{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:53:40Z","timestamp":1789588420466,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.gene.2024.148980","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T15:50:03Z","timestamp":1727970603000},"page":"148980","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Exploring the effects of naringenin on cell functioning and energy synthesis in the hippocampus of male Wistar rats with chronic tinnitus, by examining genetic indicators such as Bax, Bcl-2, Tfam, and Pgc-1\u03b1"],"prefix":"10.1016","volume":"933","author":[{"given":"Seyede-Mojdeh","family":"Safavi-Naeini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-3592","authenticated-orcid":false,"given":"Mohammad","family":"Nasehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Reza","family":"Zarrindast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed-Abbas","family":"Safavi-Naeini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.gene.2024.148980_b0005","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s12070-018-1464-7","article-title":"A comprehensive study of oxidative stress in tinnitus patients","volume":"70","author":"Celik","year":"2018","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"issue":"6","key":"10.1016\/j.gene.2024.148980_b0010","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10863-010-9321-8","article-title":"The potential role of mitochondrial dysfunction in seizure-associated cell death in the hippocampus and epileptogenesis","volume":"42","author":"Chen","year":"2010","journal-title":"J. Bioenerg. Biomembr."},{"issue":"5","key":"10.1016\/j.gene.2024.148980_b0015","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/ejn.12759","article-title":"The auditory cortex and tinnitus - a review of animal and human studies","volume":"41","author":"Eggermont","year":"2015","journal-title":"Eur. J. Neurosci."},{"issue":"11","key":"10.1016\/j.gene.2024.148980_b0020","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2174\/1389450120666190319162147","article-title":"Molecular Aspects Of Melatonin Treatment In Tinnitus: A Review","volume":"20","author":"Hosseinzadeh","year":"2019","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.gene.2024.148980_b0025","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.abb.2015.03.014","article-title":"Oxidative stress and redox regulation on hippocampal-dependent cognitive functions","volume":"576","author":"Huang","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.gene.2024.148980_b0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.15171\/apb.2019.024","article-title":"Understanding apoptosis and apoptotic pathways targeted cancer therapeutics","volume":"9","author":"Jan","year":"2019","journal-title":"Adv Pharm Bull."},{"key":"10.1016\/j.gene.2024.148980_b0035","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnsys.2019.00088","article-title":"Plasticity in limbic regions at early time points in experimental models of tinnitus","volume":"13","author":"Kapolowicz","year":"2019","journal-title":"Front. Syst. Neurosci."},{"issue":"5","key":"10.1016\/j.gene.2024.148980_b0040","first-page":"2778","article-title":"Bhagyasree PJJoP","volume":"6","author":"Kiran","year":"2017","journal-title":"Phytochemistry. Flavonoid: A Review on Naringenin."},{"key":"10.1016\/j.gene.2024.148980_b0045","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mito.2019.08.001","article-title":"Limited predictive value of TFAM in mitochondrial biogenesis","volume":"49","author":"Kozhukhar","year":"2019","journal-title":"Mitochondrion"},{"key":"10.1016\/j.gene.2024.148980_b0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2013.10.032","article-title":"Excitotoxic glutamate insults block autophagic flux in hippocampal neurons","volume":"1542","author":"Kulbe","year":"2014","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.gene.2024.148980_b0055","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11010-018-3459-9","article-title":"TFAM overexpression reduces pathological cardiac remodeling","volume":"454","author":"Kunkel","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.gene.2024.148980_b0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.compbiomed.2018.05.012","article-title":"Across the blood-brain barrier: Neurotherapeutic screening and characterization of naringenin as a novel CRMP-2 inhibitor in the treatment of Alzheimer's disease using bioinformatics and computational tools","volume":"98","author":"Lawal","year":"2018","journal-title":"Comput. Biol. Med."},{"issue":"4","key":"10.1016\/j.gene.2024.148980_b0065","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00359-019-01339-z","article-title":"Neurotoxicity of sodium salicylate to the spiral ganglion neurons: GABA(A) receptor regulates NMDA receptor by Fyn-dependent phosphorylation","volume":"205","author":"Liu","year":"2019","journal-title":"J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol."},{"issue":"1","key":"10.1016\/j.gene.2024.148980_b0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12993-020-00166-6","article-title":"Naringin provides neuroprotection in CCL2-induced cognition impairment by attenuating neuronal apoptosis in the hippocampus","volume":"16","author":"Long","year":"2020","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.gene.2024.148980_b0075","article-title":"Naringenin and naringin in cardiovascular disease prevention","author":"Moghaddam","year":"2020","journal-title":"A Preclinical Rev."