{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:42:15Z","timestamp":1782978135081,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1504802"],"award-info":[{"award-number":["U1504802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.gene.2024.149007","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T22:19:45Z","timestamp":1729289985000},"page":"149007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Identification and validation of diagnostic biomarkers and immune infiltration in dilated cardiomyopathies with heart failure and construction of diagnostic model"],"prefix":"10.1016","volume":"934","author":[{"given":"Zhaodi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobiao","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.gene.2024.149007_b0005","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/eurjpc\/zwaa147","article-title":"Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017","volume":"28","author":"Bragazzi","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"1","key":"10.1016\/j.gene.2024.149007_b0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.00607-15","article-title":"Dissection of thrombospondin-4 domains involved in intracellular adaptive endoplasmic reticulum stress-responsive signaling","volume":"36","author":"Brody","year":"2016","journal-title":"Mol. Cell Biol."},{"issue":"14","key":"10.1016\/j.gene.2024.149007_b0015","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00114-18","article-title":"Defective flux of thrombospondin-4 through the secretory pathway impairs cardiomyocyte membrane stability and causes cardiomyopathy","volume":"38","author":"Brody","year":"2018","journal-title":"Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.gene.2024.149007_b0020","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.ajpath.2019.04.009","article-title":"Heart inflammation: immune cell roles and roads to the heart","volume":"189","author":"Carrillo-Salinas","year":"2019","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.gene.2024.149007_b0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","article-title":"Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade","volume":"18","author":"Charoentong","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.gene.2024.149007_b0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s13105-019-00665-9","article-title":"THBS4 predicts poor outcomes and promotes proliferation and metastasis in gastric cancer","volume":"75","author":"Chen","year":"2019","journal-title":"J. Physiol. Biochem."},{"issue":"D1","key":"10.1016\/j.gene.2024.149007_b0035","doi-asserted-by":"crossref","first-page":"D127","DOI":"10.1093\/nar\/gkz757","article-title":"miRDB: an online database for prediction of functional microRNA targets","volume":"48","author":"Chen","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"Suppl 4","key":"10.1016\/j.gene.2024.149007_b0040","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.gene.2024.149007_b0045","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43882","article-title":"Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury","volume":"8","author":"Farbehi","year":"2019","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.gene.2024.149007_b0050","doi-asserted-by":"crossref","first-page":"C826","DOI":"10.1152\/ajpcell.00251.2021","article-title":"In the balance: how do thrombospondins contribute to the cellular pathophysiology of cardiovascular disease?","volume":"321","author":"Forbes","year":"2021","journal-title":"Am J. Physiol-Cell Ph."},{"issue":"2","key":"10.1016\/j.gene.2024.149007_b0055","first-page":"431","article-title":"Dilated cardiomyopathy: a new insight into the rare but common cause of heart failure. Heart Fail","volume":"27","author":"Giri","year":"2022","journal-title":"Rev"},{"key":"10.1016\/j.gene.2024.149007_b0060","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s00059-002-2425-0","article-title":"Sudden cardiac death in dilated cardiomyopathy \u2013 therapeutic options","volume":"27","author":"Grimm","year":"2002","journal-title":"Herz"},{"issue":"5","key":"10.1016\/j.gene.2024.149007_b0065","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s10528-021-10050-1","article-title":"Osteomodulin is a potential genetic target for hypertrophic cardiomyopathy","volume":"59","author":"Guo","year":"2021","journal-title":"Biochem. Genet."},{"issue":"8","key":"10.1016\/j.gene.2024.149007_b0070","doi-asserted-by":"crossref","first-page":"10668","DOI":"10.1096\/fj.202000043R","article-title":"THBS4 promotes HCC progression by regulating ITGB1 via FAK\/PI3K\/AKT pathway","volume":"34","author":"Guo","year":"2020","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.gene.2024.149007_b0075","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/CIRCULATIONAHA.106.632430","article-title":"Transcriptional genomics associates FOX transcription factors with human heart failure","volume":"114","author":"Hannenhalli","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2024.149007_b0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"issue":"10","key":"10.1016\/j.gene.2024.149007_b0085","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/pros.23989","article-title":"THBS4 silencing regulates the cancer stem cell-like properties in prostate cancer via blocking the PI3K\/Akt pathway","volume":"80","author":"Hou","year":"2020","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.gene.2024.149007_b0090","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.gene.2024.149007_b0095","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1056\/NEJMoa033088","article-title":"Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy","volume":"350","author":"Kadish","year":"2004","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.gene.2024.149007_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.664457","article-title":"Cells of the immune system in cardiac remodeling: main players in resolution of inflammation and repair after myocardial infarction","volume":"12","author":"Kologrivova","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2024.149007_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1058834","article-title":"WGCNA combined with machine learning algorithms for analyzing key genes and immune cell infiltration in heart failure due to ischemic cardiomyopathy","volume":"10","author":"Kong","year":"2023","journal-title":"Front Cardiovasc Med."},{"key":"10.1016\/j.gene.2024.149007_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.817514","article-title":"Pro-inflammatory derangement of the immuno-interactome in heart failure","volume":"13","author":"Kumar","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2024.149007_b0115","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/s41598-022-26277-w","article-title":"Identification of key immune-related genes in dilated cardiomyopathy using bioinformatics analysis","volume":"13","author":"Li","year":"2023","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.gene.2024.149007_b0120","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.21037\/jtd-21-168","article-title":"Identification of key immune-related genes and immune infiltration in atrial fibrillation with valvular heart disease based on bioinformatics analysis","volume":"13","author":"Li","year":"2021","journal-title":"J. Thorac. Dis."