{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:19:18Z","timestamp":1789957158926,"version":"4.0.1"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["STR\/2022\/000020"],"award-info":[{"award-number":["STR\/2022\/000020"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2020\/003837"],"award-info":[{"award-number":["CRG\/2020\/003837"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013357","name":"Indian Statistical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.gene.2024.148903","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T16:50:21Z","timestamp":1725295821000},"page":"148903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Genome-wide RNA-seq, DNA methylation and small RNA-seq analysis unraveled complex gene regulatory networks in psoriasis pathogenesis"],"prefix":"10.1016","volume":"933","author":[{"given":"Sayantan","family":"Laha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanab","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urbee","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsa","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapan","family":"Senapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gobinda","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghunath","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.gene.2024.148903_b0005","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","article-title":"p21 in cancer: intricate networks and multiple activities","volume":"9","author":"Abbas","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0010","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1186\/s12864-016-3188-y","article-title":"Network analysis of psoriasis reveals biological pathways and roles for coding and long non-coding RNAs","volume":"17","author":"Ahn","year":"2016","journal-title":"BMC Genomics"},{"issue":"10","key":"10.1016\/j.gene.2024.148903_b0015","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11101475","article-title":"The role of the cyclin dependent kinase inhibitor p21(cip1\/waf1) in targeting cancer: molecular mechanisms and novel therapeutics","volume":"11","author":"Al Bitar","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0020","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0035","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1073\/pnas.96.3.1002","article-title":"Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation","volume":"96","author":"Brugarolas","year":"1999","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molimm.2014.12.014","article-title":"Genetic and epigenetic basis of psoriasis pathogenesis","volume":"64","author":"Chandra","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.gene.2024.148903_b0045","doi-asserted-by":"crossref","first-page":"24059","DOI":"10.1038\/srep24059","article-title":"Increased risk of psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population","volume":"6","author":"Chandra","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0050","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/jhg.2016.139","article-title":"Association of IL12B risk haplotype and lack of interaction with HLA-Cw6 among the psoriasis patients in India","volume":"62","author":"Chandra","year":"2017","journal-title":"J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0055","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13148-018-0541-9","article-title":"Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis","volume":"10","author":"Chandra","year":"2018","journal-title":"Clin. Epigenetics"},{"issue":"11","key":"10.1016\/j.gene.2024.148903_b0060","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1016\/j.jid.2021.04.020","article-title":"Functional mapping of genetic interactions between HLA-Cw6 and LCE3A in psoriasis","volume":"141","author":"Chandra","year":"2021","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0065","doi-asserted-by":"crossref","first-page":"J314","DOI":"10.1016\/j.jaut.2009.12.001","article-title":"Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis","volume":"34","author":"Chandran","year":"2010","journal-title":"J. Autoimmun."},{"issue":"7","key":"10.1016\/j.gene.2024.148903_b0070","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbagrm.2012.02.014","article-title":"CpG methylation recruits sequence specific transcription factors essential for tissue specific gene expression","volume":"1819","author":"Chatterjee","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0075","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jdermsci.2019.11.003","article-title":"Integrated microRNA\/mRNA expression profiling of the skin of psoriasis patients","volume":"97","author":"Delic","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.gene.2024.148903_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdermsci.2023.07.005","article-title":"Multi-omics approach identifies PI3 as a biomarker for disease severity and hyper-keratinization in psoriasis","author":"Deng","year":"2023","journal-title":"J. Dermatol. Sci."},{"issue":"8","key":"10.1016\/j.gene.2024.148903_b0085","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015354","article-title":"Psoriasis","volume":"4","author":"Di Meglio","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.gene.2024.148903_b0095","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4103\/0378-6323.72443","article-title":"Psoriasis in India: prevalence and pattern","volume":"76","author":"Dogra","year":"2010","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"10.1016\/j.gene.2024.148903_b0100","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X19886505","article-title":"The role of epigenetics and immunological imbalance in the etiopathogenesis of psoriasis and psoriatic arthritis","volume":"11","author":"Frischknecht","year":"2019","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0105","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3892\/or.2017.5839","article-title":"Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer","volume":"38","author":"Fu","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.gene.2024.148903_b0110","article-title":"Serum miRNA profiling identified miRNAs associated with disease severity in psoriasis","author":"Ganguly","year":"2023","journal-title":"Exp. Dermatol."