},{"key":"10.1016\/j.gene.2024.148980_b0080","doi-asserted-by":"crossref","first-page":"7807426","DOI":"10.1155\/2018\/7807426","article-title":"Effect of long-term sodium salicylate administration on learning, memory, and neurogenesis in the rat hippocampus","volume":"2018","author":"Niu","year":"2018","journal-title":"Biomed Res. Int."},{"issue":"4","key":"10.1016\/j.gene.2024.148980_b0085","doi-asserted-by":"crossref","first-page":"603","DOI":"10.18632\/aging.100934","article-title":"Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies","volume":"8","author":"Pistritto","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"10.1016\/j.gene.2024.148980_b0090","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: an update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"Pt B","key":"10.1016\/j.gene.2024.148980_b0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.mad.2016.04.007","article-title":"A brewing understanding of the regulation of Bax function by Bcl-xL and Bcl-2","volume":"161","author":"Renault","year":"2017","journal-title":"Mech. Ageing Dev."},{"issue":"9","key":"10.1016\/j.gene.2024.148980_b0100","doi-asserted-by":"crossref","first-page":"14951","DOI":"10.1002\/jcp.28334","article-title":"RAS\/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression","volume":"234","author":"Rezatabar","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.gene.2024.148980_b0105","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neulet.2019.02.027","article-title":"Prolactin prevents mitochondrial dysfunction induced by glutamate excitotoxicity in hippocampal neurons","volume":"701","author":"Rivero-Segura","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.gene.2024.148980_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010023","article-title":"Neuroprotective effect of valproic acid on salicylate-induced tinnitus","volume":"23","author":"Song","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.gene.2024.148980_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214183","article-title":"Protective effect of resveratrol in an experimental model of salicylate-induced tinnitus","volume":"23","author":"Song","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2024.148980_b0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnsys.2012.00028","article-title":"Salicylate toxicity model of tinnitus","volume":"6","author":"Stolzberg","year":"2012","journal-title":"Front. Syst. Neurosci."},{"issue":"7","key":"10.1016\/j.gene.2024.148980_b0125","article-title":"Dietary flavonoid intake and chronic sensory conditions","volume":"11","author":"Tang","year":"2022","journal-title":"A Scoping Rev. Antioxidants (Basel)"},{"issue":"4","key":"10.1016\/j.gene.2024.148980_b0130","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00394-021-02784-w","article-title":"Associations between intake of dietary flavonoids and the 10-year incidence of tinnitus in older adults","volume":"61","author":"Tang","year":"2022","journal-title":"Eur. J. Nutr."},{"issue":"4","key":"10.1016\/j.gene.2024.148980_b0135","doi-asserted-by":"crossref","first-page":"232","DOI":"10.5607\/en22002","article-title":"A Review on peripheral tinnitus, causes, and treatments from the perspective of autophagy","volume":"31","author":"Vijayakumar","year":"2022","journal-title":"Exp Neurobiol."},{"issue":"4","key":"10.1016\/j.gene.2024.148980_b0140","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3390\/plants9040550","article-title":"Naringenin regulates doxorubicin-induced liver dysfunction: impact on oxidative stress and inflammation","volume":"9","author":"Wali","year":"2020","journal-title":"Plants"},{"issue":"8","key":"10.1016\/j.gene.2024.148980_b0145","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/1440-1681.12775","article-title":"Naringenin prevents ischaemic stroke damage via anti-apoptotic and anti-oxidant effects","volume":"44","author":"Wang","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.gene.2024.148980_b0150","doi-asserted-by":"crossref","unstructured":"Xu X-H, Ma C-M, Han Y-Z, Li Y, Liu C, Duan Z-H, et al. Protective effect of naringenin on glutamate-induced neurotoxicity in cultured hippocampal cells. 2015;67(2):639-46.","DOI":"10.2298\/ABS140811023X"},{"issue":"6","key":"10.1016\/j.gene.2024.148980_b0155","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1080\/15548627.2019.1569926","article-title":"Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR","volume":"15","author":"Ye","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.gene.2024.148980_b0160","doi-asserted-by":"crossref","first-page":"8833087","DOI":"10.1155\/2021\/8833087","article-title":"Noise exposure alters glutamatergic and gabaergic synaptic connectivity in the hippocampus and its relevance to tinnitus","volume":"2021","author":"Zhang","year":"2021","journal-title":"Neural Plast."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T13:25:12Z","timestamp":1733405112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924008618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":32,"alternative-id":["S0378111924008618"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148980","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the effects of naringenin on cell functioning and energy synthesis in the hippocampus of male Wistar rats with chronic tinnitus, by examining genetic indicators such as Bax, Bcl-2, Tfam, and Pgc-1\u03b1","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148980","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"148980"}}