},{"issue":"2","key":"10.1016\/j.gene.2024.149007_b0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ygeno.2014.12.002","article-title":"RNA-Seq identifies novel myocardial gene expression signatures of heart failure","volume":"105","author":"Liu","year":"2015","journal-title":"Genomics"},{"key":"10.1016\/j.gene.2024.149007_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.747803","article-title":"An robust rank aggregation and least absolute shrinkage and selection operator analysis of novel gene signatures in dilated cardiomyopathy","volume":"8","author":"Ma","year":"2021","journal-title":"Front Cardiovasc Med."},{"issue":"25","key":"10.1016\/j.gene.2024.149007_b0135","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1161\/CIRCULATIONAHA.119.041694","article-title":"Single-cell sequencing of mouse heart immune infiltrate in pressure overload-driven heart failure reveals extent of immune activation","volume":"140","author":"Martini","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.gene.2024.149007_b0140","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s12079-021-00616-4","article-title":"Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans","volume":"15","author":"Matsushima","year":"2021","journal-title":"J. Cell Commun. Signal"},{"key":"10.1016\/j.gene.2024.149007_b0145","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.carpath.2018.03.003","article-title":"Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension","volume":"35","author":"Palao","year":"2018","journal-title":"Cardiovasc. Pathol."},{"issue":"2","key":"10.1016\/j.gene.2024.149007_b0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/bib\/bbl035","article-title":"Evolving research trends in bioinformatics","volume":"8","author":"Perez-Iratxeta","year":"2007","journal-title":"Brief. Bioinform."},{"issue":"4","key":"10.1016\/j.gene.2024.149007_b0155","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/joim.12944","article-title":"Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: a translational review of current literature","volume":"286","author":"Reichart","year":"2019","journal-title":"J. Intern. Med."},{"issue":"7","key":"10.1016\/j.gene.2024.149007_b0160","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.gene.2024.149007_b0165","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf."},{"issue":"1","key":"10.1016\/j.gene.2024.149007_b0170","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41572-019-0084-1","article-title":"Dilated cardiomyopathy","volume":"5","author":"Schultheiss","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"Suppl M","key":"10.1016\/j.gene.2024.149007_b0175","doi-asserted-by":"crossref","first-page":"M40","DOI":"10.1093\/eurheartj\/suz212","article-title":"Heart failure in dilated non-ischaemic cardiomyopathy","volume":"21","author":"Seferovi\u0107","year":"2019","journal-title":"Eur. Heart J. Suppl."},{"issue":"5","key":"10.1016\/j.gene.2024.149007_b0180","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ejhf.1461","article-title":"Heart failure in cardiomyopathies: a position paper from the heart failure association of the european society of cardiology","volume":"21","author":"Seferovi\u0107","year":"2019","journal-title":"Eur. J. Heart Fail."},{"issue":"11","key":"10.1016\/j.gene.2024.149007_b0185","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"2","key":"10.1016\/j.gene.2024.149007_b0190","doi-asserted-by":"crossref","first-page":"e682","DOI":"10.1002\/ctm2.682","article-title":"Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification","volume":"12","author":"Skenteris","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.gene.2024.149007_b0195","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.matbio.2017.11.006","article-title":"Thrombospondin-4 in tissue remodeling","volume":"75\u201376","author":"Stenina-Adognravi","year":"2019","journal-title":"Matrix. Biol."},{"key":"10.1016\/j.gene.2024.149007_b0200","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2164017","article-title":"Role of inflammatory cell subtypes in heart failure","volume":"2019","author":"Strassheim","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.gene.2024.149007_b0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s42003-018-0038-2","article-title":"Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin","volume":"1","author":"Tashima","year":"2018","journal-title":"Commun. Biol."},{"issue":"3","key":"10.1016\/j.gene.2024.149007_b0210","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/imm.12728","article-title":"CD4+ CD25+ GARP+ regulatory T cells display a compromised suppressive function in patients with dilated cardiomyopathy","volume":"151","author":"Wei","year":"2017","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.gene.2024.149007_b0215","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (N Y)"},{"key":"10.1016\/j.gene.2024.149007_b0220","article-title":"Integrated bioinformatics-based analysis of hub genes and the mechanism of immune infiltration associated with acute myocardial infarction","volume":"9","author":"Wu","year":"2022","journal-title":"Front Cardiovasc. Med."},{"issue":"18","key":"10.1016\/j.gene.2024.149007_b0225","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","article-title":"DSigDB: drug signatures database for gene set analysis","volume":"31","author":"Yoo","year":"2015","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.gene.2024.149007_b0230","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/bioinformatics\/btu684","article-title":"DOSE: an R\/Bioconductor package for disease ontology semantic and enrichment analysis","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.gene.2024.149007_b0235","first-page":"1475","article-title":"Identification MNS1, FRZB, OGN, LUM, SERP1NA3 and FCN3 as the potential immune-related key genes involved in ischaemic cardiomyopathy by random forest and nomogram","volume":"15","author":"Zheng","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"W1","key":"10.1016\/j.gene.2024.149007_b0240","doi-asserted-by":"crossref","first-page":"W234","DOI":"10.1093\/nar\/gkz240","article-title":"NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2024.149007_b0245","article-title":"Identification and verification of feature biomarkers associated with immune cells in dilated cardiomyopathy by bioinformatics analysis","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.gene.2024.149007_b0250","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00380-019-01453-7","article-title":"Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes","volume":"35","author":"Zierfuss","year":"2020","journal-title":"Heart Vessels"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T18:14:49Z","timestamp":1732040089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924008886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":50,"alternative-id":["S0378111924008886"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.149007","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and validation of diagnostic biomarkers and immune infiltration in dilated cardiomyopathies with heart failure and construction of diagnostic model","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.149007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149007"}}