},{"issue":"11","key":"10.1016\/j.gene.2024.148903_b0115","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium","year":"2010","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002454","article-title":"DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes","volume":"8","author":"Gervin","year":"2012","journal-title":"PLoS Genet."},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0125","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10142-023-01057-5","article-title":"Emerging roles of non-coding RNAs in psoriasis pathogenesis","volume":"23","author":"Ghosh","year":"2023","journal-title":"Funct. Integr. Genomics"},{"key":"10.1016\/j.gene.2024.148903_b0130","article-title":"A scoping review on use of drugs targeting the JAK\/STAT pathway in psoriasis","volume":"9","author":"Gomez-Garcia","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.gene.2024.148903_b0135","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"10281","key":"10.1016\/j.gene.2024.148903_b0140","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"Griffiths","year":"2021","journal-title":"Psoriasis. Lancet"},{"issue":"3 Pt 1","key":"10.1016\/j.gene.2024.148903_b0145","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/jid.2011.364","article-title":"A role for epigenetics in psoriasis: methylated Cytosine-Guanine sites differentiate lesional from nonlesional skin and from normal skin","volume":"132","author":"Gudjonsson","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.gene.2024.148903_b0150","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1091\/mbc.6.4.387","article-title":"Inhibition of cyclin-dependent kinases by p21","volume":"6","author":"Harper","year":"1995","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0155","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2019.05.041","article-title":"Patterns of early p21 dynamics determine proliferation-senescence cell fate after chemotherapy","volume":"178","author":"Hsu","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1868-7083-3-3","article-title":"Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells","volume":"3","author":"Hsu","year":"2011","journal-title":"Clin. Epigenetics"},{"issue":"D1","key":"10.1016\/j.gene.2024.148903_b0165","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkab1079","article-title":"miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions","volume":"50","author":"Huang","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/bib\/bbr049","article-title":"Gene set enrichment analysis: performance evaluation and usage guidelines","volume":"13","author":"Hung","year":"2012","journal-title":"Brief. Bioinform."},{"issue":"6631","key":"10.1016\/j.gene.2024.148903_b0175","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/387417a0","article-title":"Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15","volume":"387","author":"Iavarone","year":"1997","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0180","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/jid.2011.267","article-title":"Transcriptional profiling of psoriasis using RNA-seq reveals previously unidentified differentially expressed genes","volume":"132","author":"Jabbari","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.gene.2024.148903_b0185","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3892\/mmr.2012.1057","article-title":"Sulforaphane inhibits proliferation by causing cell cycle arrest at the G2\/M phase in rabbit articular chondrocytes","volume":"6","author":"Jeong","year":"2012","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0190","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"issue":"20","key":"10.1016\/j.gene.2024.148903_b0195","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1093\/hmg\/ddr331","article-title":"Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome","volume":"20","author":"Joyce","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"D1","key":"10.1016\/j.gene.2024.148903_b0200","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.gene.2024.148903_b0205","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1089\/cmb.2017.0096","article-title":"cutPrimers: A new tool for accurate cutting of primers from reads of targeted next generation sequencing","volume":"24","author":"Kechin","year":"2017","journal-title":"J. Comput. Biol."},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0210","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jaci.2023.05.012","article-title":"Single-cell transcriptomics suggest distinct upstream drivers of IL-17A\/F in hidradenitis versus psoriasis","volume":"152","author":"Kim","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.gene.2024.148903_b0215","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.12688\/f1000research.9090.1","article-title":"AutoAnnotate: A Cytoscape app for summarizing networks with semantic annotations","volume":"5","author":"Kucera","year":"2016","journal-title":"F1000Res"},{"issue":"W1","key":"10.1016\/j.gene.2024.148903_b0220","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"16","key":"10.1016\/j.gene.2024.148903_b0225","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.gene.2024.148903_b0230","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/jid.2014.28","article-title":"Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms","volume":"134","author":"Li","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.gene.2024.148903_b0235","article-title":"Identification of potential biomarkers for psoriasis by DNA methylation and gene expression datasets","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Genet."