{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:35:37Z","timestamp":1750296937701,"version":"3.37.3"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005283","name":"Foundation for Scientific and Technological Development and Support of Cear\u00e1","doi-asserted-by":"publisher","award":["13192399-4"],"award-info":[{"award-number":["13192399-4"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.gene.2024.148977","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T20:42:05Z","timestamp":1728506525000},"page":"148977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Host repair polymorphisms and H. pylori genes in gastric disease outcomes: Who are the guardian and villains?"],"prefix":"10.1016","volume":"933","author":[{"given":"Morgana","family":"Maria de Oliveira Barboza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginaldo","family":"Ferreira da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Paulo Por Deus Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rommel","family":"M\u00e1rio Rodr\u00edguez Burbano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Goberl\u00e2nio de Barros Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Helena Barem Rabenhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.gene.2024.148977_b0005","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3390\/toxins11110677","article-title":"Helicobacter pylori virulence factors exploiting gastric colonization and its pathogenicity","volume":"11","author":"Ansari","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"30","key":"10.1016\/j.gene.2024.148977_b0010","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.270.30.17771","article-title":"Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration","volume":"28","author":"Atherton","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2024.148977_b0015","first-page":"195","article-title":"Exploiting the gastric epithelial barrier: Helicobacter pylori's attack on tight and adherens junctions","volume":"400","author":"Backert","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.gene.2024.148977_b0020","doi-asserted-by":"crossref","unstructured":"Baj J., Forma A., Sitarz M., et al.(2020). Helicobacter pyloriVirulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment. Cells. Dec 25;10(1):27. doi: 10.3390\/cells10010027.","DOI":"10.3390\/cells10010027"},{"key":"10.1016\/j.gene.2024.148977_b0025","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1590\/S0100-40422006000600032","article-title":"Oxidative stress, lesions in the genome and signaling processes in cell cycle control","volume":"29","author":"Berra","year":"2006","journal-title":"Quim. Nova."},{"key":"10.1016\/j.gene.2024.148977_b0030","doi-asserted-by":"crossref","unstructured":"Brenneman M.A., Wagener B.M., Miller C.A., et al. (2002). XRCC3 controls the fidelity of homologous recombination: roles for XRCC3 in late stages of recombination. Mol Cell. Aug;10(2):387-95. doi: 10.1016\/s1097-2765(02)00595-6.","DOI":"10.1016\/S1097-2765(02)00595-6"},{"key":"10.1016\/j.gene.2024.148977_b0035","doi-asserted-by":"crossref","unstructured":"Butcher L.D., Hartgog G., Ernst P.B., Crowe S.E. (2017). Oxidative Stress Resulting from Helicobacter pylori Infection Contributes to Gastric Carcinogenesis. Cell Mol Gastroenterol Hepatol. May; 3(3): 316\u2013322.doi: 10.1016\/j.jcmgh.2017.02.002.","DOI":"10.1016\/j.jcmgh.2017.02.002"},{"issue":"6","key":"10.1016\/j.gene.2024.148977_b0040","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/thy.2005.15.511","article-title":"Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1","volume":"15","author":"Chen","year":"2005","journal-title":"Thyroid"},{"key":"10.1016\/j.gene.2024.148977_b0045","doi-asserted-by":"crossref","unstructured":"Chiarella P., Capone P., Sisto R. (2023). Contribution of Genetic Polymorphisms in Human Health. Int. J. Environ. Res. Public Health. vol. 4;20(2):912. doi:10.3390\/ijerph20020912.","DOI":"10.3390\/ijerph20020912"},{"key":"10.1016\/j.gene.2024.148977_b0050","doi-asserted-by":"crossref","unstructured":"Chun J., Buechelmaier E.S., Powell S.N. (2013). Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination. Mol. Cell Biol. Jan;33(2):387-95. doi: 10.1128\/MCB.00465-12.","DOI":"10.1128\/MCB.00465-12"},{"key":"10.1016\/j.gene.2024.148977_b0055","doi-asserted-by":"crossref","unstructured":"Coelho L.G.V., Marinho J.R., Genta R. (2018). IV th Brazilian Consensus Conference on Helicobacter pylori infection. Arq Gastroenterol. vol.55(20): 97-212.","DOI":"10.1590\/s0004-2803.201800000-20"},{"key":"10.1016\/j.gene.2024.148977_b0060","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2024.148977_b0065","doi-asserted-by":"crossref","unstructured":"Cover T.L., Lacy D.B., Ohi M.D. (2020). The Helicobacter pylori Cag Type IV Secretion System. Trends Microbiol. Aug;28(8):682-695. doi: 10.1016\/j.tim.2020.02.004.","DOI":"10.1016\/j.tim.2020.02.004"},{"key":"10.1016\/j.gene.2024.148977_b0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neubiorev.2007.05.002","article-title":"Validating Psychiatric Endophenotypes: Inhibitory control and attention deficit hyperactivity disorder","volume":"32","author":"Crosbie","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.gene.2024.148977_b0075","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1007\/s10620-015-3666-0","article-title":"Characterization of gastric cardia tumors: Differences in Helicobacter pylori strains and genetic polymorphisms","volume":"60","author":"Da Costa","year":"2015","journal-title":"Dig. Dis. Sci."},{"issue":"4","key":"10.1016\/j.gene.2024.148977_b0080","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.gastro.2008.01.071","article-title":"Gastric cancer risk in patients with premalignant gastric lesions: A nationwide cohort study in the Netherlands","volume":"134","author":"De Vries","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gene.2024.148977_b0085","doi-asserted-by":"crossref","unstructured":"Della-Maria J., Hedje M.L., McNeill D.R., et al. (2012). The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA 671 alkylation damage and stable association at DNA damage sites. J. Biol. Chem. Nov 9;287(46):39233-44. doi: 10.1074\/jbc.M112.369975.","DOI":"10.1074\/jbc.M112.369975"},{"issue":"6","key":"10.1016\/j.gene.2024.148977_b0090","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1128\/JCM.37.6.2113-2114.1999","article-title":"cagA and vacA status of Spanish Helicobacter pylori clinical isolates","volume":"37","author":"Domingo","year":"1999","journal-title":"J. Clin. Microbiol."},{"issue":"42","key":"10.1016\/j.gene.2024.148977_b0095","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.3748\/wjg.v11.i42.6593","article-title":"Polymorphisms of DNA repair genes XRCC1 and XRCC3 interaction with environmental exposure and risk of chronic gastritis and gastric c\u00e2ncer","volume":"11","author":"Duarte","year":"2005","journal-title":"WJG"},{"issue":"3","key":"10.1016\/j.gene.2024.148977_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.diagmicrobio.2021.115372","article-title":"CagE, cagA and cagA 3' region polymorphism of Helicobacter pylori and their association with the intra-gastric diseases in Moroccan population","volume":"100","author":"El Khadir","year":"2021","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.gene.2024.148977_b0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2478\/10004-1254-62-2011-2098","article-title":"Association between xrcc1 arg399gln and p53 arg72pro polymorphisms and the risk of gastric and colorectal cancer in Turkish Population","volume":"62","author":"Engin","year":"2011","journal-title":"Arh Hig Rada Toksikol."},{"key":"10.1016\/j.gene.2024.148977_b0110","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1046\/j.1365-2958.2001.02714.x","article-title":"Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8","volume":"42","author":"Fischer","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.gene.2024.148977_b0115","unstructured":"Foster G.D., Tweel D. (1996). Plant Gene Isolation. Principles and Pratics. Edited by Gary D. Foster & David Twell. John Wiley & Sons Ltd., England, p 426."},{"issue":"12","key":"10.1016\/j.gene.2024.148977_b0120","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.dnarep.2013.08.015","article-title":"XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair","volume":"2","author":"Gabel","year":"2013","journal-title":"DNA Repair"},{"issue":"4","key":"10.1016\/j.gene.2024.148977_b0125","doi-asserted-by":"crossref","first-page":"e01168","DOI":"10.1128\/mBio.01168-17","article-title":"TIFA signaling in gastric epithelial cells initiates the cag type 4 secretion system-dependent innate immune response to Helicobacter pylori infection","volume":"8","author":"Gall","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.gene.2024.148977_b0130","doi-asserted-by":"crossref","unstructured":"Gastroenterologists in Sydney-histology and Helicobacter. (1990). Lancet., 2:779-78.","DOI":"10.1016\/0140-6736(90)93244-J"},{"key":"10.1016\/j.gene.2024.148977_b0135","unstructured":"Genecards. The Human gene Database. (2023). Available from: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=XRCC3, accessed September 2023."},{"key":"10.1016\/j.gene.2024.148977_b0140","unstructured":"Globocan. (2023). Available from: https:\/\/gco.iarc.fr\/today, accessed October 2023."