{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:52:08Z","timestamp":1771231928572,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.gene.2024.149004","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T10:40:45Z","timestamp":1729075245000},"page":"149004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Association of Vitamin D receptor gene polymorphism with susceptibility and prognosis of Systemic Lupus Erythematosus in Chinese patients"],"prefix":"10.1016","volume":"933","author":[{"given":"Shiyi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuman","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yantong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyu","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.gene.2024.149004_b0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cyto.2008.12.009","article-title":"1Alpha,25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes","volume":"45","author":"Almerighi","year":"2009","journal-title":"Cytokine"},{"issue":"11","key":"10.1016\/j.gene.2024.149004_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/biom11111624","article-title":"The effects of Vitamin D on immune system and inflammatory diseases","volume":"11","author":"Ao","year":"2021","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.gene.2024.149004_b0015","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/annrheumdis-2018-214819","article-title":"2019 European League Against Rheumatism\/American College of Rheumatology classification criteria for systemic lupus erythematosus","volume":"78","author":"Aringer","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.gene.2024.149004_b0020","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s10067-018-4036-z","article-title":"Vitamin D receptor FokI, TaqI, and ApaI polymorphisms and susceptibility to systemic lupus erythematosus: an updated meta-analysis","volume":"37","author":"Bae","year":"2018","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.gene.2024.149004_b0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jneuroim.2017.01.009","article-title":"Vitamin D receptor gene polymorphisms are associated with multiple sclerosis in Mexican adults","volume":"306","author":"Bermudez-Morales","year":"2017","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.gene.2024.149004_b0030","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/art.1780350606","article-title":"Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE","volume":"35","author":"Bombardier","year":"1992","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.gene.2024.149004_b0035","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.4049\/jimmunol.167.9.4974","article-title":"1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells","volume":"167","author":"Boonstra","year":"2001","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.gene.2024.149004_b0040","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1177\/0961203314566636","article-title":"Association between vitamin D receptor (VDR) gene polymorphisms and systemic lupus erythematosus in Portuguese patients","volume":"24","author":"Carvalho","year":"2015","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.gene.2024.149004_b0045","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s12026-017-8914-2","article-title":"A population association study of vitamin D receptor gene polymorphisms and haplotypes with the risk of systemic lupus erythematosus in a Chinese population","volume":"65","author":"Chen","year":"2017","journal-title":"Immunol. Res."},{"issue":"1","key":"10.1016\/j.gene.2024.149004_b0050","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"issue":"11","key":"10.1016\/j.gene.2024.149004_b0055","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1177\/0961203313500549","article-title":"Vitamin D receptor (VDR) gene polymorphisms and susceptibility to systemic lupus erythematosus clinical manifestations","volume":"22","author":"de Azevedo Silva","year":"2013","journal-title":"Lupus"},{"issue":"6","key":"10.1016\/j.gene.2024.149004_b0060","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3109\/08916934.2013.795952","article-title":"Vitamin D receptor (VDR) gene polymorphisms and age onset in type 1 diabetes mellitus","volume":"46","author":"De Azevedo Silva","year":"2013","journal-title":"Autoimmunity"},{"issue":"95","key":"10.1016\/j.gene.2024.149004_b0065","first-page":"247","article-title":"Advances in mechanisms of systemic lupus erythematosus","volume":"17","author":"Dema","year":"2014","journal-title":"Discov. Med."