},{"issue":"4","key":"10.1016\/j.gene.2024.148903_b0240","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2217\/epi-2022-0458","article-title":"Genome-wide DNA methylation and transcription analysis in psoriatic epidermis","volume":"15","author":"Liu","year":"2023","journal-title":"Epigenomics"},{"key":"10.1016\/j.gene.2024.148903_b0245","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.gene.2024.148903_b0250","doi-asserted-by":"crossref","DOI":"10.3390\/genes14081619","article-title":"Genetic and epigenetic mechanisms of psoriasis","volume":"14","author":"Mateu-Arrom","year":"2023","journal-title":"Genes (Basel)"},{"issue":"6","key":"10.1016\/j.gene.2024.148903_b0255","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/bioinformatics\/btp053","article-title":"Testing significance relative to a fold-change threshold is a TREAT","volume":"25","author":"McCarthy","year":"2009","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.gene.2024.148903_b0260","doi-asserted-by":"crossref","first-page":"e13984","DOI":"10.1371\/journal.pone.0013984","article-title":"Enrichment map: a network-based method for gene-set enrichment visualization and interpretation","volume":"5","author":"Merico","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0265","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.311","article-title":"Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways","volume":"41","author":"Nair","year":"2009","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0270","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12020465","article-title":"Loss of CDKN1A mRNA and protein expression are independent predictors of poor outcome in chromophobe renal cell carcinoma patients","volume":"12","author":"Ohashi","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0275","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.gene.2024.148903_b0280","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"issue":"Web Server issue","key":"10.1016\/j.gene.2024.148903_b0285","doi-asserted-by":"crossref","first-page":"W193","DOI":"10.1093\/nar\/gkm226","article-title":"g:Profiler\u2013a web-based toolset for functional profiling of gene lists from large-scale experiments","volume":"35","author":"Reimand","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0290","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat Protoc"},{"issue":"6","key":"10.1016\/j.gene.2024.148903_b0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis pathogenesis and treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3 Pt 1","key":"10.1016\/j.gene.2024.148903_b0300","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/jid.2011.348","article-title":"A subset of methylated CpG sites differentiate psoriatic from normal skin","volume":"132","author":"Roberson","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0305","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.gene.2024.148903_b0310","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11081178","article-title":"p21 in Cancer Research","volume":"11","author":"Shamloo","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.gene.2024.148903_b0315","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2174\/187152012800617678","article-title":"The role of Cdc25A in the regulation of cell proliferation and apoptosis","volume":"12","author":"Shen","year":"2012","journal-title":"Anticancer Agents Med Chem."},{"issue":"19","key":"10.1016\/j.gene.2024.148903_b0320","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10194307","article-title":"Role of janus kinase inhibitors in therapy of psoriasis","volume":"10","author":"Sluczanowska-Glabowska","year":"2021","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.gene.2024.148903_b0325","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/exd.14497","article-title":"MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity","volume":"31","author":"Solvin","year":"2022","journal-title":"Exp. Dermatol."},{"issue":"12","key":"10.1016\/j.gene.2024.148903_b0330","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/j.jid.2019.05.019","article-title":"Next-generation sequencing identifies the keratinocyte-specific miRNA signature of psoriasis","volume":"139","author":"Srivastava","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.gene.2024.148903_b0335","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"Stewart","year":"2003","journal-title":"RNA"},{"issue":"43","key":"10.1016\/j.gene.2024.148903_b0340","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0345","doi-asserted-by":"crossref","first-page":"18045","DOI":"10.1038\/s41598-017-18404-9","article-title":"RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin","volume":"7","author":"Swindell","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0350","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jdermsci.2018.06.001","article-title":"Integrative methylome and transcriptome analysis to dissect key biological pathways for psoriasis in Chinese Han population","volume":"91","author":"Tang","year":"2018","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0355","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ng.2827","article-title":"A large-scale screen for coding variants predisposing to psoriasis","volume":"46","author":"Tang","year":"2014","journal-title":"Nat. Genet."