-by":"crossref","first-page":"1306325","DOI":"10.3389\/fendo.2023.1306325","article-title":"Combining bioinformatics and machine learning algorithms to identify and analyze shared biomarkers and pathways in COVID-19 convalescence and diabetes mellitus","volume":"14","author":"Shen","year":"2023","journal-title":"Front Endocrinol (lausanne)"},{"key":"10.1016\/j.gene.2024.148691_b0115","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41374-020-0373-z","article-title":"TGFbeta1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial-mesenchymal transition in Sjogren's syndrome","volume":"100","author":"Sisto","year":"2020","journal-title":"Lab Invest"},{"key":"10.1016\/j.gene.2024.148691_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063203","article-title":"SMADS-Mediate Molecular Mechanisms in Sjogren's Syndrome","volume":"22","author":"Sisto","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gene.2024.148691_b0125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","article-title":"The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","author":"Smith","year":"2007","journal-title":"Ocular Surface"},{"key":"10.1016\/j.gene.2024.148691_b0130","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1084\/jem.20170369","article-title":"STAT-3-independent production of IL-17 by mouse innate-like alphabeta T cells controls ocular infection","volume":"215","author":"St Leger","year":"2018","journal-title":"J Exp Med"},{"key":"10.1016\/j.gene.2024.148691_b0135","article-title":"Autoinflammatory keratinization disease with hepatitis and autism reveals roles for JAK1 Kinase Hyperactivity in Autoinflammation","volume":"12","author":"Takeichi","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.gene.2024.148691_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2017.07.022","article-title":"Update in current diagnostics and therapeutics of dry eye disease","volume":"124","author":"Thulasi","year":"2017","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.gene.2024.148691_b0145","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jtos.2016.09.003","article-title":"Asia dry eye society. New perspectives on dry eye definition and diagnosis: A consensus report by the Asia dry eye society","volume":"15","author":"Tsubota","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.gene.2024.148691_b0150","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajo.2013.10.014","article-title":"Dry Eye disease and work productivity loss in visual display users: the osaka study","volume":"157","author":"Uchino","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.gene.2024.148691_b0155","article-title":"Analysis of tear inflammatory molecules and clinical correlations in evaporative dry eye disease caused by meibomian gland dysfunction","author":"Wu","year":"2020","journal-title":"International"},{"key":"10.1016\/j.gene.2024.148691_b0160","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/modpathol.2016.46","article-title":"ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor","volume":"29","author":"Xiao","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1016\/j.gene.2024.148691_b0165","doi-asserted-by":"crossref","first-page":"8641","DOI":"10.1038\/s41598-023-35864-4","article-title":"Development and verification of a combined diagnostic model for primary Sjogren's syndrome by integrated bioinformatics analysis and machine learning","volume":"13","author":"Yang","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.gene.2024.148691_b0170","first-page":"34","article-title":"IFN-gamma Facilitates Corneal Epithelial Cell Pyroptosis Through the JAK2\/STAT1 Pathway in Dry Eye","volume":"64","author":"Yang","year":"2023","journal-title":"Invest Ophthalmol vis Sci"},{"key":"10.1016\/j.gene.2024.148691_b0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/tvst.12.6.8","article-title":"Differentially expressed tear proteins in Sjogren's Syndrome Keratoconjunctivitis Sicca","volume":"12","author":"Yoon","year":"2023","journal-title":"Transl vis Sci Technol"},{"key":"10.1016\/j.gene.2024.148691_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311179","article-title":"Outline of Salivary Gland Pathogenesis of Sjogren's Syndrome and Current Therapeutic Approaches","volume":"24","author":"Yura","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gene.2024.148691_b0185","doi-asserted-by":"crossref","first-page":"1023248","DOI":"10.3389\/fimmu.2023.1023248","article-title":"Screening biomarkers for Sjogren's Syndrome by computer analysis and evaluating the expression correlations with the levels of immune cells","volume":"14","author":"Zhong","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.gene.2024.148691_b0190","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1021\/pr900686s","article-title":"Identification of Tear Fluid Biomarkers in Dry Eye syndrome using iTRAQ Quantitative Proteomics","volume":"8","author":"Zhou","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.gene.2024.148691_b0195","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/cei\/uxad037","article-title":"Diagnostic markers and potential therapeutic agents for Sjogren's syndrome screened through multiple machine learning and molecular docking","volume":"212","author":"Zhou","year":"2023","journal-title":"Clin Exp Immunol"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924005729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924005729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T02:38:49Z","timestamp":1721961529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924005729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":37,"alternative-id":["S0378111924005729"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148691","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"JAK1, SKI, ZBTB16 as potential biomarkers mediate the inflammatory response in keratoconjunctivitis sicca","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148691","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"148691"}}