{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:23:43Z","timestamp":1792225423837,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.gene.2024.148704","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T15:30:54Z","timestamp":1718465454000},"page":"148704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Genetic variants related to insulin metabolism are associated with gestational diabetes mellitus"],"prefix":"10.1016","volume":"927","author":[{"given":"Ravi","family":"Bhushan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafiul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Rani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Diwakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anima","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1438-3773","authenticated-orcid":false,"given":"Pawan K.","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.148704_b0005","article-title":"Association of auto-antigen SLC30A8 gene variants with type 1 diabetes mellitus","volume":"49","author":"AfreenBhatty","year":"2022","journal-title":"J. Hunan Univ. Nat. Sci."},{"key":"10.1016\/j.gene.2024.148704_b0010","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12944-019-1160-y","article-title":"Association of FTO common variant (rs9939609) with body fat in Turkish individuals","volume":"18","author":"A\u011fag\u00fcnd\u00fcz","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.gene.2024.148704_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2020.101258","article-title":"Amino-acid amendment of Arginine-325-Tryptophan in rs13266634 genetic polymorphism studies of the SLC30A8 gene with type 2 diabetes-mellitus patients featuring a positive family history in the Saudi population","volume":"33","author":"Alharbi","year":"2021","journal-title":"J. King Saud Univ. \u2013 Sci."},{"key":"10.1016\/j.gene.2024.148704_b0020","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1134\/S1022795416080032","article-title":"Association of variable rs1801282 locus of PPARG2 gene with diabetic nephropathy","volume":"52","author":"Avzaletdinova","year":"2016","journal-title":"Russ. J. Genet."},{"key":"10.1016\/j.gene.2024.148704_b0025","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10528-021-10124-0","article-title":"FTO-rs9939609 polymorphism is a predictor of future type 2 diabetes: a population-based prospective study","volume":"60","author":"Binh","year":"2022","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.gene.2024.148704_b0030","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrendo.2012.96","article-title":"Gestational diabetes mellitus: risks and management during and after pregnancy","volume":"8","author":"Buchanan","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"issue":"787\u2013835","key":"10.1016\/j.gene.2024.148704_b0035","first-page":"ix","article-title":"Pathogenesis of type 2 diabetes mellitus","volume":"88","author":"DeFronzo","year":"2004","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.gene.2024.148704_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/4612623","article-title":"Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women","volume":"2017","author":"Franzago","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.gene.2024.148704_b0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12929-020-00694-3","article-title":"Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring","volume":"27","author":"Garc\u00eda-Ricobaraza","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.gene.2024.148704_b0055","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"HAPO Study Cooperative Research Group","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2024.148704_b0070","doi-asserted-by":"crossref","unstructured":"Kalliala, I., Markozannes, G., Gunter, M.J., Paraskevaidis, E., Gabra, H., Mitra, A., Terzidou, V., Bennett, P., Martin-Hirsch, P., Tsilidis, K.K., Kyrgiou, M., 2017. Obesity and gynaecological and obstetric conditions: umbrella review of the literature. BMJ j4511. doi: 10.1136\/bmj.j4511.","DOI":"10.1136\/bmj.j4511"},{"key":"10.1016\/j.gene.2024.148704_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.humgen.2022.201133","article-title":"Association of an intronic SNP rs9939609 in FTO gene with type 2 diabetes mellitus among Bangladeshi population: A case\u2013control study combined with updated meta-analysis","volume":"35","author":"Kar","year":"2023","journal-title":"Human Gene"},{"key":"10.1016\/j.gene.2024.148704_b0080","article-title":"G Allele of the rs1801282 Polymorphism in PPAR\u03b3 Gene Confers an Increased Risk of Obesity and Hypercholesterolemia, While T Allele of the rs3856806 Polymorphism Displays a Protective Role AgainstDyslipidemia: A Systematic Review and Meta-Analysis","volume":"13","author":"Li","year":"2022","journal-title":"Front Endocrinol (lausanne)"},{"key":"10.1016\/j.gene.2024.148704_b0085","doi-asserted-by":"crossref","first-page":"e0153044","DOI":"10.1371\/journal.pone.0153044","article-title":"Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis","volume":"11","author":"Lin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2024.148704_b0090","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s12020-018-1651-z","article-title":"Association of type 2 diabetes susceptible genes GCKR, SLC30A8, and FTO polymorphisms with gestational diabetes mellitus risk: a meta-analysis","volume":"62","author":"Lin","year":"2018","journal-title":"Endocrine"},{"key":"10.1016\/j.gene.2024.148704_b0095","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00438-019-01552-0","article-title":"Heterogeneous impact of type 2 diabetes mellitus-related genetic variants on gestational glycemic traits: review and future research needs","volume":"294","author":"Liu","year":"2019","journal-title":"Mol. Genet Genomics"},{"key":"10.1016\/j.gene.2024.148704_b0100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11892-015-0709-z","article-title":"Genetics of