{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T06:55:18Z","timestamp":1777013718777,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.gene.2024.148984","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T16:00:22Z","timestamp":1728144022000},"page":"148984","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["miRNAs in umbilical Wharton\u2019s jelly in neonates with different birth weights: A pilot study"],"prefix":"10.1016","volume":"933","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-1860","authenticated-orcid":false,"given":"Cristina","family":"Garc\u00eda-Muro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Toledo-Gotor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Pasam\u00f3n-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"de Pablo-de las Heras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-3749","authenticated-orcid":false,"given":"Eduardo","family":"Esteban-Zubero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Yolanda","family":"Ruiz del Prado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Dom\u00ednguez-Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.148984_b0005","doi-asserted-by":"crossref","unstructured":"D. P. Bartel, \u201cMicroRNAs: Genomics, Biogenesis, Mechanism, and Function,\u201d Jan. 23, 2004, Cell Press. doi: 10.1016\/S0092-8674(04)00045-5.","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"10.1016\/j.gene.2024.148984_b0010","doi-asserted-by":"crossref","unstructured":"Y. Bi et al., \u201cDecreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR\/miR-4707-3p\/FOXC2 axis in esophageal squamous cell carcinoma,\u201d Cell Death Dis, vol. 11, no. 4, Apr. 2020, doi: 10.1038\/S41419-020-2492-2.","DOI":"10.1038\/s41419-020-2492-2"},{"key":"10.1016\/j.gene.2024.148984_b0015","doi-asserted-by":"crossref","unstructured":"A. Carrascosa Lezcano et al., \u201c[Spanish cross-sectional growth study 2008. Part I: weight and height values in newborns of 26-42 weeks of gestational age],\u201d An Pediatr (Barc), vol. 68, no. 6, pp. 544\u2013551, Jun. 2008, doi: 10.1157\/13123286.","DOI":"10.1157\/13123286"},{"issue":"11","key":"10.1016\/j.gene.2024.148984_b0020","doi-asserted-by":"crossref","first-page":"E1446","DOI":"10.1210\/jc.2015-2872","article-title":"Altered circulating miRNA expression profile in pregestational and gestational obesity","volume":"100","author":"Carreras-Badosa","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.gene.2024.148984_b0025","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1210\/jc.2017-00089","article-title":"Dysregulation of Placental miRNA in Maternal Obesity Is Associated With Pre- and Postnatal Growth","volume":"102","author":"Carreras-Badosa","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.gene.2024.148984_b0030","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4162\/nrp.2020.14.4.412","article-title":"Circulating microRNA expression profiling in young obese Korean women","volume":"14","author":"Choi","year":"2020","journal-title":"Nutr Res Pract"},{"key":"10.1016\/j.gene.2024.148984_b0035","doi-asserted-by":"crossref","unstructured":"B. N. Davis and A. Hata, \u201cRegulation of MicroRNA Biogenesis: A miRiad of mechanisms,\u201d 2009, Cell Commun Signal. doi: 10.1186\/1478-811X-7-18.","DOI":"10.1186\/1478-811X-7-18"},{"issue":"11","key":"10.1016\/j.gene.2024.148984_b0040","doi-asserted-by":"crossref","first-page":"e79467","DOI":"10.1371\/journal.pone.0079467","article-title":"MicroRNA miR-324-3p induces promoter-mediated espression of RelA gene","volume":"8","author":"Dharap","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gene.2024.148984_b0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000444677","article-title":"Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact?","volume":"86","author":"Fischer-Posovszky","year":"2016","journal-title":"Horm Res Paediatr"},{"issue":"D1","key":"10.1016\/j.gene.2024.148984_b0050","doi-asserted-by":"crossref","first-page":"D132","DOI":"10.1093\/nar\/gkz885","article-title":"MirGeneDB 2.0: the metazoan microRNA complement","volume":"48","author":"Fromm","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.gene.2024.148984_b0055","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41390-021-01845-4","article-title":"microRNAs in newborns with low birth weight: relation to birth size and body composition","volume":"92","author":"Garcia-Beltran","year":"2022","journal-title":"Pediatr Res"},{"issue":"1","key":"10.1016\/j.gene.2024.148984_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.53986\/ibjm.2024.0008","article-title":"MicroRNAs and their role in newborn weight","volume":"6","author":"Garc\u00eda-Muro","year":"2024","journal-title":"Iberoam J