},{"issue":"11","key":"10.1016\/j.gene.2024.149004_b0070","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1007\/s11033-013-2726-9","article-title":"Role of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D level in Egyptian female patients with systemic lupus erythematosus","volume":"40","author":"Emerah","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.gene.2024.149004_b0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.rcreue.2021.04.008","article-title":"Association of FokI polymorphism of the VDR gene with systemic lupus erythematosus in an adolescent population of the Colombian Caribbean: [[es]]Asociaci\u00f3n del poRkI del gen VDR y lupus eritematoso sist\u00e9mico en poblaci\u00f3n adolescente del Caribe colombiano","volume":"30","author":"Garavito","year":"2023","journal-title":"Revista Colombiana De Reumatolog\u00eda (english Edition)"},{"key":"10.1016\/j.gene.2024.149004_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2018.12.014","article-title":"Novel genetic associations with interferon in systemic lupus erythematosus identified by replication and fine-mapping of trait-stratified genome-wide screen","volume":"132","author":"Ghodke-Puranik","year":"2020","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.gene.2024.149004_b0085","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.4049\/jimmunol.167.4.1945","article-title":"Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance","volume":"167","author":"Gregori","year":"2001","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.gene.2024.149004_b0090","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2011.05.010","article-title":"Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2)vitamin D(3): genomic and non-genomic mechanisms","volume":"25","author":"Haussler","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"13","key":"10.1016\/j.gene.2024.149004_b0095","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1177\/0961203317725588","article-title":"Vitamin D receptor gene FokI polymorphism in Egyptian children and adolescents with SLE: A case-control study","volume":"26","author":"Imam","year":"2017","journal-title":"Lupus"},{"issue":"2","key":"10.1016\/j.gene.2024.149004_b0100","doi-asserted-by":"crossref","first-page":"106","DOI":"10.18176\/jiaci.0020","article-title":"Vitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis","volume":"26","author":"Kilic","year":"2016","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"issue":"2","key":"10.1016\/j.gene.2024.149004_b0105","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/1756-185X.13245","article-title":"Association between vitamin D receptor polymorphisms and systemic lupus erythematosus in an Indian cohort","volume":"21","author":"Mahto","year":"2018","journal-title":"Int. J. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.gene.2024.149004_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/genes13112016","article-title":"Vitamin D Receptor (VDR) genetic variants: relationship of foki genotypes with vdr expression and clinical disease activity in systemic lupus erythematosus patients","volume":"13","author":"Meza-Meza","year":"2022","journal-title":"Genes (Basel)"},{"issue":"10","key":"10.1016\/j.gene.2024.149004_b0115","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s10067-012-2021-5","article-title":"Vitamin D and polymorphisms of VDR gene in patients with systemic lupus erythematosus","volume":"31","author":"Monticielo","year":"2012","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.gene.2024.149004_b0120","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s11033-012-2118-6","article-title":"Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus","volume":"40","author":"Mostowska","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"9","key":"10.1016\/j.gene.2024.149004_b0125","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.4049\/jimmunol.164.9.4443","article-title":"Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells","volume":"164","author":"Piemonti","year":"2000","journal-title":"J. Immunol."},{"issue":"24","key":"10.1016\/j.gene.2024.149004_b0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249626","article-title":"Association of Vitamin D metabolism gene polymorphisms with autoimmunity: evidence in population genetic studies","volume":"21","author":"Ruiz-Ballesteros","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.gene.2024.149004_b0135","doi-asserted-by":"crossref","first-page":"14065","DOI":"10.1038\/s41598-018-32482-3","article-title":"Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis","volume":"8","author":"Triantos","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.gene.2024.149004_b0140","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/0961203320909432","article-title":"Associations of four common VDR polymorphisms with rheumatoid arthritis and systemic lupus erythematosus: evidence from a meta-analysis","volume":"29","author":"Zhang","year":"2020","journal-title":"Lupus"},{"issue":"1\u20132","key":"10.1016\/j.gene.2024.149004_b0145","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/08820139.2019.1674325","article-title":"VDR gene polymorphisms and allergic diseases: evidence from a meta-analysis","volume":"49","author":"Zhang","year":"2020","journal-title":"Immunol. Invest."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T13:35:06Z","timestamp":1733405706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924008850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":29,"alternative-id":["S0378111924008850"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.149004","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Vitamin D receptor gene polymorphism with susceptibility and prognosis of Systemic Lupus Erythematosus in Chinese patients","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.149004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149004"}}