{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:08:06Z","timestamp":1793912886679,"version":"4.8.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2019JJ20035"],"award-info":[{"award-number":["2019JJ20035"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.gene.2024.149009","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T22:19:57Z","timestamp":1729289997000},"page":"149009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Downregulation of ferroptosis-related ATF3 alleviates lupus nephritis progression"],"prefix":"10.1016","volume":"934","author":[{"given":"Gong","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongjing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.gene.2024.149009_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062903","article-title":"Incorporating machine learning into established bioinformatics frameworks","volume":"22","author":"Auslander","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"157","key":"10.1016\/j.gene.2024.149009_b0010","doi-asserted-by":"crossref","first-page":"157ra141","DOI":"10.1126\/scitranslmed.3004801","article-title":"NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus","volume":"4","author":"Campbell","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.gene.2024.149009_b0015","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/annrheumdis-2019-215089","article-title":"2019 update of the EULAR recommendations for the management of systemic lupus erythematosus","volume":"78","author":"Fanouriakis","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.gene.2024.149009_b0020","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/annrheumdis-2020-216924","article-title":"2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR\/ERA-EDTA) recommendations for the management of lupus nephritis","volume":"79","author":"Fanouriakis","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.gene.2024.149009_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108971","article-title":"Blockage of TIM-3 relieves lupus nephritis by expanding Treg cells and promoting their suppressive capacity in MRL\/lpr mice","volume":"110","author":"Gao","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.gene.2024.149009_b0030","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1046\/j.1523-1755.2000.00272.x","article-title":"A new morphologic index for the evaluation of renal biopsies in lupus nephritis","volume":"58","author":"Hill","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.gene.2024.149009_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.897669","article-title":"Qinghao-Biejia herb pair alleviates pristane-induced lupus-like disease and associated renal and aortic lesions in ApoE(-\/-) mice","volume":"13","author":"Hong","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.gene.2024.149009_b0040","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/art.40141","article-title":"Haploinsufficiency of NADPH oxidase subunit neutrophil cytosolic factor 2 is sufficient to accelerate full-blown lupus in NZM 2328 mice","volume":"69","author":"Jacob","year":"2017","journal-title":"Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.gene.2024.149009_b0045","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/SLA.0000000000005349","article-title":"Imaging-based machine-learning models to predict clinical outcomes and identify biomarkers in pancreatic cancer: a scoping review","volume":"275","author":"Janssen","year":"2022","journal-title":"Ann. Surg."},{"issue":"8","key":"10.1016\/j.gene.2024.149009_b0050","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0891-5849(02)01006-7","article-title":"The labile iron pool: characterization, measurement, and participation in cellular processes(1)","volume":"33","author":"Kakhlon","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.gene.2024.149009_b0055","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.cellsig.2009.07.011","article-title":"A critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: controlled by ATF3","volume":"21","author":"Kim","year":"2009","journal-title":"Cell. Signal."},{"key":"10.1016\/j.gene.2024.149009_b0060","doi-asserted-by":"crossref","first-page":"1684017","DOI":"10.1155\/2022\/1684017","article-title":"A novel diabetes healthcare disease prediction framework using machine learning techniques","volume":"2022","author":"Krishnamoorthi","year":"2022","journal-title":"J. Healthc. Eng."},{"issue":"11","key":"10.1016\/j.gene.2024.149009_b0065","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2215\/CJN.01570219","article-title":"Sensitivity and specificity of pathologic findings to diagnose lupus nephritis","volume":"14","author":"Kudose","year":"2019","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"18","key":"10.1016\/j.gene.2024.149009_b0070","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1089\/ars.2011.4271","article-title":"Mammalian iron homeostasis in health and disease: uptake, storage, transport, and molecular mechanisms of action","volume":"18","author":"Lawen","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.gene.2024.149009_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2020.104151","article-title":"Machine learning model for predicting malaria using clinical information","volume":"129","author":"Lee","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.gene.2024.149009_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114434","article-title":"Paeoniflorin ameliorates murine lupus nephritis by increasing CD4(+)Foxp3(+) Treg cells via enhancing mTNF\u03b1-TNFR2 pathway","volume":"185","author":"Liang","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.gene.2024.149009_b0085","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.683249","article-title":"Total glucosides of paeony ameliorate pristane-induced lupus nephritis by inducing PD-1 ligands(+) macrophages via activating IL-4\/STAT6\/PD-L2 signaling","volume":"12","author":"Liang","year":"2021","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.gene.2024.149009_b0090","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/ki.2013.135","article-title":"Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease","volume":"84","author":"Lu","year":"2013","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.gene.2024.149009_b0095","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000431214","article-title":"Macrophage phenotype in kidney injury and repair","volume":"1","author":"Meng","year":"2015","journal-title":"Kidney Dis. (Basel)"},{"key":"10.1016\/j.gene.2024.149009_b0100","doi-asserted-by":"crossref","first-page":"7351061","DOI":"10.1155\/2022\/7351061","article-title":"Machine learning technology-based heart disease detection models","volume":"2022","author":"Nagavelli","year":"2022","journal-title":"J. Healthc. Eng."