Med"},{"issue":"12","key":"10.1016\/j.gene.2024.148984_b0065","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1167\/iovs.17-22410","article-title":"A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma","volume":"58","author":"Ghanbari","year":"2017","journal-title":"Invest Ophthalmol vis Sci"},{"issue":"8","key":"10.1016\/j.gene.2024.148984_b0070","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"10.1016\/j.gene.2024.148984_b0075","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1111\/cns.14296","article-title":"Exosomal miR-6733-5p mediates cross-talk between glioblastoma stem cells and macrophages and promotes glioblastoma multiform progression synergistically","volume":"29","author":"Huang","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.gene.2024.148984_b0080","doi-asserted-by":"crossref","unstructured":"H. R. Jeong et al., \u201cExosomal miRNA Profile in Small-for-Gestational-Age Children: A Potential Biomarker for Catch-Up Growth,\u201d Genes (Basel), vol. 13, no. 6, Jun. 2022, doi: 10.3390\/GENES13060938\/S1.","DOI":"10.3390\/genes13060938"},{"key":"10.1016\/j.gene.2024.148984_b0085","doi-asserted-by":"crossref","unstructured":"H. Jiang, R. Lei, S. W. Ding, and S. Zhu, \u201cSkewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads,\u201d BMC Bioinformatics, vol. 15, no. 1, Jun. 2014, doi: 10.1186\/1471-2105-15-182.","DOI":"10.1186\/1471-2105-15-182"},{"key":"10.1016\/j.gene.2024.148984_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.950162","article-title":"A review on the role of miRNA-324 in various diseases","volume":"13","author":"Kadkhoda","year":"2022","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.gene.2024.148984_b0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/MED.0000000000000305","article-title":"Maternal epigenetics and fetal and neonatal growth","volume":"24","author":"Kitsiou-Tzeli","year":"2017","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.gene.2024.148984_b0100","doi-asserted-by":"crossref","unstructured":"A. Kozomara and S. Griffiths-Jones, \u201cmiRBase: annotating high confidence microRNAs using deep sequencing data,\u201d Nucleic Acids Res, vol. 42, no. Database issue, Jan. 2014, doi: 10.1093\/NAR\/GKT1181.","DOI":"10.1093\/nar\/gkt1181"},{"issue":"5","key":"10.1016\/j.gene.2024.148984_b0105","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.gene.2024.148984_b0110","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1039\/C0MB00230E","article-title":"Alteration of microRNA expression correlates to fatty acid-mediated insulin resistance in mouse myoblasts","volume":"7","author":"Li","year":"2011","journal-title":"Mol Biosyst"},{"issue":"12","key":"10.1016\/j.gene.2024.148984_b0115","first-page":"Dec","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"GenomeBiol"},{"key":"10.1016\/j.gene.2024.148984_b0120","article-title":"\u201cUmbilical Cord miRNAs in Small-for-Gestational-Age Children and Association With Catch-Up Growth","author":"Mas-Par\u00e9s","year":"2019","journal-title":"A Pilot Study\u201d"},{"issue":"2","key":"10.1016\/j.gene.2024.148984_b0125","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2217\/bmm-2017-0224","article-title":"Clinical evaluation of circulating miR-548a-3p and -20a expression in malignant pleural mesothelioma patients","volume":"12","author":"Matboli","year":"2018","journal-title":"Biomark Med"},{"issue":"5","key":"10.1016\/j.gene.2024.148984_b0130","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1042\/CS20030143","article-title":"Implication of lipids in macrosomia of diabetic pregnancy: can n-3 polyunsaturated fatty acids exert beneficial effects?","volume":"105","author":"Merzouk","year":"2003","journal-title":"Clin Sci (lond)"},{"key":"10.1016\/j.gene.2024.148984_b0135","doi-asserted-by":"crossref","unstructured":"L. Mulrane, S. F. McGee, W. M. Gallagher, and D. P. O\u2019Connor, \u201cmiRNA dysregulation in breast cancer,\u201d Nov. 15, 2013, Cancer Res. doi: 10.1158\/0008-5472.CAN-13-1841.","DOI":"10.1158\/0008-5472.CAN-13-1841"},{"issue":"5","key":"10.1016\/j.gene.2024.148984_b0140","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.beem.2016.08.001","article-title":"Circulating microRNAs as biomarkers for metabolic disease","volume":"30","author":"P\u00e1rrizas","year":"2016","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.gene.2024.148984_b0145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.atherosclerosis.2005.03.022","article-title":"Lower birth weight predicts metabolic syndrome in young adults: the Atherosclerosis Risk in Young Adults (ARYA)-study","volume":"184","author":"Ramadhani","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.gene.2024.148984_b0150","doi-asserted-by":"crossref","unstructured":"T. M. Rana, \u201cIlluminating