Gestational Diabetes Mellitus and Maternal Metabolism","volume":"16","author":"Lowe","year":"2016","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.gene.2024.148704_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145279","article-title":"SLC30A8 gene polymorphism rs13266634 associated with increased risk for developing type 2 diabetes mellitus in Jordanian population","volume":"768","author":"Mashal","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.gene.2024.148704_b0110","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1056\/NEJMra0906948","article-title":"Genomics, Type 2 Diabetes, and Obesity","volume":"363","author":"McCarthy","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2024.148704_b0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s43042-024-00484-8","article-title":"Association of SLC30A8 rs13266634 gene polymorphism with type 2 diabetes mellitus (T2DM) in a population of Noakhali, Bangladesh: a case\u2013control study","volume":"25","author":"Mitu","year":"2024","journal-title":"Egypt. J. Med. Hum. Genetics"},{"key":"10.1016\/j.gene.2024.148704_b0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40169-015-0058-1","article-title":"Association between the TCF7L2 rs12255372 (G\/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study","volume":"4","author":"Nanfa","year":"2015","journal-title":"Clin. Trans. Med."},{"key":"10.1016\/j.gene.2024.148704_b0125","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/09513590.2010.490609","article-title":"Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population","volume":"27","author":"Pappa","year":"2011","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.gene.2024.148704_b0130","article-title":"Gestational diabetes mellitus diagnosis and treatment goals: measurement and measures","author":"Popova","year":"2016","journal-title":"Minerva Endocrinol."},{"key":"10.1016\/j.gene.2024.148704_b0135","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000497100","article-title":"Role of TCF7L2 and PPARG2 Gene Polymorphisms in Renal and Cardiovascular Complications among Patients with Type 2 Diabetes: A Cohort Study","volume":"5","author":"Satirapoj","year":"2019","journal-title":"Kidney Dis."},{"key":"10.1016\/j.gene.2024.148704_b0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00125-006-0521-z","article-title":"TCF7L2 and type 2 diabetes\u2014we WNT to know","volume":"50","author":"Smith","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.gene.2024.148704_b0145","doi-asserted-by":"crossref","unstructured":"Soriguer, F., Morcillo, S., Cardona, F., Rojo-Mart\u00ednez, G., Cruz Almar\u00e1z, M. de la, Ruiz de Adana, M. de la S., Olveira, G., Tinahones, F., Esteva, I., 2006. Pro12Ala Polymorphism of the PPARG2 Gene Is Associated with Type 2 Diabetes Mellitus and Peripheral Insulin Sensitivity in a Population with a High Intake of Oleic Acid. J. Nutrition.","DOI":"10.1093\/jn\/136.9.2325"},{"key":"10.1016\/j.gene.2024.148704_b0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4274\/jcrpe.galenos.2018.2018.0195","article-title":"SLC30A8 Gene rs13266634 C\/T Polymorphism in Children with Type 1 Diabetes in Tamil Nadu, India","volume":"11","author":"Thirunavukkarasu","year":"2019","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"10.1016\/j.gene.2024.148704_b0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2350-10-15","article-title":"Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis","volume":"10","author":"Tong","year":"2009","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.gene.2024.148704_b0160","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4103\/ijem.IJEM_540_19","article-title":"Carriers of the TCF7L2 rs7903146, rs12255372 Risk Alleles in the South Tamil Nadu T2DM Patients Present with Early Incidence and Insulin Dependence","volume":"23","author":"Velayutham","year":"2019","journal-title":"Indian J. Endocrinol. Metab"},{"key":"10.1016\/j.gene.2024.148704_b0165","doi-asserted-by":"crossref","first-page":"nzac014","DOI":"10.1093\/cdn\/nzac014","article-title":"The FTO rs9939609 Variant Is Associated with Cardiometabolic Disease Risk and Dietary Energy Intakes in Children with Mental Health Disorders","volume":"6","author":"Wiedeman","year":"2022","journal-title":"Curr Dev Nutr"},{"key":"10.1016\/j.gene.2024.148704_b0170","doi-asserted-by":"crossref","first-page":"779","DOI":"10.5114\/aoms.2015.47692","article-title":"Gestational diabetes mellitus is associated with increased leukocyte peroxisome proliferator-activated receptor \u03b3 expression","volume":"11","author":"W\u00f3jcik","year":"2015","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.gene.2024.148704_b0175","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.2337\/db08-0047","article-title":"Common variants in CDKAL1, CDKN2A\/B, IGF2BP2, SLC30A8, and HHEX\/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population","volume":"57","author":"Wu","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.gene.2024.148704_b0180","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.499788","article-title":"Novel Genetic Variants of PPAR\u03b32 Promoter in Gestational Diabetes Mellitus and its Molecular Regulation in Adipogenesis","volume":"11","author":"Wu","year":"2021","journal-title":"Front. Endocrinol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924005857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924005857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T15:35:05Z","timestamp":1728228905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924005857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":33,"alternative-id":["S0378111924005857"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148704","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic variants related to insulin metabolism are associated with gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148704","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"148704"}}