},{"key":"10.1016\/j.gene.2024.148977_b0145","first-page":"1925","article-title":"Variant alleles in XRCC1 Arg194Trp and Arg399Gln polymorphisms increase risk of gastrointestinal cancer in Sabah, North Borneo","volume":"17","author":"Halim","year":"2016","journal-title":"APJCP"},{"issue":"3","key":"10.1016\/j.gene.2024.148977_b0150","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s12282-016-0719-y","article-title":"Genetic polymorphisms in APE1 Asp148Glu(rs3136820) as a modifier of the background levels of abasic sites in human leukocytes derived from breast cancer patients and controls","volume":"24","author":"Hsieh","year":"2017","journal-title":"Breast Cancer"},{"issue":"6","key":"10.1016\/j.gene.2024.148977_b0155","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/carcin\/22.6.917","article-title":"Amino Acid substitutions variants of APE and XRCC1 genes associated with ionizing radiation sensivity","volume":"22","author":"Hu","year":"2001","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.gene.2024.148977_b0160","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/carcin\/bgi084","article-title":"Selected DNA repair polymorphismsand gastric cancer in Poland","volume":"26","author":"Huang","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.gene.2024.148977_b0165","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.chom.2021.04.006","article-title":"Helicobacter pylori CagA elicits BRCA to induce genome instability that may underlie bacterial gastric carcinogenesis","volume":"29","author":"Imai","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.gene.2024.148977_b0170","unstructured":"Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva (INCA). (2023). Incid\u00eancia de c\u00e2ncer no Brasil. Available on line: https:\/\/www.gov.br\/inca\/pt-br\/assuntos\/cancer\/tipos\/estomago. Accessed mar 19 2023."},{"key":"10.1016\/j.gene.2024.148977_b0175","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fgene.2017.00020","article-title":"Inflammation, DNA damage, Helicobacter pylori and gastric tumorigenesis","volume":"8","author":"Kalisperati","year":"2017","journal-title":"Front. Genet."},{"key":"10.1016\/j.gene.2024.148977_b0180","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.3390\/ijms18081808","article-title":"Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis","volume":"18","author":"Kawanishi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2024.148977_b0185","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1053\/gast.2002.34751","article-title":"Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells","volume":"123","author":"Kim","year":"2002","journal-title":"Gastroenterol."},{"issue":"1","key":"10.1016\/j.gene.2024.148977_b0190","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yexmp.2009.04.005","article-title":"Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer","volume":"87","author":"Krupa","year":"2009","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.gene.2024.148977_b0195","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1128\/jcm.33.10.2752-2756.1995","article-title":"Diagnosis of Helicobacter pylori infection by PCR: comparison with other invasive techniques and detection of cagA gene in gastric biopsy specimens","volume":"33","author":"Lage","year":"1995","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.gene.2024.148977_b0200","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The two histological main types of gastric carcinoma: diffuse and so called intestinal-type carcinoma. An attempt at a histo-clinical classification","volume":"64","author":"Lauren","year":"1965","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"10.1016\/j.gene.2024.148977_b0205","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3835(02)00381-6","article-title":"Genetic polymorphisms of XRCC1 and risk of gastric cancer","volume":"187","author":"Lee","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.gene.2024.148977_b0210","doi-asserted-by":"crossref","unstructured":"L\u00e9vy N., Martz A., Bresson A., et al. (2006). XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage. Nucleic Acids Res. Jan 5;34(1):32- 41. doi: 10.1093\/nar\/gkj409.","DOI":"10.1093\/nar\/gkj409"},{"issue":"54","key":"10.1016\/j.gene.2024.148977_b0215","doi-asserted-by":"crossref","first-page":"93063","DOI":"10.18632\/oncotarget.21810","article-title":"Pooling-analysis on hMLH1 polymorphisms and cancer risk: evidence based on 31,484 cancer cases and 45,494 cancer-free controls","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.gene.2024.148977_b0220","first-page":"e613","article-title":"The relationship between Helicobacter pylori genes cagE and virB11 and gastric cancer","volume":"14","author":"Lima","year":"2010","journal-title":"IJID"},{"key":"10.1016\/j.gene.2024.148977_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2020.102917","article-title":"XRCC1-strategies for coordinating and assembling a versatile DNA damage response","volume":"93","author":"London","year":"2020","journal-title":"DNA Repair."