the silence: Understanding the structure and function of small RNAs,\u201d Jan. 2007, Nat Rev Mol Cell Biol. doi: 10.1038\/nrm2085.","DOI":"10.1038\/nrm2085"},{"issue":"6772","key":"10.1016\/j.gene.2024.148984_b0155","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.gene.2024.148984_b0160","doi-asserted-by":"crossref","first-page":"Dec","DOI":"10.3390\/ijms18122552","article-title":"Analysis of microRNA expression in newborns with differential birthweight using newborn screening cards","volume":"18","author":"Rodil-Garcia","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.gene.2024.148984_b0165","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1080\/15592294.2017.1358345","article-title":"Second trimester extracellular microRNAs in maternal blood and fetal growth: An exploratory study","volume":"12","author":"Rodosthenous","year":"2017","journal-title":"Epigenetics"},{"issue":"12","key":"10.1016\/j.gene.2024.148984_b0170","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/heartjnl-2013-305402","article-title":"MicroRNAs in cardiovascular disease: an introduction for clinicians","volume":"101","author":"Romaine","year":"2015","journal-title":"Heart"},{"issue":"5","key":"10.1016\/j.gene.2024.148984_b0175","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1039\/C5MB00064E","article-title":"microRNAs with different functions and roles in disease development and as potential biomarkers of diabetes: progress and challenges","volume":"11","author":"Seyhan","year":"2015","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.gene.2024.148984_b0180","doi-asserted-by":"crossref","unstructured":"A. Torimura et al., \u201cProfiling miRNAs in tear extracellular vesicles: a pilot study with implications for diagnosis of ocular diseases,\u201d Jpn J Ophthalmol, vol. 68, no. 1, Jan. 2024, doi: 10.1007\/S10384-023-01028-0.","DOI":"10.1007\/s10384-023-01028-0"},{"key":"10.1016\/j.gene.2024.148984_b0185","doi-asserted-by":"crossref","unstructured":"I. G. C. Vonh\u00f6gen et al., \u201cMiR-337-3p Promotes Adipocyte Browning by Inhibiting TWIST1,\u201d Cells, vol. 9, no. 4, Apr. 2020, doi: 10.3390\/CELLS9041056.","DOI":"10.3390\/cells9041056"},{"issue":"2","key":"10.1016\/j.gene.2024.148984_b0190","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/jcb.26659","article-title":"MiR-548a-3p regulates inflammatory response via TLR4\/NF-\u03baB signaling pathway in rheumatoid arthritis","volume":"120","author":"Wang","year":"2019","journal-title":"J Cell Biochem"},{"issue":"1","key":"10.1016\/j.gene.2024.148984_b0195","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcyt.2014.08.009","article-title":"Discarded Wharton jelly of the human umbilical cord: a viable source for mesenchymal stromal cells","volume":"17","author":"Watson","year":"2015","journal-title":"Cytotherapy"},{"issue":"11","key":"10.1016\/j.gene.2024.148984_b0200","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin Chem"},{"key":"10.1016\/j.gene.2024.148984_b0205","doi-asserted-by":"crossref","unstructured":"X. Xu et al., \u201cMiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism,\u201d iScience, vol. 26, no. 11, Nov. 2023, doi: 10.1016\/J.ISCI.2023.108352.","DOI":"10.1016\/j.isci.2023.108352"},{"key":"10.1016\/j.gene.2024.148984_b0210","doi-asserted-by":"crossref","unstructured":"L. A. Yates, C. J. Norbury, and R. J. C. Gilbert, \u201cThe long and short of microRNA,\u201d Apr. 25, 2013, Elsevier B.V. doi: 10.1016\/j.cell.2013.04.003.","DOI":"10.1016\/j.cell.2013.04.003"},{"key":"10.1016\/j.gene.2024.148984_b0215","article-title":"miRge 2.0: An updated tool to comprehensively analyze microRNA sequencing data","author":"Yin","year":"2018","journal-title":"BMC Bioinf."},{"issue":"1","key":"10.1016\/j.gene.2024.148984_b0220","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Yoav. Benjamini and Yosef. Hochberg,","year":"1995","journal-title":"J. R. Stat. Soc."},{"key":"10.1016\/j.gene.2024.148984_b0225","doi-asserted-by":"crossref","unstructured":"S. L. Yong and A. Dutta, \u201cMicroRNAs in cancer,\u201d Feb. 2009, Annu Rev Pathol. doi: 10.1146\/annurev.pathol.4.110807.092222.","DOI":"10.1146\/annurev.pathol.4.110807.092222"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T13:25:17Z","timestamp":1733405117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924008655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S0378111924008655"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.148984","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miRNAs in umbilical Wharton\u2019s jelly in neonates with different birth weights: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.148984","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"148984"}}