},{"issue":"10","key":"10.1016\/j.gene.2024.149009_b0105","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1681\/ASN.2016040415","article-title":"Current and emerging therapies for lupus nephritis","volume":"27","author":"Parikh","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"7894","key":"10.1016\/j.gene.2024.149009_b0110","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41586-021-04278-5","article-title":"Multi-omic machine learning predictor of breast cancer therapy response","volume":"601","author":"Sammut","year":"2022","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.gene.2024.149009_b0115","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/icb.2016.34","article-title":"Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-\u03b2","volume":"94","author":"Schmidt","year":"2016","journal-title":"Immunol. Cell Biol."},{"issue":"8","key":"10.1016\/j.gene.2024.149009_b0120","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/ars.2014.5987","article-title":"ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation","volume":"22","author":"Shan","year":"2015","journal-title":"Antioxid. Redox Signal."},{"issue":"12","key":"10.1016\/j.gene.2024.149009_b0125","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/s41419-020-03271-6","article-title":"Transcriptional factor ATF3 promotes liver fibrosis via activating hepatic stellate cells","volume":"11","author":"Shi","year":"2020","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.gene.2024.149009_b0130","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/imm.13294","article-title":"The role of neuraminidase in TLR4-MAPK signalling and the release of cytokines by lupus serum-stimulated mesangial cells","volume":"162","author":"Sundararaj","year":"2021","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.gene.2024.149009_b0135","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41581-019-0110-2","article-title":"Macrophages: versatile players in renal inflammation and fibrosis","volume":"15","author":"Tang","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"6","key":"10.1016\/j.gene.2024.149009_b0140","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/art.39594","article-title":"Risk of end-stage renal disease in patients with Lupus Nephritis, 1971\u20132015: a systematic review and Bayesian meta-analysis","volume":"68","author":"Tektonidou","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.gene.2024.149009_b0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1039\/C5MT00215J","article-title":"Iron transport in the kidney: implications for physiology and cadmium nephrotoxicity","volume":"8","author":"Th\u00e9venod","year":"2016","journal-title":"Metallomics"},{"issue":"1","key":"10.1016\/j.gene.2024.149009_b0150","doi-asserted-by":"crossref","first-page":"9353","DOI":"10.1038\/s41598-018-27107-8","article-title":"Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease","volume":"8","author":"van Raaij","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.gene.2024.149009_b0155","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41581-019-0197-5","article-title":"The multifaceted role of iron in renal health and disease","volume":"16","author":"van Swelm","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.gene.2024.149009_b0160","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","article-title":"ATF3 promotes erastin-induced ferroptosis by suppressing system Xc","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.gene.2024.149009_b0165","article-title":"Iron metabolism: an under investigated driver of renal pathology in lupus nephritis","volume":"8","author":"Wlazlo","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.gene.2024.149009_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107563","article-title":"Iguratimod ameliorates nephritis by modulating the Th17\/Treg paradigm in pristane-induced lupus","volume":"96","author":"Xia","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.gene.2024.149009_b0175","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3389\/fphar.2020.00929","article-title":"Coptisine alleviates pristane-induced lupus-like disease and associated kidney and cardiovascular complications in mice","volume":"11","author":"Yan","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.gene.2024.149009_b0180","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1167\/tvst.10.2.29","article-title":"Genome-wide association studies-based machine learning for prediction of age-related macular degeneration risk","volume":"10","author":"Yan","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.gene.2024.149009_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106891","article-title":"MicroRNA-10a-3p mediates Th17\/Treg cell balance and improves renal injury by inhibiting REG3A in lupus nephritis","volume":"88","author":"You","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.gene.2024.149009_b0190","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00441-020-03248-z","article-title":"LncRNA NEAT1 accelerates renal mesangial cell injury via modulating the miR-146b\/TRAF6\/NF-\u03baB axis in lupus nephritis","volume":"382","author":"Zhang","year":"2020","journal-title":"Cell Tissue Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924008904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T18:14:54Z","timestamp":1732040094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924008904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":38,"alternative-id":["S0378111924008904"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.149009","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of ferroptosis-related ATF3 alleviates lupus nephritis progression","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.149009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149009"}}