},{"key":"10.1016\/j.gene.2024.148977_b0230","first-page":"556","article-title":"Relationship between nuclear factor-\u03baB activation and virulence factors of Helicobacter pylori in Japanese clinical isolates","volume":"17","author":"Maeda","year":"2002","journal-title":"JGH"},{"key":"10.1016\/j.gene.2024.148977_b0235","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/mutage\/gez046","article-title":"Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance","volume":"35","author":"McNeill","year":"2019","journal-title":"Mutagenesis"},{"issue":"1","key":"10.1016\/j.gene.2024.148977_b0240","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/nar\/gkg925","article-title":"Domain mapping of the Rad51 paralog protein complexes","volume":"32","author":"Miller","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2024.148977_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1758835918786658","article-title":"Dancing with the DNA damage response: Next- generation anti-cancer therapeutic strategies","volume":"10","author":"Minchom","year":"2018","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.gene.2024.148977_b0250","doi-asserted-by":"crossref","unstructured":"Miyakura Y., Tahara M., Lefor A.T., Yasuda Y., Sugano K. (2014). Haplotype defined by the MLH1-93G\/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers. Miyakura et al. BMC Res. Notes. 7:835.","DOI":"10.1186\/1756-0500-7-835"},{"key":"10.1016\/j.gene.2024.148977_b0255","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1111\/cas.15357","article-title":"Helicobacter pylori- induced DNA double-stranded break in the development of gastric cancer","volume":"13","author":"Murata-Kamiya","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.gene.2024.148977_b0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3806514","article-title":"DNA repair gene XRCC1 and XPD polymorphisms and gastric cancer risk: A case-control study outcome from Kashmir, India","volume":"1","author":"Nissar","year":"2018","journal-title":"Anal. Cell. Pathol."},{"key":"10.1016\/j.gene.2024.148977_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.793096","article-title":"APE1\/Ref-1 role in inflammation and immune response","volume":"13","author":"Oliveira","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.gene.2024.148977_b0270","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/mutage\/geq042","article-title":"Polymorphic DNA repair and metabolic genes: A multigenic study on gastric cancer","volume":"25","author":"Palli","year":"2010","journal-title":"Mutagenesis"},{"key":"10.1016\/j.gene.2024.148977_b0275","unstructured":"Pereira E.S., Silva-Fernandes I.J.L, Costa D.M. et al. (2015). Association of the polymorphism in DNA Repair Enzymes and E-Cadherin Gene with Gastric Carcinoma Risk in population from Brazil. Eur. Acad. Res. Vol. III, Issue 1."},{"key":"10.1016\/j.gene.2024.148977_b0280","doi-asserted-by":"crossref","unstructured":"Pereira E.S., Albuquerque L.M., Balbino V.Q., et al. (2020). Helicobacter pylori cagE, cagG, and cagM can be a prognostic marker for intestinal and diffuse gastric cancer. Infect. Genet Evol. Oct; 84:104477. doi: 10.1016\/j.meegid.2020.104477.","DOI":"10.1016\/j.meegid.2020.104477"},{"issue":"809\u2013815","key":"10.1016\/j.gene.2024.148977_b0285","first-page":"2011","article-title":"Functional effects of the MLH1-93G>A polymorphism on MLH1\/EPM2AIP1 promoter activity","volume":"25","author":"Perera","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.gene.2024.148977_b0290","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3389\/fmicb.2018.00663","article-title":"The pivotal role of DNA repair in infection mediated- inflammation and cancer","volume":"9","author":"Sahan","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.gene.2024.148977_b0295","doi-asserted-by":"crossref","unstructured":"Santos J.C., Brianti M.T., Almeida V.R., et Al. (2016). Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway. Molecular Carcinogenesis. Doi 10.1002\/mc.22590.","DOI":"10.1002\/mc.22590"},{"issue":"10","key":"10.1016\/j.gene.2024.148977_b0300","doi-asserted-by":"crossref","first-page":"17333","DOI":"10.3390\/ijms151017333","article-title":"Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer","volume":"15","author":"Santos","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.gene.2024.148977_b0305","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1158\/1055-9965.EPI-15-0388","article-title":"DNA methylation predicts progression of human gastric lesions","volume":"24","author":"Schneider","year":"2015","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.gene.2024.148977_b0310","doi-asserted-by":"crossref","unstructured":"Silva-Fernandes I.J.L., Oliveira E.S., Santos J.C. et al. (2017) The intricate interplay between MSI and polymorphisms of DNA repair enzymes in gastric cancer H. pylori associated. Mutagenesis. Jul 1;32(4):471-478. doi: 10.1093\/mutage\/gex013.","DOI":"10.1093\/mutage\/gex013"},{"issue":"5","key":"10.1016\/j.gene.2024.148977_b0315","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.lab.2005.06.010","article-title":"Heterogeneity of cag genotypes and clinicaloutcome of Helicobacter pylori infection","volume":"146","author":"Sozzi","year":"2005","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.gene.2024.148977_b0320","first-page":"1459","article-title":"Association between genetic polymorphisms related to DNA repair or xenobiotic pathways and gastric premalignant conditions","volume":"31","author":"Tahara","year":"2011","journal-title":"Anticancer Res."