},{"issue":"6538","key":"10.1016\/j.gene.2024.148903_b0360","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/376358a0","article-title":"Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet irradiation","volume":"376","author":"Terada","year":"1995","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0365","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/bioinformatics\/bts680","article-title":"A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data","volume":"29","author":"Teschendorff","year":"2013","journal-title":"Bioinformatics"},{"issue":"24","key":"10.1016\/j.gene.2024.148903_b0370","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1093\/bioinformatics\/btx513","article-title":"ChAMP: updated methylation analysis pipeline for Illumina BeadChips","volume":"33","author":"Tian","year":"2017","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.gene.2024.148903_b0375","first-page":"367","article-title":"Understanding psoriasis: Role of miRNAs","volume":"9","author":"Timis","year":"2018","journal-title":"Biomed Rep"},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0380","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1186\/gb-2007-8-3-r39","article-title":"Reactome: a knowledge base of biologic pathways and processes","volume":"8","author":"Vastrik","year":"2007","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.gene.2024.148903_b0385","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jid.2017.11.036","article-title":"Genome-Wide DNA Methylation Profiling Identifies Differential Methylation in Uninvolved Psoriatic Epidermis","volume":"138","author":"Verma","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0390","first-page":"93","article-title":"Prediction of crucial epigenetically-associated, differentially expressed genes by integrated bioinformatics analysis and the identification of S100A9 as a novel biomarker in psoriasis","volume":"45","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.gene.2024.148903_b0395","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/bioinformatics\/btr671","article-title":"A novel significance score for gene selection and ranking","volume":"30","author":"Xiao","year":"2014","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0400","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41419-018-0286-6","article-title":"Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites","volume":"9","author":"Xie","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2024.148903_b0405","doi-asserted-by":"crossref","first-page":"7731082","DOI":"10.1155\/2022\/7731082","article-title":"Exploration of biomarkers of psoriasis through combined multiomics analysis","volume":"2022","author":"Xing","year":"2022","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.gene.2024.148903_b0410","article-title":"miRNAs flowing up and down: the concerto of psoriasis","volume":"8","author":"Xiuli","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"8","key":"10.1016\/j.gene.2024.148903_b0415","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/exd.14332","article-title":"Dysregulated epigenetic modifications in psoriasis","volume":"30","author":"Zeng","year":"2021","journal-title":"Exp. Dermatol."},{"issue":"6","key":"10.1016\/j.gene.2024.148903_b0420","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1046\/j.1523-1747.2002.19612.x","article-title":"Evidence for a major psoriasis susceptibility locus at 6p21(PSORS1) and a novel candidate region at 4q31 by genome-wide scan in Chinese hans","volume":"119","author":"Zhang","year":"2002","journal-title":"J, Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.gene.2024.148903_b0425","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng.310","article-title":"Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21","volume":"41","author":"Zhang","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2024.148903_b0430","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jaut.2013.01.001","article-title":"Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris","volume":"41","author":"Zhang","year":"2013","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.gene.2024.148903_b0435","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12859-018-2191-5","article-title":"RnaSeqSampleSize: real data based sample size estimation for RNA sequencing","volume":"19","author":"Zhao","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.gene.2024.148903_b0440","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.2147\/OTT.S274092","article-title":"Let-7c-5p inhibits cell proliferation and migration and promotes apoptosis via the CTHRC1\/AKT\/ERK pathway in esophageal squamous cell carcinoma","volume":"13","author":"Zheng","year":"2020","journal-title":"Onco Targets Ther"},{"issue":"3","key":"10.1016\/j.gene.2024.148903_b0445","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jdermsci.2010.03.004","article-title":"MicroRNAs and potential target interactions in psoriasis","volume":"58","author":"Zibert","year":"2010","journal-title":"J. Dermatol. Sci."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924007844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924007844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T13:22:33Z","timestamp":1733404953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924007844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":89,"alternative-id":["S0378111924007844"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148903","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide RNA-seq, DNA methylation and small RNA-seq analysis unraveled complex gene regulatory networks in psoriasis pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148903","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"148903"}}