},{"key":"10.1016\/j.gene.2024.148977_b0325","doi-asserted-by":"crossref","unstructured":"Tell G., Quadrifoglio F., Tiribelli C., Kelley M.R. (2009). The many functions of APE1\/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal. Mar;11(3):601-20. doi: 10.1089\/ars.2008.2194.","DOI":"10.1089\/ars.2008.2194"},{"issue":"46","key":"10.1016\/j.gene.2024.148977_b0330","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1038\/emm.2014.42","article-title":"APE1\/Ref-1 as an emerging therapeutic target for various human diseases: Phytochemical modulation of its functions","volume":"18","author":"Thakur","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.gene.2024.148977_b0335","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Research Network. (2014). Comprehensive Molecular Characterization of Gastric Adenocarcinoma. Nature. doi:10.1038\/nature13480.","DOI":"10.1038\/nature13480"},{"key":"10.1016\/j.gene.2024.148977_b0340","doi-asserted-by":"crossref","unstructured":"Valenzuela M.A., Canales J., Corval\u00e1n A.H., Quest A.F. (2015). Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis. World J Gastroenterol. Dec 7;21(45):12742-56. doi: 10.3748\/wjg. v21.i45.12742.","DOI":"10.3748\/wjg.v21.i45.12742"},{"key":"10.1016\/j.gene.2024.148977_b0345","doi-asserted-by":"crossref","unstructured":"Vallejo-Flores G., Torres J., Sandoval-Montes C. (2015). Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation. BioMed Res. Int. ID 676 761501, 12 pages.","DOI":"10.1155\/2015\/761501"},{"issue":"3","key":"10.1016\/j.gene.2024.148977_b0350","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/carcin\/bgl187","article-title":"Association of DNA repair polymorphisms with DNA repair functional outcomes in healty human subjects","volume":"28","author":"Vodicka","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.gene.2024.148977_b0355","doi-asserted-by":"crossref","unstructured":"Watari J., Chen N., Amenta P.S., et al. (2014). Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development (2014). World J Gastroenterol.14;20(18):5461-73. doi: 10.3748\/wjg.v20.i18.5461.","DOI":"10.3748\/wjg.v20.i18.5461"},{"key":"10.1016\/j.gene.2024.148977_b0360","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1242\/jcs.128272","article-title":"Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly (ADP-ribose)","volume":"126","author":"Wei","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.gene.2024.148977_b0365","first-page":"26","article-title":"Genetic variants of the XRCC1 gene and susceptibility to esophageal c\u00e2ncer: a meta-analysis","volume":"2","author":"Yin","year":"2009","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.gene.2024.148977_b0370","doi-asserted-by":"crossref","unstructured":"Zhang X-Y, Zhang P-Y, Aboul-Soud M.A.M. (2017). From inflammation to gastric cancer: Role of Helicobacter pylori (Review). Oncol. Lett. 13:543-548.","DOI":"10.3892\/ol.2016.5506"},{"key":"10.1016\/j.gene.2024.148977_b0375","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1002\/cam4.3765","article-title":"Distinct genomic profile in h. pylori- associated gastric cancer","volume":"10","author":"Zhang","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.gene.2024.148977_b0380","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12879-016-1839-x","article-title":"Classification and Regression Tree (CART) analysis to predict influenza in primary care patients","volume":"16","author":"Zimmerman","year":"2016","journal-title":"BMC Infecti. Diseases"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T13:22:26Z","timestamp":1733404946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924008588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":76,"alternative-id":["S0378111924008588"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148977","relation":{},"ISSN":["0378-1119"],"issn-type":[{"type":"print","value":"0378-1119"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Host repair polymorphisms and H. pylori genes in gastric disease outcomes: Who are the guardian and villains?","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"148977"}}